KEGG   PATHWAY: slal04914
Entry
slal04914                   Pathway                                
Name
Progesterone-mediated oocyte maturation - Seriola lalandi dorsalis (Yellowtail amberjack)
Description
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Class
Organismal Systems; Endocrine system
Pathway map
slal04914  Progesterone-mediated oocyte maturation
slal04914

Other DBs
GO: 0001556
Organism
Seriola lalandi dorsalis (Yellowtail amberjack) [GN:slal]
Gene
111654067  pgr; progesterone receptor [KO:K08556]
111651451  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
111671089  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
111670553  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
111671597  pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
111649932  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
111666834  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
111661265  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
111670636  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
111671654  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
111673607  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
111668884  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
111656807  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
111658196  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
111664771  mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
111646556  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
111650024  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
111670673  mitogen-activated protein kinase 14A-like isoform X1 [KO:K04441] [EC:2.7.11.24]
111667674  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
111667284  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
111653210  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
111661800  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
111667336  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
111670653  guanine nucleotide-binding protein G(k) subunit alpha-like [KO:K04630]
111657868  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
111660025  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
111652220  guanine nucleotide-binding protein G(i) subunit alpha-2-like [KO:K04630]
111671247  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
111671788  adenylate cyclase type 1-like isoform X1 [KO:K08041] [EC:4.6.1.1]
111670478  adenylate cyclase type 1-like isoform X1 [KO:K08041] [EC:4.6.1.1]
111671420  adcy2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
111661694  adenylate cyclase type 2-like [KO:K08042] [EC:4.6.1.1]
111655934  adenylate cyclase type 2-like [KO:K08042] [EC:4.6.1.1]
111664165  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
111672734  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
111657529  adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
111670684  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
111671536  adcy6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
111672304  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
111647103  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
111650568  adenylate cyclase type 8-like isoform X1 [KO:K08048] [EC:4.6.1.1]
111646845  adenylate cyclase type 8-like isoform X1 [KO:K08048] [EC:4.6.1.1]
111667563  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
111665544  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
111653688  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
111665555  prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
111658500  cAMP-dependent protein kinase catalytic subunit beta-like isoform X1 [KO:K04345] [EC:2.7.11.11]
111650970  aurka; aurora kinase A [KO:K11481] [EC:2.7.11.1]
111671714  cytoplasmic polyadenylation element-binding protein 2-like isoform X1 [KO:K02602]
111669519  cytoplasmic polyadenylation element-binding protein 3-like isoform X1 [KO:K02602]
111664655  cytoplasmic polyadenylation element-binding protein 4 isoform X1 [KO:K02602]
111651659  cpeb1; cytoplasmic polyadenylation element-binding protein 1 isoform X1 [KO:K02602]
111669043  cytoplasmic polyadenylation element-binding protein 4-like [KO:K02602]
111672072  cytoplasmic polyadenylation element-binding protein 4-like isoform X1 [KO:K02602]
111656284  spdya; speedy protein A [KO:K08694]
111667739  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
111669394  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
111662685  ccna1; cyclin-A1 [KO:K06627]
111644649  ccna2; cyclin-A2 [KO:K06627]
111650294  cyclin-A2-like [KO:K06627]
111665502  mos; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
111672729  heat shock protein HSP 90-alpha [KO:K04079]
111672730  heat shock protein HSP 90-alpha 1 [KO:K04079]
111661412  hsp90ab1; heat shock protein HSP 90-beta isoform X1 [KO:K04079]
111667016  map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
111657703  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
111660943  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
111645936  ribosomal protein S6 kinase alpha-2-like [KO:K04373] [EC:2.7.11.1]
111649832  ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
