KEGG   PATHWAY: pret03320
Entry
pret03320                   Pathway                                
Name
PPAR signaling pathway - Poecilia reticulata (guppy)
Description
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake.
Class
Organismal Systems; Endocrine system
Pathway map
pret03320  PPAR signaling pathway
pret03320

Organism
Poecilia reticulata (guppy) [GN:pret]
Gene
103459298  platelet glycoprotein 4-like [KO:K06259]
103463254  long-chain fatty acid transport protein 1-like [KO:K08745] [EC:6.2.1.-]
103468769  slc27a1; long-chain fatty acid transport protein 1 [KO:K08745] [EC:6.2.1.-]
103473623  slc27a4; long-chain fatty acid transport protein 4 isoform X1 [KO:K08745] [EC:6.2.1.-]
103462052  very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
103462053  very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
103466696  very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
103470119  fabp1; fatty acid-binding protein, liver [KO:K08750]
103466138  fabp2; fatty acid-binding protein, intestinal [KO:K08751]
103480658  fatty acid-binding protein, intestinal-like [KO:K08751]
103472320  fabp3; fatty acid-binding protein, heart [KO:K08752]
103472416  LOW QUALITY PROTEIN: fatty acid-binding protein, heart-like [KO:K08752]
103478618  myelin P2 protein-like [KO:K08753]
103471228  fabp6; gastrotropin [KO:K08755]
103478914  gastrotropin-like [KO:K08755]
103458738  fatty acid-binding protein, brain-like [KO:K08756]
103458739  fatty acid-binding protein, brain-like [KO:K08756]
103457217  fabp7; fatty acid-binding protein, brain [KO:K08756]
103459501  ppara; peroxisome proliferator-activated receptor alpha [KO:K07294]
103465912  peroxisome proliferator-activated receptor alpha-like [KO:K07294]
103474009  rxra; retinoic acid receptor RXR-alpha [KO:K08524]
103478548  retinoic acid receptor RXR-beta-A-like isoform X1 [KO:K08524]
103472931  retinoic acid receptor RXR-beta-A isoform X4 [KO:K08525]
103463575  retinoic acid receptor RXR-gamma-B-like isoform X1 [KO:K08526]
103467297  ppard; peroxisome proliferator-activated receptor delta [KO:K04504]
103464445  pparg; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
103473119  hydroxymethylglutaryl-CoA synthase, cytoplasmic-like isoform X1 [KO:K01641] [EC:2.3.3.10]
103474828  apolipoprotein A-I [KO:K08757]
103477577  type-4 ice-structuring protein LS-12-like [KO:K08758]
103460360  pltp; phospholipid transfer protein isoform X1 [KO:K08761]
103469024  phospholipid transfer protein-like [KO:K08761]
103478237  me1; NADP-dependent malic enzyme [KO:K00029] [EC:1.1.1.40]
103480192  NADP-dependent malic enzyme, mitochondrial-like [KO:K00029] [EC:1.1.1.40]
103466509  fatty acid desaturase 2-like [KO:K10226] [EC:1.14.19.3]
103466510  fatty acid desaturase 2-like [KO:K10226] [EC:1.14.19.3]
103466511  fatty acid desaturase 2-like [KO:K10226] [EC:1.14.19.3]
103476842  acyl-CoA desaturase isoform X1 [KO:K00507] [EC:1.14.19.1]
103481451  acyl-CoA desaturase-like [KO:K00507] [EC:1.14.19.1]
103479251  cholesterol 7-alpha-monooxygenase [KO:K00489] [EC:1.14.14.23]
103479711  7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase [KO:K07431] [EC:1.14.14.139]
103462712  nr1h3; oxysterols receptor LXR-alpha [KO:K08536]
103456753  sterol 26-hydroxylase, mitochondrial-like isoform X1 [KO:K00488] [EC:1.14.15.15]
103461862  sterol 26-hydroxylase, mitochondrial-like isoform X1 [KO:K00488] [EC:1.14.15.15]
103461863  cytochrome P450 27C1-like isoform X1 [KO:K00488] [EC:1.14.15.15]
103478550  cytochrome P450 27C1-like [KO:K00488] [EC:1.14.15.15]
103476134  acyl-CoA-binding protein-like [KO:K08762]
103478128  acyl-CoA-binding protein-like [KO:K08762]
103482497  dbi; acyl-CoA-binding protein [KO:K08762]
103463532  lipoprotein lipase-like [KO:K01059] [EC:3.1.1.34]
103463534  lpl; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
103466187  acsl1; long-chain-fatty-acid--CoA ligase 1 isoform X1 [KO:K01897] [EC:6.2.1.3]
103470507  long-chain-fatty-acid--CoA ligase 1-like [KO:K01897] [EC:6.2.1.3]
103474928  acsl3; long-chain-fatty-acid--CoA ligase 3 [KO:K01897] [EC:6.2.1.3]
103470977  long-chain-fatty-acid--CoA ligase 4-like [KO:K01897] [EC:6.2.1.3]
103471009  long-chain-fatty-acid--CoA ligase 1-like isoform X1 [KO:K01897] [EC:6.2.1.3]
103475331  long-chain-fatty-acid--CoA ligase 6 isoform X1 [KO:K01897] [EC:6.2.1.3]
103479395  long-chain-fatty-acid--CoA ligase 3-like [KO:K01897] [EC:6.2.1.3]
103481841  long-chain-fatty-acid--CoA ligase 5 [KO:K01897] [EC:6.2.1.3]
103468238  acsbg2; long-chain-fatty-acid--CoA ligase ACSBG2 isoform X1 [KO:K15013] [EC:6.2.1.3]
