KEGG PATHWAY: sge00270

PATHWAY: sge00270

Entry

sge00270                    Pathway

Name

Cysteine and methionine metabolism - Streptomyces griseorubiginosus

Description

Cysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted from serine (via acetylserine) by transfer of hydrogen sulfide [MD:M00021]. In animals, methionine-derived homocysteine is used as sulfur source and its condensation product with serine (cystathionine) is converted to cysteine [MD:M00338]. Cysteine is metabolized to pyruvate in multiple routes. Methionine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, methionine is synthesized from aspartate [MD:M00017]. S-Adenosylmethionine (SAM), synthesized from methionine and ATP, is a methyl group donor in many important transfer reactions including DNA methylation for regulation of gene expression. SAM may also be used to regenerate methionine in the methionine salvage pathway [MD:M00034].

Class

Metabolism; Amino acid metabolism

Pathway map

sge00270

Cysteine and methionine metabolism

Module

sge_M00017

Methionine biosynthesis, aspartate => homoserine => methionine [PATH:sge00270]

sge_M00338

Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:sge00270]

Other DBs

GO:	0006534 0006555

Organism

Streptomyces griseorubiginosus [GN:sge]

Gene

DWG14_07659

sbnA; putative siderophore biosynthesis protein SbnA [KO:K01738] [EC:2.5.1.47]

DWG14_04294

mdeA; L-methionine gamma-lyase [KO:K01758] [EC:4.4.1.1]

DWG14_01148

Putative cystathionine beta-lyase [KO:K14155] [EC:4.4.1.13]

DWG14_08225

mccA; O-acetylserine dependent cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]

DWG14_04990

cbs; Putative cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]

DWG14_00408

mmuM_1; Homocysteine S-methyltransferase [KO:K00547] [EC:2.1.1.10]

DWG14_01942

mmuM_2; Homocysteine S-methyltransferase [KO:K00547] [EC:2.1.1.10]

DWG14_06817

metH; Methionine synthase [KO:K00548] [EC:2.1.1.13]

DWG14_05771

metE; 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase [KO:K00549] [EC:2.1.1.14]

DWG14_07022

metK; S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]

DWG14_03968

speE_2; Polyamine aminopropyltransferase [KO:K00797] [EC:2.5.1.16]

DWG14_06811

mtnK; Methylthioribose kinase [KO:K00899] [EC:2.7.1.100]

DWG14_04868

mtnP; S-methyl-5'-thioadenosine phosphorylase [KO:K00772] [EC:2.4.2.28]

DWG14_06252

Laccase domain protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]

DWG14_06379

mtaD; 5-methylthioadenosine/S-adenosylhomocysteine deaminase [KO:K12960] [EC:3.5.4.31 3.5.4.28]

DWG14_05078

mtnA_1; Methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]

DWG14_06804

mtnA_2; Methylthioribose-1-phosphate isomerase [KO:K08963] [EC:5.3.1.23]

DWG14_06805

mtnB; Methylthioribulose-1-phosphate dehydratase [KO:K08964] [EC:4.2.1.109]

DWG14_06806

mtnC; Enolase-phosphatase E1 [KO:K09880] [EC:3.1.3.77]

DWG14_06807

mtnD; Acireductone dioxygenase [KO:K08967] [EC:1.13.11.53 1.13.11.54]

DWG14_07201

mgl_1; L-methionine gamma-lyase [KO:K01761] [EC:4.4.1.11]

DWG14_05066

ahcY; Adenosylhomocysteinase [KO:K01251] [EC:3.13.2.1]

DWG14_06484

acdS; 1-aminocyclopropane-1-carboxylate deaminase [KO:K01505] [EC:3.5.99.7]

DWG14_03911

ask; Aspartokinase [KO:K00928] [EC:2.7.2.4]

DWG14_03910

asd_1; Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]

DWG14_05483

asd_2; Aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]

DWG14_02789

hom; Homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]

DWG14_02787

thrB; Homoserine kinase [KO:K00872] [EC:2.7.1.39]

DWG14_08284

metX; Homoserine O-acetyltransferase [KO:K00641] [EC:2.3.1.31 2.3.1.46]

