KEGG   PATHWAY: pret04814
Entry
pret04814                   Pathway                                
Name
Motor proteins - Poecilia reticulata (guppy)
Class
Cellular Processes; Cell motility
Pathway map
pret04814  Motor proteins
pret04814

Organism
Poecilia reticulata (guppy) [GN:pret]
Gene
103459949  dync1h1; cytoplasmic dynein 1 heavy chain 1 isoform X1 [KO:K10413]
103474718  dync2h1; cytoplasmic dynein 2 heavy chain 1 [KO:K10414]
103458526  cytoplasmic dynein 1 intermediate chain 2-like isoform X1 [KO:K10415]
103472235  dync1i1; cytoplasmic dynein 1 intermediate chain 1 isoform X3 [KO:K10415]
103479324  cytoplasmic dynein 1 intermediate chain 2-like isoform X1 [KO:K10415]
103462369  dync1li2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
103472281  cytoplasmic dynein 1 light intermediate chain 1-like [KO:K10416]
103476404  dync2li1; cytoplasmic dynein 2 light intermediate chain 1 [KO:K10417]
103470030  dynein light chain 2, cytoplasmic-like [KO:K10418]
103474153  dynein light chain 2, cytoplasmic [KO:K10418]
103475484  dynein light chain 2, cytoplasmic-like [KO:K10418]
103464281  dynein light chain roadblock-type 1-like [KO:K10419]
103464282  dynein light chain roadblock-type 1 [KO:K10419]
103466052  dynlrb2; dynein light chain roadblock-type 2 [KO:K10419]
103456667  dynein light chain Tctex-type 1-like isoform X1 [KO:K10420]
103457504  dynlt1; dynein light chain Tctex-type 1 [KO:K10420]
103459912  dynlt3; dynein light chain Tctex-type 3 [KO:K10420]
103479024  tctex1 domain-containing protein 1-B-like [KO:K25421]
103463729  dnah8; dynein heavy chain 8, axonemal [KO:K10408]
103467502  dnah12; dynein heavy chain 12, axonemal [KO:K10408]
103470299  dnah10; dynein heavy chain 10, axonemal [KO:K10408]
103472217  dnah3; dynein heavy chain 3, axonemal isoform X1 [KO:K10408]
103478553  dnah11; dynein heavy chain 11, axonemal isoform X2 [KO:K10408]
103480560  dnah2; dynein heavy chain 2, axonemal isoform X1 [KO:K10408]
103461840  dnah7; LOW QUALITY PROTEIN: dynein heavy chain 7, axonemal [KO:K10408]
103465096  dnah1; dynein heavy chain 1, axonemal [KO:K10408]
103481913  dnah9; dynein heavy chain 9, axonemal isoform X1 [KO:K10408]
103478699  dnah5; dynein heavy chain 5, axonemal [KO:K10408]
103464981  dnai1; dynein intermediate chain 1, axonemal [KO:K10409]
103472647  dnai2; dynein intermediate chain 2, axonemal [KO:K11143]
103463077  wdr63; WD repeat-containing protein 63 isoform X1 [KO:K24722]
103479247  wdr78; WD repeat-containing protein 78 isoform X1 [KO:K24723]
103465961  WD repeat-containing protein 78-like [KO:K24723]
103477795  dnali1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
103472335  dnal1; dynein light chain 1, axonemal isoform X1 [KO:K10411]
103476474  dnal4; dynein light chain 4, axonemal [KO:K10412]
103458193  dctn1; dynactin subunit 1 isoform X1 [KO:K04648]
103480555  dynactin subunit 1-like isoform X1 [KO:K04648]
103464405  dctn2; dynactin subunit 2 isoform X1 [KO:K10424]
103477632  dctn3; dynactin subunit 3 [KO:K10425]
103471136  dctn4; dynactin subunit 4 isoform X1 [KO:K10426]
103468580  dctn5; dynactin subunit 5 [KO:K10427]
