KEGG   PATHWAY: rok00630
Entry
rok00630                    Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Roseovarius sp. AK1035
Class
Metabolism; Carbohydrate metabolism
Pathway map
rok00630  Glyoxylate and dicarboxylate metabolism
rok00630

Module
rok_M00373  Ethylmalonyl pathway [PATH:rok00630]
rok_M00621  Glycine cleavage system [PATH:rok00630]
rok_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:rok00630]
Other DBs
GO: 0046487 0043648
Organism
Roseovarius sp. AK1035 [GN:rok]
Gene
RAK1035_0532  Acetyl-coenzyme A synthetase [KO:K01895] [EC:6.2.1.1]
RAK1035_3098  Acetyl-coenzyme A synthetase [KO:K01895] [EC:6.2.1.1]
RAK1035_3849  Malate synthase G [KO:K01638] [EC:2.3.3.9]
RAK1035_0673  Malate dehydrogenase [KO:K00024] [EC:1.1.1.37]
RAK1035_3376  Citrate synthase (si) [KO:K01647] [EC:2.3.3.1]
RAK1035_3660  Aconitate hydratase [KO:K01681] [EC:4.2.1.3]
RAK1035_2338  Succinyl-CoA ligase, ADP-forming alpha chain [KO:K08692] [EC:6.2.1.9]
RAK1035_2339  Succinyl-CoA ligase, ADP-forming beta chain [KO:K14067] [EC:6.2.1.9]
RAK1035_3888  Succinyl-CoA ligase, ADP-forming beta chain [KO:K14067] [EC:6.2.1.9]
RAK1035_1986  3-ketoacyl-CoA thiolase [KO:K00626] [EC:2.3.1.9]
RAK1035_1340  Acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
RAK1035_0792  3-ketoacyl-CoA thiolase [KO:K00626] [EC:2.3.1.9]
RAK1035_0815  Acetyl-CoA acetyltransferase of ethylmalonyl-CoA pathway [KO:K00626] [EC:2.3.1.9]
RAK1035_0816  Acetoacetyl-CoA reductase of ethylmalonyl-CoA pathway [KO:K00023] [EC:1.1.1.36]
RAK1035_3265  Acyl dehydratase [KO:K17865] [EC:4.2.1.55]
RAK1035_1354  Crotonyl-CoA carboxylase/reductase, ethylmalonyl-CoA producing [KO:K14446] [EC:1.3.1.85]
RAK1035_0473  Methylmalonyl-CoA epimerase [KO:K05606] [EC:5.1.99.1]
RAK1035_1351  Ethylmalonyl-CoA mutase, methylsuccinyl-CoA-forming [KO:K14447] [EC:5.4.99.63]
RAK1035_0274  Methylsuccinyl-CoA dehydrogenase [KO:K14448] [EC:1.3.8.12]
RAK1035_0680  Mesaconyl-CoA hydratase [KO:K14449] [EC:4.2.1.148]
RAK1035_1037  Malyl-CoA lyase [KO:K08691] [EC:4.1.3.24 4.1.3.25]
RAK1035_2340  Malyl-CoA lyase [KO:K08691] [EC:4.1.3.24 4.1.3.25]
RAK1035_0677  L-malyl-CoA/beta-methylmalyl-CoA lyase [KO:K14451] [EC:3.1.2.30]
RAK1035_3912  Propionyl-CoA carboxylase biotin-containing subunit [KO:K01965] [EC:6.4.1.3]
RAK1035_3919  Propionyl-CoA carboxylase carboxyl transferase subunit [KO:K01966] [EC:6.4.1.3 2.1.3.15]
RAK1035_3908  Methylmalonyl-CoA mutase [KO:K01847] [EC:5.4.99.2]
RAK1035_1396  Glycolate dehydrogenase, subunit GlcD [KO:K00104] [EC:1.1.99.14]
RAK1035_1397  Glycolate dehydrogenase, FAD-binding subunit GlcE [KO:K11472] [EC:1.1.99.14]
RAK1035_1398  Glycolate dehydrogenase, iron-sulfur subunit GlcF [KO:K11473] [EC:1.1.99.14]
RAK1035_2177  Catalase [KO:K03781] [EC:1.11.1.6]
RAK1035_1528  Glyoxylate reductase [KO:K00015] [EC:1.1.1.26]
RAK1035_0425  D-3-phosphoglycerate dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
RAK1035_3656  Phosphoglycolate phosphatase [KO:K01091] [EC:3.1.3.18]
RAK1035_1752  hypothetical protein [KO:K01091] [EC:3.1.3.18]
RAK1035_2712  HAD-superfamily hydrolase, subfamily IA, variant 1 family protein [KO:K01091] [EC:3.1.3.18]
RAK1035_0659  Phosphoglycolate phosphatase [KO:K01091] [EC:3.1.3.18]
RAK1035_2561  Serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
RAK1035_1251  Serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
RAK1035_0940  Serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
