KEGG   PATHWAY: pmax04146
Entry
pmax04146                   Pathway                                
Name
Peroxisome - Pecten maximus (king scallop)
Description
Peroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies.
Class
Cellular Processes; Transport and catabolism
Pathway map
pmax04146  Peroxisome
pmax04146

Other DBs
GO: 0005777
Organism
Pecten maximus (king scallop) [GN:pmax]
Gene
117336264  peroxisomal membrane protein PEX16-like [KO:K13335]
117325436  peroxisomal biogenesis factor 3-like [KO:K13336]
117340878  peroxisomal biogenesis factor 19-like [KO:K13337]
117324995  ATP-binding cassette sub-family D member 3-like [KO:K05677] [EC:7.6.2.4]
117342491  peroxisome biogenesis factor 1-like [KO:K13338]
117322741  peroxisome assembly factor 2-like [KO:K13339]
117330964  peroxisome assembly protein 26-like [KO:K13340]
117327785  peroxisomal targeting signal 2 receptor-like [KO:K13341]
117314779  peroxisomal targeting signal 1 receptor-like isoform X1 [KO:K13342]
117345023  peroxisomal membrane protein PEX14-like isoform X1 [KO:K13343]
117325638  peroxisomal membrane protein PEX13-like [KO:K13344]
117332478  peroxisome assembly protein 12-like [KO:K13345]
117343552  peroxisome biogenesis factor 10-like [KO:K13346]
117345131  peroxisome biogenesis factor 2-like [KO:K06664]
117333514  peroxisomal membrane protein 2-like [KO:K13347]
117325686  mpv17-like protein 2 [KO:K13348]
117316444  protein SYM1-like [KO:K13348]
117337688  mpv17-like protein [KO:K13348]
117338081  mpv17-like protein 2 [KO:K13348]
117336215  peroxisomal membrane protein 4-like [KO:K13350]
117320726  peroxisomal membrane protein 4-like [KO:K13350]
117334047  peroxisomal membrane protein 11B-like [KO:K13352]
117314900  peroxisomal membrane protein 11C-like [KO:K13353]
117333878  peroxisomal membrane protein PMP34-like [KO:K13354]
117343704  2-hydroxyacyl-CoA lyase 1-like [KO:K12261] [EC:4.1.2.63]
117316665  alpha-methylacyl-CoA racemase-like [KO:K01796] [EC:5.1.99.4]
117331491  phytanoyl-CoA dioxygenase, peroxisomal-like [KO:K00477] [EC:1.14.11.18]
117333086  peroxisomal acyl-coenzyme A oxidase 3-like [KO:K00232] [EC:1.3.3.6]
117316412  peroxisomal acyl-coenzyme A oxidase 1-like [KO:K00232] [EC:1.3.3.6]
117316924  peroxisomal acyl-coenzyme A oxidase 1-like [KO:K00232] [EC:1.3.3.6]
117317055  peroxisomal acyl-coenzyme A oxidase 1-like [KO:K00232] [EC:1.3.3.6]
117334218  peroxisomal multifunctional enzyme type 2-like isoform X1 [KO:K12405] [EC:1.1.1.- 4.2.1.107 4.2.1.119]
117326074  non-specific lipid-transfer protein-like [KO:K08764] [EC:2.3.1.176]
117326251  non-specific lipid-transfer protein-like isoform X1 [KO:K08764] [EC:2.3.1.176]
117323580  bile acid-CoA:amino acid N-acyltransferase-like [KO:K00659] [EC:2.3.1.65 3.1.2.2]
117335375  bile acid-CoA:amino acid N-acyltransferase-like [KO:K00659] [EC:2.3.1.65 3.1.2.2]
117335376  acyl-coenzyme A amino acid N-acyltransferase 1-like [KO:K00659] [EC:2.3.1.65 3.1.2.2]
117336519  acyl-coenzyme A amino acid N-acyltransferase 1-like [KO:K00659] [EC:2.3.1.65 3.1.2.2]
117343813  peroxisomal bifunctional enzyme-like [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
117343842  3-ketoacyl-CoA thiolase B, peroxisomal-like [KO:K07513] [EC:2.3.1.16]
117332856  peroxisomal 2,4-dienoyl-CoA reductase-like isoform X1 [KO:K13237] [EC:1.3.1.124]
117324206  delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial-like [KO:K12663] [EC:5.3.3.21]
