KEGG   PATHWAY: pcan04146
Entry
pcan04146                   Pathway                                
Name
Peroxisome - Pomacea canaliculata (golden apple snail)
Description
Peroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies.
Class
Cellular Processes; Transport and catabolism
Pathway map
pcan04146  Peroxisome
pcan04146

Other DBs
GO: 0005777
Organism
Pomacea canaliculata (golden apple snail) [GN:pcan]
Gene
112560494  peroxisomal membrane protein PEX16-like [KO:K13335]
112567573  LOW QUALITY PROTEIN: peroxisomal biogenesis factor 19-like [KO:K13337]
112573909  ATP-binding cassette sub-family D member 3-like [KO:K05677] [EC:7.6.2.4]
112555518  LOW QUALITY PROTEIN: peroxisome biogenesis factor 1-like [KO:K13338]
112570038  LOW QUALITY PROTEIN: peroxisome assembly factor 2-like [KO:K13339]
112571848  uncharacterized protein LOC112571848 isoform X1 [KO:K13340]
112566119  peroxisomal targeting signal 2 receptor-like [KO:K13341]
112556429  peroxisomal targeting signal 1 receptor-like [KO:K13342]
112556161  peroxisomal membrane protein PEX14-like isoform X1 [KO:K13343]
112573572  peroxisomal membrane protein PEX13-like isoform X1 [KO:K13344]
112563282  peroxisome assembly protein 12-like isoform X1 [KO:K13345]
112563924  LOW QUALITY PROTEIN: peroxisome biogenesis factor 10-like [KO:K13346]
112556340  peroxisome biogenesis factor 2-like [KO:K06664]
112562825  peroxisomal membrane protein 2-like [KO:K13347]
112553495  mpv17-like protein 2 [KO:K13348]
112561274  protein Mpv17-like isoform X1 [KO:K13348]
112573915  mpv17-like protein 2 [KO:K13348]
112576966  mpv17-like protein [KO:K13349]
112560464  peroxisomal membrane protein 4-like [KO:K13350]
112557982  peroxisomal membrane protein 11A-like [KO:K13352]
112553727  LOW QUALITY PROTEIN: peroxisomal membrane protein 11B-like [KO:K13352]
112556782  peroxisomal membrane protein 11C-like [KO:K13353]
112569480  peroxisomal membrane protein PMP34-like isoform X1 [KO:K13354]
112564745  2-hydroxyacyl-CoA lyase 1-like isoform X1 [KO:K12261] [EC:4.1.2.63]
112553892  alpha-methylacyl-CoA racemase-like [KO:K01796] [EC:5.1.99.4]
112571426  phytanoyl-CoA dioxygenase, peroxisomal-like [KO:K00477] [EC:1.14.11.18]
112562531  peroxisomal acyl-coenzyme A oxidase 3-like [KO:K00232] [EC:1.3.3.6]
112562720  peroxisomal acyl-coenzyme A oxidase 1-like [KO:K00232] [EC:1.3.3.6]
112562721  peroxisomal acyl-coenzyme A oxidase 1-like [KO:K00232] [EC:1.3.3.6]
112553906  peroxisomal multifunctional enzyme type 2-like [KO:K12405] [EC:1.1.1.- 4.2.1.107 4.2.1.119]
112556260  non-specific lipid-transfer protein-like [KO:K08764] [EC:2.3.1.176]
112573252  non-specific lipid-transfer protein-like isoform X1 [KO:K08764] [EC:2.3.1.176]
112570289  bile acid-CoA:amino acid N-acyltransferase-like [KO:K00659] [EC:2.3.1.65 3.1.2.2]
112570277  bile acid-CoA:amino acid N-acyltransferase-like [KO:K00659] [EC:2.3.1.65 3.1.2.2]
112570596  acyl-coenzyme A thioesterase 6-like [KO:K00659] [EC:2.3.1.65 3.1.2.2]
112564830  LOW QUALITY PROTEIN: peroxisomal bifunctional enzyme-like [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
