KEGG   PATHWAY: puc00983
Entry
puc00983                    Pathway                                
Name
Drug metabolism - other enzymes - Panthera uncia (snow leopard)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
puc00983  Drug metabolism - other enzymes
puc00983

Organism
Panthera uncia (snow leopard) [GN:puc]
Gene
125932306  hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
125921336  hypoxanthine-guanine phosphoribosyltransferase-like [KO:K00760] [EC:2.4.2.8]
125929326  inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
125930890  inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
125921223  GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
125939531  thiopurine S-methyltransferase isoform X1 [KO:K00569] [EC:2.1.1.67]
125917080  xanthine dehydrogenase/oxidase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
125936146  inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
125916116  liver carboxylesterase 1 isoform X1 [KO:K01044] [EC:3.1.1.1]
125916357  LOW QUALITY PROTEIN: cocaine esterase [KO:K03927] [EC:3.1.1.1 3.1.1.84 3.1.1.56]
125922780  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
125922781  UDP-glucuronosyltransferase 2A2 isoform X1 [KO:K00699] [EC:2.4.1.17]
125911043  UDP-glucuronosyltransferase 1A1 [KO:K00699] [EC:2.4.1.17]
125911044  UDP-glucuronosyltransferase 1A3-like [KO:K00699] [EC:2.4.1.17]
125928153  beta-glucuronidase isoform X1 [KO:K01195] [EC:3.2.1.31]
125913015  cytidine deaminase isoform X1 [KO:K01489] [EC:3.5.4.5]
125913348  dihydropyrimidine dehydrogenase [NADP(+)] isoform X1 [KO:K00207] [EC:1.3.1.2]
125924481  dihydropyrimidinase [KO:K01464] [EC:3.5.2.2]
125914018  beta-ureidopropionase isoform X1 [KO:K01431] [EC:3.5.1.6]
125929762  uridine phosphorylase 1 isoform X1 [KO:K00757] [EC:2.4.2.3]
125922790  uridine-cytidine kinase 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
125925941  uridine-cytidine kinase 2 [KO:K00876] [EC:2.7.1.48]
125936388  uridine-cytidine kinase-like 1 isoform X1 [KO:K00876] [EC:2.7.1.48]
125916392  thymidine kinase 2, mitochondrial isoform X1 [KO:K00857] [EC:2.7.1.21]
125926306  thymidine kinase, cytosolic [KO:K00857] [EC:2.7.1.21]
125921794  uridine 5'-monophosphate synthase [KO:K13421] [EC:2.4.2.10 4.1.1.23]
125912643  UMP-CMP kinase [KO:K13800] [EC:2.7.4.14]
125937019  ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
125937690  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
125924777  ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
125930677  nucleoside diphosphate kinase 6 isoform X1 [KO:K00940] [EC:2.7.4.6]
125925119  nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
125926717  nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
125926718  nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
125927156  nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
125928392  nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
125932193  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like [KO:K01520] [EC:3.6.1.23]
125909980  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform X1 [KO:K01520] [EC:3.6.1.23]
125919950  deoxyuridine 5'-triphosphate nucleotidohydrolase-like [KO:K01520] [EC:3.6.1.23]
125927445  myeloperoxidase [KO:K10789] [EC:1.11.2.2]
125923850  arylamine N-acetyltransferase 1 [KO:K00622] [EC:2.3.1.5]
125933090  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
125914029  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
125914031  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
125914033  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
125914034  glutathione S-transferase theta-4-like [KO:K00799] [EC:2.5.1.18]
125914630  LOW QUALITY PROTEIN: glutathione S-transferase theta-2B-like [KO:K00799] [EC:2.5.1.18]
125938214  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
125938572  LOW QUALITY PROTEIN: glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
