KEGG   PATHWAY: slal04010
Entry
slal04010                   Pathway                                
Name
MAPK signaling pathway - Seriola lalandi dorsalis (Yellowtail amberjack)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
slal04010  MAPK signaling pathway
slal04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Seriola lalandi dorsalis (Yellowtail amberjack) [GN:slal]
Gene
111644282  [KO:K05465]
111644289  [KO:K04411]
111644323  traf6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
111644342  kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
111644345  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
111644356  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
111644421  [KO:K04407] [EC:2.7.11.1]
111644571  [KO:K04388] [EC:2.7.11.30]
111644654  fgf2; fibroblast growth factor 2 [KO:K18497]
111644663  [KO:K04358]
111644821  [KO:K05462]
111644951  [KO:K04362] [EC:2.7.10.1]
111645124  [KO:K04402]
111645145  mapkapk5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
111645162  efna5; ephrin-A5 isoform X1 [KO:K05462]
111645234  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
111645294  ppm1b; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
111645313  [KO:K04456] [EC:2.7.11.1]
111645380  pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
111645476  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
111645547  [KO:K04427] [EC:2.7.11.25]
111645622  daxx; death domain-associated protein 6 [KO:K02308]
111645629  [KO:K04446]
111645657  [KO:K03156]
111645811  [KO:K04347]
111645842  [KO:K04869]
111645897  [KO:K04866]
111645936  [KO:K04373] [EC:2.7.11.1]
111646245  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
111646336  [KO:K03283]
111646360  [KO:K04374]
111646443  [KO:K04358]
111646474  [KO:K04373] [EC:2.7.11.1]
111646476  [KO:K04348] [EC:3.1.3.16]
111646556  [KO:K04440] [EC:2.7.11.24]
111646633  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
111646663  [KO:K04358]
111646667  csf1r; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
111646711  [KO:K04344]
111646743  [KO:K04856]
111646819  fgfr3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
111647051  rasgrp3; ras guanyl-releasing protein 3 [KO:K12362]
111647316  [KO:K04373] [EC:2.7.11.1]
111647380  [KO:K04361] [EC:2.7.10.1]
111647499  [KO:K04868]
111647517  [KO:K19662] [EC:2.7.11.13]
111647526  [KO:K04855]
111647606  vegfc; vascular endothelial growth factor C [KO:K05449]
111647707  [KO:K04434]
111647918  [KO:K03173] [EC:2.3.2.27]
111647945  [KO:K08845] [EC:2.7.11.1]
111647967  [KO:K04849]
111647988  [KO:K04348] [EC:3.1.3.16]
111648041  fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
111648134  [KO:K04448]
111648147  pdgfc; platelet-derived growth factor C [KO:K05450]
111648180  egf; pro-epidermal growth factor [KO:K04357]
111648761  [KO:K02582]
111648874  ppm1a; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
111649062  [KO:K02583]
111649068  [KO:K04377]
111649083  [KO:K07827]
111649098  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
111649832  [KO:K04373] [EC:2.7.11.1]
111649908  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
111649931  jund; transcription factor jun-D [KO:K04449]
111649986  rasa2; ras GTPase-activating protein 2 [KO:K08053]
111649993  mecom; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
111650024  [KO:K04441] [EC:2.7.11.24]
111650131  [KO:K04849]
111650140  [KO:K05462]
111650192  [KO:K04527] [EC:2.7.10.1]
111650410  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
111650531  [KO:K04386]
111650536  [KO:K04386]
111650537  [KO:K04386]
111650698  [KO:K04451]
111650706  [KO:K04410] [EC:2.7.11.1]
111650973  [KO:K04353]
111651101  [KO:K05103] [EC:2.7.10.1]
111651353  [KO:K04378]
111651520  [KO:K04358]
111651557  rasa1; ras GTPase-activating protein 1 [KO:K04352]
111651570  mef2c; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
111651654  vegfd; vascular endothelial growth factor D isoform X1 [KO:K05449]
111651870  cacna1e; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
111652030  flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
111652061  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
111652149  [KO:K03283]
111652259  [KO:K02583]
111652260  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
111652357  [KO:K04409] [EC:2.7.11.1]
111652514  [KO:K04410] [EC:2.7.11.1]
111652610  [KO:K04868]
111652614  [KO:K04369] [EC:2.7.12.2]
111652623  [KO:K04868]