112564571  3-ketoacyl-CoA thiolase B, peroxisomal-like [KO:K07513] [EC:2.3.1.16]
112563050  peroxisomal 2,4-dienoyl-CoA reductase-like [KO:K13237] [EC:1.3.1.124]
112570588  delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial-like [KO:K12663] [EC:5.3.3.21]
112571597  ATP-binding cassette sub-family D member 2-like isoform X1 [KO:K05676] [EC:7.6.2.4]
112570121  ATP-binding cassette sub-family D member 4-like [KO:K05678] [EC:7.6.2.8]
112573457  LOW QUALITY PROTEIN: long-chain-fatty-acid--CoA ligase 5-like [KO:K01897] [EC:6.2.1.3]
112572438  LOW QUALITY PROTEIN: long-chain-fatty-acid--CoA ligase 5-like [KO:K01897] [EC:6.2.1.3]
112557822  long-chain-fatty-acid--CoA ligase 1-like isoform X1 [KO:K01897] [EC:6.2.1.3]
112555923  long-chain-fatty-acid--CoA ligase 4-like isoform X1 [KO:K01897] [EC:6.2.1.3]
112556683  LOW QUALITY PROTEIN: peroxisomal trans-2-enoyl-CoA reductase-like [KO:K07753] [EC:1.3.1.38]
112557643  peroxisomal trans-2-enoyl-CoA reductase-like [KO:K07753] [EC:1.3.1.38]
112576557  enoyl-CoA delta isomerase 2, mitochondrial-like [KO:K13239] [EC:5.3.3.8]
112576424  uncharacterized protein LOC112576424 [KO:K17879] [EC:3.6.1.77]
112553624  peroxisomal NADH pyrophosphatase NUDT12-like isoform X1 [KO:K03426] [EC:3.6.1.22]
112553448  nucleoside diphosphate-linked moiety X motif 19-like [KO:K13355] [EC:3.6.1.77]
112573776  LOW QUALITY PROTEIN: nucleoside diphosphate-linked moiety X motif 19-like [KO:K13355] [EC:3.6.1.77]
112553245  acyl-coenzyme A thioesterase 8-like isoform X1 [KO:K11992] [EC:3.1.2.27]
112575207  carnitine O-acetyltransferase-like isoform X1 [KO:K00624] [EC:2.3.1.7]
112564556  LOW QUALITY PROTEIN: peroxisomal carnitine O-octanoyltransferase-like [KO:K05940] [EC:2.3.1.137]
112566406  malonyl-CoA decarboxylase, mitochondrial-like isoform X1 [KO:K01578] [EC:4.1.1.9]
112570166  dihydroxyacetone phosphate acyltransferase-like [KO:K00649] [EC:2.3.1.42]
112556460  LOW QUALITY PROTEIN: alkyldihydroxyacetonephosphate synthase, peroxisomal-like [KO:K00803] [EC:2.5.1.26]
112559718  fatty acyl-CoA reductase 1-like [KO:K13356] [EC:1.2.1.84]
112560916  fatty acyl-CoA reductase 1-like [KO:K13356] [EC:1.2.1.84]
112562133  mevalonate kinase-like isoform X1 [KO:K00869] [EC:2.7.1.36]
112554646  phosphomevalonate kinase-like [KO:K13273] [EC:2.7.4.2]
112555075  LOW QUALITY PROTEIN: serine--pyruvate aminotransferase-like [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
112573874  D-amino-acid oxidase-like [KO:K00273] [EC:1.4.3.3]
112577427  uncharacterized protein LOC112577427 [KO:K00272] [EC:1.4.3.1]
112561231  isocitrate dehydrogenase [NADP], mitochondrial-like [KO:K00031] [EC:1.1.1.42]
112559489  isocitrate dehydrogenase [NADP] cytoplasmic-like [KO:K00031] [EC:1.1.1.42]
112563272  peroxisomal sarcosine oxidase-like [KO:K00306] [EC:1.5.3.1 1.5.3.7]
112562345  hydroxymethylglutaryl-CoA lyase, mitochondrial-like [KO:K01640] [EC:4.1.3.4]
112570213  hydroxyacid oxidase 1-like [KO:K11517] [EC:1.1.3.15]
112566422  catalase-like isoform X1 [KO:K03781] [EC:1.11.1.6]
112566036  catalase-like isoform X1 [KO:K03781] [EC:1.11.1.6]
112571310  peroxiredoxin-5, mitochondrial-like [KO:K11187] [EC:1.11.1.24]
