KEGG   PATHWAY: plep00564
Entry
plep00564                   Pathway                                
Name
Glycerophospholipid metabolism - Plectropomus leopardus (leopard coralgrouper)
Class
Metabolism; Lipid metabolism
Pathway map
plep00564  Glycerophospholipid metabolism
plep00564

Module
plep_M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:plep00564]
plep_M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:plep00564]
plep_M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:plep00564]
Other DBs
GO: 0006650
Organism
Plectropomus leopardus (leopard coralgrouper) [GN:plep]
Gene
121946819  glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic [KO:K00006] [EC:1.1.1.8]
121949806  glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic-like [KO:K00006] [EC:1.1.1.8]
121962731  glycerol-3-phosphate dehydrogenase 1-like protein [KO:K00006] [EC:1.1.1.8]
121962686  gpd2; glycerol-3-phosphate dehydrogenase, mitochondrial isoform X1 [KO:K00111] [EC:1.1.5.3]
121958701  gpam; glycerol-3-phosphate acyltransferase 1, mitochondrial [KO:K00629] [EC:2.3.1.15]
121944855  gpat2; glycerol-3-phosphate acyltransferase 2, mitochondrial [KO:K00629] [EC:2.3.1.15]
121960039  glycerol-3-phosphate acyltransferase 4-like [KO:K13506] [EC:2.3.1.15]
121944018  agpat9l; glycerol-3-phosphate acyltransferase 3-like [KO:K13506] [EC:2.3.1.15]
121944214  glycerol-3-phosphate acyltransferase 4 [KO:K13506] [EC:2.3.1.15]
121938731  glycerol-3-phosphate acyltransferase 3-like isoform X1 [KO:K13506] [EC:2.3.1.15]
121960237  agpat2; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta [KO:K13509] [EC:2.3.1.51]
121948868  agpat3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma [KO:K13523] [EC:2.3.1.51 2.3.1.-]
121954970  agpat4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [KO:K13523] [EC:2.3.1.51 2.3.1.-]
121954311  agpat5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [KO:K19007] [EC:2.3.1.51]
121953914  lclat1; lysocardiolipin acyltransferase 1 [KO:K13513] [EC:2.3.1.- 2.3.1.51]
121953818  mboat2a; LOW QUALITY PROTEIN: lysophospholipid acyltransferase 2 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
121955260  mboat2b; lysophospholipid acyltransferase 2b [KO:K13517] [EC:2.3.1.51 2.3.1.-]
121945822  mboat1; lysophospholipid acyltransferase 1 isoform X1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
121955297  gnpat; dihydroxyacetone phosphate acyltransferase [KO:K00649] [EC:2.3.1.42]
121955466  gnpat2; dihydroxyacetone phosphate acyltransferase [KO:K00649] [EC:2.3.1.42]
121958470  adprm; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
121940033  plpp3; phospholipid phosphatase 3 isoform X1 [KO:K01080] [EC:3.1.3.4]
121953516  plpp2a; phospholipid phosphatase 2 [KO:K01080] [EC:3.1.3.4]
121959478  plpp1a; phospholipid phosphatase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
121956235  phospholipid phosphatase 3-like [KO:K01080] [EC:3.1.3.4]
121938127  plpp2b; phospholipid phosphatase 2b [KO:K01080] [EC:3.1.3.4]
121951529  phospholipid phosphatase 3-like [KO:K01080] [EC:3.1.3.4]
121958768  lpin1a; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
121954142  zgc:123305 isoform X1 [KO:K15728] [EC:3.1.3.4]
121960484  phosphatidate phosphatase LPIN2-like [KO:K15728] [EC:3.1.3.4]
121955351  phosphatidate phosphatase LPIN1-like isoform X1 [KO:K15728] [EC:3.1.3.4]
121951413  lpin2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
121954944  plpp4; phospholipid phosphatase 4 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
121944668  plpp5; phospholipid phosphatase 5 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
121946892  dgkaa; diacylglycerol kinase, alpha a [KO:K00901] [EC:2.7.1.107]
121942068  dgke; diacylglycerol kinase epsilon [KO:K00901] [EC:2.7.1.107]
121948893  diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
