KEGG PATHWAY: psaz00270

PATHWAY: psaz00270

Entry

psaz00270                   Pathway

Name

Cysteine and methionine metabolism - Pseudoalteromonas sp. A25

Description

Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].

Class

Metabolism; Amino acid metabolism

Pathway map

psaz00270

Cysteine and methionine metabolism

Module

psaz_M00017

Methionine biosynthesis, aspartate => homoserine => methionine [PATH:psaz00270]

psaz_M00021

Cysteine biosynthesis, serine => cysteine [PATH:psaz00270]

Other DBs

GO:	0006534 0006555

Organism

Pseudoalteromonas sp. A25 [GN:psaz]

Gene

PA25_26420

serine O-acetyltransferase [KO:K00640] [EC:2.3.1.30]

PA25_20660

cysK; cysteine synthase [KO:K01738] [EC:2.5.1.47]

PA25_19950

cystathionine beta-lyase [KO:K01760] [EC:4.4.1.13]

PA25_13150

hypothetical protein [KO:K00548] [EC:2.1.1.13]

PA25_13140

hypothetical protein [KO:K00548] [EC:2.1.1.13]

PA25_38490

5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase [KO:K00549] [EC:2.1.1.14]

PA25_07930

metK; S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]

PA25_29820

speD; S-adenosylmethionine decarboxylase proenzyme [KO:K01611] [EC:4.1.1.50]

PA25_01360

speE_1; polyamine aminopropyltransferase [KO:K00797] [EC:2.5.1.16]

PA25_01880

hypothetical protein [KO:K00797] [EC:2.5.1.16]

PA25_30570

speE_2; polyamine aminopropyltransferase [KO:K00797] [EC:2.5.1.16]

PA25_25860

mtnN; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase [KO:K01243] [EC:3.2.2.9]

PA25_31430

mtnK; methylthioribose kinase [KO:K00899] [EC:2.7.1.100]

PA25_09370

laccase domain protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]

PA25_31420

mtnA; methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]

PA25_31380

mtnB; methylthioribulose-1-phosphate dehydratase [KO:K08964] [EC:4.2.1.109]

PA25_31390

mtnC; enolase-phosphatase E1 [KO:K09880] [EC:3.1.3.77]

PA25_31400

mtnD; acireductone dioxygenase [KO:K08967] [EC:1.13.11.53 1.13.11.54]

PA25_22810

mdeA; methionine gamma-lyase [KO:K01761] [EC:4.4.1.11]

PA25_17980

hypothetical protein [KO:K08968] [EC:1.8.4.14]

PA25_04920

cytosine-specific methyltransferase [KO:K00558] [EC:2.1.1.37]

PA25_02660

acdS; 1-aminocyclopropane-1-carboxylate deaminase [KO:K01505] [EC:3.5.99.7]

PA25_07280

lysC_1; aspartokinase [KO:K00928] [EC:2.7.2.4]

PA25_15800

lysC_2; aspartokinase [KO:K00928] [EC:2.7.2.4]

PA25_24290

thrA; bifunctional aspartokinase I/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]

PA25_12090

hypothetical protein [KO:K12525] [EC:2.7.2.4 1.1.1.3]

PA25_30050

metL; bifunctional aspartate kinase/homoserine dehydrogenase II [KO:K12525] [EC:2.7.2.4 1.1.1.3]

PA25_09820

asd-2; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]

PA25_33110

asd; aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]

PA25_13130

metA; homoserine O-succinyltransferase [KO:K00651] [EC:2.3.1.46 2.3.1.31]

PA25_30060

metB; O-succinylhomoserine (thiol)-lyase [KO:K01739] [EC:2.5.1.48]

PA25_30780

ilvE; branched chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]

PA25_09420

gshA; glutamate--cysteine ligase [KO:K01919] [EC:6.3.2.2]

PA25_04710

gshB_1; glutathione synthetase [KO:K01920] [EC:6.3.2.3]

PA25_38310

gshB_2; glutathione synthetase [KO:K01920] [EC:6.3.2.3]

PA25_09880

aspC; aminotransferase [KO:K00813] [EC:2.6.1.1]

PA25_28810

sulfurtransferase [KO:K01011] [EC:2.8.1.1 2.8.1.2]

PA25_09010

racD; aspartate racemase [KO:K25316] [EC:5.1.1.10]

PA25_25900

mdh; malate dehydrogenase [KO:K00024] [EC:1.1.1.37]

