KEGG   PATHWAY: ppuh00260
Entry
ppuh00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Pseudomonas putida HB3267
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
ppuh00260  Glycine, serine and threonine metabolism
ppuh00260

Module
ppuh_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:ppuh00260]
ppuh_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:ppuh00260]
ppuh_M00555  Betaine biosynthesis, choline => betaine [PATH:ppuh00260]
ppuh_M00621  Glycine cleavage system [PATH:ppuh00260]
ppuh_M00919  Ectoine degradation, ectoine => aspartate [PATH:ppuh00260]
ppuh_M00975  Betaine degradation, bacteria, betaine => pyruvate [PATH:ppuh00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Pseudomonas putida HB3267 [GN:ppuh]
Gene
B479_18970  aspartate kinase [KO:K00928] [EC:2.7.2.4]
B479_07630  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
B479_03770  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
B479_05670  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
B479_00935  homoserine kinase [KO:K02204] [EC:2.7.1.39]
B479_03760  threonine synthase [KO:K01733] [EC:4.2.3.1]
B479_05675  threonine synthase [KO:K01733] [EC:4.2.3.1]
B479_02055  threonine aldolase [KO:K01620] [EC:4.1.2.48]
B479_03790  glyA; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
B479_02060  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
B479_04305  glycerate dehydrogenase [KO:K00018] [EC:1.1.1.29]
B479_22275  D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
B479_13395  glycerate kinase [KO:K00865] [EC:2.7.1.165]
B479_18365  hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
B479_24755  phosphoglyceromutase [KO:K15633] [EC:5.4.2.12]
B479_25260  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
B479_06835  3-phosphoserine/phosphohydroxythreonine aminotransferase [KO:K00831] [EC:2.6.1.52]
B479_24010  phosphoserine phosphatase SerB [KO:K01079] [EC:3.1.3.3]
B479_02925  short-chain dehydrogenase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
B479_24380  amine oxidase [KO:K00274] [EC:1.4.3.4]
B479_05235  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
B479_25495  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
B479_05225  glycine cleavage system T protein [KO:K00605] [EC:2.1.2.10]
B479_25505  gcvT; glycine cleavage system aminomethyltransferase T [KO:K00605] [EC:2.1.2.10]
B479_26565  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
B479_17855  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
B479_18925  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
B479_05240  glycine cleavage system protein H [KO:K02437]
B479_25500  glycine cleavage system protein H [KO:K02437]
B479_11675  creatinase [KO:K08688] [EC:3.5.3.3]
B479_15730  pssA; phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
B479_22720  CDP-diacylglycerol--serine O-phosphatidyltransferase [KO:K17103] [EC:2.7.8.8]
B479_24795  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
B479_24790  betaine aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
B479_03980  putative betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
B479_02025  Rieske family iron-sulfur cluster-binding protein [KO:K00479] [EC:1.14.13.251]
B479_02030  oxidoreductase FAD-binding domain-containing protein [KO:K21832] [EC:1.14.13.251]
B479_02000  NADH:flavin oxidoreductase [KO:K21833] [EC:1.5.7.3]
B479_02005  iron-sulfur cluster-binding protein [KO:K21834]
B479_02010  electron transfer flavoprotein subunit alpha [KO:K25960]
B479_02015  electron transfer flavoprotein subunit alpha/beta-like protein [KO:K25961]
B479_02075  sarcosine oxidase subunit alpha [KO:K00302] [EC:1.5.3.24 1.5.3.1]
B479_16250  glycine cleavage T protein (aminomethyl transferase) [KO:K00302] [EC:1.5.3.24 1.5.3.1]
B479_02065  sarcosine oxidase subunit beta [KO:K00303] [EC:1.5.3.24 1.5.3.1]
B479_16240  FAD dependent oxidoreductase [KO:K00303] [EC:1.5.3.24 1.5.3.1]
B479_02080  sarcosine oxidase subunit gamma [KO:K00305] [EC:1.5.3.24 1.5.3.1]
B479_16255  hypothetical protein [KO:K00305] [EC:1.5.3.24 1.5.3.1]
B479_02070  sarcosine oxidase subunit delta [KO:K00304] [EC:1.5.3.24 1.5.3.1]
B479_16245  sarcosine oxidase subunit delta heterotetrameric [KO:K00304] [EC:1.5.3.24 1.5.3.1]
B479_19660  cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
B479_05230  L-serine dehydratase [KO:K01752] [EC:4.3.1.17]
B479_13570  L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]
B479_01920  L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]
B479_14485  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
B479_04030  EutB ectoine utilization protein [KO:K01754] [EC:4.3.1.19]
B479_25230  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
B479_14840  putative L-serine dehydratase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
B479_15795  D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
B479_15830  alanine racemase [KO:K25317] [EC:5.1.1.10]
B479_00740  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
B479_00745  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
B479_13875  diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
B479_17995  diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
B479_04040  EutD ectoine utilization protein [KO:K15783] [EC:3.5.4.44]
B479_04045  EutE ectoine utilization protein [KO:K15784] [EC:3.5.1.125]
B479_04055  hypothetical protein [KO:K15785] [EC:2.6.1.76]
B479_04050  succinate-semialdehyde dehydrogenase [KO:K15786] [EC:1.2.1.-]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
ppuh00010  Glycolysis / Gluconeogenesis
ppuh00020  Citrate cycle (TCA cycle)
ppuh00230  Purine metabolism
ppuh00250  Alanine, aspartate and glutamate metabolism
ppuh00270  Cysteine and methionine metabolism
ppuh00290  Valine, leucine and isoleucine biosynthesis
ppuh00300  Lysine biosynthesis
ppuh00330  Arginine and proline metabolism
ppuh00460  Cyanoamino acid metabolism
ppuh00470  D-Amino acid metabolism
ppuh00564  Glycerophospholipid metabolism
ppuh00620  Pyruvate metabolism
ppuh00630  Glyoxylate and dicarboxylate metabolism
ppuh00640  Propanoate metabolism
ppuh00680  Methane metabolism
ppuh00860  Porphyrin metabolism
ppuh00920  Sulfur metabolism
KO pathway
ko00260   
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