KEGG   PATHWAY: npr00564
Entry
npr00564                    Pathway                                
Name
Glycerophospholipid metabolism - Nanorana parkeri (Xizang Plateau frog)
Class
Metabolism; Lipid metabolism
Pathway map
npr00564  Glycerophospholipid metabolism
npr00564

Module
npr_M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:npr00564]
npr_M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:npr00564]
npr_M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:npr00564]
Other DBs
GO: 0006650
Organism
Nanorana parkeri (Xizang Plateau frog) [GN:npr]
Gene
108789981  GPD1; glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic [KO:K00006] [EC:1.1.1.8]
108803050  glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic-like isoform X1 [KO:K00006] [EC:1.1.1.8]
108792875  GPD1L; glycerol-3-phosphate dehydrogenase 1-like protein isoform X1 [KO:K00006] [EC:1.1.1.8]
108784354  GPD2; glycerol-3-phosphate dehydrogenase, mitochondrial [KO:K00111] [EC:1.1.5.3]
108797678  GPAT2; glycerol-3-phosphate acyltransferase 2, mitochondrial [KO:K00629] [EC:2.3.1.15]
108802399  GPAM; glycerol-3-phosphate acyltransferase 1, mitochondrial [KO:K00629] [EC:2.3.1.15]
108792828  GPAT4; glycerol-3-phosphate acyltransferase 4 [KO:K13506] [EC:2.3.1.15]
108794865  GPAT3; glycerol-3-phosphate acyltransferase 3 isoform X1 [KO:K13506] [EC:2.3.1.15]
108790233  AGPAT2; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta [KO:K13509] [EC:2.3.1.51]
108786548  AGPAT1; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha [KO:K13509] [EC:2.3.1.51]
108795775  1-acyl-sn-glycerol-3-phosphate acyltransferase alpha-like [KO:K13509] [EC:2.3.1.51]
108795047  AGPAT4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [KO:K13523] [EC:2.3.1.51 2.3.1.-]
108803654  AGPAT3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma [KO:K13523] [EC:2.3.1.51 2.3.1.-]
108796165  1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon-like [KO:K19007] [EC:2.3.1.51]
108801115  1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon-like [KO:K19007] [EC:2.3.1.51]
108796714  LCLAT1; lysocardiolipin acyltransferase 1 isoform X1 [KO:K13513] [EC:2.3.1.- 2.3.1.51]
108789864  MBOAT2; lysophospholipid acyltransferase 2 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
108786393  MBOAT1; lysophospholipid acyltransferase 1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
108786629  membrane-bound O-acyltransferase domain-containing protein 2-like [KO:K13517] [EC:2.3.1.51 2.3.1.-]
108789847  dihydroxyacetone phosphate acyltransferase-like [KO:K00649] [EC:2.3.1.42]
108789851  dihydroxyacetone phosphate acyltransferase-like [KO:K00649] [EC:2.3.1.42]
108800850  manganese-dependent ADP-ribose/CDP-alcohol diphosphatase-like [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
108801529  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
108796685  PLPP1; phospholipid phosphatase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
108791487  phospholipid phosphatase 3-like [KO:K01080] [EC:3.1.3.4]
108791241  PLPP2; phospholipid phosphatase 2 isoform X1 [KO:K01080] [EC:3.1.3.4]
108788162  PLPP3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
108784937  LPIN2; phosphatidate phosphatase LPIN2 [KO:K15728] [EC:3.1.3.4]
108787967  phosphatidate phosphatase LPIN3-like [KO:K15728] [EC:3.1.3.4]
108788601  LPIN1; phosphatidate phosphatase LPIN1 [KO:K15728] [EC:3.1.3.4]
108795391  PLPP4; phospholipid phosphatase 4 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
108800419  PLPP5; phospholipid phosphatase 5 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
108790251  DGKH; diacylglycerol kinase eta [KO:K00901] [EC:2.7.1.107]
108797321  DGKZ; diacylglycerol kinase zeta [KO:K00901] [EC:2.7.1.107]
108796650  DGKQ; diacylglycerol kinase theta [KO:K00901] [EC:2.7.1.107]
108793043  DGKD; diacylglycerol kinase delta [KO:K00901] [EC:2.7.1.107]
108788726  DGKI; diacylglycerol kinase iota isoform X1 [KO:K00901] [EC:2.7.1.107]
108785070  DGKE; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
108790519  DGKA; diacylglycerol kinase alpha isoform X1 [KO:K00901] [EC:2.7.1.107]
108788015  DGKB; diacylglycerol kinase beta [KO:K00901] [EC:2.7.1.107]
108787169  CHPT1; cholinephosphotransferase 1 [KO:K00994] [EC:2.7.8.2]
108804882  CEPT1; choline/ethanolaminephosphotransferase 1 [KO:K13644] [EC:2.7.8.1 2.7.8.2]
108800202  phospholipase D2-like [KO:K01115] [EC:3.1.4.4]
108784828  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
108794084  PLD3; phospholipase D3 [KO:K16860] [EC:3.1.4.4]
108804121  LCAT; phosphatidylcholine-sterol acyltransferase [KO:K00650] [EC:2.3.1.43]
108797108  phospholipase A2 homolog otoconin-22-like [KO:K01047] [EC:3.1.1.4]
108798204  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
108799534  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
108791727  group 10 secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
