KEGG   PATHWAY: omc04260
Entry
omc04260                    Pathway                                
Name
Cardiac muscle contraction - Onychostoma macrolepis
Description
Contraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation of voltage-dependent L-type Ca channels (DHP receptors) upon membrane depolarization triggers the release of Ca2+ via Ca2+ release channels (ryanodine receptors) of sarcoplasmic reticulum (SR) through a Ca2+ -induced Ca release (CICR) mechanism. Ca2+ ions released via the CICR mechanism diffuse through the cytosolic space to contractile proteins to bind to troponinC resulting in the release of inhibition induced by troponinI. The Ca2+ binding to troponinC thereby triggers the sliding of thin and thick filaments, that is, the activation of a crossbridge and subsequent cardiac force development and/or cell shortening. Recovery occurs as Ca2+ is pumped out of the cell by the Na+/Ca2+ exchanger (NCX) or is returned to the sarcoplasmic reticulum (SR) by sarco(endo)plasmic Ca2+ -ATPase (SERCA) pumps on the non-junctional region of the SR.
Class
Organismal Systems; Circulatory system
Pathway map
omc04260  Cardiac muscle contraction
omc04260

Other DBs
GO: 0060048
Organism
Onychostoma macrolepis [GN:omc]
Gene
131538945  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
131549742  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851]
131546233  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
131546303  cacna1fb; calcium channel, voltage-dependent, L type, alpha 1F subunit [KO:K04853]
131546383  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
131531222  cacna1sa; LOW QUALITY PROTEIN: calcium channel, voltage-dependent, L type, alpha 1S subunit, a [KO:K04857]
131545431  cacna1sb; calcium channel, voltage-dependent, L type, alpha 1S subunit, b [KO:K04857]
131536337  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
131544229  cacnb2a; voltage-dependent L-type calcium channel subunit beta-2a isoform X1 [KO:K04863]
131531922  cacnb3b; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit beta-4 [KO:K04864]
131532216  cacnb3a; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit beta-3a [KO:K04864]
131547319  cacnb4a; voltage-dependent L-type calcium channel subunit beta-4a [KO:K04865]
131542555  cacnb4b; voltage-dependent L-type calcium channel subunit beta-4b isoform X1 [KO:K04865]
131524152  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
131538580  cacna2d1a; voltage-dependent calcium channel subunit alpha-2/delta-1a [KO:K04858]
131530733  cacna2d2b; voltage-dependent calcium channel subunit alpha-2/delta-2b isoform X1 [KO:K04859]
131541863  cacna2d2a; voltage-dependent calcium channel subunit alpha-2/delta-2a isoform X1 [KO:K04859]
131549743  cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
131546144  cacna2d3a; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
131534182  cacna2d4b; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
131538522  cacna2d4a; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
131542966  cacng1a; calcium channel, voltage-dependent, gamma subunit 1a [KO:K04866]
131537820  cacng1b; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
131543041  cacng2b; calcium channel, voltage-dependent, gamma subunit 2b [KO:K04867]
131538104  cacng2a; calcium channel, voltage-dependent, gamma subunit 2a [KO:K04867]
131543370  cacng3a; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
131538056  cacng3b; voltage-dependent calcium channel gamma-3 subunit isoform X1 [KO:K04868]
131542965  cacng4a; LOW QUALITY PROTEIN: voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
131536998  cacng4b; calcium channel, voltage-dependent, gamma subunit 4b [KO:K04869]
131542553  cacng5a; calcium channel, voltage-dependent, gamma subunit 5a [KO:K04870]
131535945  cacng5b; voltage-dependent calcium channel gamma-5 subunit isoform X1 [KO:K04870]
131525937  cacng6a; calcium channel, voltage-dependent, gamma subunit 6a [KO:K04871]
131522452  cacng6b; uncharacterized protein cacng6b [KO:K04871]