DWG14_03145

metB; Cystathionine gamma-synthase [KO:K01739] [EC:2.5.1.48]

DWG14_08285

mgl_2; L-methionine gamma-lyase [KO:K01740] [EC:2.5.1.49]

DWG14_06945

ilvE_2; Branched-chain-amino-acid aminotransferase [KO:K00826] [EC:2.6.1.42]

DWG14_02543

ilvE_1; Branched-chain-amino-acid aminotransferase [KO:K00826] [EC:2.6.1.42]

DWG14_01144

egtA; Glutamate--cysteine ligase EgtA [KO:K01919] [EC:6.3.2.2]

DWG14_03482

Aspartate aminotransferase [KO:K00812] [EC:2.6.1.1]

DWG14_04561

Putative thiosulfate sulfurtransferase [KO:K01011] [EC:2.8.1.1 2.8.1.2]

DWG14_02187

sseB; Putative thiosulfate sulfurtransferase SseB [KO:K01011] [EC:2.8.1.1 2.8.1.2]

DWG14_00486

ldhA; L-lactate dehydrogenase 1 [KO:K00024] [EC:1.1.1.37]

DWG14_03312

mdh; Malate dehydrogenase [KO:K00024] [EC:1.1.1.37]

DWG14_02608

sdaA; L-serine dehydratase 1 [KO:K01752] [EC:4.3.1.17]

DWG14_05499

yoaD; Putative 2-hydroxyacid dehydrogenase YoaD [KO:K00058] [EC:1.1.1.95 1.1.1.399]

DWG14_02554

serA_2; D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]

DWG14_04724

serC; Phosphoserine aminotransferase [KO:K00831] [EC:2.6.1.52]

