KEGG   PATHWAY: ray03040
Entry
ray03040                    Pathway                                
Name
Spliceosome - Rousettus aegyptiacus (Egyptian rousette)
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
ray03040  Spliceosome
ray03040

Other DBs
GO: 0005681
Organism
Rousettus aegyptiacus (Egyptian rousette) [GN:ray]
Gene
107506808  DDX46; probable ATP-dependent RNA helicase DDX46 isoform X1 [KO:K12811] [EC:5.6.2.7]
107498472  DDX39B; spliceosome RNA helicase DDX39B isoform X1 [KO:K12812] [EC:5.6.2.7]
107498061  DHX16; putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [KO:K12813] [EC:5.6.2.6]
107511913  DHX38; pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 isoform X1 [KO:K12815] [EC:5.6.2.6]
107519366  CDC40; pre-mRNA-processing factor 17 [KO:K12816]
107504840  PRPF18; pre-mRNA-splicing factor 18 isoform X1 [KO:K12817]
107508116  DHX8; ATP-dependent RNA helicase DHX8 [KO:K12818] [EC:5.6.2.6]
107521931  SLU7; pre-mRNA-splicing factor SLU7 [KO:K12819]
107515722  DHX15; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 [KO:K12820] [EC:5.6.2.6]
107511327  SNRPB; small nuclear ribonucleoprotein-associated proteins B and B' isoform X1 [KO:K11086]
107519691  SNRPD1; small nuclear ribonucleoprotein Sm D1 [KO:K11087]
107516032  SNRPD2; small nuclear ribonucleoprotein Sm D2 [KO:K11096]
107500684  SNRPD3; small nuclear ribonucleoprotein Sm D3 [KO:K11088]
107508177  SNRPE; small nuclear ribonucleoprotein E [KO:K11097]
107498247  small nuclear ribonucleoprotein E-like [KO:K11097]
107518056  SNRPF; small nuclear ribonucleoprotein F [KO:K11098]
107519110  SNRPG; small nuclear ribonucleoprotein G [KO:K11099]
107498843  SNRNP70; U1 small nuclear ribonucleoprotein 70 kDa isoform X1 [KO:K11093]
107521788  SNRPA; U1 small nuclear ribonucleoprotein A [KO:K11091]
107511953  SNRPC; U1 small nuclear ribonucleoprotein C [KO:K11095]
107514253  PRPF40B; pre-mRNA-processing factor 40 homolog B [KO:K12821]
107513912  PRPF40A; pre-mRNA-processing factor 40 homolog A isoform X1 [KO:K12821]
107505013  RBM25; RNA-binding protein 25 isoform X1 [KO:K12822]
107502115  DDX5; probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
107500878  TCERG1; transcription elongation regulator 1 isoform X1 [KO:K12824]
107503992  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
107515781  SNRPA1; U2 small nuclear ribonucleoprotein A' [KO:K11092]
107498660  SNRPB2; U2 small nuclear ribonucleoprotein B'' [KO:K11094]
107505439  SF3A1; splicing factor 3A subunit 1 [KO:K12825]
107520135  SF3A2; LOW QUALITY PROTEIN: splicing factor 3A subunit 2 [KO:K12826]
107517060  SF3A3; splicing factor 3A subunit 3 [KO:K12827]
107503139  SF3B1; splicing factor 3B subunit 1 isoform X1 [KO:K12828]
107497528  SF3B2; splicing factor 3B subunit 2 isoform X1 [KO:K12829]
107520537  SF3B3; splicing factor 3B subunit 3 [KO:K12830]
107499054  SF3B4; splicing factor 3B subunit 4 [KO:K12831]
107497590  SF3B5; splicing factor 3B subunit 5 [KO:K12832]
107498537  SF3B6; splicing factor 3B subunit 6 [KO:K12833]
107505589  PHF5A; PHD finger-like domain-containing protein 5A [KO:K12834]
107501927  DDX42; ATP-dependent RNA helicase DDX42 isoform X1 [KO:K12835] [EC:5.6.2.7]
107510191  U2AF1; splicing factor U2AF 35 kDa subunit isoform X1 [KO:K12836]
107497628  U2AF1L4; LOW QUALITY PROTEIN: splicing factor U2AF 26 kDa subunit [KO:K12836]