117324208  delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial-like isoform X1 [KO:K12663] [EC:5.3.3.21]
117331820  ATP-binding cassette sub-family D member 2-like isoform X1 [KO:K05676] [EC:7.6.2.4]
117324164  ATP-binding cassette sub-family D member 4-like isoform X1 [KO:K05678] [EC:7.6.2.8]
117333974  very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
117333984  very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
117333987  very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
117334055  LOW QUALITY PROTEIN: very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
117334151  very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
117334417  very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
117334552  very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
117334985  very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
117341976  long-chain-fatty-acid--CoA ligase 4-like [KO:K01897] [EC:6.2.1.3]
117334787  long-chain-fatty-acid--CoA ligase 1-like isoform X1 [KO:K01897] [EC:6.2.1.3]
117329335  long-chain-fatty-acid--CoA ligase 1-like [KO:K01897] [EC:6.2.1.3]
117322381  peroxisomal trans-2-enoyl-CoA reductase-like [KO:K07753] [EC:1.3.1.38]
117338258  enoyl-CoA delta isomerase 2, mitochondrial-like [KO:K13239] [EC:5.3.3.8]
117337311  uncharacterized Nudix hydrolase NudL-like isoform X1 [KO:K17879] [EC:3.6.1.77]
117333972  peroxisomal NADH pyrophosphatase NUDT12-like [KO:K03426] [EC:3.6.1.22]
117334605  peroxisomal NADH pyrophosphatase NUDT12-like [KO:K03426] [EC:3.6.1.22]
117320057  peroxisomal NADH pyrophosphatase NUDT12-like isoform X1 [KO:K03426] [EC:3.6.1.22]
117337908  nucleoside diphosphate-linked moiety X motif 19-like [KO:K13355] [EC:3.6.1.77]
117337054  acyl-coenzyme A thioesterase 8-like [KO:K11992] [EC:3.1.2.27]
117328530  acyl-coenzyme A thioesterase 8-like [KO:K11992] [EC:3.1.2.27]
117321699  carnitine O-acetyltransferase-like isoform X1 [KO:K00624] [EC:2.3.1.7]
117343711  peroxisomal carnitine O-octanoyltransferase-like [KO:K05940] [EC:2.3.1.137]
117343902  peroxisomal carnitine O-octanoyltransferase-like isoform X1 [KO:K05940] [EC:2.3.1.137]
117327932  malonyl-CoA decarboxylase, mitochondrial-like isoform X1 [KO:K01578] [EC:4.1.1.9]
117324441  dihydroxyacetone phosphate acyltransferase-like [KO:K00649] [EC:2.3.1.42]
117314867  alkyldihydroxyacetonephosphate synthase, peroxisomal-like [KO:K00803] [EC:2.5.1.26]
117336216  fatty acyl-CoA reductase 1-like [KO:K13356] [EC:1.2.1.84]
117336217  fatty acyl-CoA reductase 1-like [KO:K13356] [EC:1.2.1.84]
117336300  fatty acyl-CoA reductase 1-like isoform X1 [KO:K13356] [EC:1.2.1.84]
117332956  mevalonate kinase-like isoform X1 [KO:K00869] [EC:2.7.1.36]
117332970  mevalonate kinase-like isoform X1 [KO:K00869] [EC:2.7.1.36]
117334960  phosphomevalonate kinase-like [KO:K13273] [EC:2.7.4.2]
117345164  serine--pyruvate aminotransferase-like [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
117324933  D-amino-acid oxidase-like [KO:K00273] [EC:1.4.3.3]
117325397  D-aspartate oxidase-like [KO:K00273] [EC:1.4.3.3]
117334628  D-aspartate oxidase-like isoform X1 [KO:K00272] [EC:1.4.3.1]
117337201  D-aspartate oxidase-like [KO:K00272] [EC:1.4.3.1]
117337205  D-aspartate oxidase-like [KO:K00272] [EC:1.4.3.1]
117338489  uncharacterized protein LOC117338489 [KO:K00272] [EC:1.4.3.1]