111652641  [KO:K06268]
111652698  [KO:K18496]
111652723  [KO:K02583]
111652838  [KO:K04358]
111652920  [KO:K06268]
111652941  egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
111653021  [KO:K04379]
111653033  [KO:K04379]
111653047  [KO:K13377]
111653118  [KO:K04429] [EC:2.7.11.1]
111653123  [KO:K04468] [EC:2.7.11.24]
111653165  [KO:K04863]
111653210  [KO:K04441] [EC:2.7.11.24]
111653282  [KO:K04852]
111653328  [KO:K05087] [EC:2.7.10.1]
111653379  [KO:K04858]
111653388  hgf; hepatocyte growth factor [KO:K05460]
111653396  ins; insulin [KO:K04526]
111653428  sos1; son of sevenless homolog 1 [KO:K03099]
111653688  [KO:K04345] [EC:2.7.11.11]
111653834  cacna2d2; voltage-dependent calcium channel subunit alpha-2/delta-2 [KO:K04859]
111653924  [KO:K03283]
111653974  [KO:K04456] [EC:2.7.11.1]
111654027  [KO:K03283]
111654048  [KO:K04457] [EC:3.1.3.16]
111654131  map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
111654133  relb; transcription factor RelB isoform X1 [KO:K09253]
111654176  [KO:K04393]
111654197  [KO:K04853]
111654226  rasgrp2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
111654253  [KO:K17333]
111654324  mapk8ip1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
111654335  [KO:K04417] [EC:2.7.11.25]
111654503  rras2; ras-related protein R-Ras2 [KO:K07830]
111654625  atf2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
111654847  [KO:K04437]
111654855  mknk2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
111654891  ereg; proepiregulin [KO:K09784]
111654897  areg; amphiregulin [KO:K09782]
111654900  fgf10; fibroblast growth factor 10 [KO:K04358]
111654973  irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
111654997  [KO:K04423] [EC:2.7.11.25]
111655148  rapgef2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
111655229  [KO:K04461] [EC:3.1.3.16]
111655272  pdgfd; platelet-derived growth factor D [KO:K05450]
111655355  kras; GTPase KRas isoform X1 [KO:K07827]
111655403  [KO:K04380]
111655428  [KO:K04467] [EC:2.7.11.10]
111655523  [KO:K04430] [EC:2.7.12.2]
111655570  dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
111655571  kitlg; kit ligand [KO:K05461]
111655609  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111655614  rras; ras-related protein R-Ras [KO:K07830]
111655640  crkl; crk-like protein [KO:K04438]
111655660  [KO:K03156]
111655673  ntrk1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
111655750  dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111655785  [KO:K13376]
111655868  nrtn; neurturin [KO:K25414]
111656006  [KO:K04457] [EC:3.1.3.16]
111656020  dusp16; dual specificity protein phosphatase 16 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111656071  [KO:K04438]
111656122  [KO:K17614] [EC:3.1.3.16 3.1.3.48]
111656210  [KO:K05103] [EC:2.7.10.1]
111656266  [KO:K04421] [EC:2.7.11.25]
111656280  [KO:K04729]
111656365  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
111656372  map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
111656568  myc; myc proto-oncogene protein [KO:K04377]
111656688  angpt2; angiopoietin-2 isoform X1 [KO:K05466]
111656706  [KO:K04429] [EC:2.7.11.1]
111656742  nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
111656807  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
111656813  [KO:K04360] [EC:2.7.10.1]
111656962  [KO:K05462]
111656986  efna1; ephrin-A1 [KO:K05462]
111656989  [KO:K05462]
111657469  [KO:K04358]
111657526  [KO:K04380]
111657545  cacnb4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
111657569  [KO:K05462]
111657623  [KO:K04388] [EC:2.7.11.30]
111657647  [KO:K05462]
111657685  ntf3; neurotrophin-3 isoform X1 [KO:K04356]
111657703  [KO:K04371] [EC:2.7.11.24]
111657787  [KO:K04433] [EC:2.7.12.2]
111658107  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
111658196  [KO:K04440] [EC:2.7.11.24]
111658207  [KO:K04467] [EC:2.7.11.10]
111658461  [KO:K04862]
111658500  [KO:K04345] [EC:2.7.11.11]
111658565  fgf16; fibroblast growth factor 16 [KO:K04358]
111658620  fgf21; fibroblast growth factor 21 [KO:K22429]
111658685  [KO:K04429] [EC:2.7.11.1]
111658704  [KO:K04464] [EC:2.7.11.24]
111658797  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
111658878  [KO:K05459]
111658940  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
111658959  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
111658987  srf; serum response factor isoform X1 [KO:K04378]
111658999  [KO:K05462]
111659091  [KO:K04349]