112570842  peroxiredoxin-5, mitochondrial-like [KO:K11187] [EC:1.11.1.24]
112572053  superoxide dismutase [Cu-Zn]-like [KO:K04565] [EC:1.15.1.1]
112566824  superoxide dismutase [Cu-Zn]-like [KO:K04565] [EC:1.15.1.1]
112567213  superoxide dismutase [Mn], mitochondrial-like isoform X1 [KO:K04564] [EC:1.15.1.1]
112573157  peroxiredoxin-like isoform X1 [KO:K13279] [EC:1.11.1.24]
112557420  glutathione S-transferase kappa 1-like [KO:K13299] [EC:2.5.1.18]
112558481  LOW QUALITY PROTEIN: xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
112558482  LOW QUALITY PROTEIN: xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
112558485  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
112558486  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
112558487  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
112560812  LOW QUALITY PROTEIN: xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
112558498  LOW QUALITY PROTEIN: xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
112558796  LOW QUALITY PROTEIN: xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
112558798  LOW QUALITY PROTEIN: xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
112558805  LOW QUALITY PROTEIN: xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
112558811  LOW QUALITY PROTEIN: xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
112560136  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
112570981  LOW QUALITY PROTEIN: xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
112571030  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
112570128  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
112570129  xanthine dehydrogenase/oxidase-like isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
112577144  dehydrogenase/reductase SDR family member 4-like isoform X1 [KO:K11147] [EC:1.1.-.-]
Reference
PMID:17055078
  Authors
Wanders RJ, Waterham HR
  Title
Peroxisomal disorders: the single peroxisomal enzyme deficiencies.
  Journal
Biochim Biophys Acta 1763:1707-20 (2006)
DOI:10.1016/j.bbamcr.2006.08.010
Reference
PMID:17055079
  Authors
Steinberg SJ, Dodt G, Raymond GV, Braverman NE, Moser AB, Moser HW
  Title
Peroxisome biogenesis disorders.
  Journal
Biochim Biophys Acta 1763:1733-48 (2006)
DOI:10.1016/j.bbamcr.2006.09.010
Reference
PMID:17010456
  Authors
Rottensteiner H, Theodoulou FL
  Title
The ins and outs of peroxisomes: co-ordination of membrane transport and peroxisomal metabolism.
  Journal
Biochim Biophys Acta 1763:1527-40 (2006)
DOI:10.1016/j.bbamcr.2006.08.012
Reference
PMID:16631601
  Authors
Iida R, Yasuda T, Tsubota E, Takatsuka H, Matsuki T, Kishi K
  Title
Human Mpv17-like protein is localized in peroxisomes and regulates expression of antioxidant enzymes.
  Journal
Biochem Biophys Res Commun 344:948-54 (2006)
DOI:10.1016/j.bbrc.2006.04.008
Related
pathway
pcan00071  Fatty acid degradation
pcan00230  Purine metabolism
pcan00564  Glycerophospholipid metabolism
pcan00565  Ether lipid metabolism
pcan00830  Retinol metabolism
pcan00900  Terpenoid backbone biosynthesis
KO pathway
ko04146   
LinkDB

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