KEGG   PATHWAY: pcoo04612
Entry
pcoo04612                   Pathway                                
Name
Antigen processing and presentation - Puma concolor (puma)
Class
Organismal Systems; Immune system
Pathway map
pcoo04612  Antigen processing and presentation
pcoo04612

Other DBs
GO: 0019885 0019886 0042591
Organism
Puma concolor (puma) [GN:pcoo]
Gene
112863468  IFNG; interferon gamma [KO:K04687]
112853630  TNF; tumor necrosis factor [KO:K03156]
112855003  PSME1; proteasome activator complex subunit 1 isoform X1 [KO:K06696]
112872178  PSME2; LOW QUALITY PROTEIN: proteasome activator complex subunit 2 [KO:K06697]
112853959  PSME3; proteasome activator complex subunit 3 isoform X1 [KO:K06698]
112865282  HSPA8; LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein [KO:K03283]
112853784  heat shock 70 kDa protein 1-like [KO:K03283]
112853785  heat shock 70 kDa protein 1-like [KO:K03283]
112855340  HSPA2; heat shock-related 70 kDa protein 2 [KO:K26598]
112861335  HSPA4; heat shock 70 kDa protein 4 isoform X1 [KO:K09489]
112855434  HSP90AA1; heat shock protein HSP 90-alpha isoform X1 [KO:K04079]
112862791  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
112861479  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
112853671  HLA class I histocompatibility antigen, A-11 alpha chain-like [KO:K06751]
112853699  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X1 [KO:K06751]
112853701  HLA class I histocompatibility antigen, Cw-6 alpha chain-like [KO:K06751]
112853765  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
112853766  HLA class I histocompatibility antigen, Cw-6 alpha chain-like [KO:K06751]
112853799  LOW QUALITY PROTEIN: class I histocompatibility antigen, Gogo-OKO alpha chain [KO:K06751]
112850502  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
112861376  CANX; calnexin isoform X1 [KO:K08054]
112855325  B2M; beta-2-microglobulin [KO:K08055]
112854989  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
112852509  CALR; calreticulin [KO:K08057]
112862480  TAPBP; tapasin [KO:K08058]
112862344  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
112862082  TAP2; LOW QUALITY PROTEIN: antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
112864235  CD8B; T-cell surface glycoprotein CD8 beta chain [KO:K06459]
112850918  LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K07980]
112867229  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
112867257  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
112867875  LOW QUALITY PROTEIN: NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
112867876  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
112867297  KLRD1; natural killer cells antigen CD94 [KO:K06516]
112852703  IFI30; gamma-interferon-inducible lysosomal thiol reductase [KO:K08059]
112855369  LGMN; legumain [KO:K01369] [EC:3.4.22.34]
112858176  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
112862042  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
112862071  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
112862094  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
112862131  HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752]
112862364  HLA class II histocompatibility antigen, DO beta chain-like [KO:K06752]
112862858  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752]
112862859  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DRB1-10 beta chain-like [KO:K06752]
112862863  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
112860492  CD74; HLA class II histocompatibility antigen gamma chain [KO:K06505]
112868510  cathepsin L1-like isoform X1 [KO:K01365] [EC:3.4.22.15]
112868585  LOW QUALITY PROTEIN: cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
112868598  cathepsin L1 isoform X1 [KO:K01365] [EC:3.4.22.15]
112868613  cathepsin L1-like isoform X1 [KO:K01365] [EC:3.4.22.15]
112868646  LOW QUALITY PROTEIN: cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
112868647  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
112868649  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
112868651  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
112868732  cathepsin L1-like isoform X1 [KO:K01365] [EC:3.4.22.15]
112868737  cathepsin L1-like isoform X1 [KO:K01365] [EC:3.4.22.15]
112872170  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
112867903  CD4; LOW QUALITY PROTEIN: T-cell surface glycoprotein CD4 [KO:K06454]
112853268  CIITA; MHC class II transactivator [KO:K08060] [EC:2.7.11.1]
112848410  RFX5; DNA-binding protein RFX5 [KO:K08061]
112852628  RFXANK; DNA-binding protein RFXANK [KO:K08062]
112860842  RFXAP; regulatory factor X-associated protein [KO:K08063]
112848555  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
112862103  NFYA; nuclear transcription factor Y subunit alpha isoform X1 [KO:K08064]
112863460  NFYB; nuclear transcription factor Y subunit beta [KO:K08065]
112848947  NFYC; nuclear transcription factor Y subunit gamma [KO:K08066]
Reference
PMID:15771591
  Authors
Trombetta ES, Mellman I.
