Entry
Name
Cardiac muscle contraction - Papio anubis (olive baboon)
Description
Contraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation of voltage-dependent L-type Ca channels (DHP receptors) upon membrane depolarization triggers the release of Ca2+ via Ca2+ release channels (ryanodine receptors) of sarcoplasmic reticulum (SR) through a Ca2+ -induced Ca release (CICR) mechanism. Ca2+ ions released via the CICR mechanism diffuse through the cytosolic space to contractile proteins to bind to troponinC resulting in the release of inhibition induced by troponinI. The Ca2+ binding to troponinC thereby triggers the sliding of thin and thick filaments, that is, the activation of a crossbridge and subsequent cardiac force development and/or cell shortening. Recovery occurs as Ca2+ is pumped out of the cell by the Na+/Ca2+ exchanger (NCX) or is returned to the sarcoplasmic reticulum (SR) by sarco(endo)plasmic Ca2+ -ATPase (SERCA) pumps on the non-junctional region of the SR.
Class
Organismal Systems; Circulatory system
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Papio anubis (olive baboon) [GN:
panu ]
Gene
101026237 CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X7 [KO:K04850 ]
101002070 CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X6 [KO:K04851 ]
101019865 CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853 ]
101025213 CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857 ]
100999288 CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862 ]
101013479 CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X5 [KO:K04863 ]
101009342 CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X2 [KO:K04864 ]
101021665 CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865 ]
101018169 CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858 ]
101003565 voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859 ]
100999030 CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860 ]
101021906 CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861 ]
101017585 CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866 ]
101009456 CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867 ]
101010591 CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868 ]
101017225 CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869 ]
101016897 CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870 ]
101024211 CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871 ]
100137334 CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872 ]
101026427 CACNG8; LOW QUALITY PROTEIN: voltage-dependent calcium channel gamma-8 subunit [KO:K04873 ]
100997092 HRC; LOW QUALITY PROTEIN: sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450 ]
101021063 ATP2A2; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853 ] [EC:7.2.2.10 ]
100999076 ATP2A1; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853 ] [EC:7.2.2.10 ]
100997019 MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351 ]
101009600 cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414 ]
101006001 cytochrome b-c1 complex subunit 6, mitochondrial isoform X2 [KO:K00416 ]
101006909 cytochrome c oxidase subunit 4 isoform 1, mitochondrial-like [KO:K02263 ]
101019045 cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform X1 [KO:K02263 ]
101003461 cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263 ]
101020469 cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1 [KO:K02263 ]
101001315 LOW QUALITY PROTEIN: cytochrome c oxidase subunit 5A, mitochondrial-like [KO:K02264 ]
101006649 COX5A; cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264 ]
101002878 cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270 ]
101019499 cytochrome c oxidase subunit 7A2, mitochondrial isoform X1 [KO:K02270 ]
116271663 cytochrome c oxidase subunit 7A1, mitochondrial isoform X1 [KO:K02270 ]
116271667 cytochrome c oxidase subunit 7A1, mitochondrial isoform X1 [KO:K02270 ]
101021606 cytochrome c oxidase subunit 7A1, mitochondrial isoform X2 [KO:K02270 ]
101026809 cytochrome c oxidase subunit 8C, mitochondrial isoform X2 [KO:K02273 ]
100126727 COX8A; cytochrome c oxidase subunit 8A, mitochondrial precursor [KO:K02273 ]
101006820 ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540 ]
101021451 ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 isoform X2 [KO:K01540 ]
101006275 ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540 ]
103877943 FXYD2; sodium/potassium-transporting ATPase subunit gamma isoform X2 [KO:K01538 ]
Compound
Reference
Authors
Bers DM
Title
Calcium cycling and signaling in cardiac myocytes.
Journal
Reference
Authors
Bers DM
Title
Cardiac excitation-contraction coupling.
Journal
Reference
Authors
Endoh M
Title
Signal transduction and Ca2+ signaling in intact myocardium.
Journal
Reference
Authors
Endoh M
Title
Cardiac Ca2+ signaling and Ca2+ sensitizers.
Journal
Reference
Authors
Bers DM, Despa S
Title
Cardiac myocytes Ca2+ and Na+ regulation in normal and failing hearts.
Journal
Reference
Authors
Gordon AM, Homsher E, Regnier M
Title
Regulation of contraction in striated muscle.
Journal
Reference
Authors
Phrommintikul A, Chattipakorn N
Title
Roles of cardiac ryanodine receptor in heart failure and sudden cardiac death.
Journal
Reference
Authors
Lacinova L
Title
Voltage-dependent calcium channels.
Journal
Gen Physiol Biophys 24 Suppl 1:1-78 (2005)
Reference
Authors
Lingrel J, Moseley A, Dostanic I, Cougnon M, He S, James P, Woo A, O'Connor K, Neumann J
Title
Functional roles of the alpha isoforms of the Na,K-ATPase.
Journal
Reference
Authors
Berg JS, Powell BC, Cheney RE
Title
A millennial myosin census.
Journal
Reference
Authors
Parmacek MS, Solaro RJ
Title
Biology of the troponin complex in cardiac myocytes.
Journal
Reference
Authors
Yamashita H, Sugiura S, Fujita H, Yasuda S, Nagai R, Saeki Y, Sunagawa K, Sugi H
Title
Myosin light chain isoforms modify force-generating ability of cardiac myosin by changing the kinetics of actin-myosin interaction.
Journal
Reference
Authors
Pritchard TJ, Kranias EG
Title
Junctin and the histidine-rich Ca2+ binding protein: potential roles in heart failure and arrhythmogenesis.
Journal
Reference
Authors
Landstrom AP, Dobrev D, Wehrens XHT
Title
Calcium Signaling and Cardiac Arrhythmias.
Journal
Related pathway
KO pathway
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