131525167  cacng7a; calcium channel, voltage-dependent, gamma subunit 7a [KO:K04872]
131521207  cacng7b; voltage-dependent calcium channel gamma-7 subunit isoform X1 [KO:K04872]
131525834  cacng8a; calcium channel, voltage-dependent, gamma subunit 8a [KO:K04873]
131521585  cacng8b; voltage-dependent calcium channel gamma-4 subunit isoform X1 [KO:K04873]
131523200  ryr2b; ryanodine receptor 2 [KO:K04962]
131551579  ryr2a; LOW QUALITY PROTEIN: ryanodine receptor 2 [KO:K04962]
131543532  unm_hu7910; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
131550439  calsequestrin-2-like isoform X1 [KO:K23445]
131546960  casq2; calsequestrin-2 isoform X1 [KO:K23445]
131526810  trdn; neurofilament heavy polypeptide isoform X1 [KO:K23449]
131551336  atp2a1l; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like isoform X1 [KO:K05853] [EC:7.2.2.10]
131536270  atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
131545542  atp2a2a; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
131528557  atp2a2b; sarcoplasmic/endoplasmic reticulum calcium ATPase 2b [KO:K05853] [EC:7.2.2.10]
131540379  atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
131554110  si:dkey-28b4.8; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
131531871  tnnc1b; troponin C type 1b (slow) [KO:K05865]
131532665  tnnc1a; troponin C type 1a (slow) [KO:K05865]
131531557  tnnt2a; troponin T type 2a (cardiac) [KO:K12045]
131542174  tnnt2b; troponin T, cardiac muscle isoforms [KO:K12045]
131534270  tnnt2d; troponin T2d, cardiac [KO:K12045]
131539610  tnnt2c; troponin T2c, cardiac [KO:K12045]
131539622  tnnt2e; troponin T2e, cardiac isoform X1 [KO:K12045]
131548108  tpm2; tropomyosin beta chain isoform X1 [KO:K10373]
131525536  tpm3; tropomyosin alpha-3 chain isoform X1 [KO:K10373]
131533898  tpm1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
131543992  tpma; tropomyosin alpha-1 chain [KO:K10373]
131550832  tpm4b; tropomyosin 4b isoform X1 [KO:K10375]
131529971  tpm4a; tropomyosin 4a isoform X1 [KO:K10375]
131522880  actc1b; actin, alpha cardiac muscle 1b [KO:K12314]
131549108  acta1a; actin alpha 1, skeletal muscle a [KO:K12314]
131533870  acte1; beta-actin-like protein 2 [KO:K12314]
131552312  acta1b; actin alpha 1, skeletal muscle b [KO:K12314]
131527718  actc1a; actin, alpha cardiac muscle 1a [KO:K12314]
131527778  actc2; actin, alpha, cardiac muscle 2 isoform X1 [KO:K12314]
131532810  myosin-7-like [KO:K17751]
131533692  myosin-7-like isoform X1 [KO:K17751]
131526903  myh6; myosin-6 [KO:K17751]
131529898  myosin-7-like isoform X1 [KO:K17751]
131529910  myh7; myosin-7 [KO:K17751]
131541642  myl2a; myosin regulatory light chain 2a [KO:K10351]
131545696  myl2b; myosin, light chain 2b, regulatory, cardiac, slow [KO:K10351]
131540894  cmlc1; cardiac myosin light chain-1 [KO:K12750]
131540931  myosin light chain 4-like [KO:K12750]
131551467  zgc:163073; myosin light chain 4 [KO:K12750]
131537148  myl4; myosin light chain 4 isoform X1 [KO:K12750]
131524300  cytochrome b-c1 complex subunit Rieske, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
131543272  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
18668129  CYTB; cytochrome b [KO:K00412]
131541842  cytochrome c1, heme protein, mitochondrial [KO:K00413]
131541915  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
131551305  cytochrome b-c1 complex subunit 2, mitochondrial isoform X1 [KO:K00415]
131538050  LOW QUALITY PROTEIN: cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
131542536  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
131526443  cytochrome b-c1 complex subunit 7 isoform X1 [KO:K00417]
131553274  cytochrome b-c1 complex subunit 8 [KO:K00418]
131528165  cytochrome b-c1 complex subunit 9 [KO:K00419]
131531024  cytochrome b-c1 complex subunit 10-like [KO:K00420]
131552319  cytochrome b-c1 complex subunit 10 [KO:K00420]
18668123  COX3; cytochrome c oxidase subunit III [KO:K02262]
18668119  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
