KEGG   PATHWAY: pteh00983
Entry
pteh00983                   Pathway                                
Name
Drug metabolism - other enzymes - Piliocolobus tephrosceles (Ugandan red Colobus)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
pteh00983  Drug metabolism - other enzymes
pteh00983

Organism
Piliocolobus tephrosceles (Ugandan red Colobus) [GN:pteh]
Gene
111531566  HPRT1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
111550178  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
111524798  LOW QUALITY PROTEIN: inosine-5'-monophosphate dehydrogenase 1-like [KO:K00088] [EC:1.1.1.205]
111536323  inosine-5'-monophosphate dehydrogenase 1-like isoform X1 [KO:K00088] [EC:1.1.1.205]
111555451  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
111550103  GMPS; GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
111541124  TPMT; thiopurine S-methyltransferase [KO:K00569] [EC:2.1.1.67]
111546045  XDH; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
111548075  ITPA; inosine triphosphate pyrophosphatase isoform X1 [KO:K01519] [EC:3.6.1.66]
113223003  cocaine esterase-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
113223015  cocaine esterase-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
111540340  cocaine esterase [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
113223004  cocaine esterase-like [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
113223553  UDP-glucuronosyltransferase 1-6 [KO:K00699] [EC:2.4.1.17]
113223554  UDP-glucuronosyltransferase 1-6 [KO:K00699] [EC:2.4.1.17]
113223555  UDP-glucuronosyltransferase 1-7 [KO:K00699] [EC:2.4.1.17]
111528188  UDP-glucuronosyltransferase 1-6 [KO:K00699] [EC:2.4.1.17]
111528189  UDP-glucuronosyltransferase 1-7 [KO:K00699] [EC:2.4.1.17]
111529609  UDP-glucuronosyltransferase 2B33-like isoform X1 [KO:K00699] [EC:2.4.1.17]
111529611  UGT2A3; UDP-glucuronosyltransferase 2A3 [KO:K00699] [EC:2.4.1.17]
111529612  UGT2B4; UDP-glucuronosyltransferase 2B4 isoform X1 [KO:K00699] [EC:2.4.1.17]
111553768  UDP-glucuronosyltransferase 1-3 isoform X1 [KO:K00699] [EC:2.4.1.17]
111529615  UDP-glucuronosyltransferase 2A1 [KO:K00699] [EC:2.4.1.17]
116418968  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 1-7-like [KO:K00699] [EC:2.4.1.17]
111523766  UDP-glucuronosyltransferase 1-8-like [KO:K00699] [EC:2.4.1.17]
111555797  UDP-glucuronosyltransferase 2B20 isoform X1 [KO:K00699] [EC:2.4.1.17]
111555799  UDP-glucuronosyltransferase 2B18 isoform X2 [KO:K00699] [EC:2.4.1.17]
111529608  LOW QUALITY PROTEIN: UDP-glucuronosyltransferase 2B23 [KO:K00699] [EC:2.4.1.17]
111535247  UDP-glucuronosyltransferase 2B9 isoform X1 [KO:K00699] [EC:2.4.1.17]
111529733  UDP-glucuronosyltransferase 1-9-like [KO:K00699] [EC:2.4.1.17]
111530452  beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
113219513  beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
111530171  cytochrome P450 3A8 isoform X1 [KO:K17689] [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
111534893  cytochrome P450 3A4-like [KO:K17689] [EC:1.14.13.32 1.14.14.55 1.14.14.56 1.14.14.57 1.14.14.73 1.14.14.-]
111547734  CDA; cytidine deaminase [KO:K01489] [EC:3.5.4.5]
111548875  TYMP; thymidine phosphorylase [KO:K00758] [EC:2.4.2.4]
111555134  DPYD; dihydropyrimidine dehydrogenase [NADP(+)] isoform X1 [KO:K00207] [EC:1.3.1.2]
111550091  DPYS; dihydropyrimidinase [KO:K01464] [EC:3.5.2.2]
111530550  UPB1; beta-ureidopropionase [KO:K01431] [EC:3.5.1.6]
111554025  cytochrome P450 2A13 isoform X1 [KO:K17683] [EC:1.14.14.-]
111552272  UPP1; uridine phosphorylase 1 isoform X2 [KO:K00757] [EC:2.4.2.3]
111546184  UPP2; LOW QUALITY PROTEIN: uridine phosphorylase 2 [KO:K00757] [EC:2.4.2.3]
111520467  UCKL1; uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