103469930  long-chain-fatty-acid--CoA ligase ACSBG2-like [KO:K15013] [EC:6.2.1.3]
103461662  ehhadh; peroxisomal bifunctional enzyme [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
103473178  acaa1; 3-ketoacyl-CoA thiolase, peroxisomal [KO:K07513] [EC:2.3.1.16]
103479011  scp2; non-specific lipid-transfer protein isoform X1 [KO:K08764] [EC:2.3.1.176]
103469727  acox1; peroxisomal acyl-coenzyme A oxidase 1 isoform X1 [KO:K00232] [EC:1.3.3.6]
103480145  acox3; peroxisomal acyl-coenzyme A oxidase 3 [KO:K00232] [EC:1.3.3.6]
103466039  cpt1b; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K08765] [EC:2.3.1.21]
103466156  carnitine O-palmitoyltransferase 1, liver isoform-like isoform X1 [KO:K08765] [EC:2.3.1.21]
103468298  carnitine O-palmitoyltransferase 1, liver isoform-like [KO:K08765] [EC:2.3.1.21]
103481241  carnitine O-palmitoyltransferase 1, liver isoform-like isoform X1 [KO:K08765] [EC:2.3.1.21]
103464005  cpt2; carnitine O-palmitoyltransferase 2, mitochondrial [KO:K08766] [EC:2.3.1.21]
103479933  acadm; medium-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00249] [EC:1.3.8.7]
103463345  angiopoietin-related protein 4-like [KO:K08767]
103479161  angptl4; angiopoietin-related protein 4 [KO:K08767]
103477189  sorbin and SH3 domain-containing protein 1 [KO:K06086]
103466009  perilipin-2-like isoform X1 [KO:K17284]
103480710  plin2; perilipin-2 [KO:K17284]
103477535  perilipin-2-like [KO:K17284]
103475517  ilk; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
103474125  integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
103481066  pdpk1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
103464655  pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
103482322  pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
103477700  gk; glycerol kinase isoform X3 [KO:K00864] [EC:2.7.1.30]
103460843  glycerol kinase-like [KO:K00864] [EC:2.7.1.30]
103465004  aquaporin-7 isoform X1 [KO:K08771]
Compound
C02165  Leukotriene B4
C14762  13(S)-HODE
C14767  9(S)-HODE
C14776  8(S)-HETE
C15493  9-cis-Retinoic acid
Reference
PMID:15828220
  Authors
Takahashi N, Goto T, Kusudo T, Moriyama T, Kawada T.
  Title
[The structures and functions of peroxisome proliferator-activated receptors (PPARs)]
  Journal
Nippon Rinsho 63:557-64 (2005)
Reference
PMID:15828221
  Authors
Fujii H.
  Title
[PPARs-mediated intracellular signal transduction]
  Journal
Nippon Rinsho 63:565-71 (2005)
Reference
PMID:15828222
  Authors
Takada I, Kato S.
  Title
[PPARs target genes]
  Journal
Nippon Rinsho 63:573-7 (2005)
Reference
PMID:15828223
  Authors
Inoue H.
  Title
[Endogenous ligands for PPARs]
  Journal
Nippon Rinsho 63:578-83 (2005)
Reference
PMID:16476485
  Authors
Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W.
  Title
From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions.
  Journal
Prog Lipid Res 45:120-59 (2006)
DOI:10.1016/j.plipres.2005.12.002
Reference
PMID:16601267
  Authors
Desvergne B, Michalik L, Wahli W.
  Title
Transcriptional regulation of metabolism.
  Journal
Physiol Rev 86:465-514 (2006)
DOI:10.1152/physrev.00025.2005
Reference
PMID:14999402
  Authors
Mandard S, Muller M, Kersten S.
  Title
Peroxisome proliferator-activated receptor alpha target genes.
  Journal
Cell Mol Life Sci 61:393-416 (2004)
DOI:10.1007/s00018-003-3216-3
Reference
PMID:10529898
  Authors
Desvergne B, Wahli W.
  Title
Peroxisome proliferator-activated receptors: nuclear control of metabolism.
  Journal
Endocr Rev 20:649-88 (1999)
DOI:10.1210/edrv.20.5.0380
Reference
PMID:15673477
  Authors
Savage DB.
  Title
PPARgamma as a metabolic regulator: insights from genomics and pharmacology.
  Journal
Expert Rev Mol Med 2005:1-16 (2005)
DOI:10.1017/S1462399405008793
Reference
PMID:16511590
  Authors
Semple RK, Chatterjee VK, O'Rahilly S.
  Title
PPAR gamma and human metabolic disease.
  Journal
J Clin Invest 116:581-9 (2006)
DOI:10.1172/JCI28003
Reference
PMID:16360030
  Authors
Lehrke M, Lazar MA.
  Title
The many faces of PPARgamma.
  Journal
Cell 123:993-9 (2005)
DOI:10.1016/j.cell.2005.11.026
Reference
PMID:11921433
  Authors
Hauner H.
  Title
The mode of action of thiazolidinediones.
  Journal
Diabetes Metab Res Rev 18 Suppl 2:S10-5 (2002)
DOI:10.1002/dmrr.249
Related
pathway
pret00071  Fatty acid degradation
pret00120  Primary bile acid biosynthesis
pret00564  Glycerophospholipid metabolism
pret04920  Adipocytokine signaling pathway
KO pathway
ko03320   
LinkDB

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