KEGG   PATHWAY: pcad04814
Entry
pcad04814                   Pathway                                
Name
Motor proteins - Physeter catodon (sperm whale)
Class
Cellular Processes; Cell motility
Pathway map
pcad04814  Motor proteins
pcad04814

Organism
Physeter catodon (sperm whale) [GN:pcad]
Gene
102988303  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
102983796  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 [KO:K10414]
102987067  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
102985559  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
102974956  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
102993572  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
102992633  DYNC2LI1; cytoplasmic dynein 2 light intermediate chain 1 [KO:K10417]
102996368  DYNLL1; dynein light chain 1, cytoplasmic [KO:K10418]
102990294  dynein light chain 1, cytoplasmic-like [KO:K10418]
102996837  DYNLL2; dynein light chain 2, cytoplasmic isoform X1 [KO:K10418]
102986513  dynein light chain 1, cytoplasmic-like [KO:K10418]
102993351  DYNLRB2; dynein light chain roadblock-type 2 [KO:K10419]
102983652  dynein light chain roadblock-type 1 [KO:K10419]
102994614  DYNLT3; dynein light chain Tctex-type 3 [KO:K10420]
102983649  DYNLT1; dynein light chain Tctex-type 1 isoform X1 [KO:K10420]
102992747  dynein light chain Tctex-type 1-like [KO:K10420]
102992822  dynein light chain Tctex-type 1-like [KO:K10420]
102977241  DYNLT2; dynein light chain Tctex-type protein 2 [KO:K25419]
102990814  DYNLT4; dynein light chain Tctex-type 4 [KO:K25420]
102976066  DYNLT5; dynein light chain Tctex-type 5 [KO:K25421]
114485201  dynein axonemal heavy chain 1-like [KO:K10408]
102977109  DNAH7; dynein axonemal heavy chain 7 [KO:K10408]
102990135  DNAH6; dynein axonemal heavy chain 6 [KO:K10408]
102980780  DNAH17; dynein axonemal heavy chain 17 [KO:K10408]
102974978  DNAH11; LOW QUALITY PROTEIN: dynein axonemal heavy chain 11 [KO:K10408]
102993765  DNAH5; dynein axonemal heavy chain 5 [KO:K10408]
102984802  DNAH2; dynein axonemal heavy chain 2 isoform X2 [KO:K10408]
102986878  DNAH3; dynein axonemal heavy chain 3 isoform X1 [KO:K10408]
102993144  DNAH8; dynein axonemal heavy chain 8 [KO:K10408]
102994941  DNAH9; dynein axonemal heavy chain 9 [KO:K10408]
114485134  dynein axonemal heavy chain 10-like isoform X3 [KO:K10408]
102978551  DNAH1; dynein axonemal heavy chain 1 [KO:K10408]
102987377  DNAH10; dynein axonemal heavy chain 10 [KO:K10408]
102990812  DNAH12; dynein axonemal heavy chain 12 [KO:K10408]
102986780  DNAI1; dynein axonemal intermediate chain 1 [KO:K10409]
102984896  DNAI2; dynein axonemal intermediate chain 2 [KO:K11143]
102993982  DNAI3; dynein axonemal intermediate chain 3 [KO:K24722]
102994899  DNAI4; LOW QUALITY PROTEIN: dynein axonemal intermediate chain 4 [KO:K24723]
102984915  DNALI1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
102979683  DNAL1; dynein axonemal light chain 1 isoform X1 [KO:K10411]
102981306  DNAL4; dynein axonemal light chain 4 [KO:K10412]
102976116  DCTN1; dynactin subunit 1 isoform X9 [KO:K04648]
102981271  DCTN2; dynactin subunit 2 isoform X3 [KO:K10424]
102985476  DCTN3; dynactin subunit 3 isoform X2 [KO:K10425]
102979074  DCTN4; dynactin subunit 4 [KO:K10426]
102975129  DCTN5; dynactin subunit 5 [KO:K10427]
102987814  DCTN6; dynactin subunit 6 isoform X2 [KO:K10428]
102996104  ACTR1B; beta-centractin [KO:K16575]
