KEGG   PATHWAY: nvi04141
Entry
nvi04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Nasonia vitripennis (jewel wasp)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
nvi04141  Protein processing in endoplasmic reticulum
nvi04141

Other DBs
GO: 0030433 0034976
Organism
Nasonia vitripennis (jewel wasp) [GN:nvi]
Gene
100114093  protein transport protein Sec61 subunit alpha isoform X1 [KO:K10956]
100114600  protein transport protein Sec61 subunit alpha [KO:K10956]
100113628  protein transport protein Sec61 subunit beta [KO:K09481]
100113939  protein transport protein Sec61 subunit gamma [KO:K07342]
100680472  translocation protein SEC62 [KO:K12275]
100116321  translocation protein SEC63 homolog [KO:K09540]
100116460  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 [KO:K12666]
100117426  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [KO:K12667]
100115214  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
100115033  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
100117025  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B isoform X1 [KO:K07151] [EC:2.4.99.18]
100117843  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
100119483  tumor suppressor candidate 3 [KO:K19478]
100115996  oligosaccharyltransferase complex subunit ostc-B [KO:K26501]
100118704  transmembrane protein 258 [KO:K26502]
100119845  mannosyl-oligosaccharide glucosidase GCS1 [KO:K01228] [EC:3.2.1.106]
100123647  kinectin isoform X1 [KO:K14000]
100122879  nucleotide exchange factor Sil1 [KO:K14001]
100122605  hypoxia up-regulated protein 1 isoform X1 [KO:K09486]
100120866  endoplasmic reticulum chaperone BiP isoform X2 [KO:K09490] [EC:3.6.4.10]
100117057  dnaJ homolog shv [KO:K09517]
100123032  dnaJ homolog subfamily C member 1 [KO:K09521]
100122253  dnaJ homolog subfamily C member 3 [KO:K09523]
100122660  dnaJ homolog subfamily C member 10 [KO:K09530] [EC:1.8.4.-]
100114164  endoplasmin [KO:K09487]
100121937  alpha glucosidase II alpha subunit-like precursor [KO:K05546] [EC:3.2.1.207]
100678569  neutral alpha-glucosidase AB-like [KO:K05546] [EC:3.2.1.207]
100115591  glucosidase 2 subunit beta [KO:K08288]
100124226  calnexin isoform X2 [KO:K08054]
100115387  protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
100116123  Crc; calreticulin precursor [KO:K08057]
100119928  mannosyl-oligosaccharide alpha-1,2-mannosidase IA isoform X2 [KO:K01230] [EC:3.2.1.113]
100119267  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase [KO:K23741] [EC:3.2.1.209]
100119012  vesicular integral-membrane protein VIP36 [KO:K10082]
100123993  protein ERGIC-53 [KO:K10080]
100119718  GTP-binding protein SAR1 [KO:K07953] [EC:3.6.5.-]
100115052  protein SEC13 homolog [KO:K14004]
100117091  protein transport protein Sec31A isoform X2 [KO:K14005]
100114786  protein transport protein Sec23A isoform X1 [KO:K14006]
100122031  protein transport protein Sec24C isoform X1 [KO:K14007]
100122827  protein transport protein Sec24A [KO:K14007]
100116665  protein transport protein Sec24C [KO:K14007]
100123883  UDP-glucose:glycoprotein glucosyltransferase isoform X2 [KO:K11718] [EC:2.4.1.-]
100122711  ER degradation-enhancing alpha-mannosidase-like protein 2 [KO:K10085]
100117725  ER degradation-enhancing alpha-mannosidase-like protein 3 [KO:K10086]
100121753  protein disulfide-isomerase [KO:K09580] [EC:5.3.4.1]
100113567  protein disulfide-isomerase A6 homolog [KO:K09584] [EC:5.3.4.1]
100120620  endoplasmic reticulum resident protein 29 [KO:K09586]
100122444  ero1-like protein [KO:K10950] [EC:1.8.4.-]
100121066  endoplasmic reticulum lectin 1 isoform X1 [KO:K14008]
100117250  Ssr1; signal sequence receptor, alpha precursor [KO:K13249]
100117024  translocon-associated protein subunit beta [KO:K13250]
100120928  translocon-associated protein subunit gamma [KO:K13251]
100115407  translocon-associated protein subunit delta [KO:K04571]
100116814  B-cell receptor-associated protein 31 [KO:K14009]
100123113  translocating chain-associated membrane protein 1-like 1 [KO:K14010]
100113511  derlin-1 [KO:K11519]
100118748  derlin-2 [KO:K13989]
100117055  UBX domain-containing protein 4 isoform X1 [KO:K24348]
100118419  UBX domain-containing protein 6 [KO:K14011]
100116785  NSFL1 cofactor p47 [KO:K14012]
100124203  uncharacterized protein LOC100124203 [KO:K14014]
100121887  transitional endoplasmic reticulum ATPase TER94 [KO:K13525]
100122578  nuclear protein localization protein 4 homolog isoform X1 [KO:K14015]
100121764  ubiquitin fusion degradation protein 1 homolog [KO:K14016]
