KEGG   PATHWAY: pmur04142
Entry
pmur04142                   Pathway                                
Name
Lysosome - Protobothrops mucrosquamatus (Taiwan habu)
Description
Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy.
Class
Cellular Processes; Transport and catabolism
Pathway map
pmur04142  Lysosome
pmur04142

Other DBs
GO: 0005764
Organism
Protobothrops mucrosquamatus (Taiwan habu) [GN:pmur]
Gene
107282653  ATP6V0A1; V-type proton ATPase 116 kDa subunit a [KO:K02154]
107285456  ATP6V0A2; V-type proton ATPase 116 kDa subunit a [KO:K02154]
107293634  TCIRG1; V-type proton ATPase 116 kDa subunit a [KO:K02154]
107291333  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
107284959  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
107284169  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
107291185  ATP6V1H; V-type proton ATPase subunit H [KO:K02144]
107293157  V-type proton ATPase subunit S1-like [KO:K03662]
107286697  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
107292229  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
107283442  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X1 [KO:K03661]
107294347  DMXL1; dmX-like protein 1 [KO:K24155]
107298089  DMXL2; dmX-like protein 2 [KO:K24155]
107286034  WD repeat-containing protein 7-like [KO:K24738]
107298445  CTSA; lysosomal protective protein [KO:K13289] [EC:3.4.16.5]
107301213  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
107289312  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
107294161  CTSC; dipeptidyl peptidase 1 [KO:K01275] [EC:3.4.14.1]
107290778  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
107282504  cathepsin D-like [KO:K01379] [EC:3.4.23.5]
107292374  CTSE; cathepsin E [KO:K01382] [EC:3.4.23.34]
107283823  cathepsin E-like [KO:K01382] [EC:3.4.23.34]
107293806  cathepsin F-like [KO:K01373] [EC:3.4.22.41]
107283909  CTSH; pro-cathepsin H [KO:K01366] [EC:3.4.22.16]
107292918  CTSK; cathepsin K [KO:K01371] [EC:3.4.22.38]
107301120  cathepsin S-like [KO:K01365] [EC:3.4.22.15]
107295321  cathepsin L1 [KO:K01365] [EC:3.4.22.15]
107300486  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
107300965  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
107298633  cathepsin L1 [KO:K01365] [EC:3.4.22.15]
107297057  cathepsin L1-like [KO:K01365] [EC:3.4.22.15]
107287975  CTSO; cathepsin O [KO:K01374] [EC:3.4.22.42]
107292919  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
107297107  CTSW; cathepsin W [KO:K08569] [EC:3.4.22.-]
107294709  cathepsin Z [KO:K08568] [EC:3.4.18.1]
107295542  cathepsin Z [KO:K08568] [EC:3.4.18.1]
107298068  LGMN; legumain [KO:K01369] [EC:3.4.22.34]
107288659  TPP1; tripeptidyl-peptidase 1 [KO:K01279] [EC:3.4.14.9]
107291584  GLA; alpha-galactosidase A [KO:K01189] [EC:3.2.1.22]
107293627  GLB1; beta-galactosidase [KO:K12309] [EC:3.2.1.23]
107290641  lysosomal alpha-glucosidase-like [KO:K12316] [EC:3.2.1.20]
107288787  GAA; lysosomal alpha-glucosidase [KO:K12316] [EC:3.2.1.20]
107299550  lysosomal acid glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
107299551  lysosomal acid glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
107299552  lysosomal acid glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
107299553  lysosomal acid glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
107299554  lysosomal acid glucosylceramidase-like [KO:K01201] [EC:3.2.1.45]
107291845  IDUA; alpha-L-iduronidase [KO:K01217] [EC:3.2.1.76]
107284005  alpha-N-acetylgalactosaminidase-like [KO:K01204] [EC:3.2.1.49]
107285348  NAGA; alpha-N-acetylgalactosaminidase [KO:K01204] [EC:3.2.1.49]
107282677  NAGLU; alpha-N-acetylglucosaminidase [KO:K01205] [EC:3.2.1.50]
107291164  GALC; galactocerebrosidase [KO:K01202] [EC:3.2.1.46]
107287132  GUSB; beta-glucuronidase [KO:K01195] [EC:3.2.1.31]
107286870  FUCA2; plasma alpha-L-fucosidase isoform X1 [KO:K01206] [EC:3.2.1.51]
107290746  FUCA1; tissue alpha-L-fucosidase [KO:K01206] [EC:3.2.1.51]