18668120  COX2; cytochrome c oxidase subunit II [KO:K02261]
131531775  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
131524109  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
131533523  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
131524533  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
131534534  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
131548241  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
131551774  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
131546215  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
131535963  cytochrome c oxidase subunit 6A, mitochondrial [KO:K02266]
131533807  cytochrome c oxidase subunit 6B1 [KO:K02267]
131521792  cytochrome c oxidase subunit 6B1 [KO:K02267]
131542468  cytochrome c oxidase subunit 6C-1 [KO:K02268]
131551087  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
131527187  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
131551723  cytochrome c oxidase subunit 7A-related protein, mitochondrial-like [KO:K02270]
131522825  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
131554365  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
131529040  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
131541171  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
131534899  cytochrome c oxidase subunit 8B, mitochondrial [KO:K02273]
131527440  si:dkey-85n7.8; COX8 domain-containing protein [KO:K02273]
131529209  cytochrome c oxidase subunit 8B, mitochondrial [KO:K02273]
131523126  slc8a1b; sodium/calcium exchanger 1b isoform X1 [KO:K05849]
131540989  slc8a2a; sodium/calcium exchanger 2a isoform X1 [KO:K05849]
131548935  slc8a1a; sodium/calcium exchanger 1a isoform X1 [KO:K05849]
131544764  slc8a4b; solute carrier family 8 member 4b [KO:K05849]
131520791  slc8a2b; sodium/calcium exchanger 2b isoform X1 [KO:K05849]
131552694  slc8a3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
131528552  slc8a4a; solute carrier family 8 member 4a [KO:K05849]
131548116  slc9a6b; sodium/hydrogen exchanger 6b [KO:K12041]
131541921  slc9a7; sodium/hydrogen exchanger 7 isoform X1 [KO:K12041]
131553825  slc9a6a; sodium/hydrogen exchanger 6a [KO:K12041]
131531947  atp1a1a.3; sodium/potassium-transporting ATPase subunit alpha-1a.3 [KO:K01539] [EC:7.2.2.13]
131525364  atp1a3a; sodium/potassium-transporting ATPase subunit alpha-3a isoform X1 [KO:K01539] [EC:7.2.2.13]
131521306  atp1a3b; sodium/potassium-transporting ATPase subunit alpha-3b [KO:K01539] [EC:7.2.2.13]
131538102  atp1a1a.1; sodium/potassium-transporting ATPase subunit alpha-1a.1 isoform X1 [KO:K01539] [EC:7.2.2.13]
131538119  atp1a1a.4; LOW QUALITY PROTEIN: sodium/potassium-transporting ATPase subunit alpha-1a.4 [KO:K01539] [EC:7.2.2.13]
131553198  atp1a2a; sodium/potassium-transporting ATPase subunit alpha-2 isoform X1 [KO:K01539] [EC:7.2.2.13]
131546812  atp1a1b; sodium/potassium-transporting ATPase subunit alpha-1b [KO:K01539] [EC:7.2.2.13]
131530404  sodium/potassium-transporting ATPase subunit alpha-1-like isoform X1 [KO:K01539] [EC:7.2.2.13]
131531675  atp1b2a; sodium/potassium-transporting ATPase subunit beta-2a [KO:K01540]
131541625  atp1b2b; sodium/potassium-transporting ATPase subunit beta-2b [KO:K01540]
131542379  atp1b1a; sodium/potassium-transporting ATPase subunit beta-1a [KO:K01540]
131550503  atp1b1b; sodium/potassium-transporting ATPase subunit beta-1b [KO:K01540]
131520424  atp1b3b; sodium/potassium-transporting ATPase subunit beta-3b [KO:K01540]
131553339  atp1b4; protein ATP1B4 isoform X1 [KO:K01540]
131529573  atp1b3a; sodium/potassium-transporting ATPase subunit beta-3a [KO:K01540]
131540742  fxyd2; sodium/potassium-transporting ATPase subunit gamma [KO:K01538]
131525995  slc9a1b; sodium/hydrogen exchanger 1b isoform X1 [KO:K05742]
131521599  slc9a1a; sodium/hydrogen exchanger 1 [KO:K05742]
Compound
C00076  Calcium cation
C00080  H+
C00238  Potassium cation
C01330  Sodium cation
Reference
PMID:17988210
  Authors
Bers DM
  Title
Calcium cycling and signaling in cardiac myocytes.
