KEGG   PATHWAY: sko00260
Entry
sko00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Saccoglossus kowalevskii (acorn worm)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
sko00260  Glycine, serine and threonine metabolism
sko00260

Module
sko_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:sko00260]
sko_M00047  Creatine pathway [PATH:sko00260]
sko_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:sko00260]
sko_M00555  Betaine biosynthesis, choline => betaine [PATH:sko00260]
sko_M00621  Glycine cleavage system [PATH:sko00260]
sko_M00974  Betaine metabolism, animals, betaine => glycine [PATH:sko00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Saccoglossus kowalevskii (acorn worm) [GN:sko]
Gene
102802143  uncharacterized LOC102802143 [KO:K01620] [EC:4.1.2.48]
100379038  serine hydroxymethyltransferase, mitochondrial-like [KO:K00600] [EC:2.1.2.1]
100371236  serine hydroxymethyltransferase, mitochondrial-like [KO:K00600] [EC:2.1.2.1]
100374584  serine--pyruvate aminotransferase, mitochondrial-like [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
100375265  glyoxylate reductase/hydroxypyruvate reductase-like [KO:K00049] [EC:1.1.1.79 1.1.1.81]
100369136  glycerate kinase-like [KO:K11529] [EC:2.7.1.165]
100374181  2,3-bisphosphoglycerate-independent phosphoglycerate mutase-like [KO:K15633] [EC:5.4.2.12]
100374791  d-3-phosphoglycerate dehydrogenase-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
100368293  d-3-phosphoglycerate dehydrogenase-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
100378872  phosphoserine aminotransferase-like [KO:K00831] [EC:2.6.1.52]
100367966  phosphoserine phosphatase-like [KO:K01079] [EC:3.1.3.3]
100376961  2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial-like [KO:K00639] [EC:2.3.1.29]
100367216  L-threonine 3-dehydrogenase, mitochondrial-like [KO:K15789] [EC:1.1.1.103]
100374546  5-aminolevulinate synthase, nonspecific, mitochondrial-like [KO:K00643] [EC:2.3.1.37]
102809169  probable flavin-containing monoamine oxidase A-like [KO:K00274] [EC:1.4.3.4]
102806201  amine oxidase [flavin-containing]-like [KO:K00274] [EC:1.4.3.4]
100372044  amine oxidase [flavin-containing]-like [KO:K00274] [EC:1.4.3.4]
100368936  amine oxidase [flavin-containing] B-like [KO:K00274] [EC:1.4.3.4]
100376603  amine oxidase [flavin-containing]-like [KO:K00274] [EC:1.4.3.4]
100366996  glycine dehydrogenase (decarboxylating), mitochondrial-like [KO:K00281] [EC:1.4.4.2]
100379028  aminomethyltransferase, mitochondrial-like [KO:K00605] [EC:2.1.2.10]
100375492  dihydrolipoyl dehydrogenase, mitochondrial-like [KO:K00382] [EC:1.8.1.4]
100376988  D-amino-acid oxidase 2-like [KO:K00273] [EC:1.4.3.3]
100366449  glycine amidinotransferase, mitochondrial-like [KO:K00613] [EC:2.1.4.1]
100366596  glycine amidinotransferase, mitochondrial-like [KO:K00613] [EC:2.1.4.1]
100375259  glycine amidinotransferase, mitochondrial-like [KO:K00613] [EC:2.1.4.1]
100376812  glycine amidinotransferase, mitochondrial-like [KO:K00613] [EC:2.1.4.1]
100376150  guanidinoacetate N-methyltransferase-like [KO:K00542] [EC:2.1.1.2]
100373430  choline monooxygenase, chloroplastic-like [KO:K00499] [EC:1.14.15.7]
100369278  choline monooxygenase, chloroplastic-like [KO:K00499] [EC:1.14.15.7]
102802673  choline monooxygenase, chloroplastic-like [KO:K00499] [EC:1.14.15.7]
100366344  choline dehydrogenase, mitochondrial-like [KO:K00108] [EC:1.1.99.1]
100370075  alpha-aminoadipic semialdehyde dehydrogenase-like [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
100372758  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
100372908  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
100378580  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
100378727  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
100378429  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
100374951  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
102807376  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
100376137  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
100376292  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
100376443  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
100376597  betaine--homocysteine S-methyltransferase 1-like [KO:K00544] [EC:2.1.1.5]
100371248  uncharacterized LOC100371248 [KO:K00544] [EC:2.1.1.5]
100377832  dimethylglycine dehydrogenase, mitochondrial-like [KO:K00315] [EC:1.5.8.4]
100377978  dimethylglycine dehydrogenase, mitochondrial-like [KO:K00315] [EC:1.5.8.4]
100377713  peroxisomal sarcosine oxidase-like [KO:K00306] [EC:1.5.3.1 1.5.3.7]
100374616  Sardh; sarcosine dehydrogenase, mitochondrial [KO:K00314] [EC:1.5.8.3]
100378448  glycine N-methyltransferase-like [KO:K00552] [EC:2.1.1.20]
100378497  cystathionine beta-synthase-like [KO:K01697] [EC:4.2.1.22]
102809819  cystathionine beta-synthase-like [KO:K01697] [EC:4.2.1.22]
100373567  cystathionine gamma-lyase-like [KO:K01758] [EC:4.4.1.1]
100367547  cystathionine gamma-lyase-like [KO:K01758] [EC:4.4.1.1]
100370087  cystathionine gamma-lyase-like [KO:K01758] [EC:4.4.1.1]
100375322  threo-3-hydroxyaspartate ammonia-lyase-like [KO:K01754] [EC:4.3.1.19]
100367535  serine dehydratase-like [KO:K17989] [EC:4.3.1.17 4.3.1.19]
100376523  serine racemase-like [KO:K12235] [EC:5.1.1.18]
100370513  serine racemase-like [KO:K12235] [EC:5.1.1.18]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
sko00010  Glycolysis / Gluconeogenesis
sko00020  Citrate cycle (TCA cycle)
sko00230  Purine metabolism
sko00250  Alanine, aspartate and glutamate metabolism
sko00270  Cysteine and methionine metabolism
sko00290  Valine, leucine and isoleucine biosynthesis
sko00330  Arginine and proline metabolism
sko00470  D-Amino acid metabolism
sko00564  Glycerophospholipid metabolism
sko00600  Sphingolipid metabolism
sko00620  Pyruvate metabolism
sko00630  Glyoxylate and dicarboxylate metabolism
sko00640  Propanoate metabolism
sko00860  Porphyrin metabolism
sko00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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