111545825  UCK1; uridine-cytidine kinase 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
111539285  UCK2; uridine-cytidine kinase 2 [KO:K00876] [EC:2.7.1.48]
111542355  TK1; thymidine kinase, cytosolic isoform X2 [KO:K00857] [EC:2.7.1.21]
111541314  TK2; LOW QUALITY PROTEIN: thymidine kinase 2, mitochondrial [KO:K00857] [EC:2.7.1.21]
111544533  UMPS; uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
111548801  CMPK1; UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
111540914  RRM1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
111551597  RRM2B; LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
111531878  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
111524041  NME4; nucleoside diphosphate kinase, mitochondrial isoform X1 [KO:K00940] [EC:2.7.4.6]
111524090  NME3; nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
111555564  NME6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
111537587  NME2; nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
111537588  nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
111539313  NME7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
111552759  DUT; LOW QUALITY PROTEIN: deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial [KO:K01520] [EC:3.6.1.23]
111521661  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial [KO:K01520] [EC:3.6.1.23]
111537628  MPO; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
111545658  arylamine N-acetyltransferase 1 [KO:K00622] [EC:2.3.1.5]
111545783  NAT2; LOW QUALITY PROTEIN: arylamine N-acetyltransferase 2 [KO:K00622] [EC:2.3.1.5]
111522057  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
113224602  glutathione S-transferase A1-like [KO:K00799] [EC:2.5.1.18]
113224603  glutathione S-transferase A1-like [KO:K00799] [EC:2.5.1.18]
113224604  glutathione S-transferase A1-like [KO:K00799] [EC:2.5.1.18]
113224605  glutathione S-transferase A1-like [KO:K00799] [EC:2.5.1.18]
111551904  MGST2; microsomal glutathione S-transferase 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
111552074  MGST1; microsomal glutathione S-transferase 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
111548322  glutathione S-transferase Mu 5-like [KO:K00799] [EC:2.5.1.18]
113225053  glutathione S-transferase A5-like [KO:K00799] [EC:2.5.1.18]
111549804  glutathione S-transferase A3 isoform X1 [KO:K00799] [EC:2.5.1.18]
111535138  glutathione S-transferase A1 [KO:K00799] [EC:2.5.1.18]
111556007  glutathione S-transferase Mu 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
111522012  GSTT2B; glutathione S-transferase theta-2B [KO:K00799] [EC:2.5.1.18]
111522013  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
111536478  glutathione S-transferase omega-1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
116418391  glutathione S-transferase Mu 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
111556009  glutathione S-transferase Mu 3 isoform X1 [KO:K00799] [EC:2.5.1.18]
111538879  GSTO1; LOW QUALITY PROTEIN: glutathione S-transferase omega-1 [KO:K00799] [EC:2.5.1.18]
111538880  GSTO2; glutathione S-transferase omega-2 isoform X1 [KO:K00799] [EC:2.5.1.18]
111539279  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
111534279  glutathione S-transferase Mu 5 [KO:K00799] [EC:2.5.1.18]
111549770  GSTA4; glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
111549802  LOW QUALITY PROTEIN: glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
111549909  glutathione S-transferase Mu 3-like [KO:K00799] [EC:2.5.1.18]
111522006  glutathione S-transferase theta-4-like [KO:K00799] [EC:2.5.1.18]
113219771  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
111522339  GSTP1; glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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