PATHWAY: rn00300 Help
Entry
Name
Lysine biosynthesis
Class
Metabolism; Amino acid metabolism
Pathway map
Ortholog table
Module
M00016 Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine [PATH:rn00300 ]
M00030 Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine [PATH:rn00300 ]
M00031 Lysine biosynthesis, mediated by LysW, 2-aminoadipate => lysine [PATH:rn00300 ]
M00433 Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate [PATH:rn00300 ]
M00525 Lysine biosynthesis, acetyl-DAP pathway, aspartate => lysine [PATH:rn00300 ]
M00526 Lysine biosynthesis, DAP dehydrogenase pathway, aspartate => lysine [PATH:rn00300 ]
M00527 Lysine biosynthesis, DAP aminotransferase pathway, aspartate => lysine [PATH:rn00300 ]
M00608 2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate [PATH:rn00300 ]
Other DBs
Reaction
R00271 acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming)
R00451 meso-2,6-diaminoheptanedioate carboxy-lyase (L-lysine-forming)
R00480 ATP:L-aspartate 4-phosphotransferase
R00715 N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)
R01773 L-homoserine:NAD+ oxidoreductase
R01775 L-homoserine:NADP+ oxidoreductase
R01934 (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating)
R01939 L-2-aminoadipate:2-oxoglutarate aminotransferase
R02291 L-aspartate-4-semialdehyde:NADP+ oxidoreductase (phosphorylating)
R02315 N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase
R02733 N6-acetyl-LL-2,6-diaminoheptanedioate amidohydrolase
R02734 N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase
R02735 LL-2,6-diaminoheptanedioate 2-epimerase
R02755 meso-2,6-diaminoheptanedioate:NADP+ oxidoreductase (deaminating)
R02788 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:(L)-meso-2,6-diaminoheptanedioate gamma-ligase (ADP-forming)
R03098 L-2-aminoadipate-6-semialdehyde:NADP+ 6-oxidoreductase
R03444 (R)-2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase
R04198 2,3,4,5-tetrahydrodipicolinate:NAD+ 4-oxidoreductase
R04199 2,3,4,5-tetrahydrodipicolinate:NADP+ 4-oxidoreductase
R04364 acetyl-CoA:L-2,3,4,5-tetrahydrodipicolinate N2-acetyltransferase
R04365 succinyl-CoA:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase
R04371 homoisocitrate hydro-lyase
R04390 L-2-aminoadipate-6-semialdehyde:NADP+ 6-oxidoreductase
R04475 N-succinyl-L-2,6-diaminoheptanedioate:2-oxoglutarate amino-transferase
R04617 UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate:D-alanyl-D-alanine ligase (ADP-forming)
R04863 L-2-aminoadipate-6-semialdehyde:NADP+ 6-oxidoreductase
R07613 LL-2,6-diaminoheptanedioate:2-oxoglutarate aminotransferase
R09775 LysW:L-2-aminoadipate ligase (ADP-forming)
R09776 ATP:LysW-gamma-L-alpha-aminoadipate 6-phosphotransferase
R09777 LysW-gamma-L-alpha-aminoadipate 6-semialdehyde:NADP+ 6-oxidoreductase (phosphorylating)
R09778 LysW-gamma-L-lysine:2-oxoglutarate 6-aminotransferase
R09779 LysW-gamma-L-lysine amidohydrolase
R10010 L-lysine carboxy-aminomethylmutase
R10147 L-aspartate-4-semialdehyde hydro-lyase [adding pyruvate and cyclizing; (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate-forming]
Compound
C00441 L-Aspartate 4-semialdehyde
C00449 N6-(L-1,3-Dicarboxypropyl)-L-lysine
C00666 LL-2,6-Diaminoheptanedioate
C00680 meso-2,6-Diaminoheptanedioate
C01251 (R)-2-Hydroxybutane-1,2,4-tricarboxylate
C03871 L-2-Amino-6-oxoheptanedioate
C03972 2,3,4,5-Tetrahydrodipicolinate
C04002 (Z)-But-1-ene-1,2,4-tricarboxylate
C04076 L-2-Aminoadipate 6-semialdehyde
C04390 N6-Acetyl-LL-2,6-diaminoheptanedioate
C04421 N-Succinyl-LL-2,6-diaminoheptanedioate
C04462 N-Succinyl-2-L-amino-6-oxoheptanedioate
C04877 UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimelate
C04882 UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine
C05535 alpha-Aminoadipoyl-S-acyl enzyme
C05539 N-Acetyl-L-2-amino-6-oxopimelate
C05560 L-2-Aminoadipate adenylate
C19886 LysW-gamma-L-alpha-aminoadipate
C19887 LysW-gamma-L-alpha-aminoadipyl 6-phosphate
C19888 LysW-gamma-L-alpha-aminoadipate 6-semialdehyde
C20258 (2S,4S)-4-Hydroxy-2,3,4,5-tetrahydrodipicolinate
C20277 (2R,3R)-3-Methylornithine
C20278 (2R,3R)-3-Methylornithinyl-N6-lysine
C20279 (2R,3R)-3-Methylglutamyl-5-semialdehyde-N6-lysine
Reference
Authors
Ledwidge R, Blanchard JS.
