KEGG   PATHWAY: sey00520
Entry
sey00520                    Pathway                                
Name
Amino sugar and nucleotide sugar metabolism - Salmonella enterica subsp. enterica serovar Typhimurium SL1344
Class
Metabolism; Carbohydrate metabolism
Pathway map
sey00520  Amino sugar and nucleotide sugar metabolism
sey00520

Module
sey_M00549  Nucleotide sugar biosynthesis, glucose => UDP-glucose [PATH:sey00520]
sey_M00554  Nucleotide sugar biosynthesis, galactose => UDP-galactose [PATH:sey00520]
sey_M00761  Undecaprenylphosphate alpha-L-Ara4N biosynthesis, UDP-GlcA => undecaprenyl phosphate alpha-L-Ara4N [PATH:sey00520]
sey_M00909  UDP-N-acetyl-D-glucosamine biosynthesis, prokaryotes, glucose => UDP-GlcNAc [PATH:sey00520]
Other DBs
GO: 0006040 0009225
Organism
Salmonella enterica subsp. enterica serovar Typhimurium SL1344 [GN:sey]
Gene
SL1344_1146  nagZ; Beta-hexosaminidase [KO:K01207] [EC:3.2.1.52]
SL1344_2396  crr; pts system, glucose-specific IIA component [KO:K02777] [EC:2.7.1.-]
SL1344_0667  nagE; pts system, N-acetylglucosamine-specific IIABC component [KO:K02804] [EC:2.7.1.193]
SL1344_1157  ycfX; hypothetical ROK-family protein [KO:K00884] [EC:2.7.1.59]
SL1344_0665  nagA; N-acetylglucosamine-6-phosphate deacetylase [KO:K01443] [EC:3.5.1.25]
SL1344_0666  nagB; glucosamine-6-phosphate deaminase [KO:K02564] [EC:3.5.99.6]
SL1344_0388  yajF; hypothetical ROK-family protein [KO:K00847] [EC:2.7.1.4]
SL1344_3828  glmS; glucosamine--fructose-6-phosphate aminotransferase [KO:K00820] [EC:2.6.1.16]
SL1344_3265  glmM; PGM/PMM-family protein [KO:K03431] [EC:5.4.2.10]
SL1344_3829  glmU; UDP-N-acetylglucosamine pyrophosphorylase [KO:K04042] [EC:2.7.7.23 2.3.1.157]
SL1344_2533  murQ; hypothetical phophosugar binding protein [KO:K07106] [EC:4.2.1.126]
SL1344_1378  anmK; conserved hypothetical protein [KO:K09001] [EC:2.7.1.170]
SL1344_3279  murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [KO:K00790] [EC:2.5.1.7]
SL1344_4081  murB; UDP-N-acetylenolpyruvoylglucosamine reductase [KO:K00075] [EC:1.3.1.98]
SL1344_3308  nanK; possible kinase [KO:K00885] [EC:2.7.1.60]
SL1344_1067  conserved hypothetical protein [KO:K01788] [EC:5.1.3.9]
SL1344_3309  nanE; hypothetical N-acetylmannosamine-6-phosphate 2-epimerase 2 (ec 5.1.3.9) (mannac-6-p epimerase 2) [KO:K01788] [EC:5.1.3.9]
SL1344_3311  nanA; N-acetylneuraminate lyase [KO:K01639] [EC:4.1.3.3]
SL1344_3879  rffE; UDP-N-acetyl-D-glucosamine 2-epimerase [KO:K01791] [EC:5.1.3.14]
SL1344_3880  rffD; UDP-ManNAc dehydrogenase [KO:K02472] [EC:1.1.1.336]
SL1344_2268  yfbG; hypothetical lipopolysaccharide modification protein [KO:K10011] [EC:2.1.2.13 1.1.1.305]
SL1344_2266  yfbE; hypothetical lipopolysaccharide biosynthesis protein [KO:K07806] [EC:2.6.1.87]
SL1344_2267  pmrF; hypothetical lipopolysaccharide modification protein [KO:K10012] [EC:2.4.2.53]
SL1344_2269  conserved hypothetical protein [KO:K13014] [EC:3.5.1.-]
SL1344_1140  ptsG; PTS system, glucose-specific IIBC component [KO:K02779] [EC:2.7.1.199]
SL1344_2742  PTS system, glucose-specific IIbc component [KO:K20118] [EC:2.7.1.199]
SL1344_2371  glk; Glucokinase [KO:K00845] [EC:2.7.1.2]