107299997  HEXA; beta-hexosaminidase subunit alpha [KO:K12373] [EC:3.2.1.52]
107291173  HEXB; beta-hexosaminidase subunit beta [KO:K12373] [EC:3.2.1.52]
107299013  MANBA; beta-mannosidase [KO:K01192] [EC:3.2.1.25]
107286892  MAN2B1; lysosomal alpha-mannosidase [KO:K12311] [EC:3.2.1.24]
107298256  NEU1; sialidase-1 [KO:K01186] [EC:3.2.1.18]
107293071  hyaluronidase-4-like [KO:K01197] [EC:3.2.1.35]
107296493  hyaluronidase-4-like [KO:K01197] [EC:3.2.1.35]
107293142  hyaluronidase [KO:K01197] [EC:3.2.1.35]
107288720  HYAL2; hyaluronidase-2 [KO:K01197] [EC:3.2.1.35]
107288729  HYAL1; hyaluronidase-1 isoform X1 [KO:K01197] [EC:3.2.1.35]
107288731  HYAL3; hyaluronidase-3 [KO:K01197] [EC:3.2.1.35]
107298546  ARSA; arylsulfatase A [KO:K01134] [EC:3.1.6.8]
107287875  ARSB; arylsulfatase B [KO:K01135] [EC:3.1.6.12]
107282575  ARSG; arylsulfatase G [KO:K12381] [EC:3.1.6.-]
107283519  GALNS; N-acetylgalactosamine-6-sulfatase [KO:K01132] [EC:3.1.6.4]
107287959  N-acetylglucosamine-6-sulfatase [KO:K01137] [EC:3.1.6.14]
107291795  GNS; N-acetylglucosamine-6-sulfatase isoform X2 [KO:K01137] [EC:3.1.6.14]
107291666  IDS; iduronate 2-sulfatase [KO:K01136] [EC:3.1.6.13]
107288798  SGSH; N-sulphoglucosamine sulphohydrolase [KO:K01565] [EC:3.10.1.1]
107293843  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase [KO:K01052] [EC:3.1.1.13]
107302726  lysosomal acid lipase/cholesteryl ester hydrolase-like [KO:K01052] [EC:3.1.1.13]
114923095  LOW QUALITY PROTEIN: lipase member K-like [KO:K01052] [EC:3.1.1.13]
107297626  PLA2G15; group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
107285126  DNASE2; deoxyribonuclease-2-alpha [KO:K01158] [EC:3.1.22.1]
107289837  ACP2; lysosomal acid phosphatase [KO:K14410] [EC:3.1.3.2]
107285149  ACP5; tartrate-resistant acid phosphatase type 5 [KO:K14379] [EC:3.1.3.2]
107288653  SMPD1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
107301677  ASAH1; acid ceramidase [KO:K12348] [EC:3.5.1.23]
107285704  AGA; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase [KO:K01444] [EC:3.5.1.26]
107285431  prosaposin [KO:K12382]
114922409  prosaposin-like [KO:K12382]
107295507  GM2A; ganglioside GM2 activator [KO:K12383]
107294851  PPT2; lysosomal thioesterase PPT2 [KO:K01074] [EC:3.1.2.22]
107301587  PPT1; palmitoyl-protein thioesterase 1 [KO:K01074] [EC:3.1.2.22]
107302746  LAMP2; lysosome-associated membrane glycoprotein 2 [KO:K06528]
107290442  LAMP1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
107293261  LAMP3; lysosome-associated membrane glycoprotein 3 [KO:K06562]
114923461  CD68; macrosialin [KO:K06501]
107294929  CD63; CD63 antigen [KO:K06497]
107297787  SCARB2; lysosome membrane protein 2 [KO:K12384]
107292297  NPC1; NPC intracellular cholesterol transporter 1 isoform X2 [KO:K12385]
107293074  NPC2; NPC intracellular cholesterol transporter 2 [KO:K13443]
107297140  CTNS; cystinosin [KO:K12386]
107288828  SLC17A5; sialin isoform X1 [KO:K12301]
107291471  SLC11A1; natural resistance-associated macrophage protein 1 isoform X1 [KO:K12347]
107291517  SLC11A2; natural resistance-associated macrophage protein 2 isoform X2 [KO:K21398]
107285396  LAPTM4B; lysosomal-associated transmembrane protein 4B [KO:K12387]
107290367  LAPTM4A; lysosomal-associated transmembrane protein 4A [KO:K12387]
107297250  ABCA2; ATP-binding cassette sub-family A member 2 [KO:K05642]
107285439  ABCB9; ATP-binding cassette sub-family B member 9 [KO:K05656]
107293144  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 [KO:K12305] [EC:3.6.1.6]
107302526  SORT1; sortilin [KO:K12388]
107289892  battenin-like [KO:K12389]
107282464  CLN3; battenin [KO:K12389]
107303130  CLN5; ceroid-lipofuscinosis neuronal protein 5 [KO:K12390]
107298409  major facilitator superfamily domain-containing protein 8 [KO:K12307]
107290571  MFSD8; major facilitator superfamily domain-containing protein 8 [KO:K12307]
107302378  HGSNAT; heparan-alpha-glucosaminide N-acetyltransferase [KO:K10532] [EC:2.3.1.78]
107296296  SUMF1; formylglycine-generating enzyme [KO:K13444] [EC:1.8.3.7]