107515411  U2AF2; splicing factor U2AF 65 kDa subunit isoform X1 [KO:K12837]
107507898  PUF60; poly(U)-binding-splicing factor PUF60 isoform X1 [KO:K12838]
107511383  SMNDC1; survival of motor neuron-related-splicing factor 30 isoform X1 [KO:K12839]
107505981  RBM17; splicing factor 45 isoform X1 [KO:K12840]
107517251  CHERP; calcium homeostasis endoplasmic reticulum protein isoform X1 [KO:K12841]
107500838  U2SURP; U2 snRNP-associated SURP motif-containing protein isoform X1 [KO:K12842]
107518456  RP9; retinitis pigmentosa 9 protein [KO:K19604]
107518490  LOW QUALITY PROTEIN: retinitis pigmentosa 9 protein-like [KO:K19604]
107498478  LSM2; U6 snRNA-associated Sm-like protein LSm2 [KO:K12621]
107509406  LSM3; U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
107503753  LSM4; U6 snRNA-associated Sm-like protein LSm4 isoform X1 [KO:K12623]
107518524  LSM5; U6 snRNA-associated Sm-like protein LSm5 [KO:K12624]
107520352  LSM6; U6 snRNA-associated Sm-like protein LSm6 [KO:K12625]
107520086  LSM7; U6 snRNA-associated Sm-like protein LSm7 [KO:K12626]
107519977  LSM8; LSM8 homolog, U6 small nuclear RNA associated [KO:K12627]
107499045  PRPF3; U4/U6 small nuclear ribonucleoprotein Prp3 isoform X1 [KO:K12843]
107500745  PRPF4; U4/U6 small nuclear ribonucleoprotein Prp4 isoform X1 [KO:K12662]
107508296  PPIH; peptidyl-prolyl cis-trans isomerase H isoform X1 [KO:K09567] [EC:5.2.1.8]
107503043  PRPF31; U4/U6 small nuclear ribonucleoprotein Prp31 [KO:K12844]
107505582  SNU13; NHP2-like protein 1 [KO:K12845]
107507484  NHP2-like protein 1 [KO:K12845]
107519104  SNRNP27; U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846]
107506125  USP39; U4/U6.U5 tri-snRNP-associated protein 2 [KO:K12847]
107497530  SART1; LOW QUALITY PROTEIN: U4/U6.U5 tri-snRNP-associated protein 1 [KO:K11984]
107521555  ZMAT2; zinc finger matrin-type protein 2 [KO:K12848]
107497918  PRPF38A; pre-mRNA-splicing factor 38A [KO:K12849]
107518297  PRPF38B; pre-mRNA-splicing factor 38B isoform X1 [KO:K12850]
107508152  EFTUD2; 116 kDa U5 small nuclear ribonucleoprotein component [KO:K12852]
107509952  SNRNP200; U5 small nuclear ribonucleoprotein 200 kDa helicase [KO:K12854] [EC:5.6.2.6]
107511845  PRPF6; pre-mRNA-processing factor 6 [KO:K12855]
107507719  PRPF8; pre-mRNA-processing-splicing factor 8 [KO:K12856]
107503566  SNRNP40; U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857]
107514226  DDX23; probable ATP-dependent RNA helicase DDX23 isoform X1 [KO:K12858] [EC:5.6.2.7]
107500857  TXNL4A; thioredoxin-like protein 4A [KO:K12859]
107497348  PRPF19; pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
107502006  CDC5L; cell division cycle 5-like protein [KO:K12860]
107498672  cell division cycle 5-like protein [KO:K12860]
107499852  BCAS2; pre-mRNA-splicing factor SPF27 [KO:K12861]
107507541  PLRG1; pleiotropic regulator 1 isoform X1 [KO:K12862]
107517705  CWC15; spliceosome-associated protein CWC15 homolog [KO:K12863]
107512595  CTNNBL1; beta-catenin-like protein 1 isoform X1 [KO:K12864]
107503644  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
107498470  LOW QUALITY PROTEIN: heat shock 70 kDa protein 1-like [KO:K03283]
107498471  heat shock 70 kDa protein 1-like isoform X1 [KO:K03283]
107498469  HSPA1A; heat shock 70 kDa protein 1A [KO:K03283]
107515018  PQBP1; polyglutamine-binding protein 1 isoform X1 [KO:K12865]
