KEGG   PATHWAY: sbq04530
Entry
sbq04530                    Pathway                                
Name
Tight junction - Saimiri boliviensis boliviensis (Bolivian squirrel monkey)
Description
Tight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of transmembrane protein -occludin, claudin and junctional adhesion molecules (JAMs)- and a cytoplasmic 'plaque' consisting of many different proteins that form large complexes. These are proposed to be involved in junction assembly, barrier regulation, cell polarity, gene transcription, and other pathways.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
sbq04530  Tight junction
sbq04530

Other DBs
GO: 0005923
Organism
Saimiri boliviensis boliviensis (Bolivian squirrel monkey) [GN:sbq]
Gene
101051868  CRB3; protein crumbs homolog 3 [KO:K06090]
101028968  uncharacterized protein LOC101028968 [KO:K06087]
101046831  CLDN8; claudin-8 [KO:K06087]
101047147  CLDN17; claudin-17 [KO:K06087]
101053096  CLDN14; claudin-14 [KO:K06087]
101050561  CLDN18; claudin-18 isoform X2 [KO:K06087]
101043979  CLDN20; claudin-20 [KO:K06087]
101046803  CLDN11; claudin-11 [KO:K06087]
101035609  CLDN23; claudin-23 [KO:K06087]
101050547  CLDN10; claudin-10 isoform X1 [KO:K06087]
101028531  CLDN3; claudin-3 [KO:K06087]
101041994  CLDN2; claudin-2 [KO:K06087]
101041538  CLDN9; claudin-9 [KO:K06087]
101041849  CLDN6; claudin-6 [KO:K06087]
101052606  CLDN19; claudin-19 isoform X1 [KO:K06087]
101029911  CLDN4; claudin-4 [KO:K06087]
101033923  CLDN15; claudin-15 [KO:K06087]
101039259  CLDN1; claudin-1 [KO:K06087]
101039565  CLDN16; claudin-16 [KO:K06087]
101033458  CLDN5; claudin-5 [KO:K06087]
101030947  CLDN7; claudin-7 [KO:K06087]
104652330  CLDN22; claudin-22 [KO:K06087]
101029400  CLDN12; claudin-12 [KO:K06087]
101051867  claudin-12 [KO:K06087]
101052327  OCLN; occludin [KO:K06088]
101044121  F11R; junctional adhesion molecule A [KO:K06089]
101029808  JAM2; junctional adhesion molecule B [KO:K06735]
101046095  JAM3; junctional adhesion molecule C [KO:K06785]
101032230  BVES; blood vessel epicardial substance isoform X5 [KO:K21108]
101050895  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101035488  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
101031506  PARD6A; partitioning defective 6 homolog alpha isoform X2 [KO:K06093]
101043414  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
101031949  MPP5; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
101050524  MPP4; MAGUK p55 subfamily member 4 isoform X1 [KO:K21109]
101035417  TJP3; tight junction protein ZO-3 [KO:K06097]
101030677  INADL; inaD-like protein [KO:K06092]
101049472  MPDZ; multiple PDZ domain protein isoform X1 [KO:K06095]
101039978  PRKCZ; protein kinase C zeta type isoform X4 [KO:K18952] [EC:2.7.11.13]
101037993  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
101053027  AMOT; angiomotin isoform X1 [KO:K16819]
101045160  AMOTL1; angiomotin-like protein 1 isoform X1 [KO:K06104]
101041347  AMOTL2; angiomotin-like protein 2 isoform X1 [KO:K06104]
101041864  ARHGAP17; rho GTPase-activating protein 17 isoform X5 [KO:K20638]
101042808  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101049530  NF2; merlin [KO:K16684]
101037927  LLGL2; lethal(2) giant larvae protein homolog 2 isoform X1 [KO:K06094]
101045260  LLGL1; lethal(2) giant larvae protein homolog 1 [KO:K06094]
101032502  DLG1; disks large homolog 1 isoform X2 [KO:K12076]
101045554  SCRIB; protein scribble homolog [KO:K16175]
101028752  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
101037428  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
101034311  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
101033118  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
101038903  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
101052911  PPP2R2B; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
101031700  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
101054317  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
101039526  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
101042162  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
101045649  TJP1; tight junction protein ZO-1 isoform X1 [KO:K05701]
101035955  TJAP1; tight junction-associated protein 1 isoform X2 [KO:K06105]
101032013  DLG2; disks large homolog 2 isoform X1 [KO:K12075]
101038838  DLG3; disks large homolog 3 isoform X3 [KO:K21098]
101028535  NEDD4; E3 ubiquitin-protein ligase NEDD4 isoform X5 [KO:K10591] [EC:2.3.2.26]
101049039  NEDD4L; E3 ubiquitin-protein ligase NEDD4-like isoform X6 [KO:K13305] [EC:2.3.2.26]
101035865  CGN; cingulin [KO:K06102]
