KEGG   PATHWAY: mmur04814
Entry
mmur04814                   Pathway                                
Name
Motor proteins - Microcebus murinus (gray mouse lemur)
Class
Cellular Processes; Cell motility
Pathway map
mmur04814  Motor proteins
mmur04814

Organism
Microcebus murinus (gray mouse lemur) [GN:mmur]
Gene
105861057  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
105874585  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 [KO:K10414]
105867254  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
105880719  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
105873877  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
105858981  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
105866823  DYNC2LI1; cytoplasmic dynein 2 light intermediate chain 1 [KO:K10417]
105866898  DYNLL1; dynein light chain 1, cytoplasmic [KO:K10418]
105875622  dynein light chain 1, cytoplasmic [KO:K10418]
105870284  DYNLL2; dynein light chain 2, cytoplasmic isoform X1 [KO:K10418]
105861217  dynein light chain roadblock-type 2 [KO:K10419]
105865826  DYNLRB1; dynein light chain roadblock-type 1 isoform X1 [KO:K10419]
105868612  DYNLT1; dynein light chain Tctex-type 1 [KO:K10420]
105855599  DYNLT3; dynein light chain Tctex-type 3 [KO:K10420]
105881072  TCTE3; tctex1 domain-containing protein 3 [KO:K25419]
105877451  TCTEX1D4; tctex1 domain-containing protein 4 [KO:K25420]
105872837  TCTEX1D1; tctex1 domain-containing protein 1 [KO:K25421]
105866712  DNAH17; dynein heavy chain 17, axonemal [KO:K10408]
105875044  DNAH1; dynein heavy chain 1, axonemal isoform X1 [KO:K10408]
105861424  DNAH8; dynein heavy chain 8, axonemal [KO:K10408]
105875939  DNAH11; dynein heavy chain 11, axonemal [KO:K10408]
105876574  DNAH6; dynein heavy chain 6, axonemal isoform X1 [KO:K10408]
105877376  DNAH2; dynein heavy chain 2, axonemal isoform X1 [KO:K10408]
105885311  DNAH3; dynein heavy chain 3, axonemal [KO:K10408]
105885375  DNAH5; dynein heavy chain 5, axonemal isoform X1 [KO:K10408]
105877921  DNAH7; dynein heavy chain 7, axonemal isoform X1 [KO:K10408]
105863729  DNAH14; LOW QUALITY PROTEIN: dynein heavy chain 14, axonemal [KO:K10408]
105878285  DNAH9; LOW QUALITY PROTEIN: dynein heavy chain 9, axonemal [KO:K10408]
105880824  DNAH10; dynein heavy chain 10, axonemal [KO:K10408]
105874348  DNAI1; dynein intermediate chain 1, axonemal [KO:K10409]
105878894  DNAI2; dynein intermediate chain 2, axonemal [KO:K11143]
105861807  WDR63; WD repeat-containing protein 63 isoform X1 [KO:K24722]
105872842  WD repeat-containing protein 78-like isoform X1 [KO:K24723]
105872843  WD repeat-containing protein 78-like isoform X1 [KO:K24723]
105879573  DNALI1; LOW QUALITY PROTEIN: axonemal dynein light intermediate polypeptide 1 [KO:K10410]
105858419  DNAL1; dynein light chain 1, axonemal isoform X1 [KO:K10411]
105858621  DNAL4; dynein light chain 4, axonemal isoform X1 [KO:K10412]
105884583  DCTN1; dynactin subunit 1 isoform X7 [KO:K04648]
105877983  DCTN2; dynactin subunit 2 isoform X1 [KO:K10424]
105874344  DCTN3; dynactin subunit 3 isoform X1 [KO:K10425]
105885876  DCTN4; dynactin subunit 4 isoform X1 [KO:K10426]
105879725  DCTN5; dynactin subunit 5 [KO:K10427]
105882061  DCTN6; dynactin subunit 6 [KO:K10428]
105874296  ACTR1A; alpha-centractin [KO:K16575]
105883658  ACTR1B; beta-centractin [KO:K16575]
105860188  LOW QUALITY PROTEIN: actin-related protein 10-like [KO:K16576]
105882889  ACTR10; actin-related protein 10 [KO:K16576]