107508613  WBP11; WW domain-binding protein 11 [KO:K12866]
107516674  SNW1; SNW domain-containing protein 1 [KO:K06063]
107519922  XAB2; pre-mRNA-splicing factor SYF1 [KO:K12867]
107502534  SYF2; pre-mRNA-splicing factor SYF2 [KO:K12868]
107511626  CRNKL1; crooked neck-like protein 1 isoform X1 [KO:K12869]
107504879  ISY1; pre-mRNA-splicing factor ISY1 homolog isoform X1 [KO:K12870]
107514685  PPIL1; peptidyl-prolyl cis-trans isomerase-like 1 isoform X1 [KO:K12733] [EC:5.2.1.8]
107508331  PPIE; peptidyl-prolyl cis-trans isomerase E isoform X1 [KO:K09564] [EC:5.2.1.8]
107509110  CCDC12; coiled-coil domain-containing protein 12 [KO:K12871]
107497152  RBM22; pre-mRNA-splicing factor RBM22 [KO:K12872]
107517859  BUD31; protein BUD31 homolog [KO:K12873]
107508079  AQR; intron-binding protein aquarius isoform X1 [KO:K12874]
107497999  ACIN1; LOW QUALITY PROTEIN: apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
107510084  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
107509974  RBM8A; RNA-binding protein 8A isoform X1 [KO:K12876]
107516571  protein mago nashi homolog 2 isoform X1 [KO:K12877]
107497965  MAGOH; protein mago nashi homolog [KO:K12877]
107520582  THOC1; THO complex subunit 1 isoform X1 [KO:K12878]
107497748  THOC2; THO complex subunit 2 isoform X1 [KO:K12879]
107515940  THOC3; THO complex subunit 3 [KO:K12880]
107520286  ALYREF; THO complex subunit 4 [KO:K12881]
107511680  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
107505278  NCBP2; nuclear cap-binding protein subunit 2 [KO:K12883]
107521075  HNRNPA1; heterogeneous nuclear ribonucleoprotein A1 isoform X1 [KO:K12741]
107508350  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
107514670  HNRNPA3; heterogeneous nuclear ribonucleoprotein A3 isoform X1 [KO:K12741]
107514871  heterogeneous nuclear ribonucleoprotein A1-like 2 [KO:K12741]
107500742  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A3-like [KO:K12741]
107521146  HNRNPC; heterogeneous nuclear ribonucleoproteins C1/C2 isoform X1 [KO:K12884]
107497096  RBMX; RNA-binding motif protein, X chromosome [KO:K12885]
107502817  HNRNPK; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886]
107519903  HNRNPM; heterogeneous nuclear ribonucleoprotein M isoform X1 [KO:K12887]
107513988  HNRNPU; heterogeneous nuclear ribonucleoprotein U isoform X1 [KO:K12888]
107519096  PCBP1; poly(rC)-binding protein 1 [KO:K12889]
107497739  LOW QUALITY PROTEIN: poly(rC)-binding protein 1-like [KO:K12889]
107503030  SRSF1; serine/arginine-rich splicing factor 1 [KO:K12890]
107510046  SRSF2; serine/arginine-rich splicing factor 2 [KO:K12891]
107514680  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
107514585  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
107503268  SRSF5; serine/arginine-rich splicing factor 5 [KO:K12893]
107503529  SRSF4; serine/arginine-rich splicing factor 4 [KO:K12893]
107519534  SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
107501249  SRSF9; serine/arginine-rich splicing factor 9 [KO:K21123]
107518150  TRA2A; transformer-2 protein homolog alpha isoform X1 [KO:K12897]
107518250  TRA2B; transformer-2 protein homolog beta isoform X1 [KO:K12897]
107501025  SRSF10; serine/arginine-rich splicing factor 10 isoform X1 [KO:K12900]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

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