PA25_20520

sdaA-2; L-serine ammonia-lyase [KO:K01752] [EC:4.3.1.17]

PA25_26860

serA; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

PA25_16970

serC; phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]

Compound

C00019

S-Adenosyl-L-methionine

C00021

S-Adenosyl-L-homocysteine

C00022

Pyruvate

C00041

L-Alanine

C00049

L-Aspartate

C00051

Glutathione

C00059

Sulfate

C00065

L-Serine

C00073

L-Methionine

C00094

Sulfite

C00097

L-Cysteine

C00109

2-Oxobutanoate

C00155

L-Homocysteine

C00170

5'-Methylthioadenosine

C00197

3-Phospho-D-glycerate

C00263

L-Homoserine

C00283

Hydrogen sulfide

C00409

Methanethiol

C00441

L-Aspartate 4-semialdehyde

C00491

L-Cystine

C00506

L-Cysteate

C00606

3-Sulfino-L-alanine

C00793

D-Cysteine

C00957

Mercaptopyruvate

C00979

O-Acetyl-L-serine

C01005

O-Phospho-L-serine

C01077

O-Acetyl-L-homoserine

C01118

O-Succinyl-L-homoserine

C01137

S-Adenosylmethioninamine

C01180

4-Methylthio-2-oxobutanoic acid

C01234

1-Aminocyclopropane-1-carboxylate

C01817

L-Homocystine

C01962

Thiocysteine

C02218

Dehydroalanine

C02291

L-Cystathionine

C02356

(S)-2-Aminobutanoate

C02989

L-Methionine S-oxide

C03082

4-Phospho-L-aspartate

C03089

5-Methylthio-D-ribose

C03145

N-Formylmethionine

C03232

3-Phosphonooxypyruvate

C03431

S-Inosyl-L-homocysteine

C03539

S-Ribosyl-L-homocysteine

C04188

S-Methyl-5-thio-D-ribose 1-phosphate

C04582

S-Methyl-5-thio-D-ribulose 1-phosphate

C05324

Nicotianamine

C05524

Aminoacyl-L-methionine

C05526

S-Glutathionyl-L-cysteine

C05527

3-Sulfinylpyruvate

C05528

3-Sulfopyruvate

C05823

3-Mercaptolactate

C05824

S-Sulfo-L-cysteine

C06547

Ethylene

C08276

3-(Methylthio)propanoate

C09306

Sulfur dioxide

C11437

1-Deoxy-D-xylulose 5-phosphate

C11481

HSO3-

C11499

(S)-3-Sulfolactate

C11537

(2R)-3-Sulfolactate

C15606

1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one

C15650

2,3-Diketo-5-methylthiopentyl-1-phosphate

C15651

2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate

C18049

N-Acyl-L-homoserine lactone

C19787

5'-S-Methyl-5'-thioinosine

C21015

gamma-L-Glutamyl-L-2-aminobutyrate

C21016

Ophthalmate

C22359

S-Methyl-1-thio-D-xylulose 5-phosphate

Reference

PMID:15102328

Authors

Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A

Title

Bacterial variations on the methionine salvage pathway.

Journal

BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9

Reference

PMID:14551435

Authors

Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.

Title

A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.

Journal

Science 302:286-90 (2003)
DOI:10.1126/science.1086997

Reference

PMID:12022921

Authors

Sekowska A, Danchin A.

Title

The methionine salvage pathway in Bacillus subtilis.

Journal

BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8

Reference

PMID:12670965

Authors

Berger BJ, English S, Chan G, Knodel MH.

Title

Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.

Journal

J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003

Reference

PMID:17169919

Authors

Goyer A, Collakova E, Shachar-Hill Y, Hanson AD

Title

Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.

Journal

Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055

Reference

PMID:17030798

Authors

Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S

Title

Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.

Journal

Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103

Reference

PMID:18625006

Authors

Pirkov I, Norbeck J, Gustafsson L, Albers E

Title

A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.

Journal

FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x

Reference

PMID:18391471

Authors

Ashida H, Saito Y, Kojima C, Yokota A

Title

Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.

Journal

Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651

Reference

PMID:10613873

Authors

Kitabatake M, So MW, Tumbula DL, Soll D

Title

Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?

Journal

J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000

Reference

PMID:12644499

Authors

Mino K, Ishikawa K

Title

Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.

Journal

J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003

Reference

PMID:18520135

Authors

Tanabe S

Title

Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.

Journal

Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:19270684

Authors