105882822  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
105869361  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
105878755  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
105884014  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
105866866  BICDL1; BICD family-like cargo adapter 1 isoform X1 [KO:K16756]
105859735  BICDL2; BICD family-like cargo adapter 2 isoform X1 [KO:K16756]
105878135  HOOK3; protein Hook homolog 3 isoform X1 [KO:K16536]
105860065  tubulin alpha-8 chain [KO:K07374]
105861860  TUBA8; tubulin alpha-8 chain [KO:K07374]
105869479  tubulin alpha-1A chain-like isoform X1 [KO:K07374]
105869496  tubulin alpha-1A chain [KO:K07374]
105869504  TUBA1C; tubulin alpha-1C chain [KO:K07374]
105877774  tubulin alpha-3 chain [KO:K07374]
105857673  TUBA4A; tubulin alpha-4A chain [KO:K07374]
105858209  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
105874513  TUBB1; tubulin beta-1 chain [KO:K07375]
105882254  TUBB4B; tubulin beta-4B chain [KO:K07375]
105860986  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
105869676  TUBB4A; tubulin beta-4A chain [KO:K07375]
105855398  TUBB; tubulin beta chain [KO:K07375]
105877917  tubulin beta chain-like [KO:K07375]
105873482  tubulin beta-2A chain isoform X1 [KO:K07375]
105859402  tubulin gamma-2 chain [KO:K10389]
105859406  TUBG1; tubulin gamma-1 chain [KO:K10389]
105877255  LOW QUALITY PROTEIN: tubulin gamma-2 chain-like [KO:K10389]
105874878  TUBD1; tubulin delta chain isoform X1 [KO:K10390]
105864936  TUBE1; tubulin epsilon chain isoform X1 [KO:K10391]
105881706  KIF5B; kinesin-1 heavy chain [KO:K10396]
105877979  KIF5A; kinesin heavy chain isoform X1 [KO:K10396]
105857620  KIF5C; kinesin heavy chain [KO:K10396]
105867447  KLC2; kinesin light chain 2 [KO:K10407]
105861075  kinesin light chain 1 [KO:K10407]
105875830  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
105869527  KLC3; kinesin light chain 3 isoform X1 [KO:K10407]
105869956  KIF3A; kinesin-like protein KIF3A isoform X1 [KO:K10394]
105865861  KIF3B; kinesin-like protein KIF3B [KO:K20196]
105870803  kinesin-associated protein 3 [KO:K25388]
105884360  KIF3C; kinesin-like protein KIF3C [KO:K20197]
105883989  KIF17; LOW QUALITY PROTEIN: kinesin-like protein KIF17 [KO:K20198]
105886058  KIF1B; kinesin-like protein KIF1B isoform X3 [KO:K10392]
105879260  KIF1C; kinesin-like protein KIF1C [KO:K10392]
105866358  KIF1A; kinesin-like protein KIF1A [KO:K10392]
105877165  KIF13B; LOW QUALITY PROTEIN: kinesin-like protein KIF13B [KO:K17914]
105865161  KIF13A; LOW QUALITY PROTEIN: kinesin-like protein KIF13A [KO:K17914]
105859993  KIF14; kinesin-like protein KIF14 [KO:K17915]
105868535  KIF16B; kinesin-like protein KIF16B isoform X4 [KO:K17916]
105872508  STARD9; stAR-related lipid transfer protein 9 isoform X1 [KO:K16491]
105862378  chromosome-associated kinesin KIF4A-like [KO:K10395]
105855326  KIF4A; chromosome-associated kinesin KIF4A [KO:K10395]
105870619  KIF7; kinesin-like protein KIF7 isoform X2 [KO:K18806]
105860051  KIF21B; kinesin-like protein KIF21B isoform X2 [KO:K24185]
105880999  KIF21A; LOW QUALITY PROTEIN: kinesin-like protein KIF21A [KO:K24185]
105879509  KIF27; kinesin-like protein KIF27 isoform X1 [KO:K24186]
105875651  KIF11; kinesin-like protein KIF11 [KO:K10398]
105862615  KIF20A; kinesin-like protein KIF20A [KO:K10402]
105871785  KIF20B; kinesin-like protein KIF20B isoform X1 [KO:K10402]
