KEGG   PATHWAY: pic00600
Entry
pic00600                    Pathway                                
Name
Sphingolipid metabolism - Scheffersomyces stipitis
Class
Metabolism; Lipid metabolism
Pathway map
pic00600  Sphingolipid metabolism
pic00600

Module
pic_M00094  Ceramide biosynthesis [PATH:pic00600]
pic_M00100  Sphingosine degradation [PATH:pic00600]
Other DBs
GO: 0006665
Organism
Scheffersomyces stipitis [GN:pic]
Gene
PICST_90811  LCB1; serine palmitoyltransferase component [KO:K00654] [EC:2.3.1.50]
PICST_84331  LCB2; palmitoyl transferase [KO:K00654] [EC:2.3.1.50]
PICST_36953  TSC10; 3-ketosphinganine reductase [KO:K04708] [EC:1.1.1.102]
PICST_32904  LAG1.1; Acyl-CoA-dependent ceramide synthase [KO:K04709] [EC:2.3.1.297]
PICST_45900  LAG1.3; longevity-assurance protein Acyl-CoA-dependent ceramide synthase [KO:K04709] [EC:2.3.1.297]
PICST_41505  LAG1.2; Longevity-assurance protein 1 (Longevity assurance factor 1) [KO:K04709] [EC:2.3.1.297]
PICST_63351  predicted protein [KO:K04711] [EC:3.5.1.-]
PICST_54788  FAD3; fatty acid desaturase (DSD1) [KO:K04712] [EC:1.14.19.17 1.14.18.5]
PICST_77904  SUR2; Sphingolipid hydroxylase [KO:K04713] [EC:1.14.18.5]
PICST_33012  ISC1; phospholipase C type enzyme [KO:K12351] [EC:3.1.4.12]
PICST_28253  YSR3; Yeast Sphingolipid Resistance Gene [KO:K23451] [EC:3.1.3.-]
PICST_54239  SPH1; Sphingosine kinase, involved in sphingolipid metabolism Lipid transport and metabolism [KO:K04718] [EC:2.7.1.91]
PICST_87778  DPL1; dihydrosphingosine-1-phosphate lyase [KO:K01634] [EC:4.1.2.27]
PICST_34303  CGT1; ceramide glucosyltransferase [KO:K00720] [EC:2.4.1.80]
PICST_30036  LAC4; Beta-galactosidase (Lactase) [KO:K01190] [EC:3.2.1.23]
PICST_32069  HEX1; Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase [KO:K12373] [EC:3.2.1.52]
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
pic00260  Glycine, serine and threonine metabolism
pic00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   
LinkDB

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