117316070  isocitrate dehydrogenase [NADP], mitochondrial-like isoform X1 [KO:K00031] [EC:1.1.1.42]
117335833  isocitrate dehydrogenase [NADP] cytoplasmic-like [KO:K00031] [EC:1.1.1.42]
117328961  spermine oxidase-like isoform X1 [KO:K00308] [EC:1.5.3.13]
117332913  peroxisomal sarcosine oxidase-like [KO:K00306] [EC:1.5.3.1 1.5.3.7]
117332915  peroxisomal sarcosine oxidase-like [KO:K00306] [EC:1.5.3.1 1.5.3.7]
117333440  peroxisomal sarcosine oxidase-like [KO:K00306] [EC:1.5.3.1 1.5.3.7]
117333756  peroxisomal sarcosine oxidase-like [KO:K00306] [EC:1.5.3.1 1.5.3.7]
117316085  hydroxymethylglutaryl-CoA lyase, mitochondrial-like [KO:K01640] [EC:4.1.3.4]
117327092  LOW QUALITY PROTEIN: catalase-like [KO:K03781] [EC:1.11.1.6]
117327094  catalase-like [KO:K03781] [EC:1.11.1.6]
117322951  peroxiredoxin-5, mitochondrial-like [KO:K11187] [EC:1.11.1.24]
117324134  peroxiredoxin-5, mitochondrial-like isoform X1 [KO:K11187] [EC:1.11.1.24]
117319777  peroxiredoxin-5, mitochondrial-like [KO:K11187] [EC:1.11.1.24]
117325274  uncharacterized protein LOC117325274 [KO:K04565] [EC:1.15.1.1]
117327826  superoxide dismutase [Cu-Zn]-like [KO:K04565] [EC:1.15.1.1]
117327308  superoxide dismutase [Mn], mitochondrial-like [KO:K04564] [EC:1.15.1.1]
117317590  superoxide dismutase [Mn]-like [KO:K04564] [EC:1.15.1.1]
117325535  LOW QUALITY PROTEIN: peroxiredoxin-like [KO:K13279] [EC:1.11.1.24]
117345230  glutathione S-transferase kappa 1-like [KO:K13299] [EC:2.5.1.18]
117321650  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
117324561  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
117314925  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
117335971  xanthine dehydrogenase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
117336390  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
117317704  xanthine dehydrogenase/oxidase-like [KO:K00106] [EC:1.17.1.4 1.17.3.2]
117337776  dehydrogenase/reductase SDR family member 4-like [KO:K11147] [EC:1.1.-.-]
117337778  dehydrogenase/reductase SDR family member 4-like [KO:K11147] [EC:1.1.-.-]
Reference
PMID:17055078
  Authors
Wanders RJ, Waterham HR
  Title
Peroxisomal disorders: the single peroxisomal enzyme deficiencies.
  Journal
Biochim Biophys Acta 1763:1707-20 (2006)
DOI:10.1016/j.bbamcr.2006.08.010
Reference
PMID:17055079
  Authors
Steinberg SJ, Dodt G, Raymond GV, Braverman NE, Moser AB, Moser HW
  Title
Peroxisome biogenesis disorders.
  Journal
Biochim Biophys Acta 1763:1733-48 (2006)
DOI:10.1016/j.bbamcr.2006.09.010
Reference
PMID:17010456
  Authors
Rottensteiner H, Theodoulou FL
  Title
The ins and outs of peroxisomes: co-ordination of membrane transport and peroxisomal metabolism.
  Journal
Biochim Biophys Acta 1763:1527-40 (2006)
DOI:10.1016/j.bbamcr.2006.08.012
Reference
PMID:16631601
  Authors
Iida R, Yasuda T, Tsubota E, Takatsuka H, Matsuki T, Kishi K
  Title
Human Mpv17-like protein is localized in peroxisomes and regulates expression of antioxidant enzymes.
  Journal
Biochem Biophys Res Commun 344:948-54 (2006)
DOI:10.1016/j.bbrc.2006.04.008
Related
pathway
pmax00071  Fatty acid degradation
pmax00230  Purine metabolism
pmax00564  Glycerophospholipid metabolism
pmax00565  Ether lipid metabolism
pmax00830  Retinol metabolism
pmax00900  Terpenoid backbone biosynthesis
KO pathway
ko04146   
LinkDB

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