107289471  GNPTAB; N-acetylglucosamine-1-phosphotransferase subunits alpha/beta [KO:K08239] [EC:2.7.8.17]
107302623  GNPTG; N-acetylglucosamine-1-phosphotransferase subunit gamma [KO:K10087]
107295339  NAGPA; N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [KO:K01125] [EC:3.1.4.45]
107297935  cation-independent mannose-6-phosphate receptor [KO:K06564]
107292065  cation-independent mannose-6-phosphate receptor [KO:K06564]
107295563  M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089]
107293129  CLTA; clathrin light chain A [KO:K04644]
107292443  CLTB; clathrin light chain B [KO:K04645]
107292966  CLTCL1; clathrin heavy chain 2 [KO:K04646]
107293105  AP1G2; AP-1 complex subunit gamma-like 2 [KO:K12391]
107283529  AP1G1; AP-1 complex subunit gamma-1 [KO:K12391]
107288783  AP1B1; AP-1 complex subunit beta-1 isoform X1 [KO:K12392]
107291621  AP1M2; AP-1 complex subunit mu-2 isoform X1 [KO:K12393]
107282208  AP1M1; AP-1 complex subunit mu-1 [KO:K12393]
107296335  AP1S2; AP-1 complex subunit sigma-2 isoform X1 [KO:K12394]
107285054  AP1S1; AP-1 complex subunit sigma-1A [KO:K12394]
107290158  AP1S3; AP-1 complex subunit sigma-3 [KO:K12395]
107282258  AP3D1; AP-3 complex subunit delta-1 [KO:K12396]
107289654  AP3B2; AP-3 complex subunit beta-2 isoform X1 [KO:K12397]
107284602  AP3B1; AP-3 complex subunit beta-1 [KO:K12397]
107287899  AP3M1; AP-3 complex subunit mu-1 [KO:K12398]
107287971  AP3M2; AP-3 complex subunit mu-2 [KO:K12398]
107290892  AP3S1; AP-3 complex subunit sigma-1 [KO:K12399]
107288672  AP4E1; AP-4 complex subunit epsilon-1 [KO:K12400]
107299884  AP4B1; AP-4 complex subunit beta-1 [KO:K12401]
107296116  AP4M1; AP-4 complex subunit mu-1 [KO:K12402]
107287622  AP4S1; AP-4 complex subunit sigma-1 [KO:K12403]
107292718  GGA3; ADP-ribosylation factor-binding protein GGA3 [KO:K12404]
107288634  GGA1; ADP-ribosylation factor-binding protein GGA1 [KO:K12404]
107287121  MCOLN1; mucolipin-1 [KO:K04992]
107296637  lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog [KO:K19363]
107284006  LITAF; lipopolysaccharide-induced tumor necrosis factor-alpha factor [KO:K19363]
Compound
C00002  ATP
C00008  ADP
C00159  D-Mannose
C00275  D-Mannose 6-phosphate
Reference
PMID:12628346
  Authors
Eskelinen EL, Tanaka Y, Saftig P
  Title
At the acidic edge: emerging functions for lysosomal membrane proteins.
  Journal
Trends Cell Biol 13:137-45 (2003)
DOI:10.1016/S0962-8924(03)00005-9
Reference
PMID:1883197
  Authors
Neufeld EF
  Title
Lysosomal storage diseases.
  Journal
Annu Rev Biochem 60:257-80 (1991)
DOI:10.1146/annurev.bi.60.070191.001353
Reference
PMID:2943218
  Authors
von Figura K, Hasilik A
  Title
Lysosomal enzymes and their receptors.
  Journal
Annu Rev Biochem 55:167-93 (1986)
DOI:10.1146/annurev.bi.55.070186.001123
Reference
PMID:15987739
  Authors
Janvier K, Bonifacino JS
  Title
Role of the endocytic machinery in the sorting of lysosome-associated membrane proteins.
  Journal
Mol Biol Cell 16:4231-42 (2005)
DOI:10.1091/mbc.E05-03-0213
Reference
PMID:18635948
  Authors
Vergarajauregui S, Puertollano R
  Title
Mucolipidosis type IV: the importance of functional lysosomes for efficient autophagy.
  Journal
Autophagy 4:832-4 (2008)
DOI:10.4161/auto.6567
Reference
PMID:34249946
  Authors
Jaskolka MC, Winkley SR, Kane PM
  Title
RAVE and Rabconnectin-3 Complexes as Signal Dependent Regulators of Organelle Acidification.
  Journal
Front Cell Dev Biol 9:698190 (2021)
DOI:10.3389/fcell.2021.698190
Reference
PMID:34646033
  Authors
Majdoul S, Compton AA
  Title
Lessons in self-defence: inhibition of virus entry by intrinsic immunity.
  Journal
Nat Rev Immunol 10.1038/s41577-021-00626-8 (2021)
DOI:10.1038/s41577-021-00626-8
Related
pathway
pmur00511  Other glycan degradation
pmur00531  Glycosaminoglycan degradation
pmur04130  SNARE interactions in vesicular transport
pmur04140  Autophagy - animal
pmur04144  Endocytosis
KO pathway
ko04142   
LinkDB

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