121948990  dgkh; LOW QUALITY PROTEIN: diacylglycerol kinase eta [KO:K00901] [EC:2.7.1.107]
121944070  LOW QUALITY PROTEIN: diacylglycerol kinase delta-like [KO:K00901] [EC:2.7.1.107]
121961887  si:dkey-172j4.3; diacylglycerol kinase eta isoform X1 [KO:K00901] [EC:2.7.1.107]
121945562  dgkb; diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
121962649  dgkza; diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
121957507  dgkab; diacylglycerol kinase, alpha b [KO:K00901] [EC:2.7.1.107]
121961578  chpt1; cholinephosphotransferase 1 [KO:K00994] [EC:2.7.8.2]
121939199  cholinephosphotransferase 1-like [KO:K00994] [EC:2.7.8.2]
121960020  cept1b; choline/ethanolaminephosphotransferase 1b isoform X1 [KO:K13644] [EC:2.7.8.1 2.7.8.2]
121952268  pld2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
121953347  pld1a; phospholipase D1a [KO:K01115] [EC:3.1.4.4]
121947749  pld7; 5'-3' exonuclease PLD3 isoform X1 [KO:K16860] [EC:3.1.4.4]
121953669  5'-3' exonuclease PLD4 [KO:K16860] [EC:3.1.4.4]
121943391  pld3; LOW QUALITY PROTEIN: 5'-3' exonuclease PLD3 [KO:K16860] [EC:3.1.4.4]
121950629  lcat; phosphatidylcholine-sterol acyltransferase [KO:K00650] [EC:2.3.1.43]
121941534  group XIIB secretory phospholipase A2-like protein [KO:K01047] [EC:3.1.1.4]
121942230  pla2g12a; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
121942762  proca1; uncharacterized protein proca1 isoform X1 [KO:K01047] [EC:3.1.1.4]
121959454  pla2g3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
121959930  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
121960226  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
121955038  pla2g12b; group XIIB secretory phospholipase A2-like protein [KO:K01047] [EC:3.1.1.4]
121944602  group 3 secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
121944768  pla2g1b; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
121944867  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
121956505  pla2g10; group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
121966943  pla2g4ab; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
121957031  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
121942265  pla2g6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
121953970  phospholipase B1, membrane-associated-like [KO:K14621] [EC:3.1.1.4 3.1.1.5]
121955855  phospholipase B1, membrane-associated-like [KO:K14621] [EC:3.1.1.4 3.1.1.5]
121953560  phospholipase B1, membrane-associated-like [KO:K14621] [EC:3.1.1.4 3.1.1.5]
121947982  phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
121953808  phospholipase A and acyltransferase 4-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
121937683  plaat1l; phospholipase A and acyltransferase 2 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
121958043  lpcat1; lysophosphatidylcholine acyltransferase 1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
121966800  lpcat2; lysophosphatidylcholine acyltransferase 2 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
121945648  lysophosphatidylcholine acyltransferase 1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
121962369  lpcat4; lysophospholipid acyltransferase LPCAT4 [KO:K13512] [EC:2.3.1.23 2.3.1.-]
121945266  lpcat3; lysophospholipid acyltransferase 5 [KO:K13515] [EC:2.3.1.23 2.3.1.-]
121960642  lypla1; acyl-protein thioesterase 1 [KO:K06128] [EC:3.1.1.5]
121950585  pla2g15; group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
121957654  lypla2; acyl-protein thioesterase 2 [KO:K06130] [EC:3.1.1.5]
121941829  pnpla6; patatin-like phospholipase domain-containing protein 6 isoform X1 [KO:K14676] [EC:3.1.1.5]
121959423  patatin-like phospholipase domain-containing protein 7 isoform X1 [KO:K14676] [EC:3.1.1.5]
121944649  pnpla7b; patatin-like phospholipase domain-containing protein 7 [KO:K14676] [EC:3.1.1.5]
121955275  gpcpd1; glycerophosphocholine phosphodiesterase GPCPD1 [KO:K18695] [EC:3.1.4.2]
