KEGG   PATHWAY: pon00564
Entry
pon00564                    Pathway                                
Name
Glycerophospholipid metabolism - Pongo abelii (Sumatran orangutan)
Class
Metabolism; Lipid metabolism
Pathway map
pon00564  Glycerophospholipid metabolism
pon00564

Module
pon_M00090  Phosphatidylcholine (PC) biosynthesis, choline => PC [PATH:pon00564]
pon_M00091  Phosphatidylcholine (PC) biosynthesis, PE => PC [PATH:pon00564]
pon_M00092  Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE [PATH:pon00564]
Other DBs
GO: 0006650
Organism
Pongo abelii (Sumatran orangutan) [GN:pon]
Gene
100172201  GPD1; glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic [KO:K00006] [EC:1.1.1.8]
100173675  GPD1L; glycerol-3-phosphate dehydrogenase 1-like protein [KO:K00006] [EC:1.1.1.8]
100452414  GPD2; glycerol-3-phosphate dehydrogenase, mitochondrial isoform X1 [KO:K00111] [EC:1.1.5.3]
100434054  GPAM; glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X1 [KO:K00629] [EC:2.3.1.15]
100456255  GPAT2; glycerol-3-phosphate acyltransferase 2, mitochondrial isoform X1 [KO:K00629] [EC:2.3.1.15]
100438689  LOW QUALITY PROTEIN: glycerol-3-phosphate acyltransferase 2, mitochondrial-like [KO:K00629] [EC:2.3.1.15]
112132105  glycerol-3-phosphate acyltransferase 2, mitochondrial-like isoform X1 [KO:K00629] [EC:2.3.1.15]
100454430  glycerol-3-phosphate acyltransferase 2, mitochondrial-like [KO:K00629] [EC:2.3.1.15]
100173520  GPAT4; glycerol-3-phosphate acyltransferase 6 [KO:K13506] [EC:2.3.1.15]
100450687  GPAT3; glycerol-3-phosphate acyltransferase 3 [KO:K13506] [EC:2.3.1.15]
100449893  AGPAT2; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta [KO:K13509] [EC:2.3.1.51]
100432876  AGPAT1; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform X2 [KO:K13509] [EC:2.3.1.51]
100174477  AGPAT3; 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma [KO:K13523] [EC:2.3.1.51 2.3.1.-]
100173400  AGPAT4; 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [KO:K13523] [EC:2.3.1.51 2.3.1.-]
100171477  AGPAT5; 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [KO:K19007] [EC:2.3.1.51]
100457286  LCLAT1; lysocardiolipin acyltransferase 1 isoform X1 [KO:K13513] [EC:2.3.1.- 2.3.1.51]
100446075  MBOAT1; lysophospholipid acyltransferase 1 isoform X1 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
100441988  MBOAT2; lysophospholipid acyltransferase 2 [KO:K13517] [EC:2.3.1.51 2.3.1.-]
100172931  GNPAT; dihydroxyacetone phosphate acyltransferase [KO:K00649] [EC:2.3.1.42]
100436862  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
100442989  PLPP2; phospholipid phosphatase 2 isoform X1 [KO:K01080] [EC:3.1.3.4]
100448168  PLPP1; phospholipid phosphatase 1 isoform X1 [KO:K01080] [EC:3.1.3.4]
100455097  PLPP3; phospholipid phosphatase 3 [KO:K01080] [EC:3.1.3.4]
100458857  LPIN1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
100451550  LPIN2; phosphatidate phosphatase LPIN2 [KO:K15728] [EC:3.1.3.4]
100459035  PLPP5; phospholipid phosphatase 5 isoform X1 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
100431802  PLPP4; phospholipid phosphatase 4 isoform X1 [KO:K18693] [EC:3.6.1.75 3.1.3.4]
100431923  DGKZ; diacylglycerol kinase zeta isoform X1 [KO:K00901] [EC:2.7.1.107]
100172456  DGKA; diacylglycerol kinase alpha [KO:K00901] [EC:2.7.1.107]
100457783  DGKQ; diacylglycerol kinase theta [KO:K00901] [EC:2.7.1.107]
100438777  DGKH; diacylglycerol kinase eta isoform X1 [KO:K00901] [EC:2.7.1.107]
