KEGG   PATHWAY: sdm03013
Entry
sdm03013                    Pathway                                
Name
Nucleocytoplasmic transport - Stegodyphus dumicola
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
sdm03013  Nucleocytoplasmic transport
sdm03013

Other DBs
GO: 0050658
Organism
Stegodyphus dumicola [GN:sdm]
Gene
118200477  nucleoporin NUP42-like [KO:K14321]
118199687  nucleoporin GLE1-like isoform X1 [KO:K18723]
118201529  ATP-dependent RNA helicase DDX19A-like [KO:K18655] [EC:5.6.2.7]
118179747  LOW QUALITY PROTEIN: DEAD-box helicase Dbp80-like [KO:K18655] [EC:5.6.2.7]
118185950  DEAD-box helicase Dbp80-like [KO:K18655] [EC:5.6.2.7]
118186478  ATP-dependent RNA helicase DDX19A-like [KO:K18655] [EC:5.6.2.7]
118202985  mRNA export factor-like [KO:K14298]
118200497  nuclear pore complex protein Nup98-Nup96-like [KO:K14297]
118204557  nucleoporin 88-like [KO:K14318]
118193117  E3 SUMO-protein ligase RanBP2-like isoform X1 [KO:K12172] [EC:2.3.2.-]
118182187  ran GTPase-activating protein 1-like [KO:K14319]
118185293  SUMO-conjugating enzyme UBC9 [KO:K10577]
118183501  small ubiquitin-related modifier-like isoform X1 [KO:K12160]
118187468  nuclear pore complex protein Nup85-like isoform X1 [KO:K14304]
118197999  protein SEC13 homolog [KO:K14004]
118195728  nuclear pore complex protein Nup107-like isoform X1 [KO:K14301]
118186058  nuclear pore complex protein Nup133-like [KO:K14300]
118198288  nucleoporin SEH1-like [KO:K14299]
118184699  nucleoporin Nup43-like isoform X1 [KO:K14305]
118182373  protein ELYS-like isoform X1 [KO:K25129]
118195323  nuclear pore complex protein NUP62-like [KO:K14306]
118197310  nuclear pore glycoprotein p62-like [KO:K14306]
118204342  nucleoporin p58/p45-like [KO:K14307]
118198901  nucleoporin p54-like [KO:K14308]
118192550  nuclear pore complex protein Nup205-like [KO:K14310]
118202816  nucleoporin NUP188 homolog [KO:K14311]
118204911  nuclear pore complex protein Nup155-like [KO:K14312]
118183567  nuclear pore complex protein Nup93-like isoform X1 [KO:K14309]
118184786  nucleoporin NUP35-like [KO:K14313]
118193465  nucleoporin NDC1-like isoform X1 [KO:K14315]
118182114  nuclear pore membrane glycoprotein 210-like isoform X1 [KO:K14314]
118182413  nuclear pore membrane glycoprotein 210-like [KO:K14314]
118201425  transmembrane protein 33-like [KO:K20724]
118200699  nucleoprotein TPR-like [KO:K09291]
118203702  nuclear pore complex protein Nup50-like [KO:K14295]
118191565  nuclear pore complex protein Nup153-like [KO:K14296]
118182875  importin subunit alpha-1-like [KO:K15043]
118201138  importin subunit alpha-3-like [KO:K23583]
118196543  importin subunit alpha-3-like isoform X1 [KO:K23583]
118200690  importin subunit alpha-7-like [KO:K15042]
118181706  importin subunit beta-1-like isoform X1 [KO:K14293]
118204880  transportin-1-like [KO:K18752]
118185505  transportin-1-like [KO:K18752]
118181370  transportin-3-like [KO:K15436]
118198447  importin-4-like isoform X1 [KO:K20221]
118187930  importin-5-like [KO:K20222]
118204137  importin-7-like [KO:K20223]
118199851  LOW QUALITY PROTEIN: importin-9-like [KO:K20224]
118186028  importin-11-like [KO:K25201]
118190150  importin-13-like [KO:K25202]
118192578  snurportin-1-like [KO:K13151]
118197728  exportin-1-like [KO:K14290]
118182516  exportin-2-like [KO:K18423]
118192950  exportin-T-like [KO:K14288]
118187659  exportin-4-like [KO:K25203]
118204279  exportin-6-like [KO:K25204]
118188208  exportin-7-like isoform X1 [KO:K18460]
118198923  GTP-binding nuclear protein Ran [KO:K07936]
118201264  elongation factor 1-alpha-like [KO:K03231]
118193758  elongation factor 1-alpha [KO:K03231]
118199074  phosphorylated adapter RNA export protein-like [KO:K14291]
118195635  nuclear cap-binding protein subunit 1-like [KO:K12882]
118188779  nuclear cap-binding protein subunit 2-like [KO:K12883]
118183277  60S ribosomal export protein NMD3-like [KO:K07562]
118184924  RNA-binding protein 8A-like [KO:K12876]
118183840  protein mago nashi homolog [KO:K12877]
118190457  LOW QUALITY PROTEIN: eukaryotic initiation factor 4A-III-like [KO:K13025] [EC:5.6.2.7]
118198444  eukaryotic initiation factor 4A-III-like isoform X1 [KO:K13025] [EC:5.6.2.7]
118184613  apoptotic chromatin condensation inducer in the nucleus-like isoform X1 [KO:K12875]
118179279  histone deacetylase complex subunit SAP18-like [KO:K14324]
118187958  histone deacetylase complex subunit SAP18-like [KO:K14324]
118194977  RNA-binding protein with serine-rich domain 1-like isoform X1 [KO:K14325]
118201053  THO complex subunit 4-A-like [KO:K12881]
118191391  THO complex subunit 4-like [KO:K12881]
118202993  regulator of nonsense transcripts 1-like [KO:K14326] [EC:5.6.2.5 5.6.2.3]
118193122  regulator of nonsense transcripts 2-like [KO:K14327]
118194043  regulator of nonsense transcripts 3A-like [KO:K14328]
118185983  nuclear RNA export factor 1-like isoform X1 [KO:K14284]
118202471  spliceosome RNA helicase DDX39B-like [KO:K12812] [EC:5.6.2.7]
118193681  serine/arginine repetitive matrix protein 1-like isoform X1 [KO:K13171]
118198145  partner of Y14 and mago-like [KO:K14294]
118182706  THO complex subunit 1-like isoform X1 [KO:K12878]
118184067  LOW QUALITY PROTEIN: THO complex subunit 2-like [KO:K12879]
118200324  THO complex subunit 5 homolog [KO:K13174]
118193811  THO complex subunit 6 homolog [KO:K13175]
118182233  THO complex subunit 3-like [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
sdm03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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