102985703  ACTR1A; alpha-centractin isoform X1 [KO:K16575]
102976018  ACTR10; actin-related protein 10 [KO:K16576]
102987297  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
112064330  LOW QUALITY PROTEIN: F-actin-capping protein subunit alpha-1-like [KO:K10364]
102978759  LOW QUALITY PROTEIN: F-actin-capping protein subunit alpha-1-like [KO:K10364]
102987809  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
102988639  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
102978446  CAPZB; F-actin-capping protein subunit beta isoform X3 [KO:K10365]
102995399  BICDL2; BICD family-like cargo adapter 2 isoform X1 [KO:K16756]
102978771  BICDL1; BICD family-like cargo adapter 1 [KO:K16756]
102977245  HOOK3; protein Hook homolog 3 [KO:K16536]
102979938  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
102982837  tubulin alpha-4A chain [KO:K07374]
102990956  tubulin alpha-1D chain-like [KO:K07374]
102987728  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
102980636  tubulin alpha-1C chain [KO:K07374]
102990900  tubulin alpha-1B chain [KO:K07374]
112064711  tubulin alpha-1B chain [KO:K07374]
112067146  tubulin alpha-1B chain-like [KO:K07374]
102992310  tubulin alpha-3 chain [KO:K07374]
102985147  TUBB2A; tubulin beta-2A chain isoform X2 [KO:K07375]
102975630  TUBB3; tubulin beta-3 chain isoform X1 [KO:K07375]
102979859  TUBB; tubulin beta chain [KO:K07375]
102987503  TUBB4A; tubulin beta-4A chain isoform X1 [KO:K07375]
102981831  TUBB4B; tubulin beta-4B chain isoform X1 [KO:K07375]
102996007  TUBB6; tubulin beta-6 chain [KO:K07375]
102986688  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
102984856  tubulin beta-2B chain-like [KO:K07375]
102995502  tubulin gamma-2 chain isoform X1 [KO:K10389]
102974162  TUBG1; tubulin gamma-1 chain isoform X1 [KO:K10389]
114485269  tubulin gamma-2 chain-like [KO:K10389]
102989938  TUBD1; tubulin delta chain [KO:K10390]
102982456  TUBE1; tubulin epsilon chain [KO:K10391]
102981918  KIF5A; kinesin heavy chain [KO:K10396]
102976660  KIF5B; kinesin-1 heavy chain isoform X1 [KO:K10396]
102993084  KIF5C; kinesin heavy chain [KO:K10396]
102983908  KLC2; kinesin light chain 2 isoform X1 [KO:K10407]
102982780  KLC1; LOW QUALITY PROTEIN: kinesin light chain 1 [KO:K10407]
102979365  KLC3; LOW QUALITY PROTEIN: kinesin light chain 3 [KO:K10407]
102996447  KLC4; kinesin light chain 4 isoform X2 [KO:K10407]
102984455  KIF3A; kinesin-like protein KIF3A isoform X3 [KO:K10394]
102979364  KIF3B; kinesin-like protein KIF3B [KO:K20196]
102974645  KIFAP3; kinesin-associated protein 3 [KO:K25388]
102973466  KIF3C; kinesin-like protein KIF3C isoform X1 [KO:K20197]
102994481  KIF17; kinesin-like protein KIF17 [KO:K20198]
102974145  KIF1B; kinesin-like protein KIF1B isoform X1 [KO:K10392]
114487654  kinesin-like protein KIF1C [KO:K10392]
102982878  kinesin-like protein KIF1C [KO:K10392]
102986354  KIF1A; kinesin-like protein KIF1A [KO:K10392]
102991948  KIF13B; kinesin-like protein KIF13B isoform X1 [KO:K17914]
102995545  KIF13A; LOW QUALITY PROTEIN: kinesin-like protein KIF13A [KO:K17914]
102982320  KIF14; kinesin-like protein KIF14 [KO:K17915]
102982904  KIF16B; kinesin-like protein KIF16B [KO:K17916]
102990240  STARD9; stAR-related lipid transfer protein 9 [KO:K16491]
102994964  chromosome-associated kinesin KIF4A isoform X1 [KO:K10395]
102975922  KIF7; kinesin-like protein KIF7 isoform X5 [KO:K18806]