100446422  DGKD; diacylglycerol kinase delta isoform X1 [KO:K00901] [EC:2.7.1.107]
100460596  DGKG; diacylglycerol kinase gamma isoform X1 [KO:K00901] [EC:2.7.1.107]
100439722  DGKB; diacylglycerol kinase beta isoform X1 [KO:K00901] [EC:2.7.1.107]
100440522  DGKE; diacylglycerol kinase epsilon isoform X2 [KO:K00901] [EC:2.7.1.107]
100439951  DGKK; diacylglycerol kinase kappa isoform X1 [KO:K00901] [EC:2.7.1.107]
100452590  DGKI; LOW QUALITY PROTEIN: diacylglycerol kinase iota [KO:K00901] [EC:2.7.1.107]
100440613  CHPT1; cholinephosphotransferase 1 [KO:K00994] [EC:2.7.8.2]
100439046  CEPT1; choline/ethanolaminephosphotransferase 1 [KO:K13644] [EC:2.7.8.1 2.7.8.2]
100439813  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
100457163  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
100173883  PLD3; phospholipase D3 [KO:K16860] [EC:3.1.4.4]
100444658  PLD4; phospholipase D4 isoform X2 [KO:K16860] [EC:3.1.4.4]
103892697  LCAT; phosphatidylcholine-sterol acyltransferase [KO:K00650] [EC:2.3.1.43]
100454621  PLA2G2F; group IIF secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100458003  PLA2G2D; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100459828  PLA2G5; calcium-dependent phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
100460828  PLA2G2A; phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
100459011  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100456441  PLA2G10; group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100445241  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100440854  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
100444815  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100458359  PLA2G2C; putative inactive group IIC secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100458726  PLA2G2E; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
100454614  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
100173125  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
100447631  PLA2G4B; cytosolic phospholipase A2 beta [KO:K16342] [EC:3.1.1.4]
100434495  PLA2G4C; cytosolic phospholipase A2 gamma isoform X3 [KO:K16342] [EC:3.1.1.4]
100454977  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
100448616  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
100445065  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X2 [KO:K16343] [EC:3.1.1.4]
100460209  PLB1; phospholipase B1, membrane-associated isoform X1 [KO:K14621] [EC:3.1.1.4 3.1.1.5]
100190820  PLA2G16; HRAS-like suppressor 3 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
100436443  HRASLS2; HRAS-like suppressor 2 isoform X1 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
100435855  LPCAT1; lysophosphatidylcholine acyltransferase 1 isoform X1 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
100449928  LPCAT2; lysophosphatidylcholine acyltransferase 2 [KO:K13510] [EC:2.3.1.23 2.3.1.67]
100438914  LPCAT4; lysophospholipid acyltransferase LPCAT4 [KO:K13512] [EC:2.3.1.23 2.3.1.-]
100449193  LPCAT3; lysophospholipid acyltransferase 5 isoform X2 [KO:K13515] [EC:2.3.1.23 2.3.1.-]
100172358  LYPLA1; acyl-protein thioesterase 1 [KO:K06128] [EC:3.1.1.5]
100172651  PLA2G15; group XV phospholipase A2 precursor [KO:K06129] [EC:3.1.1.5]
100458661  acyl-protein thioesterase 2 [KO:K06130] [EC:3.1.1.5]
100455471  LYPLA2; acyl-protein thioesterase 2 [KO:K06130] [EC:3.1.1.5]