SL1344_0680  pgm; phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
SL1344_2075  galF; UTP-glucose-1-phosphate uridylyltransferase [KO:K00963] [EC:2.7.7.9]
SL1344_1683  galU; glucose-1-phosphate uridylyltransferase [KO:K00963] [EC:2.7.7.9]
SL1344_2057  udg; UDP-glucose 6-dehydrogenase [KO:K00012] [EC:1.1.1.22]
SL1344_0751  galK; galactokinase [KO:K00849] [EC:2.7.1.6]
SL1344_0752  galT; galactose-1-phosphate uridylyltransferase [KO:K00965] [EC:2.7.7.12]
SL1344_0753  galE; UDP-glucose 4-epimerase [KO:K01784] [EC:5.1.3.2]
SL1344_0565  hypothetical protein [KO:K02793] [EC:2.7.1.191]
SL1344_1759  PTS system, mannose-specific IIAB component [KO:K02794] [EC:2.7.1.191]
SL1344_1760  phosphotransferase enzyme II, C component [KO:K02795]
SL1344_1761  phosphotransferase enzyme II, D component [KO:K02796]
SL1344_4157  pgi; glucose-6-phosphate isomerase [KO:K01810] [EC:5.3.1.9]
SL1344_2741  hypothetical glucose-6-phosphate isomerase [KO:K06859] [EC:5.3.1.9]
SL1344_1397  manA; mannose-6-phosphate isomerase [KO:K01809] [EC:5.3.1.8]
SL1344_2060  rfbK; phosphomannomutase [KO:K01840] [EC:5.4.2.8]
SL1344_2081  cpsG; phosphomannomutase [KO:K01840] [EC:5.4.2.8]
SL1344_2082  cpsB; mannose-1-phosphate guanylyltransferase [KO:K00971] [EC:2.7.7.13]
SL1344_2061  cpsB2; mannose-1-phosphate guanylyltransferase [KO:K00971] [EC:2.7.7.13]
SL1344_2086  gmd; GDP-mannose 4,6-dehydratase [KO:K01711] [EC:4.2.1.47]
SL1344_2085  fcl; GDP-fucose synthetase [KO:K02377] [EC:1.1.1.271]
SL1344_2069  rfbF; glucose-1-phosphate cytidylyltransferase [KO:K00978] [EC:2.7.7.33]
SL1344_2068  rfbG; CDP-glucose 4,6-dehydratase [KO:K01709] [EC:4.2.1.45]
SL1344_2067  rfbH; dehydratase [KO:K12452] [EC:1.17.1.1]
SL1344_2070  rfbI; reductase [KO:K00523] [EC:1.17.1.1]
SL1344_2066  rfbJ; CDP-abequose synthase [KO:K12455] [EC:1.1.1.341]
SL1344_3503  glgC; glucose-1-phosphate adenylyltransferase [KO:K00975] [EC:2.7.7.27]
Compound
C00029  UDP-glucose
C00031  D-Glucose
C00043  UDP-N-acetyl-alpha-D-glucosamine
C00052  UDP-alpha-D-galactose
C00085  D-Fructose 6-phosphate
C00095  D-Fructose
C00096  GDP-mannose
C00103  D-Glucose 1-phosphate
C00128  CMP-N-acetylneuraminate
C00140  N-Acetyl-D-glucosamine
C00159  D-Mannose
C00167  UDP-glucuronate
C00181  D-Xylose
C00190  UDP-D-xylose
C00191  D-Glucuronate
C00203  UDP-N-acetyl-D-galactosamine
C00216  D-Arabinose
C00259  L-Arabinose
C00267  alpha-D-Glucose
C00270  N-Acetylneuraminate
C00275  D-Mannose 6-phosphate
C00325  GDP-L-fucose
C00329  D-Glucosamine
C00333  D-Galacturonate
C00352  D-Glucosamine 6-phosphate
C00357  N-Acetyl-D-glucosamine 6-phosphate
C00394  GDP-glucose
C00446  alpha-D-Galactose 1-phosphate
C00461  Chitin
C00498  ADP-glucose
C00501  CDP-glucose
C00617  UDP-D-galacturonate
C00636  D-Mannose 1-phosphate
C00645  N-Acetyl-D-mannosamine
C00668  alpha-D-Glucose 6-phosphate
C00714  Pectin
C00734  Chitosan
C00935  UDP-L-arabinose
C00976  GDP-D-mannuronate
C00984  alpha-D-Galactose
C00996  Ferricytochrome b5
C00999  Ferrocytochrome b5
C01019  L-Fucose
C01050  UDP-N-acetylmuramate
C01132  N-Acetyl-D-galactosamine
C01170  UDP-N-acetyl-D-mannosamine
C01219  CDP-4-dehydro-6-deoxy-D-glucose
C01222  GDP-4-dehydro-6-deoxy-D-mannose