111646474  ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
111647316  ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
111652267  pkmyt1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [KO:K06633] [EC:2.7.11.1]
111650108  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
111656616  ccnb2; G2/mitotic-specific cyclin-B2 [KO:K21770]
111665458  cntd2; cyclin N-terminal domain-containing protein 2 [KO:K21770]
111667104  ccnb3; G2/mitotic-specific cyclin-B3 [KO:K21771]
111672132  serine/threonine-protein kinase 10-like [KO:K08837] [EC:2.7.11.1]
111672930  plk1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
111672807  M-phase inducer phosphatase 1-like [KO:K05866] [EC:3.1.3.48]
111653396  ins; insulin [KO:K04526]
111672131  insulin-like [KO:K04526]
111664630  insulin-like [KO:K04526]
111664700  igf1; insulin-like growth factor I [KO:K05459]
111658878  insulin-like growth factor I [KO:K05459]
111672288  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
111653328  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
111665447  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111659458  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
111673263  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111653974  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
111645313  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111654499  pde3b; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
111649083  GTPase HRas-like [KO:K07827]
111655355  kras; GTPase KRas isoform X1 [KO:K07827]
111647945  serine/threonine-protein kinase A-Raf-like [KO:K08845] [EC:2.7.11.1]
111664218  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
111672203  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
111645188  bub1; mitotic checkpoint serine/threonine-protein kinase BUB1 isoform X1 [KO:K02178] [EC:2.7.11.1]
111672999  mad1l1; mitotic spindle assembly checkpoint protein MAD1 [KO:K06679]
111668008  mad2l1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
111656219  mad2l2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
111652616  fizzy-related protein homolog [KO:K03364]
111670545  fizzy-related protein homolog [KO:K03364]
111650176  fizzy-related protein homolog isoform X1 [KO:K03364]
111645306  anapc1; anaphase-promoting complex subunit 1 isoform X1 [KO:K03348]
111651170  anapc2; anaphase-promoting complex subunit 2 [KO:K03349]
111657528  cdc27; cell division cycle protein 27 homolog [KO:K03350]
111665035  cell division cycle protein 27 homolog [KO:K03350]
111660125  anapc4; anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
111644882  anapc5; anaphase-promoting complex subunit 5 [KO:K03352]
111653849  cdc16; cell division cycle protein 16 homolog [KO:K03353]
111648033  anapc7; anaphase-promoting complex subunit 7 [KO:K03354]
111666235  cdc23; cell division cycle protein 23 homolog [KO:K03355]
111673192  anapc10; anaphase-promoting complex subunit 10 [KO:K03357]
111660402  anapc11; anaphase-promoting complex subunit 11 [KO:K03358]
111670249  cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
111666109  anapc13; anaphase-promoting complex subunit 13 [KO:K12456]
111655307  anapc15; anaphase-promoting complex subunit 15 [KO:K25228]
111660209  anapc16; anaphase-promoting complex subunit 16 [KO:K25229]
111658691  kif22; kinesin-like protein KIF22 [KO:K10403]
Compound
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:12045215
  Authors
Schmitt A, Nebreda AR.
  Title
Signalling pathways in oocyte meiotic maturation.
  Journal
J Cell Sci 115:2457-9 (2002)
Reference
PMID:12084906
  Authors
Cato AC, Nestl A, Mink S.
  Title
Rapid actions of steroid receptors in cellular signaling pathways.
  Journal
Sci STKE 2002:RE9 (2002)
DOI:10.1126/stke.2002.138.re9
Reference
PMID:11730319
  Authors
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
  Title
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
  Journal
Biol Cell 93:27-33 (2001)
DOI:10.1016/S0248-4900(01)01127-3
Reference
PMID:11063930
  Authors
Nebreda AR, Ferby I.
  Title
Regulation of the meiotic cell cycle in oocytes.
  Journal
Curr Opin Cell Biol 12:666-75 (2000)
DOI:10.1016/S0955-0674(00)00150-2
Reference
PMID:10497333
  Authors
Ferrell JE Jr.
  Title
Xenopus oocyte maturation: new lessons from a good egg.
  Journal
Bioessays 21:833-42 (1999)
DOI:10.1002/(SICI)1521-1878(199910)21:10<833::AID-BIES5>3.0.CO;2-P
Reference
PMID:12374568
  Authors
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
  Title
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
  Journal
Biochem J 369:227-38 (2003)
DOI:10.1042/BJ20021243
Reference
PMID:12477927
  Authors
Duckworth BC, Weaver JS, Ruderman JV.
  Title
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
  Journal
Proc Natl Acad Sci U S A 99:16794-9 (2002)
DOI:10.1073/pnas.222661299
Reference
PMID:11148128
  Authors
Abrieu A, Doree M, Fisher D.
  Title
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
  Journal
J Cell Sci 114:257-67 (2001)
Related
pathway
slal04010  MAPK signaling pathway
slal04110  Cell cycle
KO pathway
ko04914   
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