111659127  nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
111659275  [KO:K04412]
111659458  [KO:K04456] [EC:2.7.11.1]
111659477  [KO:K07830]
111659489  [KO:K04519]
111659587  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
111659673  cacng5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
111659681  cacng4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
111659692  [KO:K02677] [EC:2.7.11.13]
111659711  cacng1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
111659787  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
111659798  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
111659926  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
111659966  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
111660016  fgf23; fibroblast growth factor 23 [KO:K22428]
111660017  [KO:K04358]
111660057  [KO:K04381]
111660430  [KO:K04867]
111660531  [KO:K04466] [EC:2.7.11.25]
111660589  map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
111660720  [KO:K04851]
111660748  tgfa; protransforming growth factor alpha isoform X1 [KO:K08774]
111660766  [KO:K04859]
111660873  [KO:K04860]
111660921  [KO:K05452]
111660942  [KO:K04519]
111660943  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
111660950  ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
111660964  [KO:K04519]
111660967  fgf5; fibroblast growth factor 5 [KO:K04358]
111660999  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111661021  rasgrf2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
111661121  fgf7; fibroblast growth factor 7 [KO:K04358]
111661161  map2k5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
111661173  [KO:K04873]
111661188  [KO:K04871]
111661224  [KO:K04872]
111661236  [KO:K04347]
111661237  [KO:K04402]
111661323  [KO:K07836]
111661356  dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
111661445  max; protein max isoform X1 [KO:K04453]
111661471  map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
111661524  map3k7; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
111661628  [KO:K04426] [EC:2.7.11.25]
111661793  [KO:K18018] [EC:3.1.3.48]
111661800  [KO:K04441] [EC:2.7.11.24]
111661802  dusp8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111661823  hras; GTPase HRas [KO:K02833]
111661852  igf2; insulin-like growth factor II [KO:K13769]
111661944  [KO:K04465]
111661945  [KO:K04353]
111661987  ppp3r1; calcineurin subunit B type 1 [KO:K06268]
111661998  map4k3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
111662034  [KO:K04377]
111662245  ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
111662248  [KO:K04856]
111662255  [KO:K13375]
111662274  [KO:K04350]
111662311  [KO:K04457] [EC:3.1.3.16]
111662349  [KO:K04381]
111662357  [KO:K02582]
111662484  [KO:K17614] [EC:3.1.3.16 3.1.3.48]
111662554  nf1; neurofibromin isoform X1 [KO:K08052]
111662558  nlk; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
111662605  [KO:K04402]
111662606  [KO:K04347]
111662654  [KO:K04429] [EC:2.7.11.1]
111662725  [KO:K05085] [EC:2.7.10.1]
111662923  flt1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
111662946  flt3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
111663079  taok3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
111663127  tgfb3; transforming growth factor beta-3 [KO:K13377]
111663130  pgf; placenta growth factor [KO:K16859]
111663201  rasgrp1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
111663204  [KO:K04379]
111663215  [KO:K04453]
111663254  [KO:K04868]
111663270  [KO:K19662] [EC:2.7.11.13]
111663289  gna12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
111663309  [KO:K02187] [EC:3.4.22.56]
111663357  il1rap; interleukin-1 receptor accessory protein [KO:K04723]
111663363  [KO:K04439]
111663462  [KO:K04358]
111663602  [KO:K04358]
111663642  [KO:K04861]
111663653  [KO:K05461]
111663802  [KO:K17534] [EC:2.7.11.25]
111663926  [KO:K16510] [EC:2.7.11.1]
111663958  hspb1; heat shock protein beta-1 [KO:K04455]
111664155  tgfb2; transforming growth factor beta-2 [KO:K13376]
111664160  [KO:K05448]
111664183  [KO:K04388] [EC:2.7.11.30]
111664218  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
111664323  [KO:K04433] [EC:2.7.12.2]
111664334  rac3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
111664391  [KO:K04466] [EC:2.7.11.25]
111664458  [KO:K04454]
111664470  [KO:K04362] [EC:2.7.10.1]
111664577  [KO:K05091] [EC:2.7.10.1]
111664630  [KO:K04526]