103469288  dctn6; dynactin subunit 6 [KO:K10428]
103480656  dynactin subunit 6-like [KO:K10428]
103473156  beta-centractin [KO:K16575]
103457898  actr10; actin-related protein 10 [KO:K16576]
103465634  capza2; F-actin-capping protein subunit alpha-2 [KO:K10364]
103467451  capza1; F-actin-capping protein subunit alpha-1 [KO:K10364]
103465173  capzb; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
103469532  bicdl1; bicaudal D-related protein 1 isoform X1 [KO:K16756]
103474564  bicaudal D-related protein 1-like [KO:K16756]
103475462  bicaudal D-related protein 2-like isoform X1 [KO:K16756]
103473588  hook3; protein Hook homolog 3 isoform X1 [KO:K16536]
103456704  tuba4a; tubulin alpha-4A chain [KO:K07374]
103463573  tubulin alpha-1C chain-like [KO:K07374]
103463315  tubulin alpha chain-like [KO:K07374]
103463343  tubulin alpha-1B chain-like [KO:K07374]
103460255  tubulin alpha-1B chain-like [KO:K07374]
103461627  tubulin alpha chain-like [KO:K07374]
103461628  tubulin alpha chain-like [KO:K07374]
103461629  tubulin alpha chain [KO:K07374]
103467752  tubulin alpha-8 chain-like [KO:K07374]
103467815  tubulin alpha-1B chain [KO:K07374]
103467914  tubulin alpha-1A chain isoform X1 [KO:K07374]
103467923  tubulin alpha-1B chain-like [KO:K07374]
103473792  tubulin alpha chain-like [KO:K07374]
103474941  tubulin alpha-1C chain-like [KO:K07374]
103458135  tubulin beta-1 chain-like [KO:K07375]
103465067  tubulin beta-4B chain-like [KO:K07375]
103464382  tubulin beta chain-like [KO:K07375]
103469594  tubb4b; tubulin beta-4B chain [KO:K07375]
103468788  tubulin beta-4B chain-like [KO:K07375]
103474183  tubulin beta-4B chain-like [KO:K07375]
103472951  tubulin beta chain-like [KO:K07375]
103475019  tubulin beta-4B chain-like [KO:K07375]
103477960  tubulin beta chain [KO:K07375]
103478996  tubulin beta-4B chain-like [KO:K07375]
103479562  tubulin beta chain-like isoform X1 [KO:K07375]
103475018  tubulin beta chain-like [KO:K07375]
103468647  tubg1; tubulin gamma-1 chain [KO:K10389]
103474394  tubd1; tubulin delta chain [KO:K10390]
103458007  tube1; tubulin epsilon chain [KO:K10391]
103457469  kif5c; kinesin heavy chain [KO:K10396]
103464406  kinesin heavy chain isoform X1 [KO:K10396]
103460122  kinesin heavy chain-like [KO:K10396]
103467251  kinesin heavy chain-like [KO:K10396]
103479480  kinesin-1 heavy chain [KO:K10396]
103482337  kif5b; kinesin-1 heavy chain isoform X1 [KO:K10396]
103458139  klc1; kinesin light chain 1 isoform X1 [KO:K10407]
103475168  klc3; kinesin light chain 3 [KO:K10407]
103477283  klc4; kinesin light chain 4 isoform X1 [KO:K10407]
103475919  klc2; kinesin light chain 2 isoform X1 [KO:K10407]
103471214  kif3a; kinesin-like protein KIF3A isoform X2 [KO:K10394]
103466932  kif3b; kinesin-like protein KIF3B [KO:K20196]
103479309  kinesin-associated protein 3-like [KO:K25388]
103463193  kifap3; kinesin-associated protein 3 isoform X1 [KO:K25388]
103458379  kif3c; kinesin-like protein KIF3C [KO:K20197]
103457278  kinesin-like protein KIF3C isoform X1 [KO:K20197]
103464753  kif17; kinesin-like protein KIF17 [KO:K20198]
103463957  kinesin-like protein KIF1A isoform X5 [KO:K10392]