102989788  KIF21A; kinesin-like protein KIF21A isoform X1 [KO:K24185]
102986826  kinesin-like protein KIF21B [KO:K24185]
102974937  KIF27; kinesin-like protein KIF27 isoform X2 [KO:K24186]
102984191  KIF11; kinesin-like protein KIF11 isoform X2 [KO:K10398]
102980486  KIF20A; kinesin-like protein KIF20A [KO:K10402]
102994466  KIF20B; kinesin-like protein KIF20B [KO:K10402]
102988560  KIF23; kinesin-like protein KIF23 isoform X1 [KO:K17387]
102976736  CENPE; centromere-associated protein E isoform X5 [KO:K11498]
102990128  KIF18A; kinesin-like protein KIF18A [KO:K10401]
102986720  KIF18B; kinesin-like protein KIF18B [KO:K26156]
102984329  KIF19; kinesin-like protein KIF19 [KO:K26157]
102977059  KIF9; kinesin-like protein KIF9 isoform X3 [KO:K10397]
102978527  KIF6; kinesin-like protein KIF6 [KO:K10397]
102994602  KIF22; kinesin-like protein KIF22 isoform X2 [KO:K10403]
112066775  KIF26A; kinesin-like protein KIF26A [KO:K10404]
102981441  KIF26B; kinesin-like protein KIF26B isoform X2 [KO:K10404]
102983634  KIF12; kinesin-like protein KIF12 [KO:K10399]
102983485  KIF15; kinesin-like protein KIF15 isoform X1 [KO:K10400]
102994123  KIF2B; LOW QUALITY PROTEIN: kinesin-like protein KIF2B [KO:K10393]
102978957  KIF2A; kinesin-like protein KIF2A isoform X1 [KO:K10393]
102988939  KIF24; kinesin-like protein KIF24 isoform X2 [KO:K10393]
102989562  KIF2C; kinesin-like protein KIF2C isoform X1 [KO:K10393]
102987020  KIFC1; kinesin-like protein KIFC1 isoform X4 [KO:K10405]
102973150  KIFC2; kinesin-like protein KIFC2 isoform X1 [KO:K10406]
102994981  KIFC3; kinesin-like protein KIFC3 isoform X2 [KO:K10406]
102973796  MYO1A; unconventional myosin-Ia isoform X1 [KO:K10356]
102996005  MYO1F; unconventional myosin-If [KO:K10356]
102983004  MYO1G; unconventional myosin-Ig [KO:K10356]
102982001  MYO1C; unconventional myosin-Ic [KO:K10356]
102981501  MYO1D; unconventional myosin-Id isoform X1 [KO:K10356]
102980826  MYO1B; unconventional myosin-Ib isoform X1 [KO:K10356]
114485013  unconventional myosin-Ic isoform X1 [KO:K10356]
102994157  MYO1H; unconventional myosin-Ih [KO:K10356]
102973272  MYO1E; unconventional myosin-Ie isoform X1 [KO:K10356]
102973813  MYO3B; myosin-IIIb [KO:K08834] [EC:2.7.11.1]
102988914  MYO3A; myosin-IIIa isoform X5 [KO:K08834] [EC:2.7.11.1]
102980327  MYO5B; unconventional myosin-Vb [KO:K10357]
102992233  MYO5A; unconventional myosin-Va isoform X1 [KO:K10357]
102995103  MYO5C; unconventional myosin-Vc [KO:K10357]
102979281  MYO6; unconventional myosin-VI isoform X1 [KO:K10358]
114485433  unconventional myosin-VIIa-like [KO:K10359]
102976835  MYO7A; unconventional myosin-VIIa [KO:K10359]
102987491  MYO7B; unconventional myosin-VIIb isoform X2 [KO:K21868]
102988810  MYO9A; unconventional myosin-IXa isoform X1 [KO:K10360]
102991058  MYO10; unconventional myosin-X isoform X1 [KO:K12559]
102981149  MYO15A; unconventional myosin-XV [KO:K10361]
102980963  MYO15B; LOW QUALITY PROTEIN: myosin XVB [KO:K10361]
102979347  MYO16; unconventional myosin-XVI [KO:K17481]
114487570  MYO18A; unconventional myosin-XVIIIa isoform X1 [KO:K10362]
102979620  MYO18B; unconventional myosin-XVIIIb [KO:K10362]
102976086  unconventional myosin-XVIIIa isoform X1 [KO:K10362]
102973385  MYO19; unconventional myosin-XIX isoform X1 [KO:K25838]
102994112  myosin-2 [KO:K24220]
102977477  myosin-3 [KO:K24220]
102989053  myosin-8 isoform X1 [KO:K24220]
102993832  LOW QUALITY PROTEIN: myosin-4 [KO:K24220]