105873416  KIF23; kinesin-like protein KIF23 isoform X1 [KO:K17387]
105879038  CENPE; centromere-associated protein E isoform X1 [KO:K11498]
105861796  KIF18A; kinesin-like protein KIF18A [KO:K10401]
105883578  KIF18B; kinesin-like protein KIF18B isoform X1 [KO:K26156]
105878897  kinesin-like protein KIF19 isoform X1 [KO:K26157]
105878898  kinesin-like protein KIF19 [KO:K26157]
105868233  kinesin-like protein KIF19 [KO:K26157]
105874897  KIF9; kinesin-like protein KIF9 isoform X1 [KO:K10397]
105878631  KIF6; kinesin-like protein KIF6 isoform X1 [KO:K10397]
105871096  KIF22; kinesin-like protein KIF22 [KO:K10403]
105861158  KIF26A; kinesin-like protein KIF26A [KO:K10404]
105863778  KIF26B; kinesin-like protein KIF26B isoform X1 [KO:K10404]
105873691  KIF12; kinesin-like protein KIF12 isoform X1 [KO:K10399]
105874465  KIF15; kinesin-like protein KIF15 isoform X1 [KO:K10400]
105881998  KIF2A; kinesin-like protein KIF2A isoform X1 [KO:K10393]
105874354  KIF24; kinesin-like protein KIF24 isoform X1 [KO:K10393]
105877446  KIF2C; kinesin-like protein KIF2C isoform X1 [KO:K10393]
105870655  KIF2B; kinesin-like protein KIF2B [KO:K10393]
105885987  KIFC1; kinesin-like protein KIFC1 isoform X1 [KO:K10405]
105859794  KIFC3; kinesin-like protein KIFC3 isoform X1 [KO:K10406]
105868883  KIFC2; LOW QUALITY PROTEIN: kinesin-like protein KIFC2 [KO:K10406]
105877877  KIF25; kinesin-like protein KIF25 [KO:K18627]
105881363  MYO1E; unconventional myosin-Ie [KO:K10356]
105866892  MYO1H; unconventional myosin-Ih [KO:K10356]
105854911  MYO1D; unconventional myosin-Id isoform X1 [KO:K10356]
105870658  MYO1G; unconventional myosin-Ig [KO:K10356]
105877911  MYO1B; unconventional myosin-Ib isoform X1 [KO:K10356]
105877962  MYO1A; unconventional myosin-Ia [KO:K10356]
105885672  MYO1F; unconventional myosin-If [KO:K10356]
105857913  MYO1C; unconventional myosin-Ic isoform X1 [KO:K10356]
105878119  MYO3A; myosin-IIIa isoform X1 [KO:K08834] [EC:2.7.11.1]
105880704  MYO3B; myosin-IIIb [KO:K08834] [EC:2.7.11.1]
105874244  MYO5B; unconventional myosin-Vb isoform X1 [KO:K10357]
105870692  MYO5A; unconventional myosin-Va isoform X1 [KO:K10357]
105870694  MYO5C; unconventional myosin-Vc isoform X1 [KO:K10357]
105859385  MYO6; unconventional myosin-VI isoform X1 [KO:K10358]
105860339  MYO7A; unconventional myosin-VIIa [KO:K10359]
105857524  MYO7B; unconventional myosin-VIIb isoform X1 [KO:K21868]
105866271  MYO9B; LOW QUALITY PROTEIN: unconventional myosin-IXb [KO:K10360]
105873393  MYO9A; unconventional myosin-IXa isoform X1 [KO:K10360]
105861920  MYO10; LOW QUALITY PROTEIN: unconventional myosin-X [KO:K12559]
105861971  MYO15A; unconventional myosin-XV [KO:K10361]
105878884  MYO15B; myosin XVB [KO:K10361]
105864219  MYO16; unconventional myosin-XVI isoform X1 [KO:K17481]
105866900  MYO18B; unconventional myosin-XVIIIb [KO:K10362]
105857964  MYO18A; unconventional myosin-XVIIIa isoform X1 [KO:K10362]
105878305  MYO19; unconventional myosin-XIX isoform X1 [KO:K25838]
105868191  LOW QUALITY PROTEIN: myosin-3-like [KO:K24220]
105878050  MYH15; LOW QUALITY PROTEIN: myosin-15 [KO:K24220]
105878349  myosin-4 [KO:K24220]
105878352  myosin-2 [KO:K24220]
105878358  myosin-1 [KO:K24220]
105878375  myosin-8 [KO:K24220]
105878427  myosin-3 [KO:K24220]
105878437  LOW QUALITY PROTEIN: myosin-13 [KO:K24220]
105865852  MYH7B; myosin-7B isoform X1 [KO:K24220]
105861220  myosin-7 [KO:K17751]
105861221  myosin-6 [KO:K17751]