C01623  UDP-apiose
C01674  Chitobiose
C01788  CDP-abequose
C02199  UDP-L-rhamnose
C02280  GDP-L-galactose
C02352  1,4-beta-D-Xylan
C02474  Arabinan
C02713  N-Acetylmuramate
C02977  GDP-6-deoxy-D-talose
C02985  L-Fucose 1-phosphate
C03117  GDP-6-deoxy-D-mannose
C03410  N-Glycoloyl-neuraminate
C03598  CDP-3,6-dideoxy-D-glucose
C03599  CDP-3,6-dideoxy-D-mannose
C03691  CMP-N-glycoloylneuraminate
C03733  UDP-alpha-D-galactofuranose
C03906  beta-L-Arabinose 1-phosphate
C04037  1-Phospho-alpha-D-galacturonate
C04089  UDP-4-dehydro-6-deoxy-D-glucose
C04257  N-Acetyl-D-mannosamine 6-phosphate
C04297  CDP-4-dehydro-3,6-dideoxy-D-glucose
C04501  N-Acetyl-alpha-D-glucosamine 1-phosphate
C04573  UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate
C04613  UDP-2-acetamido-4-dehydro-2,6-dideoxyglucose
C04630  UDP-2-acetamido-4-amino-2,4,6-trideoxy-alpha-D-glucose
C04631  UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine
C05385  D-Glucuronate 1-phosphate
C06023  D-Glucosaminide
C06156  alpha-D-Glucosamine 1-phosphate
C06240  UDP-N-acetyl-D-mannosaminouronate
C06241  N-Acetylneuraminate 9-phosphate
C06377  D-Galactosamine 6-phosphate
C11521  UDP-6-sulfoquinovose
C13952  UDP-N-acetyl-D-galactosaminuronic acid
C15925  GDP-L-gulose
C16153  UDP-L-Ara4N
C16154  UDP-L-Ara4FN
C16155  UDP-L-Ara4O
C16156  Undecaprenyl phosphate alpha-L-Ara4FN
C16157  Undecaprenyl phosphate alpha-L-Ara4N
C16183  alpha-D-Arabinopyranose 1-phosphate
C16698  N-Acetylmuramic acid 6-phosphate
C17269  GDP-D-arabinopyranose
C17326  CDP-4-dehydro-3,6-dideoxy-D-glucose epimer
C17327  CDP-ascarylose
C17328  UDP-4-keto-rhamnose
C18060  N-Acetyl-alpha-D-galactosamine 1-phosphate
C18094  UDP-L-arabinofuranose
C19725  UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate
C19745  UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate
C19769  1,6-Anhydro-N-acetyl-beta-muramate
C19823  UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hexos-4-ulose
C19961  UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine
C19971  UDP-2,4-bis(acetamido)-2,4,6-trideoxy-beta-L-altropyranose
C19972  2,4-Bis(acetamido)-2,4,6-trideoxy-beta-L-altropyranose
C20082  Pseudaminic acid
C20083  CMP-pseudaminic acid
C20357  UDP-N,N'-diacetylbacillosamine
C20359  UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate
C20395  UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate
C20418  N,N'-Diacetyllegionaminate
C20419  CMP-N,N'-diacetyllegionaminate
C20424  2,4-Diacetamido-2,4,6-trideoxy-D-mannopyranose
C20638  GDP-4-amino-4,6-dideoxy-alpha-D-mannose
C20672  GDP-4-acetamido-4,6-dideoxy-alpha-D-mannose
C20934  3-Deoxy-D-glycero-D-galacto-non-2-ulopyranosonate
C21027  N-Acetylmuramic acid alpha-1-phosphate
C21383  3-Deoxy-D-glycero-D-galacto-non-2-ulopyranosonate 9-phosphate
C21384  CMP-3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate
C22029  alpha-D-Galactosamine 1-phosphate
C22938  UDP-N-acetyl-alpha-D-xylosamine
Reference
PMID:2793832
  Authors
Wyk P, Reeves P
  Title
Identification and sequence of the gene for abequose synthase, which confers antigenic specificity on group B salmonellae: homology with galactose epimerase.
