KEGG   PATHWAY: nasi03015
Entry
nasi03015                   Pathway                                
Name
mRNA surveillance pathway - Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise)
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
Pathway map
nasi03015  mRNA surveillance pathway
nasi03015

Other DBs
GO: 0071028
Organism
Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise) [GN:nasi]
Gene
112392610  NCBP1; nuclear cap-binding protein subunit 1 [KO:K12882]
112404251  NCBP2; nuclear cap-binding protein subunit 2 isoform X1 [KO:K12883]
112404042  UPF3B; regulator of nonsense transcripts 3B isoform X1 [KO:K14328]
112404602  UPF3A; regulator of nonsense transcripts 3A [KO:K14328]
112391358  RBM8A; RNA-binding protein 8A isoform X1 [KO:K12876]
112395870  MAGOH; protein mago nashi homolog [KO:K12877]
112391814  MAGOHB; protein mago nashi homolog 2 isoform X1 [KO:K12877]
112399226  CASC3; protein CASC3 [KO:K14323]
112410468  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
112405133  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
112411127  PNN; pinin [KO:K13114]
112397490  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
112409403  RNPS1; RNA-binding protein with serine-rich domain 1 isoform X1 [KO:K14325]
112397693  RNA-binding protein with serine-rich domain 1-like [KO:K14325]
112410196  ALYREF; THO complex subunit 4 [KO:K12881]
112393354  DDX19A; ATP-dependent RNA helicase DDX19A [KO:K18655] [EC:5.6.2.7]
112393355  ATP-dependent RNA helicase DDX19B-like isoform X1 [KO:K18655] [EC:5.6.2.7]
112411424  GLE1; nucleoporin GLE1 [KO:K18723]
112402107  NXF1; nuclear RNA export factor 1 [KO:K14284]
112404600  nuclear RNA export factor 2-like [KO:K14284]
112411694  LOW QUALITY PROTEIN: nuclear RNA export factor 2-like [KO:K14284]
112400918  NXF3; nuclear RNA export factor 3 [KO:K14284]
112402105  NXT2; NTF2-related export protein 2 isoform X1 [KO:K14285]
112403371  NXT1; NTF2-related export protein 1 isoform X1 [KO:K14285]
112395394  DDX39B; spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
112393943  PYM1; partner of Y14 and mago [KO:K14294]
112414260  SRRM1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
112401252  RNGTT; mRNA-capping enzyme isoform X1 [KO:K13917] [EC:2.7.7.50 3.6.1.74]
112412217  RNMT; mRNA cap guanine-N7 methyltransferase isoform X1 [KO:K00565] [EC:2.1.1.56]
112399306  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
112402703  TARDBP; TAR DNA-binding protein 43 [KO:K23600]
112405011  LOW QUALITY PROTEIN: polyadenylate-binding protein 2-like [KO:K14396]
112406628  LOW QUALITY PROTEIN: polyadenylate-binding protein 2-like [KO:K14396]
112393527  PABPN1L; embryonic polyadenylate-binding protein 2 isoform X1 [KO:K14396]
112403825  NUDT21; cleavage and polyadenylation specificity factor subunit 5 [KO:K14397]
112394018  CPSF6; cleavage and polyadenylation specificity factor subunit 6 isoform X1 [KO:K14398]
112402039  CPSF7; cleavage and polyadenylation specificity factor subunit 7 isoform X1 [KO:K14398]
112409533  PAPOLA; poly(A) polymerase alpha isoform X1 [KO:K14376] [EC:2.7.7.19]
112404836  PAPOLG; poly(A) polymerase gamma [KO:K14376] [EC:2.7.7.19]
112412083  PAPOLB; LOW QUALITY PROTEIN: poly(A) polymerase beta [KO:K14376] [EC:2.7.7.19]
112402508  CLP1; polyribonucleotide 5'-hydroxyl-kinase Clp1 isoform X1 [KO:K14399] [EC:2.7.1.78]
112412094  PCF11; pre-mRNA cleavage complex 2 protein Pcf11 isoform X1 [KO:K14400]
112397022  CPSF1; LOW QUALITY PROTEIN: cleavage and polyadenylation specificity factor subunit 1 [KO:K14401]
112393884  CPSF2; cleavage and polyadenylation specificity factor subunit 2 isoform X1 [KO:K14402]
112394800  CPSF3; cleavage and polyadenylation specificity factor subunit 3 isoform X1 [KO:K14403] [EC:3.1.27.-]
112410103  CPSF4L; putative cleavage and polyadenylation specificity factor subunit 4-like protein [KO:K14404]
112400004  CPSF4; cleavage and polyadenylation specificity factor subunit 4 isoform X1 [KO:K14404]
112400741  FIP1L1; pre-mRNA 3'-end-processing factor FIP1 isoform X1 [KO:K14405]
112395007  WDR33; pre-mRNA 3' end processing protein WDR33 isoform X1 [KO:K15542]