103460316  kinesin-like protein KIF1C [KO:K10392]
103467218  kif1b; kinesin-like protein KIF1B isoform X1 [KO:K10392]
103479609  kinesin-like protein KIF1A isoform X7 [KO:K10392]
103457764  kif13b; kinesin-like protein KIF13B isoform X1 [KO:K17914]
103462194  kinesin-like protein KIF13B isoform X1 [KO:K17914]
103478594  kif13a; kinesin-like protein KIF13A isoform X2 [KO:K17914]
103463508  LOW QUALITY PROTEIN: kinesin-like protein KIF14 [KO:K17915]
103477227  uncharacterized protein LOC103477227 isoform X1 [KO:K17916]
103472074  kif16b; LOW QUALITY PROTEIN: kinesin-like protein KIF16B [KO:K17916]
103458401  stard9; stAR-related lipid transfer protein 9 isoform X1 [KO:K16491]
103460459  chromosome-associated kinesin KIF4-like [KO:K10395]
103462564  kif7; kinesin-like protein KIF7 [KO:K18806]
103465735  kif21a; kinesin-like protein KIF21A isoform X1 [KO:K24185]
103459533  kinesin-like protein KIF21A isoform X1 [KO:K24185]
103464904  kif21b; kinesin-like protein KIF21B isoform X1 [KO:K24185]
103470209  kif27; kinesin-like protein KIF27 [KO:K24186]
103477380  kif11; kinesin-like protein KIF11 isoform X1 [KO:K10398]
103475851  kif20a; kinesin-like protein KIF20A [KO:K10402]
103482274  kinesin-like protein KIF20A [KO:K10402]
103477196  kinesin-like protein KIF20B [KO:K10402]
103482151  kinesin-like protein KIF20A isoform X1 [KO:K10402]
103462116  kif23; kinesin-like protein KIF23 isoform X4 [KO:K17387]
103459690  cenpe; centromere-associated protein E [KO:K11498]
103462398  kif18a; kinesin-like protein KIF18A [KO:K10401]
103481640  kif19; kinesin-like protein KIF19 [KO:K26157]
103458669  kif6; kinesin-like protein KIF6 [KO:K10397]
103481383  kif22; kinesin-like protein KIF22 [KO:K10403]
103457780  kinesin-like protein KIF26B isoform X1 [KO:K10404]
103462774  kif26b; kinesin-like protein KIF26B isoform X1 [KO:K10404]
103459002  kif26a; kinesin-like protein KIF26A isoform X2 [KO:K10404]
103457178  kinesin-like protein KIF26A [KO:K10404]
103458915  kif15; kinesin-like protein KIF15 isoform X1 [KO:K10400]
103470415  kif2a; kinesin-like protein KIF2A isoform X1 [KO:K10393]
103473261  kinesin-like protein KIF2A [KO:K10393]
103470246  kinesin heavy chain-like isoform X1 [KO:K10393]
103479623  kif2c; kinesin-like protein KIF2C [KO:K10393]
103460087  kifc3; kinesin-like protein KIFC3 isoform X1 [KO:K10406]
103478606  kinesin-like protein KIFC3 [KO:K10406]
103470579  kinesin-like calmodulin-binding protein homolog isoform X1 [KO:K10406]
103462510  myo1e; unconventional myosin-Ie isoform X1 [KO:K10356]
103460577  myo1b; unconventional myosin-Ib isoform X1 [KO:K10356]
103468235  unconventional myosin-If [KO:K10356]
103473745  unconventional myosin-Ih-like isoform X1 [KO:K10356]
103475744  unconventional myosin-Ic-like isoform X1 [KO:K10356]
103477465  unconventional myosin-Ie-like isoform X1 [KO:K10356]
103474896  myo1c; unconventional myosin-Ic isoform X1 [KO:K10356]
103470343  myo1h; unconventional myosin-Ih isoform X1 [KO:K10356]
103481712  myo1d; unconventional myosin-Id [KO:K10356]
103473050  unconventional myosin-Ig-like [KO:K10356]
103456774  myo3a; myosin-IIIa isoform X4 [KO:K08834] [EC:2.7.11.1]