Compound

C00019

S-Adenosyl-L-methionine

C00021

S-Adenosyl-L-homocysteine

C00022

Pyruvate

C00041

L-Alanine

C00049

L-Aspartate

C00051

Glutathione

C00059

Sulfate

C00065

L-Serine

C00073

L-Methionine

C00094

Sulfite

C00097

L-Cysteine

C00109

2-Oxobutanoate

C00155

L-Homocysteine

C00170

5'-Methylthioadenosine

C00197

3-Phospho-D-glycerate

C00263

L-Homoserine

C00283

Hydrogen sulfide

C00409

Methanethiol

C00441

L-Aspartate 4-semialdehyde

C00491

L-Cystine

C00506

L-Cysteate

C00606

3-Sulfino-L-alanine

C00793

D-Cysteine

C00957

Mercaptopyruvate

C00979

O-Acetyl-L-serine

C01005

O-Phospho-L-serine

C01077

O-Acetyl-L-homoserine

C01102

O-Phospho-L-homoserine

C01118

O-Succinyl-L-homoserine

C01137

S-Adenosylmethioninamine

C01180

4-Methylthio-2-oxobutanoic acid

C01234

1-Aminocyclopropane-1-carboxylate

C01817

L-Homocystine

C01962

Thiocysteine

C02218

Dehydroalanine

C02291

L-Cystathionine

C02356

(S)-2-Aminobutanoate

C02989

L-Methionine S-oxide

C03082

4-Phospho-L-aspartate

C03089

5-Methylthio-D-ribose

C03145

N-Formylmethionine

C03232

3-Phosphonooxypyruvate

C03431

S-Inosyl-L-homocysteine

C03539

S-Ribosyl-L-homocysteine

C04188

S-Methyl-5-thio-D-ribose 1-phosphate

C04582

S-Methyl-5-thio-D-ribulose 1-phosphate

C05324

Nicotianamine

C05524

Aminoacyl-L-methionine

C05526

S-Glutathionyl-L-cysteine

C05527

3-Sulfinylpyruvate

C05528

3-Sulfopyruvate

C05823

3-Mercaptolactate

C05824

S-Sulfo-L-cysteine

C06547

Ethylene

C08276

3-(Methylthio)propanoate

C09306

Sulfur dioxide

C11437

1-Deoxy-D-xylulose 5-phosphate

C11481

HSO3-

C11499

(S)-3-Sulfolactate

C11537

(2R)-3-Sulfolactate

C15606

1,2-Dihydroxy-5-(methylthio)pent-1-en-3-one

C15650

2,3-Diketo-5-methylthiopentyl-1-phosphate

C15651

2-Hydroxy-3-keto-5-methylthiopentenyl-1-phosphate

C18049

N-Acyl-L-homoserine lactone

C19787

5'-S-Methyl-5'-thioinosine

C21015

gamma-L-Glutamyl-L-2-aminobutyrate

C21016

Ophthalmate

C22359

S-Methyl-1-thio-D-xylulose 5-phosphate

Reference

PMID:15102328

Authors

Sekowska A, Denervaud V, Ashida H, Michoud K, Haas D, Yokota A, Danchin A

Title

Bacterial variations on the methionine salvage pathway.

Journal

BMC Microbiol 4:9 (2004)
DOI:10.1186/1471-2180-4-9

Reference

PMID:14551435

Authors

Ashida H, Saito Y, Kojima C, Kobayashi K, Ogasawara N, Yokota A.

Title

A functional link between RuBisCO-like protein of Bacillus and photosynthetic RuBisCO.

Journal

Science 302:286-90 (2003)
DOI:10.1126/science.1086997

Reference

PMID:12022921

Authors

Sekowska A, Danchin A.

Title

The methionine salvage pathway in Bacillus subtilis.

Journal

BMC Microbiol 2:8 (2002)
DOI:10.1186/1471-2180-2-8

Reference

PMID:12670965

Authors

Berger BJ, English S, Chan G, Knodel MH.

Title

Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.

Journal

J Bacteriol 185:2418-31 (2003)
DOI:10.1128/JB.185.8.2418-2431.2003

Reference

PMID:17169919

Authors

Goyer A, Collakova E, Shachar-Hill Y, Hanson AD

Title

Functional characterization of a methionine gamma-lyase in Arabidopsis and its implication in an alternative to the reverse trans-sulfuration pathway.

Journal

Plant Cell Physiol 48:232-42 (2007)
DOI:10.1093/pcp/pcl055

Reference

PMID:17030798

Authors

Rebeille F, Jabrin S, Bligny R, Loizeau K, Gambonnet B, Van Wilder V, Douce R, Ravanel S

Title

Methionine catabolism in Arabidopsis cells is initiated by a gamma-cleavage process and leads to S-methylcysteine and isoleucine syntheses.

Journal

Proc Natl Acad Sci U S A 103:15687-92 (2006)
DOI:10.1073/pnas.0606195103

Reference

PMID:18625006

Authors

Pirkov I, Norbeck J, Gustafsson L, Albers E

Title

A complete inventory of all enzymes in the eukaryotic methionine salvage pathway.

Journal

FEBS J 275:4111-20 (2008)
DOI:10.1111/j.1742-4658.2008.06552.x

Reference

PMID:18391471

Authors

Ashida H, Saito Y, Kojima C, Yokota A

Title

Enzymatic characterization of 5-methylthioribulose-1-phosphate dehydratase of the methionine salvage pathway in Bacillus subtilis.

Journal

Biosci Biotechnol Biochem 72:959-67 (2008)
DOI:10.1271/bbb.70651

Reference

PMID:10613873

Authors

Kitabatake M, So MW, Tumbula DL, Soll D

Title

Cysteine biosynthesis pathway in the archaeon Methanosarcina barkeri encoded by acquired bacterial genes?

Journal

J Bacteriol 182:143-5 (2000)
DOI:10.1128/JB.182.1.143-145.2000

Reference

PMID:12644499

Authors

Mino K, Ishikawa K

Title

Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1.

Journal

J Bacteriol 185:2277-84 (2003)
DOI:10.1128/JB.185.7.2277-2284.2003

Reference

PMID:18520135

Authors

Tanabe S

Title

Development of assay methods for endogenous inorganic sulfur compounds and sulfurtransferases and evaluation of the physiological functions of bound sulfur.

Journal

Yakugaku Zasshi 128:881-900 (2008)
DOI:10.1248/yakushi.128.881

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:19270684

Authors