  Journal
J Bacteriol 171:5687-93 (1989)
DOI:10.1128/JB.171.10.5687-5693.1989
Reference
PMID:8071227
  Authors
Thorson JS, Lo SF, Ploux O, He X, Liu HW
  Title
Studies of the biosynthesis of 3,6-dideoxyhexoses: molecular cloning and characterization of the asc (ascarylose) region from Yersinia pseudotuberculosis serogroup VA.
  Journal
J Bacteriol 176:5483-93 (1994)
DOI:10.1128/JB.176.17.5483-5493.1994
Reference
PMID:8444803
  Authors
Kessler AC, Haase A, Reeves PR
  Title
Molecular analysis of the 3,6-dideoxyhexose pathway genes of Yersinia pseudotuberculosis serogroup IIA.
  Journal
J Bacteriol 175:1412-22 (1993)
DOI:10.1128/JB.175.5.1412-1422.1993
Reference
PMID:9811644
  Authors
Danese PN, Oliver GR, Barr K, Bowman GD, Rick PD, Silhavy TJ
  Title
Accumulation of the enterobacterial common antigen lipid II biosynthetic intermediate stimulates degP transcription in Escherichia coli.
  Journal
J Bacteriol 180:5875-84 (1998)
DOI:10.1128/JB.180.22.5875-5884.1998
Reference
  Authors
Skurnik M, Peippo A, Ervela E
  Title
Characterization of the O-antigen gene clusters of Yersinia pseudotuberculosis and the cryptic O-antigen gene cluster of Yersinia pestis shows that the plague bacillus is most closely related to and has evolved from Y. pseudotuberculosis serotype O:1b.
  Journal
Mol Microbiol 37:316-30 (2000)
DOI:10.1046/j.1365-2958.2000.01993.x
Reference
  Authors
Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV
  Title
Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.
  Journal
Nature 406:959-64 (2000)
DOI:10.1038/35023079
Reference
  Authors
Ringenberg M, Lichtensteiger C, Vimr E
  Title
Redirection of sialic acid metabolism in genetically engineered Escherichia coli.
  Journal
Glycobiology 11:533-9 (2001)
DOI:10.1093/glycob/11.7.533
Reference
  Authors
McCoy AJ, Sandlin RC, Maurelli AT
  Title
In vitro and in vivo functional activity of Chlamydia MurA, a UDP-N-acetylglucosamine enolpyruvyl transferase involved in peptidoglycan synthesis and fosfomycin resistance.
  Journal
J Bacteriol 185:1218-28 (2003)
DOI:10.1128/JB.185.4.1218-1228.2003
Reference
  Authors
JACOBSON B, DAVIDSON EA
  Title
Biosynthesis of uronic acids by skin enzymes. I. Uridine diphosphate-D-glucuronic acid-5-epimerase.
  Journal
J Biol Chem 237:638-42 (1962)
Reference
  Authors
Seifert GJ
  Title
Nucleotide sugar interconversions and cell wall biosynthesis: how to bring the inside to the outside.
  Journal
Curr Opin Plant Biol 7:277-84 (2004)
DOI:10.1016/j.pbi.2004.03.004
Reference
  Authors
Uehara T, Park JT
  Title
The N-acetyl-D-glucosamine kinase of Escherichia coli and its role in murein recycling.
  Journal
J Bacteriol 186:7273-9 (2004)
DOI:10.1128/JB.186.21.7273-7279.2004
Reference
  Authors
Breazeale SD, Ribeiro AA, McClerren AL, Raetz CR.
  Title
A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-Amino-4-deoxy-L-arabinose. Identification and function oF UDP-4-deoxy-4-formamido-L-arabinose.
  Journal
J Biol Chem 280:14154-67 (2005)
DOI:10.1074/jbc.M414265200
Reference
  Authors
Williams GJ, Breazeale SD, Raetz CR, Naismith JH.
  Title
Structure and function of both domains of ArnA, a dual function decarboxylase and a formyltransferase, involved in 4-amino-4-deoxy-L-arabinose biosynthesis.