100114478  ubiquitin recognition factor in ER-associated degradation protein 1-like [KO:K14016]
100114493  HSC70; heat shock cognate 70 [KO:K03283]
100114907  heat shock protein 68 [KO:K03283]
100114095  heat shock cognate 71 kDa protein-like isoform X2 [KO:K03283]
100120280  heat shock 70 kDa protein cognate 4-like [KO:K03283]
100119971  heat shock protein 68 [KO:K03283]
100113492  heat shock protein 68-like [KO:K03283]
100115836  dnaJ homolog subfamily A member 1 [KO:K09502]
100679552  dnaJ protein homolog 1 [KO:K09507]
100117525  dnaJ homolog subfamily B member 12 isoform X2 [KO:K09518]
100120456  dnaJ homolog subfamily C member 5 isoform X3 [KO:K09525]
100117412  heat shock protein 83 [KO:K04079]
100116702  heat shock protein 83 [KO:K04079]
100123502  heat shock 70 kDa protein 4L isoform X1 [KO:K09485]
100118370  BAG family molecular chaperone regulator 2 [KO:K09556]
100122338  hsp70-binding protein 1 isoform X2 [KO:K09562]
100118094  protein lethal(2)essential for life [KO:K09542]
100120946  protein lethal(2)essential for life [KO:K09542]
100120922  protein lethal(2)essential for life [KO:K09542]
100120971  protein lethal(2)essential for life [KO:K09542]
100118132  protein lethal(2)essential for life [KO:K09542]
100120896  protein lethal(2)essential for life [KO:K09542]
100114572  protein lethal(2)essential for life [KO:K09542]
100122756  ubiquitin thioesterase OTU1 [KO:K13719] [EC:3.1.2.-]
100122476  phospholipase A-2-activating protein isoform X4 [KO:K14018]
100124240  UV excision repair protein RAD23 homolog B [KO:K10839]
100114641  ubiquilin-1 [KO:K04523]
100119034  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase [KO:K01456] [EC:3.5.1.52]
100123779  ataxin-3 [KO:K11863] [EC:3.4.22.-]
100118546  ubiquitin conjugation factor E4 B isoform X1 [KO:K10597] [EC:2.3.2.27]
100119627  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
100122826  uncharacterized protein LOC100122826 isoform X1 [KO:K04374]
100122162  cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1 [KO:K09054]
100118973  wolframin isoform X1 [KO:K14020]
100123523  membrane-bound transcription factor site-1 protease [KO:K08653] [EC:3.4.21.112]
100123289  S2P; membrane-bound transcription factor site-2 protease [KO:K07765] [EC:3.4.24.85]
116417701  LOW QUALITY PROTEIN: uncharacterized protein LOC116417701 [KO:K09027]
100124019  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
100123601  mitogen-activated protein kinase kinase kinase 15 isoform X1 [KO:K04426] [EC:2.7.11.25]
100121060  dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
100121916  stress-activated protein kinase JNK isoform X1 [KO:K04440] [EC:2.7.11.24]
100122375  E3 ubiquitin-protein ligase MARCH6 isoform X1 [KO:K10661] [EC:2.3.2.27]
100115617  ubiquitin-conjugating enzyme E2 J1 [KO:K10578] [EC:2.3.2.23]
100122204  ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
100120247  ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
100116275  Crl; courtless [KO:K04555] [EC:2.3.2.23]
100116247  E3 ubiquitin-protein ligase synoviolin A isoform X1 [KO:K10601] [EC:2.3.2.27]
100113547  E3 ubiquitin-protein ligase RNF185 isoform X2 [KO:K10666] [EC:2.3.2.27]
100115557  selenoprotein S B [KO:K14025]
100116910  protein sel-1 homolog 1 [KO:K14026]
100120659  E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
100115948  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
100122062  E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
100115578  RING-box protein 1A isoform X1 [KO:K03868] [EC:2.3.2.32]
100123219  cullin-1 isoform X1 [KO:K03347]
100119117  Skp1; S phase kinase associated protein 1 [KO:K03094]
103316687  S-phase kinase-associated protein 1 isoform X2 [KO:K03094]
100116118  S-phase kinase-associated protein 1-like [KO:K03094]
100118143  S-phase kinase-associated protein 1 [KO:K03094]
100118180  S-phase kinase-associated protein 1 [KO:K03094]
100679731  S-phase kinase-associated protein 1 [KO:K03094]
100679758  S-phase kinase-associated protein 1 [KO:K03094]
100679791  S-phase kinase-associated protein 1 [KO:K03094]
103317975  E3 ubiquitin ligase complex SCF subunit sconC isoform X2 [KO:K03094]
100115606  F-box only protein 44 [KO:K10099]
100115647  F-box only protein 6 [KO:K10099]
100116256  F-box only protein 6 isoform X2 [KO:K10100]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
nvi00510  N-Glycan biosynthesis
nvi03050  Proteasome
nvi03060  Protein export
KO pathway
ko04141   
LinkDB

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