100453292  PNPLA6; neuropathy target esterase [KO:K14676] [EC:3.1.1.5]
100444987  PNPLA7; LOW QUALITY PROTEIN: patatin-like phospholipase domain-containing protein 7 [KO:K14676] [EC:3.1.1.5]
100457313  GPCPD1; glycerophosphocholine phosphodiesterase GPCPD1 isoform X1 [KO:K18695] [EC:3.1.4.2]
100444631  CHAT; choline O-acetyltransferase isoform X1 [KO:K00623] [EC:2.3.1.6]
100939726  ACHE; acetylcholinesterase isoform X1 [KO:K01049] [EC:3.1.1.7]
100445305  CHKB; choline/ethanolamine kinase [KO:K14156] [EC:2.7.1.32 2.7.1.82]
100451626  CHKA; choline kinase alpha isoform X1 [KO:K14156] [EC:2.7.1.32 2.7.1.82]
100453832  PHOSPHO1; phosphoethanolamine/phosphocholine phosphatase isoform X2 [KO:K06124] [EC:3.1.3.75]
100435111  PCYT1A; choline-phosphate cytidylyltransferase A [KO:K00968] [EC:2.7.7.15]
100462209  PCYT1B; choline-phosphate cytidylyltransferase B isoform X1 [KO:K00968] [EC:2.7.7.15]
100174185  SELENOI; ethanolaminephosphotransferase 1 [KO:K00993] [EC:2.7.8.1]
100444524  ETNK2; ethanolamine kinase 2 isoform X6 [KO:K00894] [EC:2.7.1.82]
100456883  ETNK1; ethanolamine kinase 1 isoform X1 [KO:K00894] [EC:2.7.1.82]
100174551  PCYT2; ethanolamine-phosphate cytidylyltransferase isoform X1 [KO:K00967] [EC:2.7.7.14]
100448531  ETNPPL; ethanolamine-phosphate phospho-lyase isoform X2 [KO:K14286] [EC:4.2.3.2]
100435357  PEMT; phosphatidylethanolamine N-methyltransferase [KO:K00551] [EC:2.1.1.17 2.1.1.71]
100460482  CDS2; phosphatidate cytidylyltransferase 2 [KO:K00981] [EC:2.7.7.41]
100172760  CDS1; phosphatidate cytidylyltransferase 1 [KO:K00981] [EC:2.7.7.41]
100171726  PLA1A; phospholipase A1 member A precursor [KO:K13618] [EC:3.1.1.111]
100441574  PTDSS1; phosphatidylserine synthase 1 [KO:K08729] [EC:2.7.8.-]
100458699  PTDSS2; phosphatidylserine synthase 2 isoform X1 [KO:K08730] [EC:2.7.8.29]
100173069  PISD; phosphatidylserine decarboxylase proenzyme, mitochondrial [KO:K01613] [EC:4.1.1.65]
100173056  PGS1; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial precursor [KO:K00995] [EC:2.7.8.5]
100459367  CRLS1; cardiolipin synthase (CMP-forming) isoform X1 [KO:K08744] [EC:2.7.8.41]
100446947  TAZ; tafazzin isoform X2 [KO:K13511] [EC:2.3.1.-]
100450766  LPGAT1; acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X2 [KO:K13514] [EC:2.3.1.-]
100443337  CDIPT; CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform X2 [KO:K00999] [EC:2.7.8.11]
100457310  MBOAT7; lysophospholipid acyltransferase 7 isoform X1 [KO:K13516] [EC:2.3.1.-]
Compound
C00040  Acyl-CoA
C00065  L-Serine
C00084  Acetaldehyde
C00093  sn-Glycerol 3-phosphate
C00111  Glycerone phosphate
C00114  Choline
C00157  Phosphatidylcholine
C00189  Ethanolamine
C00269  CDP-diacylglycerol
C00307  CDP-choline
C00344  Phosphatidylglycerol
C00346  Ethanolamine phosphate
C00350  Phosphatidylethanolamine
C00416  Phosphatidate
C00513  CDP-glycerol
C00570  CDP-ethanolamine
C00588  Choline phosphate
C00623  sn-Glycerol 1-phosphate
C00641  1,2-Diacyl-sn-glycerol
C00670  sn-Glycero-3-phosphocholine
C00681  1-Acyl-sn-glycerol 3-phosphate
C01194  1-Phosphatidyl-D-myo-inositol
C01210  N-Methylethanolamine phosphate
C01233  sn-Glycero-3-phosphoethanolamine
C01241  Phosphatidyl-N-methylethanolamine
C01996  Acetylcholine
C02737  Phosphatidylserine
C03372  Acylglycerone phosphate
C03819  1-Acylglycerophosphoinositol
C03872  L-Serine-phosphoethanolamine
C03892  Phosphatidylglycerophosphate
C03974  2-Acyl-sn-glycerol 3-phosphate