  Title
Cell biology of antigen processing in vitro and in vivo.
  Journal
Annu Rev Immunol 23:975-1028 (2005)
DOI:10.1146/annurev.immunol.22.012703.104538
Reference
PMID:15814328
  Authors
Inaba K, Inaba M.
  Title
Antigen recognition and presentation by dendritic cells.
  Journal
Int J Hematol 81:181-7 (2005)
DOI:10.1532/IJH97.04200
Reference
PMID:11905820
  Authors
Heath WR, Carbone FR.
  Title
Cross-presentation in viral immunity and self-tolerance.
  Journal
Nat Rev Immunol 1:126-34 (2001)
DOI:10.1038/35100512
Reference
PMID:15304636
  Authors
Abele R, Tampe R.
  Title
The ABCs of immunology: structure and function of TAP, the transporter associated with antigen processing.
  Journal
Physiology (Bethesda) 19:216-24 (2004)
DOI:10.1152/physiol.00002.2004
Reference
PMID:16200082
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
PMID:12776207
  Authors
Honey K, Rudensky AY.
  Title
Lysosomal cysteine proteases regulate antigen presentation.
  Journal
Nat Rev Immunol 3:472-82 (2003)
DOI:10.1038/nri1110
Reference
PMID:12974477
  Authors
Sercarz EE, Maverakis E.
  Title
Mhc-guided processing: binding of large antigen fragments.
  Journal
Nat Rev Immunol 3:621-9 (2003)
DOI:10.1038/nri1149
Reference
PMID:15224093
  Authors
Ackerman AL, Cresswell P.
  Title
Cellular mechanisms governing cross-presentation of exogenous antigens.
  Journal
Nat Immunol 5:678-84 (2004)
DOI:10.1038/ni1082
Reference
PMID:16181333
  Authors
Cresswell P, Ackerman AL, Giodini A, Peaper DR, Wearsch PA.
  Title
Mechanisms of MHC class I-restricted antigen processing and cross-presentation.
  Journal
Immunol Rev 207:145-57 (2005)
DOI:10.1111/j.0105-2896.2005.00316.x
Reference
PMID:15653312
  Authors
Zika E, Ting JP.
  Title
Epigenetic control of MHC-II: interplay between CIITA and histone-modifying enzymes.
  Journal
Curr Opin Immunol 17:58-64 (2005)
DOI:10.1016/j.coi.2004.11.008
Reference
PMID:11244040
  Authors
Reith W, Mach B.
  Title
The bare lymphocyte syndrome and the regulation of MHC expression.
  Journal
Annu Rev Immunol 19:331-73 (2001)
DOI:10.1146/annurev.immunol.19.1.331
Reference
PMID:15745856
  Authors
Lizee G, Basha G, Jefferies WA.
  Title
Tails of wonder: endocytic-sorting motifs key for exogenous antigen presentation.
  Journal
Trends Immunol 26:141-9 (2005)
DOI:10.1016/j.it.2005.01.005
Reference
PMID:15224094
  Authors
Watts C.
  Title
The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules.
  Journal
Nat Immunol 5:685-92 (2004)
DOI:10.1038/ni1088
Reference
PMID:15653315
  Authors
Kaufmann SH, Schaible UE.
  Title
Antigen presentation and recognition in bacterial infections.
  Journal
Curr Opin Immunol 17:79-87 (2005)
DOI:10.1016/j.coi.2004.12.004
Reference
PMID:20010787
  Authors
Groettrup M, Kirk CJ, Basler M
  Title
Proteasomes in immune cells: more than peptide producers?
  Journal
Nat Rev Immunol 10:73-8 (2010)
DOI:10.1038/nri2687
Related
pathway
pcoo03050  Proteasome
pcoo04650  Natural killer cell mediated cytotoxicity
pcoo04660  T cell receptor signaling pathway
KO pathway
ko04612   
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