KEGG   PATHWAY: rphi00600
Entry
rphi00600                   Pathway                                
Name
Sphingolipid metabolism - Ruditapes philippinarum (Manila clam)
Class
Metabolism; Lipid metabolism
Pathway map
rphi00600  Sphingolipid metabolism
rphi00600

Module
rphi_M00094  Ceramide biosynthesis [PATH:rphi00600]
rphi_M00099  Sphingosine biosynthesis [PATH:rphi00600]
rphi_M00100  Sphingosine degradation [PATH:rphi00600]
Other DBs
GO: 0006665
Organism
Ruditapes philippinarum (Manila clam) [GN:rphi]
Gene
132713294  [KO:K01202] [EC:3.2.1.46]
132714046  [KO:K12349] [EC:3.5.1.23]
132715192  [KO:K04711] [EC:3.5.1.-]
132715247  [KO:K01080] [EC:3.1.3.4]
132715248  [KO:K01080] [EC:3.1.3.4]
132717314  [KO:K12383]
132718310  [KO:K26283]
132718606  [KO:K01019] [EC:2.8.2.11]
132720661  [KO:K04716] [EC:3.1.3.-]
132721327  [KO:K12348] [EC:3.5.1.23]
132721328  [KO:K12348] [EC:3.5.1.23]
132721411  [KO:K12373] [EC:3.2.1.52]
132721412  [KO:K12373] [EC:3.2.1.52]
132722418  [KO:K00654] [EC:2.3.1.50]
132723157  [KO:K01019] [EC:2.8.2.11]
132724529  [KO:K12383]
132724650  [KO:K12383]
132724651  [KO:K12383]
132724698  [KO:K12350] [EC:3.1.4.12]
132724700  [KO:K12350] [EC:3.1.4.12]
132724704  [KO:K12350] [EC:3.1.4.12]
132725323  [KO:K04715] [EC:2.7.1.138]
132725698  [KO:K17108] [EC:3.2.1.45]
132726947  [KO:K01202] [EC:3.2.1.46]
132727663  [KO:K01201] [EC:3.2.1.45]
132727905  [KO:K01201] [EC:3.2.1.45]
132728528  [KO:K24621]
132728529  [KO:K24621]
132728532  [KO:K24621]
132728645  [KO:K01080] [EC:3.1.3.4]
132728892  [KO:K01202] [EC:3.2.1.46]
132729245  [KO:K26283]
132729855  [KO:K04715] [EC:2.7.1.138]
132729939  [KO:K01019] [EC:2.8.2.11]
132730266  [KO:K12309] [EC:3.2.1.23]
132731059  [KO:K00654] [EC:2.3.1.50]
132731244  [KO:K00654] [EC:2.3.1.50]
132731289  [KO:K04718] [EC:2.7.1.91]
132731919  [KO:K01189] [EC:3.2.1.22]
132732306  [KO:K12383]
132732408  [KO:K01202] [EC:3.2.1.46]
132732755  [KO:K01634] [EC:4.1.2.27]
132732908  [KO:K23727]
132732912  [KO:K01019] [EC:2.8.2.11]
132733360  [KO:K01080] [EC:3.1.3.4]
132733364  [KO:K01080] [EC:3.1.3.4]
132733709  [KO:K01634] [EC:4.1.2.27]
132734174  [KO:K01080] [EC:3.1.3.4]
132734296  [KO:K01080] [EC:3.1.3.4]
132734414  [KO:K12383]
132735295  [KO:K00654] [EC:2.3.1.50]
132737638  [KO:K04716] [EC:3.1.3.-]
132737970  [KO:K24621]
132738674  [KO:K01080] [EC:3.1.3.4]
132738675  [KO:K01080] [EC:3.1.3.4]
132739554  [KO:K04708] [EC:1.1.1.102]
132739590  [KO:K00720] [EC:2.4.1.80]
132739746  [KO:K12383]
132739761  [KO:K12383]
132740486  [KO:K23727]
132742072  [KO:K01019] [EC:2.8.2.11]
132743323  [KO:K01019] [EC:2.8.2.11]
132743926  [KO:K12353] [EC:3.1.4.12]
132744106  [KO:K01019] [EC:2.8.2.11]
132744109  [KO:K01019] [EC:2.8.2.11]
132744111  [KO:K01019] [EC:2.8.2.11]
132744112  [KO:K01019] [EC:2.8.2.11]
132744223  [KO:K04717] [EC:3.1.3.-]
132745953  [KO:K12383]
132746686  [KO:K12373] [EC:3.2.1.52]
132747613  [KO:K01019] [EC:2.8.2.11]
132747978  [KO:K01019] [EC:2.8.2.11]
132748472  [KO:K12383]
132749128  [KO:K23727]
132749210  [KO:K01080] [EC:3.1.3.4]
132749211  [KO:K01080] [EC:3.1.3.4]
132749253  [KO:K12383]
132750412  [KO:K12373] [EC:3.2.1.52]
132750928  [KO:K12352] [EC:3.1.4.12]
132751841  [KO:K23727]
132752154  [KO:K01019] [EC:2.8.2.11]
132752201  [KO:K01080] [EC:3.1.3.4]
132752481  [KO:K23727]
132752532  [KO:K24621]
132752558  [KO:K01080] [EC:3.1.3.4]
132752856  [KO:K01019] [EC:2.8.2.11]
132753612  [KO:K01201] [EC:3.2.1.45]