112400548  WDR82; WD repeat-containing protein 82 [KO:K14962]
112402102  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
112408799  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
112390556  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
112409866  SSU72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 isoform X1 [KO:K15544] [EC:3.1.3.16]
112402974  CSTF1; cleavage stimulation factor subunit 1 [KO:K14406]
112399589  CSTF2T; cleavage stimulation factor subunit 2 tau variant [KO:K14407]
112400677  CSTF2; cleavage stimulation factor subunit 2 isoform X1 [KO:K14407]
112404547  CSTF3; cleavage stimulation factor subunit 3 isoform X1 [KO:K14408]
112415440  SYMPK; symplekin [KO:K06100]
112396277  DAZAP1; DAZ-associated protein 1 isoform X1 [KO:K14411]
112397331  MSI1; RNA-binding protein Musashi homolog 1 [KO:K14411]
112408130  MSI2; RNA-binding protein Musashi homolog 2 isoform X1 [KO:K14411]
112395561  PABPC4; polyadenylate-binding protein 4 isoform X1 [KO:K13126]
112397877  PABPC5; polyadenylate-binding protein 5 [KO:K13126]
112399758  PABPC4L; LOW QUALITY PROTEIN: polyadenylate-binding protein 4-like [KO:K13126]
112400763  LOW QUALITY PROTEIN: polyadenylate-binding protein 4-like [KO:K13126]
112407308  PABPC1; polyadenylate-binding protein 1 isoform X1 [KO:K13126]
112400854  PABPC1L; polyadenylate-binding protein 1-like isoform X1 [KO:K13126]
112392030  polyadenylate-binding protein 1-like 2 [KO:K13126]
112404390  ETF1; eukaryotic peptide chain release factor subunit 1 [KO:K03265]
112399235  GSPT1; eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform X1 [KO:K03267]
112407734  eukaryotic peptide chain release factor GTP-binding subunit ERF3B [KO:K03267]
112414816  UPF1; regulator of nonsense transcripts 1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
112392438  UPF2; regulator of nonsense transcripts 2 isoform X1 [KO:K14327]
112399178  SMG1; serine/threonine-protein kinase SMG1 isoform X1 [KO:K08873] [EC:2.7.11.1]
112391166  SMG7; protein SMG7 isoform X1 [KO:K14409]
112401743  SMG5; protein SMG5 isoform X1 [KO:K11125]
112394058  SMG6; telomerase-binding protein EST1A isoform X1 [KO:K11124] [EC:3.1.-.-]
112413111  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
112399680  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
112405714  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
112415426  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
112410281  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform-like [KO:K04354]
112411217  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
112393770  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
112414997  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
112390441  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
112411138  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
112400485  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
112415231  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
112402324  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
112409649  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
112403384  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
112403461  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
112413816  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
112409117  HBS1L; HBS1-like protein isoform X1 [KO:K14416]
112396547  PELO; protein pelota homolog [KO:K06965]
Reference
PMID:15040442
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
DOI:10.1038/nrm1310
Reference
PMID:16723977
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
DOI:10.1038/nrm1942
Reference
PMID:17183357
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
DOI:10.1038/nrm2080
Reference
PMID:18158581
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
DOI:10.1007/s00018-007-7474-3
Reference
PMID:16715045
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
DOI:10.1038/nsmb0406-299
Related
pathway
nasi03013  Nucleocytoplasmic transport
nasi03018  RNA degradation
nasi03040  Spliceosome
KO pathway
ko03015   
LinkDB

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