114487067  myosin-7-like [KO:K17751]
102979950  MYH6; myosin-6 isoform X1 [KO:K17751]
102978583  myosin-7 [KO:K17751]
102974680  MYH10; myosin-10 [KO:K10352]
102975034  MYH14; myosin-14 [KO:K10352]
102984553  MYH9; myosin-9 [KO:K10352]
112065101  myosin light chain 1/3, skeletal muscle isoform-like [KO:K05738]
102995144  myosin light chain 1/3, skeletal muscle isoform isoform X2 [KO:K05738]
102978650  MYL3; myosin light chain 3 [KO:K12749]
102988459  MYL4; myosin light chain 4 isoform X2 [KO:K12750]
102977633  MYL6; myosin light polypeptide 6 isoform X1 [KO:K12751]
102976722  MYL6B; myosin light chain 6B [KO:K12751]
102983557  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
102985354  MYL5; myosin light chain 5 [KO:K12753]
102975231  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
102985793  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
102973456  MYL10; myosin regulatory light chain 10 [KO:K12756]
102993300  myosin regulatory light polypeptide 9 isoform X1 [KO:K12757]
102993761  myosin regulatory light chain 12B [KO:K12757]
102996446  MYL11; myosin regulatory light chain 11 [KO:K12758]
102976743  ACTA1; actin, alpha skeletal muscle [KO:K10354]
102985765  ACTA2; actin, aortic smooth muscle [KO:K12313]
102996486  ACTC1; actin, alpha cardiac muscle 1 [KO:K12314]
102981804  ACTG2; actin, gamma-enteric smooth muscle isoform X1 [KO:K12315]
102988048  ACTG1; actin, cytoplasmic 2 [KO:K05692]
102988905  actin, cytoplasmic 1 [KO:K05692]
112063645  actin, cytoplasmic 1 isoform X2 [KO:K05692]
102985457  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
102984102  TNNI1; troponin I, slow skeletal muscle [KO:K10371]
102986421  TNNT1; troponin T, slow skeletal muscle isoform X1 [KO:K10372]
102996114  TNNC2; troponin C, skeletal muscle [KO:K12042]
102976404  TNNI2; troponin I, fast skeletal muscle [KO:K12043]
102973617  TNNT3; troponin T, fast skeletal muscle isoform X7 [KO:K12046]
102986127  TNNI3; troponin I, cardiac muscle isoform X2 [KO:K12044]
102987963  TNNT2; troponin T, cardiac muscle isoform X1 [KO:K12045]
102986180  TPM1; tropomyosin alpha-1 chain isoform X2 [KO:K10373]
102988158  TPM2; tropomyosin beta chain isoform X2 [KO:K10374]
102975708  tropomyosin beta chain-like [KO:K10374]
102987698  TPM3; tropomyosin alpha-3 chain isoform X4 [KO:K09290]
102992634  TPM4; tropomyosin alpha-4 chain isoform X1 [KO:K10375]
Reference
PMID:21092854
  Authors
Hirokawa N, Niwa S, Tanaka Y
  Title
Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease.
  Journal
Neuron 68:610-38 (2010)
DOI:10.1016/j.neuron.2010.09.039
Reference
PMID:25470043 (PDB:4RH7)
  Authors
Schmidt H, Zalyte R, Urnavicius L, Carter AP
  Title
Structure of human cytoplasmic dynein-2 primed for its power stroke.
  Journal
Nature 518:435-438 (2015)
DOI:10.1038/nature14023
Reference
PMID:22398446 (PDB:3VKG 3VKH)
  Authors
Kon T, Oyama T, Shimo-Kon R, Imamula K, Shima T, Sutoh K, Kurisu G
  Title
The 2.8 A crystal structure of the dynein motor domain.
  Journal
Nature 484:345-50 (2012)
DOI:10.1038/nature10955
Reference
PMID:22997337 (PDB:3J1T 3J1U)
  Authors
Redwine WB, Hernandez-Lopez R, Zou S, Huang J, Reck-Peterson SL, Leschziner AE
  Title
Structural basis for microtubule binding and release by dynein.
  Journal
Science 337:1532-1536 (2012)
DOI:10.1126/science.1224151
Reference
PMID:26410600
  Authors
Gibbs KL, Greensmith L, Schiavo G
  Title
Regulation of Axonal Transport by Protein Kinases.