101039586  CGNL1; cingulin-like protein 1 [KO:K21110]
101050808  ARHGEF2; rho guanine nucleotide exchange factor 2 isoform X1 [KO:K12791]
101052068  RHOA; transforming protein RhoA [KO:K04513]
104650592  ras-like GTP-binding protein O-RHO [KO:K04513]
104652261  RHOC; rho-related GTP-binding protein RhoC [KO:K04513]
101047242  GATA4; transcription factor GATA-4 isoform X2 [KO:K09183]
101028784  MARVELD3; MARVEL domain-containing protein 3 isoform X2 [KO:K21099]
101054366  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
101039160  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101027742  MAPK9; mitogen-activated protein kinase 9 isoform X4 [KO:K04440] [EC:2.7.11.24]
101048066  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101043809  JUN; transcription factor AP-1 [KO:K04448]
104652882  T-cell surface glycoprotein CD1a-like [KO:K06448]
101046248  CD1D; antigen-presenting glycoprotein CD1d isoform X1 [KO:K06448]
101045925  CD1B; T-cell surface glycoprotein CD1b [KO:K06448]
101044987  CD1E; T-cell surface glycoprotein CD1e, membrane-associated isoform X1 [KO:K06448]
101036459  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
101040767  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
101030548  YBX3; Y-box-binding protein 3 [KO:K06099]
101052305  SYMPK; symplekin [KO:K06100]
101054404  PCNA; proliferating cell nuclear antigen [KO:K04802]
101047858  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
101043415  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X2 [KO:K05083] [EC:2.7.10.1]
101047789  RUNX1; runt-related transcription factor 1 [KO:K08367]
101033095  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
101047062  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
101050249  EZR; ezrin isoform X1 [KO:K08007]
101037449  RDX; radixin isoform X1 [KO:K05762]
101031642  MSN; moesin [KO:K05763]
101053832  PRKCE; protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
101037287  ACTB; actin, cytoplasmic 1 [KO:K05692]
101050060  actin, cytoplasmic 2-like isoform X1 [KO:K05692]
101049910  ACTG1; actin, cytoplasmic 2 [KO:K05692]
104651678  actin, cytoplasmic 1-like [KO:K05692]
101043152  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
101034123  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
101047840  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
101051959  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
101041507  CTTN; src substrate cortactin [KO:K06106]
101041938  HCLS1; hematopoietic lineage cell-specific protein [KO:K06106]
101034581  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
101040892  ACTR3; actin-related protein 3 [KO:K18584]
101050762  ACTR3B; actin-related protein 3B [KO:K18584]
101038366  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
101038677  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
101035752  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
101043265  LOW QUALITY PROTEIN: actin-related protein 2/3 complex subunit 3-like [KO:K05756]
101043531  ARPC4; actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755]
101033977  ARPC5; actin-related protein 2/3 complex subunit 5 isoform X2 [KO:K05754]
101052542  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
101031834  WHAMM; WASP homolog-associated protein with actin, membranes and microtubules [KO:K20479]
101051876  WAS; wiskott-Aldrich syndrome protein isoform X1 [KO:K05747]
101049548  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
101034152  cAMP-dependent protein kinase catalytic subunit gamma-like [KO:K04345] [EC:2.7.11.11]
101036705  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
101043989  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma isoform X1 [KO:K04345] [EC:2.7.11.11]
101047300  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101042342  RAB13; ras-related protein Rab-13 isoform X2 [KO:K06109]
101029727  rho guanine nucleotide exchange factor 18 isoform X1 [KO:K21066]
101051787  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
101028677  LOW QUALITY PROTEIN: rho-associated protein kinase 1-like [KO:K04514] [EC:2.7.11.1]
101039371  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
101050353  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
101031446  EPB41L4B; band 4.1-like protein 4B [KO:K21111]
101053621  STK11; serine/threonine-protein kinase STK11 isoform X2 [KO:K07298] [EC:2.7.11.1]
101030830  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X2 [KO:K07198] [EC:2.7.11.31]
101033212  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
101029046  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