Title
The dual biosynthetic capability of N-acetylornithine aminotransferase in arginine and lysine biosynthesis.
Journal
Reference
Authors
Fuchs TM, Schneider B, Krumbach K, Eggeling L, Gross R.
Title
Characterization of a bordetella pertussis diaminopimelate (DAP) biosynthesis locus identifies dapC, a novel gene coding for an N-succinyl-L,L-DAP aminotransferase.
Journal
Reference
Authors
Zabriskie TM, Jackson MD.
Title
Lysine biosynthesis and metabolism in fungi.
Journal
Reference
Authors
Rodionov DA, Vitreschak AG, Mironov AA, Gelfand MS.
Title
Regulation of lysine biosynthesis and transport genes in bacteria: yet another RNA riboswitch?
Journal
Reference
Authors
Velasco AM, Leguina JI, Lazcano A.
Title
Molecular evolution of the lysine biosynthetic pathways.
Journal
Reference
Authors
Miyazaki T, Miyazaki J, Yamane H, Nishiyama M.
Title
alpha-Aminoadipate aminotransferase from an extremely thermophilic bacterium, Thermus thermophilus.
Journal
Reference
Authors
Goh DL, Patel A, Thomas GH, Salomons GS, Schor DS, Jakobs C, Geraghty MT.
Title
Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT).
Journal
Reference
Authors
Nishiyama M.
Title
[Novel lysine biosynthesis: a key to elucidate evolution of metabolic and biosynthetic pathways]
Journal
Tanpakushitsu Kakusan Koso 49:758-63 (2004)
Reference
Authors
Nishida H, Nishiyama M, Kobashi N, Kosuge T, Hoshino T, Yamane H.
Title
A prokaryotic gene cluster involved in synthesis of lysine through the amino adipate pathway: a key to the evolution of amino acid biosynthesis.
Journal
Reference
Authors
Sakai H, Vassylyeva MN, Matsuura T, Sekine S, Gotoh K, Nishiyama M, Terada T, Shirouzu M, Kuramitsu S, Vassylyev DG, Yokoyama S.
Title
Crystal structure of a lysine biosynthesis enzyme, LysX, from Thermus thermophilus HB8.
Journal
Reference
Authors
Hudson AO, Singh BK, Leustek T, Gilvarg C.
Title
An LL-diaminopimelate aminotransferase defines a novel variant of the lysine biosynthesis pathway in plants.
Journal
Reference
Authors
Horie A, Tomita T, Saiki A, Kono H, Taka H, Mineki R, Fujimura T, Nishiyama C, Kuzuyama T, Nishiyama M
Title
Discovery of proteinaceous N-modification in lysine biosynthesis of Thermus thermophilus.
Journal
Reference
Authors
Dairi T, Kuzuyama T, Nishiyama M, Fujii I
Title
Convergent strategies in biosynthesis.
Journal
Reference
Authors
Gaston MA, Jiang R, Krzycki JA
Title
Functional context, biosynthesis, and genetic encoding of pyrrolysine.
Journal
Related pathway
rn00010 Glycolysis / Gluconeogenesis
rn00250 Alanine, aspartate and glutamate metabolism
rn00260 Glycine, serine and threonine metabolism
rn00960 Tropane, piperidine and pyridine alkaloid biosynthesis
KO pathway
LinkDB
All DBs