  Journal
Trends Biochem Sci 40:597-610 (2015)
DOI:10.1016/j.tibs.2015.08.003
Reference
PMID:28602352 (PDB:5NUG 5NVS 5NVU 5NW4)
  Authors
Zhang K, Foster HE, Rondelet A, Lacey SE, Bahi-Buisson N, Bird AW, Carter AP
  Title
Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated.
  Journal
Cell 169:1303-1314.e18 (2017)
DOI:10.1016/j.cell.2017.05.025
Reference
PMID:25814576 (PDB:5ADX 5AFR 5AFU)
  Authors
Urnavicius L, Zhang K, Diamant AG, Motz C, Schlager MA, Yu M, Patel NA, Robinson CV, Carter AP
  Title
The structure of the dynactin complex and its interaction with dynein.
  Journal
Science 347:1441-1446 (2015)
DOI:10.1126/science.aaa4080
Reference
PMID:29420470 (PDB:5OWO 6F1T 6F1U 6F1V 6F1Y 6F1Z 6F38 6F3A)
  Authors
Urnavicius L, Lau CK, Elshenawy MM, Morales-Rios E, Motz C, Yildiz A, Carter AP
  Title
Cryo-EM shows how dynactin recruits two dyneins for faster movement.
  Journal
Nature 554:202-206 (2018)
DOI:10.1038/nature25462
Reference
PMID:29662141
  Authors
Reck-Peterson SL, Redwine WB, Vale RD, Carter AP
  Title
The cytoplasmic dynein transport machinery and its many cargoes.
  Journal
Nat Rev Mol Cell Biol 19:382-398 (2018)
DOI:10.1038/s41580-018-0004-3
Reference
PMID:23434508 (PDB:3J2U)
  Authors
Asenjo AB, Chatterjee C, Tan D, DePaoli V, Rice WJ, Diaz-Avalos R, Silvestry M, Sosa H
  Title
Structural model for tubulin recognition and deformation by kinesin-13 microtubule depolymerases.
  Journal
Cell Rep 3:759-68 (2013)
DOI:10.1016/j.celrep.2013.01.030
Reference
PMID:10338210 (PDB:1B7T)
  Authors
Houdusse A, Kalabokis VN, Himmel D, Szent-Gyorgyi AG, Cohen C
  Title
Atomic structure of scallop myosin subfragment S1 complexed with MgADP: a novel conformation of the myosin head.
  Journal
Cell 97:459-70 (1999)
DOI:10.1016/s0092-8674(00)80756-4
Reference
PMID:9428521 (PDB:3KIN)
  Authors
Kozielski F, Sack S, Marx A, Thormahlen M, Schonbrunn E, Biou V, Thompson A, Mandelkow EM, Mandelkow E
  Title
The crystal structure of dimeric kinesin and implications for microtubule-dependent motility.
  Journal
Cell 91:985-94 (1997)
DOI:10.1016/s0092-8674(00)80489-4
Reference
PMID:8316857 (PDB:2MYS)
  Authors
Rayment I, Rypniewski WR, Schmidt-Base K, Smith R, Tomchick DR, Benning MM, Winkelmann DA, Wesenberg G, Holden HM
  Title
Three-dimensional structure of myosin subfragment-1: a molecular motor.
  Journal
Science 261:50-8 (1993)
DOI:10.1126/science.8316857
Reference
PMID:20428469
  Authors
Parker D, Bryant Z, Delp SL
  Title
Coarse-Grained Structural Modeling of Molecular Motors Using Multibody Dynamics.
  Journal
Cell Mol Bioeng 2:366-374 (2009)
DOI:10.1007/s12195-009-0084-4
Reference
PMID:21314430
  Authors
Dominguez R, Holmes KC
  Title
Actin structure and function.
  Journal
Annu Rev Biophys 40:169-86 (2011)
DOI:10.1146/annurev-biophys-042910-155359
Reference
PMID:31919429 (PDB:6KN7 6KN8)
  Authors
Yamada Y, Namba K, Fujii T
  Title
Cardiac muscle thin filament structures reveal calcium regulatory mechanism.
  Journal
Nat Commun 11:153 (2020)
DOI:10.1038/s41467-019-14008-1
Reference
PMID:33912943
  Authors
Kruppa AJ, Buss F
  Title
Motor proteins at the mitochondria-cytoskeleton interface.
  Journal
J Cell Sci 134:239092 (2021)
DOI:10.1242/jcs.226084
KO pathway
ko04814   
LinkDB

DBGET integrated database retrieval system