103458636  myo3b; myosin-IIIb isoform X1 [KO:K08834] [EC:2.7.11.1]
103463657  unconventional myosin-Vb-like [KO:K10357]
103462168  myo5a; unconventional myosin-Va isoform X1 [KO:K10357]
103466454  unconventional myosin-Va-like [KO:K10357]
103466456  myo5c; unconventional myosin-Vc isoform X1 [KO:K10357]
103474068  myo5b; unconventional myosin-Vb isoform X1 [KO:K10357]
103457075  unconventional myosin-VI-like [KO:K10358]
103458802  unconventional myosin-VI-like [KO:K10358]
103475091  myo7a; unconventional myosin-VIIa isoform X7 [KO:K10359]
103476307  unconventional myosin-VIIa-like isoform X1 [KO:K10359]
103463943  myo7b; unconventional myosin-VIIb [KO:K21868]
103478950  unconventional myosin-VIIa-like [KO:K21868]
103464107  myo9b; unconventional myosin-IXb isoform X1 [KO:K10360]
103462133  unconventional myosin-IXa isoform X1 [KO:K10360]
103461672  unconventional myosin-X-like isoform X1 [KO:K12559]
103480045  myo10; unconventional myosin-X isoform X1 [KO:K12559]
103462207  unconventional myosin-XV-like isoform X2 [KO:K10361]
103482152  myo15b; myosin XVB [KO:K10361]
103468567  myo15a; unconventional myosin-XV isoform X1 [KO:K10361]
103459708  myo16; unconventional myosin-XVI isoform X1 [KO:K17481]
103475883  unconventional myosin-XVIIIa-like isoform X1 [KO:K10362]
103473185  myo18b; unconventional myosin-XVIIIb isoform X1 [KO:K10362]
103476053  myo19; unconventional myosin-XIX isoform X1 [KO:K25838]
103468121  myosin-7-like [KO:K24220]
103464607  myosin heavy chain, fast skeletal muscle [KO:K24220]
103479338  myosin-7-like [KO:K17751]
103482310  myosin-6 [KO:K17751]
103479335  myosin-6-like [KO:K17751]
103464768  myh11; myosin-11 isoform X3 [KO:K10352]
103467583  myosin-10-like isoform X1 [KO:K10352]
103467636  myosin-9-like isoform X1 [KO:K10352]
103468362  myh9; myosin-9 isoform X1 [KO:K10352]
103468406  myosin-10 isoform X1 [KO:K10352]
103461533  myosin light chain 1, skeletal muscle isoform [KO:K05738]
103473836  myosin light chain 4-like [KO:K12750]
103465374  myosin light polypeptide 6 [KO:K12751]
103467339  myosin light polypeptide 6 isoform X1 [KO:K12751]
103464970  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
103469530  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
103470002  myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
103464948  myosin regulatory light polypeptide 9 [KO:K12755]
103456858  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
103479826  myosin regulatory light polypeptide 9 [KO:K12757]
103468934  mylpf; myosin regulatory light chain 2, skeletal muscle isoform isoform X1 [KO:K12758]
103481362  myosin regulatory light chain 2, skeletal muscle isoform-like [KO:K12758]
103457336  actin, alpha cardiac-like [KO:K12314]
103458530  actin, alpha cardiac [KO:K12314]
103462807  acta1; actin, alpha skeletal muscle [KO:K12314]
103458759  actc1; actin, alpha cardiac muscle 1 [KO:K12314]
103468476  actb; actin, beta [KO:K05692]
103462148  actin, cytoplasmic 2 [KO:K05692]
103468062  troponin C, slow skeletal and cardiac muscles-like [KO:K05865]
103467588  troponin C, slow skeletal and cardiac muscles isoform X1 [KO:K05865]