125938573  glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
125938574  glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
125938576  glutathione S-transferase alpha M14-like [KO:K00799] [EC:2.5.1.18]
125923708  microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
125932940  glutathione S-transferase omega-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
125932941  glutathione S-transferase omega-2 isoform X1 [KO:K00799] [EC:2.5.1.18]
125925943  microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
125918878  microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
125912286  glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
125912288  glutathione S-transferase Mu 4-like [KO:K00799] [EC:2.5.1.18]
125930454  glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
Compound
C00003  NAD+
C00006  NADP+
C02320  R-S-Glutathione
C02380  6-Mercaptopurine
C04242  5-Fluorodeoxyuridine monophosphate
C04646  6-Thioinosine-5'-monophosphate
C05361  Hydrazine
C06108  Fluoroacetate
C06837  Azathioprine
C07054  Isoniazid
C07446  Isonicotinic acid
C07447  Acetylhydrazine
C07585  N-Acetylisoniazid
C07648  Thioguanine
C07649  5-FU
C11173  SN-38
C11376  SN38 glucuronide
C11736  5-Fluorodeoxyuridine
C12650  Capecitabine
C12673  Tegafur
C12739  5'-Deoxy-5-fluorouridine
C13252  Carmofur
C16542  APC
C16543  NPC
C16613  6-Thiourate
C16614  6-Methylmercaptopurine
C16615  6-Methylthiopurine 5'-monophosphate ribonucleotide
C16616  6-Mercaptopurine ribonucleoside 5'-diphosphate
C16617  6-Mercaptopurine ribonucleoside triphosphate
C16618  6-Thioxanthine 5'-monophosphate
C16619  6-Thioguanosine monophosphate
C16620  6-Methylthioguanosine monophosphate
C16621  1-Methyl-4-nitroimidazole
C16622  N,N'-Diacetylhydrazine
C16623  Isonicotinylglycine
C16624  Isoniazid pyruvate
C16625  Isoniazid alpha-ketoglutaric acid
C16630  5,6-Dihydro-5-fluorouracil
C16631  alpha-Fluoro-beta-ureidopropionic acid
C16632  alpha-Fluoro-beta-alanine
C16633  5-Fluorouridine
C16634  5-Fluorouridine monophosphate
C16635  5'-Deoxy-5-fluorocytidine
C16641  Irinotecan
C21748  5-Fluorouridine diphosphate
C21749  5-Fluorouridine triphosphate
C21750  5-Fluorodeoxyuridine diphosphate
C21751  5-Fluorodeoxyuridine triphosphate
C21754  Isonicotinoyl radical
C21758  Hepatotoxins
C21759  Isonicotinoyl-NAD adduct
C21760  Isonicotinoyl-NADP adduct
D00238  Azathioprine (JP18/USP/INN)
D00346  Isoniazid (JP18/USP/INN)
D00584  Fluorouracil (JP18/USP/INN)
D01223  Capecitabine (JAN/USP/INN)
D01244  Tegafur (JP18/USAN/INN)
D01309  Doxifluridine (JP18/INN)
D01784  Carmofur (JP18/INN)
D04197  Floxuridine (USP/INN)
D04931  Mercaptopurine (INN)
D08086  Irinotecan (INN)
D08603  Tioguanine (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Al Hadithy AF, de Boer NK, Derijks LJ, Escher JC, Mulder CJ, Brouwers JR.
  Title
Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations.
  Journal
Dig Liver Dis 37:282-97 (2005)
DOI:10.1016/j.dld.2004.09.029
Reference
  Authors
Gearry RB, Barclay ML.
  Title
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease.
  Journal
J Gastroenterol Hepatol 20:1149-57 (2005)
DOI:10.1111/j.1440-1746.2005.03832.x
Reference
  Authors
Gilissen LP, Derijks LJ, Verhoeven HM, Bierau J, Hooymans PM, Hommes DW, Engels LG.
  Title
Pancytopenia due to high 6-methylmercaptopurine levels in a 6-mercaptopurine treated patient with Crohn's disease.
  Journal
Dig Liver Dis 39:182-6 (2007)
DOI:10.1016/j.dld.2006.05.026
Reference
  Authors
Fischel JL, Formento P, Ciccolini J, Etienne-Grimaldi MC, Milano G.
  Title
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
  Journal
Anticancer Drugs 15:969-74 (2004)
DOI:10.1097/00001813-200411000-00006
Reference
  Authors
Shimma N, Umeda I, Arasaki M, Murasaki C, Masubuchi K, Kohchi Y, Miwa M, Ura M, Sawada N, Tahara H, Kuruma I, Horii I, Ishitsuka H.