  Journal
J Biol Chem 280:23000-8 (2005)
DOI:10.1074/jbc.M501534200
Reference
  Authors
Maliekal P, Vertommen D, Delpierre G, Van Schaftingen E
  Title
Identification of the sequence encoding N-acetylneuraminate-9-phosphate phosphatase.
  Journal
Glycobiology 16:165-72 (2006)
DOI:10.1093/glycob/cwj050
Reference
  Authors
Campbell CT, Yarema KJ
  Title
Large-scale approaches for glycobiology.
  Journal
Genome Biol 6:236 (2005)
DOI:10.1186/gb-2005-6-11-236
Reference
  Authors
Uehara T, Suefuji K, Jaeger T, Mayer C, Park JT
  Title
MurQ Etherase is required by Escherichia coli in order to metabolize anhydro-N-acetylmuramic acid obtained either from the environment or from its own cell wall.
  Journal
J Bacteriol 188:1660-2 (2006)
DOI:10.1128/JB.188.4.1660-1662.2006
Reference
  Authors
Lanot A, Hodge D, Jackson RG, George GL, Elias L, Lim EK, Vaistij FE, Bowles DJ
  Title
The glucosyltransferase UGT72E2 is responsible for monolignol 4-O-glucoside production in Arabidopsis thaliana.
  Journal
Plant J 48:286-95 (2006)
DOI:10.1111/j.1365-313X.2006.02872.x
Reference
  Authors
Muller R, Morant M, Jarmer H, Nilsson L, Nielsen TH
  Title
Genome-wide analysis of the Arabidopsis leaf transcriptome reveals interaction of phosphate and sugar metabolism.
  Journal
Plant Physiol 143:156-71 (2007)
DOI:10.1104/pp.106.090167
Reference
  Authors
Oka T, Nemoto T, Jigami Y
  Title
Functional analysis of Arabidopsis thaliana RHM2/MUM4, a multidomain protein involved in UDP-D-glucose to UDP-L-rhamnose conversion.
  Journal
J Biol Chem 282:5389-403 (2007)
DOI:10.1074/jbc.M610196200
Reference
  Authors
Greenberg DE, Porcella SF, Zelazny AM, Virtaneva K, Sturdevant DE, Kupko JJ 3rd, Barbian KD, Babar A, Dorward DW, Holland SM.
  Title
Genome sequence analysis of the emerging human pathogenic acetic acid bacterium Granulibacter bethesdensis.
  Journal
J Bacteriol 189:8727-36 (2007)
DOI:10.1128/JB.00793-07
Reference
  Authors
Kotake T, Hojo S, Tajima N, Matsuoka K, Koyama T, Tsumuraya Y
  Title
A bifunctional enzyme with L-fucokinase and GDP-L-fucose pyrophosphorylase activities salvages free L-fucose in Arabidopsis.
  Journal
J Biol Chem 283:8125-35 (2008)
DOI:10.1074/jbc.M710078200
Reference
  Authors
Vorholter FJ, Schneiker S, Goesmann A, Krause L, Bekel T, Kaiser O, Linke B, Patschkowski T, Ruckert C, Schmid J, Sidhu VK, Sieber V, Tauch A, Watt SA, Weisshaar B, Becker A, Niehaus K, Puhler A.
  Title
The genome of Xanthomonas campestris pv. campestris B100 and its use for the reconstruction of metabolic pathways involved in xanthan biosynthesis.
  Journal
J Biotechnol 134:33-45 (2008)
DOI:10.1016/j.jbiotec.2007.12.013
Reference
  Authors
Albermann C, Piepersberg W
  Title
Expression and identification of the RfbE protein from Vibrio cholerae O1 and its use for the enzymatic synthesis of GDP-D-perosamine.
  Journal
Glycobiology 11:655-61 (2001)
DOI:10.1093/glycob/11.8.655
Related
pathway
sey00010  Glycolysis / Gluconeogenesis
sey00040  Pentose and glucuronate interconversions
sey00051  Fructose and mannose metabolism
sey00052  Galactose metabolism
sey00053  Ascorbate and aldarate metabolism
sey00500  Starch and sucrose metabolism
sey00523  Polyketide sugar unit biosynthesis
sey00525  Acarbose and validamycin biosynthesis
sey00540  Lipopolysaccharide biosynthesis
sey00550  Peptidoglycan biosynthesis
KO pathway
ko00520   
LinkDB

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