101051388  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
101028682  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X1 [KO:K07200]
101044457  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
101042380  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 [KO:K07200]
101029258  MYH10; myosin-10 isoform X7 [KO:K10352]
101029673  MYH11; myosin-11 [KO:K10352]
101037279  MYH9; myosin-9 [KO:K10352]
101045437  MYH14; LOW QUALITY PROTEIN: myosin-14 [KO:K10352]
101029561  myosin light polypeptide 6-like [KO:K12751]
101030693  MYL6B; myosin light chain 6B [KO:K12751]
101031208  MYL6; myosin light polypeptide 6 isoform X1 [KO:K12751]
101039422  myosin light polypeptide 6-like [KO:K12751]
101034006  myosin light polypeptide 6-like [KO:K12751]
101040386  myosin regulatory light polypeptide 9-like isoform X1 [KO:K12755]
101037608  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
101053931  myosin regulatory light polypeptide 9-like isoform X1 [KO:K12757]
101029210  myosin regulatory light polypeptide 9-like isoform X1 [KO:K12757]
101033130  myosin regulatory light polypeptide 9 isoform X2 [KO:K12757]
101049446  uncharacterized protein LOC101049446 [KO:K12757]
101042369  IGSF5; immunoglobulin superfamily member 5 [KO:K06786]
101032590  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
101044638  SYNPO; synaptopodin isoform X1 [KO:K21112]
101050047  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
101039348  ACTN1; alpha-actinin-1 isoform X2 [KO:K05699]
101037573  MICALL2; MICAL-like protein 2 isoform X1 [KO:K21068]
101052643  RAB8A; ras-related protein Rab-8A [KO:K07901]
101030265  RAB8B; ras-related protein Rab-8B isoform X1 [KO:K07902]
101041774  rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
101048450  RAP1A; ras-related protein Rap-1A [KO:K04353]
101040620  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
101044596  MLLT4; afadin isoform X11 [KO:K05702]
101032876  TJP2; tight junction protein ZO-2 [KO:K06098]
101033151  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X8 [KO:K08018]
104651896  RAP2C; ras-related protein Rap-2c [KO:K07839]
101029014  MARVELD2; MARVEL domain-containing protein 2 [KO:K17291]
101046265  tubulin alpha-1B chain [KO:K07374]
101047200  tubulin alpha-1A chain [KO:K07374]
101046886  tubulin alpha-1C chain [KO:K07374]
101039362  TUBA8; tubulin alpha-8 chain [KO:K07374]
101040729  TUBAL3; tubulin alpha chain-like 3 isoform X2 [KO:K07374]
101027836  TUBA4A; LOW QUALITY PROTEIN: tubulin alpha-4A chain [KO:K07374]
Compound
C00076  Calcium cation
Reference
PMID:27353478
  Authors
Zihni C, Mills C, Matter K, Balda MS
  Title
Tight junctions: from simple barriers to multifunctional molecular gates.
  Journal
Nat Rev Mol Cell Biol 17:564-80 (2016)
DOI:10.1038/nrm.2016.80
Reference
PMID:22169974
  Authors
Martin-Belmonte F, Perez-Moreno M
  Title
Epithelial cell polarity, stem cells and cancer.
  Journal
Nat Rev Cancer 12:23-38 (2011)
DOI:10.1038/nrc3169
Reference
PMID:17525755
  Authors
Weber C, Fraemohs L, Dejana E
  Title
The role of junctional adhesion molecules in vascular inflammation.
  Journal
Nat Rev Immunol 7:467-77 (2007)
DOI:10.1038/nri2096
Reference
PMID:15820555
  Authors
Miyoshi J, Takai Y
  Title
Molecular perspective on tight-junction assembly and epithelial polarity.
  Journal
Adv Drug Deliv Rev 57:815-55 (2005)
DOI:10.1016/j.addr.2005.01.008
Reference
PMID:16650994
  Authors
Mertens AE, Pegtel DM, Collard JG
  Title
Tiam1 takes PARt in cell polarity.
  Journal
Trends Cell Biol 16:308-16 (2006)
DOI:10.1016/j.tcb.2006.04.001
Reference
PMID:16771626
  Authors
Shin K, Fogg VC, Margolis B
  Title
Tight junctions and cell polarity.
  Journal
Annu Rev Cell Dev Biol 22:207-35 (2006)
DOI:10.1146/annurev.cellbio.22.010305.104219
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:17950242
  Authors
Gonzalez-Mariscal L, Tapia R, Chamorro D
  Title
Crosstalk of tight junction components with signaling pathways.
  Journal
Biochim Biophys Acta 1778:729-56 (2008)
DOI:10.1016/j.bbamem.2007.08.018
Reference
PMID:18005931
  Authors
Assemat E, Bazellieres E, Pallesi-Pocachard E, Le Bivic A, Massey-Harroche D
  Title
Polarity complex proteins.
  Journal
Biochim Biophys Acta 1778:614-30 (2008)
DOI:10.1016/j.bbamem.2007.08.029
Reference
PMID:18946474
  Authors
Iden S, Collard JG
  Title
Crosstalk between small GTPases and polarity proteins in cell polarization.
  Journal
Nat Rev Mol Cell Biol 9:846-59 (2008)
DOI:10.1038/nrm2521
Reference
PMID:20094051
  Authors
Rosse C, Linch M, Kermorgant S, Cameron AJ, Boeckeler K, Parker PJ
  Title
PKC and the control of localized signal dynamics.