103465819  troponin I, slow skeletal muscle-like [KO:K10371]
103465820  troponin I, slow skeletal muscle-like [KO:K10371]
103465821  troponin I, slow skeletal muscle-like [KO:K10371]
103465822  troponin I, slow skeletal muscle-like [KO:K10371]
103459244  troponin I, slow skeletal muscle-like isoform X1 [KO:K10371]
103464710  troponin I, slow skeletal muscle-like [KO:K10371]
103467418  tnni1; troponin I, slow skeletal muscle [KO:K10371]
103468510  troponin T, slow skeletal muscle-like [KO:K10372]
103481239  tnnt1; troponin T, slow skeletal muscle isoform X1 [KO:K10372]
103466898  troponin C, skeletal muscle [KO:K12042]
103466900  troponin C, skeletal muscle-like [KO:K12042]
103465645  troponin I, fast skeletal muscle-like [KO:K12043]
103465646  troponin I, fast skeletal muscle-like [KO:K12043]
103462935  troponin I, fast skeletal muscle-like isoform X1 [KO:K12043]
103465678  troponin I, fast skeletal muscle-like [KO:K12043]
103465649  troponin T, fast skeletal muscle isoforms-like isoform X1 [KO:K12046]
103462939  troponin T, fast skeletal muscle isoforms-like [KO:K12046]
103459481  troponin T, cardiac muscle isoforms-like isoform X1 [KO:K12045]
103465824  troponin T, cardiac muscle isoforms-like [KO:K12045]
103464708  troponin T, cardiac muscle isoforms-like [KO:K12045]
103467415  troponin T, cardiac muscle isoforms isoform X4 [KO:K12045]
103462590  tropomyosin alpha-1 chain-like [KO:K10373]
103466597  tpm1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
103477449  tropomyosin alpha-4 chain-like isoform X1 [KO:K09290]
103461027  tropomyosin alpha-4 chain-like [KO:K09290]
103471928  tropomyosin alpha-3 chain [KO:K09290]
103463529  tpm4; tropomyosin alpha-4 chain isoform X1 [KO:K10375]
103479776  tropomyosin alpha-4 chain-like isoform X1 [KO:K10375]
Reference
PMID:21092854
  Authors
Hirokawa N, Niwa S, Tanaka Y
  Title
Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease.
  Journal
Neuron 68:610-38 (2010)
DOI:10.1016/j.neuron.2010.09.039
Reference
PMID:25470043 (PDB:4RH7)
  Authors
Schmidt H, Zalyte R, Urnavicius L, Carter AP
  Title
Structure of human cytoplasmic dynein-2 primed for its power stroke.
  Journal
Nature 518:435-438 (2015)
DOI:10.1038/nature14023
Reference
PMID:22398446 (PDB:3VKG 3VKH)
  Authors
Kon T, Oyama T, Shimo-Kon R, Imamula K, Shima T, Sutoh K, Kurisu G
  Title
The 2.8 A crystal structure of the dynein motor domain.
  Journal
Nature 484:345-50 (2012)
DOI:10.1038/nature10955
Reference
PMID:22997337 (PDB:3J1T 3J1U)
  Authors
Redwine WB, Hernandez-Lopez R, Zou S, Huang J, Reck-Peterson SL, Leschziner AE
  Title
Structural basis for microtubule binding and release by dynein.
  Journal
Science 337:1532-1536 (2012)
DOI:10.1126/science.1224151
Reference
PMID:26410600
  Authors
Gibbs KL, Greensmith L, Schiavo G
  Title
Regulation of Axonal Transport by Protein Kinases.
  Journal
Trends Biochem Sci 40:597-610 (2015)
DOI:10.1016/j.tibs.2015.08.003
Reference
PMID:28602352 (PDB:5NUG 5NVS 5NVU 5NW4)
  Authors
Zhang K, Foster HE, Rondelet A, Lacey SE, Bahi-Buisson N, Bird AW, Carter AP
  Title
Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated.