  Title
The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine.
  Journal
Bioorg Med Chem 8:1697-706 (2000)
DOI:10.1016/S0968-0896(00)00087-0
Reference
  Authors
Chung YL, Troy H, Judson IR, Leek R, Leach MO, Stubbs M, Harris AL, Griffiths JR
  Title
Noninvasive measurements of capecitabine metabolism in bladder tumors overexpressing thymidine phosphorylase by fluorine-19 magnetic resonance spectroscopy.
  Journal
Clin Cancer Res 10:3863-70 (2004)
DOI:10.1158/1078-0432.CCR-03-0237
Reference
  Authors
Mathijssen RH, van Alphen RJ, Verweij J, Loos WJ, Nooter K, Stoter G, Sparreboom A
  Title
Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
  Journal
Clin Cancer Res 7:2182-94 (2001)
Reference
  Authors
Kita T, Tanigawara Y, Chikazawa S, Hatanaka H, Sakaeda T, Komada F, Iwakawa S, Okumura K.
  Title
N-Acetyltransferase2 genotype correlated with isoniazid acetylation in Japanese tuberculous patients.
  Journal
Biol Pharm Bull 24:544-9 (2001)
DOI:10.1248/bpb.24.544
Reference
  Authors
Miura K, Kinouchi M, Ishida K, Fujibuchi W, Naitoh T, Ogawa H, Ando T, Yazaki N, Watanabe K, Haneda S, Shibata C, Sasaki I
  Title
5-fu metabolism in cancer and orally-administrable 5-fu drugs.
  Journal
Cancers (Basel) 2:1717-30 (2010)
DOI:10.3390/cancers2031717
Reference
  Authors
Wang P, Pradhan K, Zhong XB, Ma X
  Title
Isoniazid metabolism and hepatotoxicity.
  Journal
Acta Pharm Sin B 6:384-392 (2016)
DOI:10.1016/j.apsb.2016.07.014
Reference
  Authors
Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE
  Title
PharmGKB summary: isoniazid pathway, pharmacokinetics.
  Journal
Pharmacogenet Genomics 26:436-44 (2016)
DOI:10.1097/FPC.0000000000000232
Reference
  Authors
Yamada S, Richardson K, Tang M, Halaschek-Wiener J, Cook VJ, Fitzgerald JM, Elwood K, Marra F, Brooks-Wilson A
  Title
Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity.
  Journal
Pharmacogenomics J 10:524-36 (2010)
DOI:10.1038/tpj.2010.5
Reference
  Authors
Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmuller PG, Obinger C
  Title
Mechanisms of catalase activity of heme peroxidases.
  Journal
Arch Biochem Biophys 500:74-81 (2010)
DOI:10.1016/j.abb.2010.04.018
Reference
  Authors
Khan SR, Morgan AG, Michail K, Srivastava N, Whittal RM, Aljuhani N, Siraki AG
  Title
Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.
  Journal
Biochem Pharmacol 106:46-55 (2016)
DOI:10.1016/j.bcp.2016.02.003
Reference
  Authors
Forbes LV, Furtmuller PG, Khalilova I, Turner R, Obinger C, Kettle AJ
  Title
Isoniazid as a substrate and inhibitor of myeloperoxidase: identification of amine adducts and the influence of superoxide dismutase on their formation.
  Journal
Biochem Pharmacol 84:949-60 (2012)
DOI:10.1016/j.bcp.2012.07.020
Reference
  Authors
Nguyen M, Quemard A, Broussy S, Bernadou J, Meunier B
  Title
Mn(III) pyrophosphate as an efficient tool for studying the mode of action of isoniazid on the InhA protein of Mycobacterium tuberculosis.
  Journal
Antimicrob Agents Chemother 46:2137-44 (2002)
DOI:10.1128/AAC.46.7.2137-2144.2002
Reference
PMID:9417034
  Authors
Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC
  Title
Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.
  Journal
Science 279:98-102 (1998)
DOI:10.1126/science.279.5347.98
Reference
  Authors
Argyrou A, Vetting MW, Blanchard JS
  Title
New insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP.
  Journal
J Am Chem Soc 129:9582-3 (2007)
DOI:10.1021/ja073160k
KO pathway
ko00983   
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