C04230  1-Acyl-sn-glycero-3-phosphocholine
C04233  2-Acyl-sn-glycero-3-phosphocholine
C04308  Phosphatidyl-N-dimethylethanolamine
C04438  1-Acyl-sn-glycero-3-phosphoethanolamine
C04590  3-(O-Geranylgeranyl)-sn-glycerol 1-phosphate
C04638  2,3-Bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate
C05973  2-Acyl-sn-glycero-3-phosphoethanolamine
C05974  2-Acyl-sn-glycero-3-phosphoserine
C05976  Aminoacyl-phosphatidylglycerol
C05980  Cardiolipin
C06771  Triethanolamine
C06772  Diethanolamine
C13482  Phosphodimethylethanolamine
C18059  CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol
C18125  1-Acyl-sn-glycero-3-phosphoserine
C18126  1-Acyl-sn-glycero-3-phosphoglycerol
C18129  Monolysocardiolipin
C18168  Diacylglycerylhomoserine
C18169  Diacylglyceryl-N,N,N-trimethylhomoserine
C20466  2,3-Bis-(O-geranylgeranyl)-sn-glycero-1-phospho-L-serine
C20518  2,3-Bis-(O-phytanyl)-sn-glycerol 1-phosphate
C22340  Heptaprenylglyceryl phosphate
C22341  Heptaprenylglycerol
C22342  Diacetylheptaprenylglycerol
Reference
PMID:1512203
  Authors
Racenis PV, Lai JL, Das AK, Mullick PC, Hajra AK, Greenberg ML.
  Title
The acyl dihydroxyacetone phosphate pathway enzymes for glycerolipid biosynthesis are present in the yeast Saccharomyces cerevisiae.
  Journal
J Bacteriol 174:5702-10 (1992)
DOI:10.1128/JB.174.17.5702-5710.1992
Reference
PMID:10092508
  Authors
Taniyama Y, Shibata S, Kita S, Horikoshi K, Fuse H, Shirafuji H, Sumino Y, Fujino M.
  Title
Cloning and expression of a novel lysophospholipase which structurally resembles lecithin cholesterol acyltransferase.
  Journal
Biochem Biophys Res Commun 257:50-6 (1999)
DOI:10.1006/bbrc.1999.0411
Reference
PMID:10542045
  Authors
Athenstaedt K, Daum G.
  Title
Phosphatidic acid, a key intermediate in lipid metabolism.
  Journal
Eur J Biochem 266:1-16 (1999)
DOI:10.1046/j.1432-1327.1999.00822.x
Reference
PMID:12431977
  Authors
Shields DJ, Lehner R, Agellon LB, Vance DE.
  Title
Membrane topography of human phosphatidylethanolamine N-methyltransferase.
  Journal
J Biol Chem 278:2956-62 (2003)
DOI:10.1074/jbc.M210904200
Reference
PMID:14663079
  Authors
Martinez-Morales F, Schobert M, Lopez-Lara IM, Geiger O.
  Title
Pathways for phosphatidylcholine biosynthesis in bacteria.
  Journal
Microbiology 149:3461-71 (2003)
DOI:10.1099/mic.0.26522-0
Reference
PMID:15522832
  Authors
Burgermeister M, Birner-Grunberger R, Nebauer R, Daum G.
  Title
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1686:161-8 (2004)
DOI:10.1016/j.bbalip.2004.09.007
Reference
PMID:1649829
  Authors
Hsu L, Jackowski S, Rock CO
  Title
Isolation and characterization of Escherichia coli K-12 mutants lacking both 2-acyl-glycerophosphoethanolamine acyltransferase and acyl-acyl carrier protein synthetase activity.
  Journal
J Biol Chem 266:13783-8 (1991)
Reference
PMID:10938271
  Authors
Stone SJ, Vance JE.
  Title
Phosphatidylserine synthase-1 and -2 are localized to mitochondria-associated membranes.
  Journal
J Biol Chem 275:34534-40 (2000)
DOI:10.1074/jbc.M002865200
Related
pathway
pon00010  Glycolysis / Gluconeogenesis
pon00260  Glycine, serine and threonine metabolism
pon00561  Glycerolipid metabolism
pon00562  Inositol phosphate metabolism
pon00563  Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
pon00565  Ether lipid metabolism
pon00620  Pyruvate metabolism
KO pathway
ko00564   
LinkDB

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