121959181  choline O-acetyltransferase-like [KO:K00623] [EC:2.3.1.6]
121954585  chata; choline O-acetyltransferase [KO:K00623] [EC:2.3.1.6]
121962063  ache; acetylcholinesterase [KO:K01049] [EC:3.1.1.7]
121961628  cAMP-regulated D2 protein [KO:K01049] [EC:3.1.1.7]
121950189  chka; choline kinase alpha [KO:K14156] [EC:2.7.1.32 2.7.1.82]
121950564  chkb; choline/ethanolamine kinase [KO:K14156] [EC:2.7.1.32 2.7.1.82]
121956975  phospho1; probable phosphatase phospho1 isoform X1 [KO:K06124] [EC:3.1.3.75]
121964601  probable phosphatase phospho1 [KO:K06124] [EC:3.1.3.75]
121952557  pcyt1bb; phosphate cytidylyltransferase 1B, choline b [KO:K00968] [EC:2.7.7.15]
121960421  pcyt1ba; choline-phosphate cytidylyltransferase B isoform X1 [KO:K00968] [EC:2.7.7.15]
121951444  pcyt1aa; choline-phosphate cytidylyltransferase A [KO:K00968] [EC:2.7.7.15]
121955949  selenoi; LOW QUALITY PROTEIN: ethanolaminephosphotransferase 1 [KO:K00993] [EC:2.7.8.1]
121954634  etnk2; ethanolamine kinase 2 [KO:K00894] [EC:2.7.1.82]
121961305  etnk1; ethanolamine kinase 1 isoform X1 [KO:K00894] [EC:2.7.1.82]
121950465  ethanolamine kinase 1-like isoform X1 [KO:K00894] [EC:2.7.1.82]
121942540  pcyt2; ethanolamine-phosphate cytidylyltransferase [KO:K00967] [EC:2.7.7.14]
121956772  ethanolamine-phosphate cytidylyltransferase-like [KO:K00967] [EC:2.7.7.14]
121947644  pmt; phosphoethanolamine methyltransferase isoform X1 [KO:K05929] [EC:2.1.1.103]
121962060  etnppl; ethanolamine-phosphate phospho-lyase [KO:K14286] [EC:4.2.3.2]
121958811  pemt; phosphatidylethanolamine N-methyltransferase [KO:K00551] [EC:2.1.1.17 2.1.1.71]
121944026  cds2; phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
121944656  phosphatidate cytidylyltransferase 2-like [KO:K00981] [EC:2.7.7.41]
121944716  phosphatidate cytidylyltransferase 2-like [KO:K00981] [EC:2.7.7.41]
121948884  pla1a; LOW QUALITY PROTEIN: phospholipase A1 member A [KO:K13618] [EC:3.1.1.111]
121957807  ptdss1b; phosphatidylserine synthase 1 [KO:K08729] [EC:2.7.8.-]
121945720  ptdss1a; phosphatidylserine synthase 1 [KO:K08729] [EC:2.7.8.-]
121950042  ptdss2; phosphatidylserine synthase 2 [KO:K08730] [EC:2.7.8.29]
121960169  pisd; phosphatidylserine decarboxylase proenzyme, mitochondrial isoform X1 [KO:K01613] [EC:4.1.1.65]
121963939  crls1; cardiolipin synthase (CMP-forming) [KO:K08744] [EC:2.7.8.41]
121937585  tafazzin [KO:K13511] [EC:2.3.1.-]
121955290  lpgat1; acyl-CoA:lysophosphatidylglycerol acyltransferase 1 [KO:K13514] [EC:2.3.1.-]
121939533  CDP-diacylglycerol--inositol 3-phosphatidyltransferase-like [KO:K00999] [EC:2.7.8.11]
121966902  cdipt; CDP-diacylglycerol--inositol 3-phosphatidyltransferase [KO:K00999] [EC:2.7.8.11]
121945610  mboat7; lysophospholipid acyltransferase 7 [KO:K13516] [EC:2.3.1.-]
Compound
C00040  Acyl-CoA
C00065  L-Serine
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
C22340  Heptaprenylglyceryl phosphate
C22341  Heptaprenylglycerol
C22342  Diacetylheptaprenylglycerol
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
PMID:10092508
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
PMID:10542045
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
PMID:12431977
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
PMID:14663079
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
PMID:15522832
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
PMID:10938271
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
Related
pathway
plep00010  Glycolysis / Gluconeogenesis
plep00260  Glycine, serine and threonine metabolism
plep00561  Glycerolipid metabolism
plep00562  Inositol phosphate metabolism
plep00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
plep00565  Ether lipid metabolism
plep00620  Pyruvate metabolism
KO pathway
ko00564   
LinkDB

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