  Journal
Nat Rev Mol Cell Biol 11:103-12 (2010)
DOI:10.1038/nrm2847
Reference
PMID:20134025
  Authors
Terry S, Nie M, Matter K, Balda MS
  Title
Rho signaling and tight junction functions.
  Journal
Physiology (Bethesda) 25:16-26 (2010)
DOI:10.1152/physiol.00034.2009
Reference
PMID:21283798
  Authors
Russ PK, Pino CJ, Williams CS, Bader DM, Haselton FR, Chang MS
  Title
Bves modulates tight junction associated signaling.
  Journal
PLoS One 6:e14563 (2011)
DOI:10.1371/journal.pone.0014563
Reference
PMID:21781017
  Authors
Citi S, Spadaro D, Schneider Y, Stutz J, Pulimeno P
  Title
Regulation of small GTPases at epithelial cell-cell junctions.
  Journal
Mol Membr Biol 28:427-44 (2011)
DOI:10.3109/09687688.2011.603101
Reference
PMID:22896795
  Authors
Lickert H, Van Campenhout CA
  Title
Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.
  Journal
Commun Integr Biol 5:287-90 (2012)
DOI:10.4161/cib.19792
Reference
PMID:22928510
  Authors
Spadaro D, Tapia R, Pulimeno P, Citi S
  Title
The control of gene expression and cell proliferation by the epithelial apical junctional complex.
  Journal
Essays Biochem 53:83-93 (2012)
DOI:10.1042/bse0530083
Reference
PMID:24548561
  Authors
Moleirinho S, Guerrant W, Kissil JL
  Title
The Angiomotins--from discovery to function.
  Journal
FEBS Lett 588:2693-703 (2014)
DOI:10.1016/j.febslet.2014.02.006
Reference
PMID:24651541
  Authors
Rodriguez-Boulan E, Macara IG
  Title
Organization and execution of the epithelial polarity programme.
  Journal
Nat Rev Mol Cell Biol 15:225-42 (2014)
DOI:10.1038/nrm3775
Reference
PMID:25152334
  Authors
Gonzalez-Mariscal L, Dominguez-Calderon A, Raya-Sandino A, Ortega-Olvera JM, Vargas-Sierra O, Martinez-Revollar G
  Title
Tight junctions and the regulation of gene expression.
  Journal
Semin Cell Dev Biol 36:213-23 (2014)
DOI:10.1016/j.semcdb.2014.08.009
Reference
PMID:25469537
  Authors
Mack NA, Georgiou M
  Title
The interdependence of the Rho GTPases and apicobasal cell polarity.
  Journal
Small GTPases 5:10 (2014)
DOI:10.4161/21541248.2014.973768
Reference
PMID:25483301
  Authors
Citi S, Guerrera D, Spadaro D, Shah J
  Title
Epithelial junctions and Rho family GTPases: the zonular signalosome.
  Journal
Small GTPases 5:1-15 (2014)
DOI:10.4161/21541248.2014.973760
Reference
PMID:25757376
  Authors
Zihni C, Terry SJ
  Title
RhoGTPase signalling at epithelial tight junctions: Bridging the GAP between polarity and cancer.
  Journal
Int J Biochem Cell Biol 64:120-5 (2015)
DOI:10.1016/j.biocel.2015.02.020
Reference
PMID:22892070
  Authors
Nakano A, Takashima S
  Title
LKB1 and AMP-activated protein kinase: regulators of cell polarity.
  Journal
Genes Cells 17:737-47 (2012)
DOI:10.1111/j.1365-2443.2012.01629.x
Reference
PMID:12042308
  Authors
Patrie KM, Drescher AJ, Welihinda A, Mundel P, Margolis B
  Title
Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1.
  Journal
J Biol Chem 277:30183-90 (2002)
DOI:10.1074/jbc.M203072200
Reference
PMID:18094055
  Authors
Yamamura R, Nishimura N, Nakatsuji H, Arase S, Sasaki T
  Title
The interaction of JRAB/MICAL-L2 with Rab8 and Rab13 coordinates the assembly of tight junctions and adherens junctions.
  Journal
Mol Biol Cell 19:971-83 (2008)
DOI:10.1091/mbc.E07-06-0551
Reference
PMID:23885123
  Authors
Monteiro AC, Sumagin R, Rankin CR, Leoni G, Mina MJ, Reiter DM, Stehle T, Dermody TS, Schaefer SA, Hall RA, Nusrat A, Parkos CA
  Title
JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function.
  Journal
Mol Biol Cell 24:2849-60 (2013)
DOI:10.1091/mbc.E13-06-0298
Related
pathway
sbq04520  Adherens junction
sbq04810  Regulation of actin cytoskeleton
KO pathway
ko04530   
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