  Journal
Annu Rev Physiol 70:23-49 (2008)
DOI:10.1146/annurev.physiol.70.113006.100455
Reference
PMID:11805843
  Authors
Bers DM
  Title
Cardiac excitation-contraction coupling.
  Journal
Nature 415:198-205 (2002)
DOI:10.1038/415198a
Reference
PMID:16799263
  Authors
Endoh M
  Title
Signal transduction and Ca2+ signaling in intact myocardium.
  Journal
J Pharmacol Sci 100:525-37 (2006)
DOI:10.1254/jphs.CPJ06009X
Reference
PMID:18981594
  Authors
Endoh M
  Title
Cardiac Ca2+ signaling and Ca2+ sensitizers.
  Journal
Circ J 72:1915-25 (2008)
DOI:10.1253/circj.CJ-08-0838
Reference
PMID:16552170
  Authors
Bers DM, Despa S
  Title
Cardiac myocytes Ca2+ and Na+ regulation in normal and failing hearts.
  Journal
J Pharmacol Sci 100:315-22 (2006)
DOI:10.1254/jphs.CPJ06001X
Reference
PMID:10747208
  Authors
Gordon AM, Homsher E, Regnier M
  Title
Regulation of contraction in striated muscle.
  Journal
Physiol Rev 80:853-924 (2000)
DOI:10.1152/physrev.2000.80.2.853
Reference
PMID:16701909
  Authors
Phrommintikul A, Chattipakorn N
  Title
Roles of cardiac ryanodine receptor in heart failure and sudden cardiac death.
  Journal
Int J Cardiol 112:142-52 (2006)
DOI:10.1016/j.ijcard.2005.11.106
Reference
PMID:16096350
  Authors
Lacinova L
  Title
Voltage-dependent calcium channels.
  Journal
Gen Physiol Biophys 24 Suppl 1:1-78 (2005)
Reference
PMID:12763850
  Authors
Lingrel J, Moseley A, Dostanic I, Cougnon M, He S, James P, Woo A, O'Connor K, Neumann J
  Title
Functional roles of the alpha isoforms of the Na,K-ATPase.
  Journal
Ann N Y Acad Sci 986:354-9 (2003)
DOI:10.1111/j.1749-6632.2003.tb07214.x
Reference
PMID:11294886
  Authors
Berg JS, Powell BC, Cheney RE
  Title
A millennial myosin census.
  Journal
Mol Biol Cell 12:780-94 (2001)
DOI:10.1091/mbc.12.4.780
Reference
PMID:15736582
  Authors
Parmacek MS, Solaro RJ
  Title
Biology of the troponin complex in cardiac myocytes.
  Journal
Prog Cardiovasc Dis 47:159-76 (2004)
DOI:10.1016/j.pcad.2004.07.003
Reference
PMID:14659803
  Authors
Yamashita H, Sugiura S, Fujita H, Yasuda S, Nagai R, Saeki Y, Sunagawa K, Sugi H
  Title
Myosin light chain isoforms modify force-generating ability of cardiac myosin by changing the kinetics of actin-myosin interaction.
  Journal
Cardiovasc Res 60:580-8 (2003)
DOI:10.1016/j.cardiores.2003.09.011
Reference
PMID:19403607
  Authors
Pritchard TJ, Kranias EG
  Title
Junctin and the histidine-rich Ca2+ binding protein: potential roles in heart failure and arrhythmogenesis.
  Journal
J Physiol 587:3125-33 (2009)
DOI:10.1113/jphysiol.2009.172171
Reference
PMID:28596175
  Authors
Landstrom AP, Dobrev D, Wehrens XHT
  Title
Calcium Signaling and Cardiac Arrhythmias.
  Journal
Circ Res 120:1969-1993 (2017)
DOI:10.1161/CIRCRESAHA.117.310083
Related
pathway
omc04020  Calcium signaling pathway
KO pathway
ko04260   
LinkDB

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