105864629  myosin-7-like [KO:K17751]
105883690  MYH9; myosin-9 [KO:K10352]
105877077  MYH10; myosin-10 [KO:K10352]
105885335  MYH11; myosin-11 isoform X1 [KO:K10352]
105865520  MYH14; myosin-14 [KO:K10352]
105863915  MYL1; myosin light chain 1/3, skeletal muscle isoform isoform X1 [KO:K05738]
105874892  MYL3; myosin light chain 3 [KO:K12749]
105863661  MYL4; myosin light chain 4 [KO:K12750]
105865166  MYL6B; myosin light chain 6B isoform X1 [KO:K12751]
105865263  MYL6; myosin light polypeptide 6 isoform X1 [KO:K12751]
105880933  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
105881667  MYL5; LOW QUALITY PROTEIN: myosin light chain 5 [KO:K12753]
105858424  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
105865848  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
105868270  MYL10; myosin regulatory light chain 10 isoform X1 [KO:K12756]
105860934  myosin regulatory light polypeptide 9 isoform X2 [KO:K12757]
105860935  myosin regulatory light chain 12B [KO:K12757]
105860936  myosin regulatory light chain 12B [KO:K12757]
105871086  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
105871143  ACTA1; actin, alpha skeletal muscle [KO:K10354]
105871641  ACTA2; actin, aortic smooth muscle [KO:K12313]
105872390  ACTC1; actin, alpha cardiac muscle 1 [KO:K12314]
105884602  ACTG2; actin, gamma-enteric smooth muscle [KO:K12315]
105868294  ACTB; actin, cytoplasmic 1 [KO:K05692]
105884969  ACTG1; actin, cytoplasmic 2 [KO:K05692]
105875049  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
105859996  TNNI1; troponin I, slow skeletal muscle [KO:K10371]
105877193  TNNT1; troponin T, slow skeletal muscle isoform X1 [KO:K10372]
105859260  TNNC2; troponin C, skeletal muscle [KO:K12042]
105859826  TNNI2; troponin I, fast skeletal muscle [KO:K12043]
105859830  TNNT3; troponin T, fast skeletal muscle isoform X1 [KO:K12046]
105877194  TNNI3; troponin I, cardiac muscle [KO:K12044]
105860064  TNNT2; troponin T, cardiac muscle isoform X1 [KO:K12045]
105868097  TPM1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
105874309  TPM2; tropomyosin beta chain isoform X1 [KO:K10374]
105873395  GOLGA6B; LOW QUALITY PROTEIN: golgin subfamily A member 6B [KO:K10374]
105855383  tropomyosin alpha-3 chain [KO:K09290]
105885920  TPM3; tropomyosin alpha-3 chain isoform X2 [KO:K09290]
105867958  TPM4; tropomyosin alpha-4 chain isoform X1 [KO:K10375]
Reference
PMID:21092854
  Authors
Hirokawa N, Niwa S, Tanaka Y
  Title
Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease.
  Journal
Neuron 68:610-38 (2010)
DOI:10.1016/j.neuron.2010.09.039
Reference
PMID:25470043 (PDB:4RH7)
  Authors
Schmidt H, Zalyte R, Urnavicius L, Carter AP
  Title
Structure of human cytoplasmic dynein-2 primed for its power stroke.
  Journal
Nature 518:435-438 (2015)
DOI:10.1038/nature14023
Reference
PMID:22398446 (PDB:3VKG 3VKH)
  Authors
Kon T, Oyama T, Shimo-Kon R, Imamula K, Shima T, Sutoh K, Kurisu G
  Title
The 2.8 A crystal structure of the dynein motor domain.
  Journal
Nature 484:345-50 (2012)
DOI:10.1038/nature10955
Reference
PMID:22997337 (PDB:3J1T 3J1U)
  Authors
Redwine WB, Hernandez-Lopez R, Zou S, Huang J, Reck-Peterson SL, Leschziner AE
  Title
Structural basis for microtubule binding and release by dynein.
  Journal
Science 337:1532-1536 (2012)
DOI:10.1126/science.1224151
Reference
PMID:26410600
  Authors
Gibbs KL, Greensmith L, Schiavo G
  Title
Regulation of Axonal Transport by Protein Kinases.