  Journal
Cell 169:1303-1314.e18 (2017)
DOI:10.1016/j.cell.2017.05.025
Reference
PMID:25814576 (PDB:5ADX 5AFR 5AFU)
  Authors
Urnavicius L, Zhang K, Diamant AG, Motz C, Schlager MA, Yu M, Patel NA, Robinson CV, Carter AP
  Title
The structure of the dynactin complex and its interaction with dynein.
  Journal
Science 347:1441-1446 (2015)
DOI:10.1126/science.aaa4080
Reference
PMID:29420470 (PDB:5OWO 6F1T 6F1U 6F1V 6F1Y 6F1Z 6F38 6F3A)
  Authors
Urnavicius L, Lau CK, Elshenawy MM, Morales-Rios E, Motz C, Yildiz A, Carter AP
  Title
Cryo-EM shows how dynactin recruits two dyneins for faster movement.
  Journal
Nature 554:202-206 (2018)
DOI:10.1038/nature25462
Reference
PMID:29662141
  Authors
Reck-Peterson SL, Redwine WB, Vale RD, Carter AP
  Title
The cytoplasmic dynein transport machinery and its many cargoes.
  Journal
Nat Rev Mol Cell Biol 19:382-398 (2018)
DOI:10.1038/s41580-018-0004-3
Reference
PMID:23434508 (PDB:3J2U)
  Authors
Asenjo AB, Chatterjee C, Tan D, DePaoli V, Rice WJ, Diaz-Avalos R, Silvestry M, Sosa H
  Title
Structural model for tubulin recognition and deformation by kinesin-13 microtubule depolymerases.
  Journal
Cell Rep 3:759-68 (2013)
DOI:10.1016/j.celrep.2013.01.030
Reference
PMID:10338210 (PDB:1B7T)
  Authors
Houdusse A, Kalabokis VN, Himmel D, Szent-Gyorgyi AG, Cohen C
  Title
Atomic structure of scallop myosin subfragment S1 complexed with MgADP: a novel conformation of the myosin head.
  Journal
Cell 97:459-70 (1999)
DOI:10.1016/s0092-8674(00)80756-4
Reference
PMID:9428521 (PDB:3KIN)
  Authors
Kozielski F, Sack S, Marx A, Thormahlen M, Schonbrunn E, Biou V, Thompson A, Mandelkow EM, Mandelkow E
  Title
The crystal structure of dimeric kinesin and implications for microtubule-dependent motility.
  Journal
Cell 91:985-94 (1997)
DOI:10.1016/s0092-8674(00)80489-4
Reference
PMID:8316857 (PDB:2MYS)
  Authors
Rayment I, Rypniewski WR, Schmidt-Base K, Smith R, Tomchick DR, Benning MM, Winkelmann DA, Wesenberg G, Holden HM
  Title
Three-dimensional structure of myosin subfragment-1: a molecular motor.
  Journal
Science 261:50-8 (1993)
DOI:10.1126/science.8316857
Reference
PMID:20428469
  Authors
Parker D, Bryant Z, Delp SL
  Title
Coarse-Grained Structural Modeling of Molecular Motors Using Multibody Dynamics.
  Journal
Cell Mol Bioeng 2:366-374 (2009)
DOI:10.1007/s12195-009-0084-4
Reference
PMID:21314430
  Authors
Dominguez R, Holmes KC
  Title
Actin structure and function.
  Journal
Annu Rev Biophys 40:169-86 (2011)
DOI:10.1146/annurev-biophys-042910-155359
Reference
PMID:31919429 (PDB:6KN7 6KN8)
  Authors
Yamada Y, Namba K, Fujii T
  Title
Cardiac muscle thin filament structures reveal calcium regulatory mechanism.
  Journal
Nat Commun 11:153 (2020)
DOI:10.1038/s41467-019-14008-1
Reference
PMID:33912943
  Authors
Kruppa AJ, Buss F
  Title
Motor proteins at the mitochondria-cytoskeleton interface.
  Journal
J Cell Sci 134:239092 (2021)
DOI:10.1242/jcs.226084
KO pathway
ko04814   
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