RAK1035_2341  Serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
RAK1035_0947  Glutamine synthetase family protein [KO:K01915] [EC:6.3.1.2]
RAK1035_3437  Glutamine synthetase family protein [KO:K01915] [EC:6.3.1.2]
RAK1035_3439  Glutamine synthetase family protein [KO:K01915] [EC:6.3.1.2]
RAK1035_3454  Glutamine synthetase type I [KO:K01915] [EC:6.3.1.2]
RAK1035_1865  Glutamine synthetase family protein [KO:K01915] [EC:6.3.1.2]
RAK1035_2880  Glutamine synthetase type I [KO:K01915] [EC:6.3.1.2]
RAK1035_0118  Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
RAK1035_2660  Serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
RAK1035_2541  Glycine dehydrogenase, decarboxylating (glycine cleavage system P protein) [KO:K00281] [EC:1.4.4.2]
RAK1035_2525  Aminomethyltransferase (glycine cleavage system T protein) [KO:K00605] [EC:2.1.2.10]
RAK1035_2878  Sarcosine oxidase alpha subunit [KO:K00605] [EC:2.1.2.10]
RAK1035_2887  Sarcosine oxidase alpha subunit [KO:K00605] [EC:2.1.2.10]
RAK1035_2452  Aminomethyltransferase [KO:K00605] [EC:2.1.2.10]
RAK1035_3780  Dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
RAK1035_0666  Dihydrolipoamide dehydrogenase of 2-oxoglutarate dehydrogenase [KO:K00382] [EC:1.8.1.4]
RAK1035_2526  Glycine cleavage system H protein [KO:K02437]
RAK1035_0699  D-glycerate 2-kinase [KO:K11529] [EC:2.7.1.165]
RAK1035_1142  Fumarate hydratase class I, aerobic [KO:K03779] [EC:4.2.1.32]
RAK1035_1143  Fumarate hydratase class I, aerobic [KO:K03780] [EC:4.2.1.32]
RAK1035_1785  4-Hydroxy-2-oxoglutarate aldolase [KO:K01625] [EC:4.1.2.14 4.1.3.42]
RAK1035_2781  NAD-dependent formate dehydrogenase delta subunit [KO:K00126] [EC:1.17.1.9]
RAK1035_2779  NAD-dependent formate dehydrogenase alpha subunit [KO:K00123] [EC:1.17.1.9]
RAK1035_2035  Formate dehydrogenase-O, major subunit [KO:K00123] [EC:1.17.1.9]
RAK1035_3687  Tungsten-containing formate dehydrogenase alpha subunit [KO:K00123] [EC:1.17.1.9]
RAK1035_2497  Tungsten-containing formate dehydrogenase beta subunit [KO:K22515] [EC:1.17.1.9]
RAK1035_2778  NAD-dependent formate dehydrogenase beta subunit [KO:K00124]
RAK1035_2036  Formate dehydrogenase-O, iron-sulfur subunit [KO:K00124]
RAK1035_2777  NAD-dependent formate dehydrogenase gamma subunit [KO:K00127]
RAK1035_2037  Formate dehydrogenase -O, gamma subunit [KO:K00127]
RAK1035_1404  Putative esterase [KO:K01432] [EC:3.5.1.9]
RAK1035_0546  N-formylglutamate deformylase [KO:K01458] [EC:3.5.1.68]
RAK1035_3882  Oxalyl-CoA decarboxylase [KO:K01577] [EC:4.1.1.8]
RAK1035_3881  Formyl-coenzyme A transferase [KO:K07749] [EC:2.8.3.16]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
PMID:10978349
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
PMID:16407450
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
PMID:11513957
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
rok00010  Glycolysis / Gluconeogenesis
rok00020  Citrate cycle (TCA cycle)
rok00030  Pentose phosphate pathway
rok00053  Ascorbate and aldarate metabolism
rok00071  Fatty acid degradation
rok00230  Purine metabolism
rok00250  Alanine, aspartate and glutamate metabolism
rok00260  Glycine, serine and threonine metabolism
rok00620  Pyruvate metabolism
rok00710  Carbon fixation by Calvin cycle
rok00750  Vitamin B6 metabolism
rok00910  Nitrogen metabolism
KO pathway
ko00630   
LinkDB

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