KEGG   PATHWAY: ocu00260
Entry
ocu00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Oryctolagus cuniculus (rabbit)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
ocu00260  Glycine, serine and threonine metabolism
ocu00260

Module
ocu_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:ocu00260]
ocu_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:ocu00260]
ocu_M00555  Betaine biosynthesis, choline => betaine [PATH:ocu00260]
ocu_M00621  Glycine cleavage system [PATH:ocu00260]
ocu_M00974  Betaine metabolism, animals, betaine => glycine [PATH:ocu00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Oryctolagus cuniculus (rabbit) [GN:ocu]
Gene
100337875  uncharacterized protein LOC100337875 isoform X1 [KO:K01620] [EC:4.1.2.48]
100009293  SHMT2; serine hydroxymethyltransferase, mitochondrial precursor [KO:K00600] [EC:2.1.2.1]
100009147  AGXT; alanine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
100347792  glyoxylate reductase/hydroxypyruvate reductase isoform X1 [KO:K00049] [EC:1.1.1.79 1.1.1.81]
100346884  glycerate kinase [KO:K11529] [EC:2.7.1.165]
100357743  phosphoglycerate mutase 2 [KO:K01834] [EC:5.4.2.11]
100352195  phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
100009096  BPGM; bisphosphoglycerate mutase [KO:K01837] [EC:5.4.2.4 5.4.2.11]
100344669  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
100009099  PSAT1; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]
100349039  phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
100353494  2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [KO:K00639] [EC:2.3.1.29]
103345257  L-threonine 3-dehydrogenase, mitochondrial [KO:K15789] [EC:1.1.1.103]
100345273  5-aminolevulinate synthase, erythroid-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]
100345847  5-aminolevulinate synthase, non-specific, mitochondrial [KO:K00643] [EC:2.3.1.37]
100357007  amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
100345623  amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
100346229  LOW QUALITY PROTEIN: membrane primary amine oxidase [KO:K00276] [EC:1.4.3.21]
100353463  membrane primary amine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]
127482583  retina-specific copper amine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]
100343694  glycine dehydrogenase (decarboxylating), mitochondrial isoform X1 [KO:K00281] [EC:1.4.4.2]
100350743  aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
100345929  dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
100358789  LOW QUALITY PROTEIN: dihydrolipoyl dehydrogenase, mitochondrial-like [KO:K00382] [EC:1.8.1.4]
100009476  GCSH; glycine cleavage system H protein, mitochondrial precursor [KO:K02437]
100351120  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
100338787  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
103352010  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
103350231  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
100357312  glycine cleavage system H protein, mitochondrial [KO:K02437]
100338632  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
100008977  DAO; D-amino-acid oxidase [KO:K00273] [EC:1.4.3.3]
100352336  alanine--glyoxylate aminotransferase 2, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
100338260  glycine amidinotransferase, mitochondrial [KO:K00613] [EC:2.1.4.1]
127483785  glycine amidinotransferase, mitochondrial isoform X1 [KO:K00613] [EC:2.1.4.1]
100350567  choline dehydrogenase, mitochondrial [KO:K00108] [EC:1.1.99.1]
100344302  alpha-aminoadipic semialdehyde dehydrogenase isoform X1 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
100339955  betaine--homocysteine S-methyltransferase 1 [KO:K00544] [EC:2.1.1.5]
100340207  dimethylglycine dehydrogenase, mitochondrial [KO:K00315] [EC:1.5.8.4]
100343592  peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
100009512  glycine N-methyltransferase [KO:K00552] [EC:2.1.1.20]
100008766  CBS; cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
100348407  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
100356325  L-serine dehydratase/L-threonine deaminase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
100342075  serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
100355322  serine racemase isoform X1 [KO:K12235] [EC:5.1.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
ocu00010  Glycolysis / Gluconeogenesis
ocu00020  Citrate cycle (TCA cycle)
ocu00230  Purine metabolism
ocu00250  Alanine, aspartate and glutamate metabolism
ocu00270  Cysteine and methionine metabolism
ocu00290  Valine, leucine and isoleucine biosynthesis
ocu00330  Arginine and proline metabolism
ocu00470  D-Amino acid metabolism
ocu00564  Glycerophospholipid metabolism
ocu00600  Sphingolipid metabolism
ocu00620  Pyruvate metabolism
ocu00630  Glyoxylate and dicarboxylate metabolism
ocu00640  Propanoate metabolism
ocu00860  Porphyrin metabolism
ocu00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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