132754248  [KO:K12351] [EC:3.1.4.12]
132754451  [KO:K12383]
132754452  [KO:K12383]
132754454  [KO:K12383]
132754789  [KO:K00720] [EC:2.4.1.80]
132754880  [KO:K01080] [EC:3.1.3.4]
132754881  [KO:K01080] [EC:3.1.3.4]
132755336  [KO:K04712] [EC:1.14.19.17 1.14.18.5]
132756223  [KO:K01634] [EC:4.1.2.27]
132756735  [KO:K12383]
132756736  [KO:K12383]
132756737  [KO:K12383]
132756738  [KO:K12383]
132756849  [KO:K04708] [EC:1.1.1.102]
132756850  [KO:K04708] [EC:1.1.1.102]
132757655  [KO:K12383]
132757659  [KO:K12383]
132757840  [KO:K01019] [EC:2.8.2.11]
132757992  [KO:K22697] [EC:2.7.8.48 3.1.4.62]
132758356  [KO:K26283]
132758510  [KO:K01019] [EC:2.8.2.11]
132758960  [KO:K12383]
132758961  [KO:K12383]
132760259  [KO:K12383]
132760425  [KO:K01080] [EC:3.1.3.4]
Compound
C00065  L-Serine
C00154  Palmitoyl-CoA
C00195  N-Acylsphingosine
C00319  Sphingosine
C00346  Ethanolamine phosphate
C00550  Sphingomyelin
C00836  Sphinganine
C01120  Sphinganine 1-phosphate
C01190  Glucosylceramide
C01290  Lactosylceramide
C01747  Psychosine
C02686  Galactosylceramide
C02934  3-Dehydrosphinganine
C02960  Ceramide 1-phosphate
C03108  D-Glucosylsphingosine
C03272  Globoside
C03405  Lactosylceramide sulfate
C03640  Sphingosyl-phosphocholine
C04730  GM3
C04737  alpha-D-Galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
C04884  N-Acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C04911  D-Galactosyl-N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide
C05681  Ceramide 2-aminoethylphosphonate
C06062  Ceramide phosphoethanolamine
C06124  Sphingosine 1-phosphate
C06125  Sulfatide
C06126  Digalactosylceramide
C06127  Digalactosylceramide sulfate
C06128  GM4
C06135  GA2
C06136  GA1
C12126  Dihydroceramide
C12144  Phytosphingosine
C12145  Phytoceramide
C22467  Gangliotriaosylceramide-II3 sulfate
C23072  Oxidized ceramide
Reference
PMID:12011104
  Authors
Merrill AH Jr.
  Title
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway.
  Journal
J Biol Chem 277:25843-6 (2002)
DOI:10.1074/jbc.R200009200
Reference
PMID:10652340
  Authors
Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M.
  Title
Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized.
  Journal
J Biol Chem 275:3462-8 (2000)
DOI:10.1074/jbc.275.5.3462
Reference
PMID:11305904
  Authors
Hannun YA, Luberto C, Argraves KM.
  Title
Enzymes of sphingolipid metabolism: from modular to integrative signaling.
  Journal
Biochemistry 40:4893-903 (2001)
DOI:10.1021/bi002836k
Reference
PMID:1495423
  Authors
Merrill AH Jr, Wang E.
  Title
Enzymes of ceramide biosynthesis.
  Journal
Methods Enzymol 209:427-37 (1992)
DOI:10.1016/0076-6879(92)09053-6
Reference
PMID:8457204
  Authors
Hirschberg K, Rodger J, Futerman AH.
  Title
The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver.
  Journal
Biochem J 290 ( Pt 3):751-7 (1993)
DOI:10.1042/bj2900751
Reference
PMID:10366774
  Authors
Dickson RC, Lester RL.
  Title
Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae.
  Journal
Biochim Biophys Acta 1438:305-21 (1999)
DOI:10.1016/S1388-1981(99)00068-2
Related
pathway
rphi00260  Glycine, serine and threonine metabolism
rphi00601  Glycosphingolipid biosynthesis - lacto and neolacto series
rphi00603  Glycosphingolipid biosynthesis - globo and isoglobo series
rphi00604  Glycosphingolipid biosynthesis - ganglio series
KO pathway
ko00600   

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