  Journal
Trends Biochem Sci 40:597-610 (2015)
DOI:10.1016/j.tibs.2015.08.003
Reference
PMID:28602352 (PDB:5NUG 5NVS 5NVU 5NW4)
  Authors
Zhang K, Foster HE, Rondelet A, Lacey SE, Bahi-Buisson N, Bird AW, Carter AP
  Title
Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated.
  Journal
Cell 169:1303-1314.e18 (2017)
DOI:10.1016/j.cell.2017.05.025
Reference
PMID:25814576 (PDB:5ADX 5AFR 5AFU)
  Authors
Urnavicius L, Zhang K, Diamant AG, Motz C, Schlager MA, Yu M, Patel NA, Robinson CV, Carter AP
  Title
The structure of the dynactin complex and its interaction with dynein.
  Journal
Science 347:1441-1446 (2015)
DOI:10.1126/science.aaa4080
Reference
PMID:29420470 (PDB:5OWO 6F1T 6F1U 6F1V 6F1Y 6F1Z 6F38 6F3A)
  Authors
Urnavicius L, Lau CK, Elshenawy MM, Morales-Rios E, Motz C, Yildiz A, Carter AP
  Title
Cryo-EM shows how dynactin recruits two dyneins for faster movement.
  Journal
Nature 554:202-206 (2018)
DOI:10.1038/nature25462
Reference
PMID:29662141
  Authors
Reck-Peterson SL, Redwine WB, Vale RD, Carter AP
  Title
The cytoplasmic dynein transport machinery and its many cargoes.
  Journal
Nat Rev Mol Cell Biol 19:382-398 (2018)
DOI:10.1038/s41580-018-0004-3
Reference
PMID:23434508 (PDB:3J2U)
  Authors
Asenjo AB, Chatterjee C, Tan D, DePaoli V, Rice WJ, Diaz-Avalos R, Silvestry M, Sosa H
  Title
Structural model for tubulin recognition and deformation by kinesin-13 microtubule depolymerases.
  Journal
Cell Rep 3:759-68 (2013)
DOI:10.1016/j.celrep.2013.01.030
Reference
PMID:10338210 (PDB:1B7T)
  Authors
Houdusse A, Kalabokis VN, Himmel D, Szent-Gyorgyi AG, Cohen C
  Title
Atomic structure of scallop myosin subfragment S1 complexed with MgADP: a novel conformation of the myosin head.
  Journal
Cell 97:459-70 (1999)
DOI:10.1016/s0092-8674(00)80756-4
Reference
PMID:9428521 (PDB:3KIN)
  Authors
Kozielski F, Sack S, Marx A, Thormahlen M, Schonbrunn E, Biou V, Thompson A, Mandelkow EM, Mandelkow E
  Title
The crystal structure of dimeric kinesin and implications for microtubule-dependent motility.
  Journal
Cell 91:985-94 (1997)
DOI:10.1016/s0092-8674(00)80489-4
Reference
PMID:8316857 (PDB:2MYS)
  Authors
Rayment I, Rypniewski WR, Schmidt-Base K, Smith R, Tomchick DR, Benning MM, Winkelmann DA, Wesenberg G, Holden HM
  Title
Three-dimensional structure of myosin subfragment-1: a molecular motor.
  Journal
Science 261:50-8 (1993)
DOI:10.1126/science.8316857
Reference
PMID:20428469
  Authors
Parker D, Bryant Z, Delp SL
  Title
Coarse-Grained Structural Modeling of Molecular Motors Using Multibody Dynamics.
  Journal
Cell Mol Bioeng 2:366-374 (2009)
DOI:10.1007/s12195-009-0084-4
Reference
PMID:21314430
  Authors
Dominguez R, Holmes KC
  Title
Actin structure and function.
  Journal
Annu Rev Biophys 40:169-86 (2011)
DOI:10.1146/annurev-biophys-042910-155359
Reference
PMID:31919429 (PDB:6KN7 6KN8)
  Authors
Yamada Y, Namba K, Fujii T
  Title
Cardiac muscle thin filament structures reveal calcium regulatory mechanism.
  Journal
Nat Commun 11:153 (2020)
DOI:10.1038/s41467-019-14008-1
Reference
PMID:33912943
  Authors
Kruppa AJ, Buss F
  Title
Motor proteins at the mitochondria-cytoskeleton interface.
  Journal
J Cell Sci 134:239092 (2021)
DOI:10.1242/jcs.226084
KO pathway
ko04814   
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