KEGG   PATHWAY: ngi00983
Entry
ngi00983                    Pathway                                
Name
Drug metabolism - other enzymes - Nannospalax galili (Upper Galilee mountains blind mole rat)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
ngi00983  Drug metabolism - other enzymes
ngi00983

Organism
Nannospalax galili (Upper Galilee mountains blind mole rat) [GN:ngi]
Gene
103728778  Hprt1; hypoxanthine phosphoribosyltransferase 1 [KO:K00760] [EC:2.4.2.8]
103744564  Impdh1; inosine monophosphate dehydrogenase 1 [KO:K00088] [EC:1.1.1.205]
103750205  Impdh2; inosine monophosphate dehydrogenase 2 [KO:K00088] [EC:1.1.1.205]
103740086  Gmps; guanine monophosphate synthase [KO:K01951] [EC:6.3.5.2]
103733006  thiopurine S-methyltransferase-like [KO:K00569] [EC:2.1.1.67]
103745166  Tpmt; thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
103748365  Xdh; xanthine dehydrogenase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
103751121  Itpa; inosine triphosphatase [KO:K01519] [EC:3.6.1.66]
103731689  carboxylesterase 1D [KO:K01044] [EC:3.1.1.1]
103731688  carboxylesterase 1C-like [KO:K01044] [EC:3.1.1.1]
103749862  carboxylesterase 1E-like [KO:K01044] [EC:3.1.1.1]
103750054  carboxylesterase 1D-like [KO:K01044] [EC:3.1.1.1]
103749871  liver carboxylesterase 1-like [KO:K01044] [EC:3.1.1.1]
103749868  liver carboxylesterase 1-like [KO:K01044] [EC:3.1.1.1]
103738920  acylcarnitine hydrolase-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
103744494  acylcarnitine hydrolase-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
103738931  pyrethroid hydrolase Ces2e-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
103733793  UDP-glucuronosyltransferase 2B1-like [KO:K00699] [EC:2.4.1.17]
103731167  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
103731320  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
103731120  UDP-glucuronosyltransferase 2A1 [KO:K00699] [EC:2.4.1.17]
103731152  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
103731173  UDP-glucuronosyltransferase 2B1-like [KO:K00699] [EC:2.4.1.17]
103739868  UDP-glucuronosyltransferase 2B1-like [KO:K00699] [EC:2.4.1.17]
103739357  UDP-glucuronosyltransferase 2B1-like [KO:K00699] [EC:2.4.1.17]
103739359  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
103735258  UDP-glucuronosyltransferase 1-6 [KO:K00699] [EC:2.4.1.17]
103742355  UDP-glucuronosyltransferase 2B1-like [KO:K00699] [EC:2.4.1.17]
103725531  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
103725532  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
108490920  UDP-glucuronosyltransferase 1-7-like [KO:K00699] [EC:2.4.1.17]
103741264  UDP-glucuronosyltransferase 1-8-like [KO:K00699] [EC:2.4.1.17]
103738948  Gusb; glucuronidase beta [KO:K01195] [EC:3.2.1.31]
103738563  Cda; cytidine deaminase [KO:K01489] [EC:3.5.4.5]
103735486  Tymp; thymidine phosphorylase [KO:K00758] [EC:2.4.2.4]
103734644  Dpyd; dihydropyrimidine dehydrogenase [KO:K00207] [EC:1.3.1.2]
103748763  Dpys; dihydropyrimidinase [KO:K01464] [EC:3.5.2.2]
103736275  Upb1; beta-ureidopropionase 1 [KO:K01431] [EC:3.5.1.6]
103741621  Upp2; uridine phosphorylase 2 [KO:K00757] [EC:2.4.2.3]
103741426  Upp1; uridine phosphorylase 1 [KO:K00757] [EC:2.4.2.3]
103742276  Uckl1; uridine-cytidine kinase 1 like 1 [KO:K00876] [EC:2.7.1.48]
103746124  Uck2; uridine-cytidine kinase 2 [KO:K00876] [EC:2.7.1.48]
103727616  Uck1; uridine-cytidine kinase 1 [KO:K00876] [EC:2.7.1.48]
108490411  Tk2; thymidine kinase 2, mitochondrial [KO:K00857] [EC:2.7.1.21]
103746017  Tk1; thymidine kinase 1 [KO:K00857] [EC:2.7.1.21]
103741998  Umps; uridine monophosphate synthetase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
103733674  Cmpk1; cytidine/uridine monophosphate kinase 1 [KO:K13800] [EC:2.7.4.14]
103750826  Rrm1; ribonucleotide reductase catalytic subunit M1 [KO:K10807] [EC:1.17.4.1]
103747619  Rrm2; ribonucleotide reductase regulatory subunit M2 [KO:K10808] [EC:1.17.4.1]
103751596  Rrm2b; ribonucleotide reductase regulatory TP53 inducible subunit M2B [KO:K10808] [EC:1.17.4.1]
103738404  Nme1; NME/NM23 nucleoside diphosphate kinase 1 [KO:K00940] [EC:2.7.4.6]
103738405  Nme2; nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
103748227  Nme4; NME/NM23 nucleoside diphosphate kinase 4 [KO:K00940] [EC:2.7.4.6]
103750229  Nme6; NME/NM23 nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
103752431  Nme3; NME/NM23 nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
103727108  Nme7; NME/NM23 family member 7 [KO:K00940] [EC:2.7.4.6]
103750020  Dut; deoxyuridine triphosphatase [KO:K01520] [EC:3.6.1.23]
103741805  Mpo; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
103745813  arylamine N-acetyltransferase 2-like [KO:K00622] [EC:2.3.1.5]
103745803  arylamine N-acetyltransferase 2 [KO:K00622] [EC:2.3.1.5]
103745801  arylamine N-acetyltransferase 1-like [KO:K00622] [EC:2.3.1.5]
103725848  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
103734296  glutathione S-transferase theta-2-like [KO:K00799] [EC:2.5.1.18]
103738073  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
103740065  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
103734428  Mgst1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
103742372  Mgst2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
103744054  Gsto2; glutathione S-transferase omega 2 [KO:K00799] [EC:2.5.1.18]
103744053  Gsto1; glutathione S-transferase omega 1 [KO:K00799] [EC:2.5.1.18]
103744353  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
103744359  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
103748819  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
103747825  Gstm3; glutathione S-transferase mu 3 [KO:K00799] [EC:2.5.1.18]
103747828  glutathione S-transferase Mu 6 [KO:K00799] [EC:2.5.1.18]
103747829  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
103747827  glutathione S-transferase Mu 7 [KO:K00799] [EC:2.5.1.18]
103747826  glutathione S-transferase Mu 2-like [KO:K00799] [EC:2.5.1.18]
103747831  glutathione S-transferase Mu 2 [KO:K00799] [EC:2.5.1.18]
103747832  Gstm4; glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
103746121  Mgst3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
103727361  glutathione S-transferase alpha-3 [KO:K00799] [EC:2.5.1.18]
103727364  glutathione S-transferase alpha-3-like [KO:K00799] [EC:2.5.1.18]
103727363  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
103727380  glutathione S-transferase A6 [KO:K00799] [EC:2.5.1.18]
103752503  glutathione S-transferase A6 [KO:K00799] [EC:2.5.1.18]
103752502  glutathione S-transferase A6-like [KO:K00799] [EC:2.5.1.18]
103727382  glutathione S-transferase alpha-3-like [KO:K00799] [EC:2.5.1.18]
103729179  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
103734295  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
103725597  glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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