108801127  phospholipase A2, minor isoenzyme-like [KO:K01047] [EC:3.1.1.4]
108785849  PROCA1; protein PROCA1 [KO:K01047] [EC:3.1.1.4]
108787770  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
108786243  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
108798704  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
108789917  cytosolic phospholipase A2 delta-like [KO:K16342] [EC:3.1.1.4]
108793921  cytosolic phospholipase A2 delta-like [KO:K16342] [EC:3.1.1.4]
108789293  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
108799210  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 [KO:K16343] [EC:3.1.1.4]
108794251  HRAS-like suppressor 2 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
108795131  LPCAT1; lysophosphatidylcholine acyltransferase 1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
108797887  LPCAT2; lysophosphatidylcholine acyltransferase 2 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
108788452  LPCAT4; lysophospholipid acyltransferase LPCAT4 [KO:K13512] [EC:2.3.1.23 2.3.1.-]
108784381  LPCAT3; lysophospholipid acyltransferase 5 [KO:K13515] [EC:2.3.1.23 2.3.1.-]
108795940  LYPLA1; acyl-protein thioesterase 1 isoform X1 [KO:K06128] [EC:3.1.1.5]
108801424  group XV phospholipase A2-like [KO:K06129] [EC:3.1.1.5]
108793531  LYPLA2; acyl-protein thioesterase 2 [KO:K06130] [EC:3.1.1.5]
108787266  PNPLA7; patatin-like phospholipase domain-containing protein 7 [KO:K14676] [EC:3.1.1.5]
108795662  neuropathy target esterase-like [KO:K14676] [EC:3.1.1.5]
108795467  GPCPD1; glycerophosphocholine phosphodiesterase GPCPD1 [KO:K18695] [EC:3.1.4.2]
108788608  CHAT; choline O-acetyltransferase [KO:K00623] [EC:2.3.1.6]
108791493  ACHE; acetylcholinesterase isoform X1 [KO:K01049] [EC:3.1.1.7]
108793461  CHKB; choline/ethanolamine kinase [KO:K14156] [EC:2.7.1.32 2.7.1.82]
108784146  CHKA; choline kinase alpha [KO:K14156] [EC:2.7.1.32 2.7.1.82]
108784014  PHOSPHO1; phosphoethanolamine/phosphocholine phosphatase [KO:K06124] [EC:3.1.3.75]
108790792  PCYT1B; choline-phosphate cytidylyltransferase B isoform X1 [KO:K00968] [EC:2.7.7.15]
108791181  PCYT1A; choline-phosphate cytidylyltransferase A [KO:K00968] [EC:2.7.7.15]
108792229  ethanolaminephosphotransferase 1-like [KO:K00993] [EC:2.7.8.1]
108802987  SELENOI; ethanolaminephosphotransferase 1 [KO:K00993] [EC:2.7.8.1]
108789884  ETNK1; ethanolamine kinase 1 [KO:K00894] [EC:2.7.1.82]
108784737  PCYT2; ethanolamine-phosphate cytidylyltransferase isoform X1 [KO:K00967] [EC:2.7.7.14]
108784145  phosphomethylethanolamine N-methyltransferase-like [KO:K05929] [EC:2.1.1.103]
108798298  ETNPPL; ethanolamine-phosphate phospho-lyase [KO:K14286] [EC:4.2.3.2]
108788740  PEMT; phosphatidylethanolamine N-methyltransferase isoform X1 [KO:K00551] [EC:2.1.1.17 2.1.1.71]
108796139  phosphatidate cytidylyltransferase 1-like [KO:K00981] [EC:2.7.7.41]
108800173  CDS2; phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
108804443  phosphatidate cytidylyltransferase 1-like [KO:K00981] [EC:2.7.7.41]
108803036  PLA1A; phospholipase A1 member A [KO:K13618] [EC:3.1.1.111]
108786783  PTDSS1; phosphatidylserine synthase 1 isoform X1 [KO:K08729] [EC:2.7.8.-]
108797710  PTDSS2; phosphatidylserine synthase 2 [KO:K08730] [EC:2.7.8.29]
108787792  PISD; phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X1 [KO:K01613] [EC:4.1.1.65]
108801442  PGS1; LOW QUALITY PROTEIN: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial [KO:K00995] [EC:2.7.8.5]
108795302  CRLS1; cardiolipin synthase (CMP-forming) [KO:K08744] [EC:2.7.8.41]
108789217  TAZ; tafazzin [KO:K13511] [EC:2.3.1.-]
108804783  LPGAT1; acyl-CoA:lysophosphatidylglycerol acyltransferase 1 [KO:K13514] [EC:2.3.1.-]
108789162  CDIPT; CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform X1 [KO:K00999] [EC:2.7.8.11]
108794942  MBOAT7; lysophospholipid acyltransferase 7 isoform X1 [KO:K13516] [EC:2.3.1.-]
Compound
C00040  Acyl-CoA
C00065  L-Serine
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
C22340  Heptaprenylglyceryl phosphate
C22341  Heptaprenylglycerol
C22342  Diacetylheptaprenylglycerol
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
PMID:10092508
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
PMID:10542045
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
PMID:12431977
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
PMID:14663079
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
PMID:15522832
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
PMID:10938271
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
Related
pathway
npr00010  Glycolysis / Gluconeogenesis
npr00260  Glycine, serine and threonine metabolism
npr00561  Glycerolipid metabolism
npr00562  Inositol phosphate metabolism
npr00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
npr00565  Ether lipid metabolism
npr00620  Pyruvate metabolism
KO pathway
ko00564   
LinkDB

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