111664700  igf1; insulin-like growth factor I [KO:K05459]
111664735  [KO:K04429] [EC:2.7.11.1]
111664767  [KO:K04455]
111664771  [KO:K04440] [EC:2.7.11.24]
111664857  gdnf; glial cell line-derived neurotrophic factor [KO:K05452]
111664872  [KO:K03173] [EC:2.3.2.27]
111664909  [KO:K04381]
111664988  [KO:K03283]
111665025  ptprr; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
111665163  [KO:K04863]
111665293  erbb4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
111665294  [KO:K04865]
111665367  [KO:K05449]
111665447  [KO:K04456] [EC:2.7.11.1]
111665471  [KO:K04362] [EC:2.7.10.1]
111665555  prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
111665614  [KO:K02580]
111665625  [KO:K04344]
111665643  [KO:K25416]
111665702  [KO:K04393]
111665874  [KO:K04410] [EC:2.7.11.1]
111665903  sos2; son of sevenless homolog 2 [KO:K03099]
111665990  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
111666015  [KO:K03173] [EC:2.3.2.27]
111666035  [KO:K12326]
111666059  [KO:K22428]
111666074  [KO:K04519]
111666097  [KO:K04358]
111666135  [KO:K04348] [EC:3.1.3.16]
111666336  [KO:K04389]
111666345  [KO:K05096] [EC:2.7.10.1]
111666541  jun; transcription factor AP-1 [KO:K04448]
111666638  [KO:K04358]
111666877  [KO:K03158]
111667016  map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
111667052  [KO:K04349]
111667084  [KO:K04430] [EC:2.7.12.2]
111667188  [KO:K04443] [EC:2.7.11.1]
111667284  [KO:K04441] [EC:2.7.11.24]
111667336  [KO:K04441] [EC:2.7.11.24]
111667451  mras; ras-related protein M-Ras [KO:K07831]
111667531  [KO:K04870]
111667536  [KO:K04392]
111667551  pdgfa; platelet-derived growth factor subunit A [KO:K04359]
111667575  [KO:K02677] [EC:2.7.11.13]
111667597  [KO:K02187] [EC:3.4.22.56]
111667598  [KO:K04407] [EC:2.7.11.1]
111667674  [KO:K04441] [EC:2.7.11.24]
111667775  [KO:K04465]
111667810  mapkapk2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
111667812  erbb3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
111667875  [KO:K04444] [EC:2.7.11.1]
111667942  arrb2; beta-arrestin-2 [KO:K04439]
111667961  ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
111667984  map4k2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
111668243  [KO:K05462]
111668292  bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
111668520  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111668535  map3k20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
111668619  [KO:K04857]
111668623  [KO:K04393]
111668637  elk4; ETS domain-containing protein Elk-4 isoform X1 [KO:K04376]
111668898  [KO:K05084] [EC:2.7.10.1]
111668912  [KO:K04857]
111668970  [KO:K04860]
111669009  [KO:K02582]
111669127  [KO:K04527] [EC:2.7.10.1]
111669238  map3k8; mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
111669267  fgf4; fibroblast growth factor 4 [KO:K04358]
111669279  fgf3; fibroblast growth factor 3 [KO:K04358]
111669309  fgf19; fibroblast growth factor 19 [KO:K22603]
111669329  [KO:K04402]
111669331  [KO:K04402]
111669451  fgf8; fibroblast growth factor 8 isoform X1 [KO:K04358]
111669539  ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
111669627  [KO:K04375]
111669629  [KO:K04853]
111669721  pla2g4c; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
111669797  [KO:K04439]
111669824  [KO:K19663] [EC:2.7.11.13]
111669837  [KO:K04872]
111669879  cacng6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
111669911  [KO:K03158]
111669926  [KO:K04393]
111669944  [KO:K04873]
111670053  [KO:K04390]
111670187  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111670210  map3k12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
111670445  map3k11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
111670446  rela; transcription factor p65 isoform X1 [KO:K04735]
111670673  [KO:K04441] [EC:2.7.11.24]
111670707  [KO:K04851]
111670746  [KO:K03283]
111670810  [KO:K04864]
111670948  [KO:K04444] [EC:2.7.11.1]
111671081  [KO:K25415]
111671104  [KO:K04424] [EC:2.7.11.25]
111671132  [KO:K04449]
111671142  [KO:K05089] [EC:2.7.10.1]
111671143  [KO:K05090] [EC:2.7.10.1]
111671162  [KO:K04348] [EC:3.1.3.16]
111671237  mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
111671297  [KO:K04438]
111671514  map3k13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
111671542  [KO:K04864]
111671627  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
111671679  [KO:K25415]
111671826  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
111671828  [KO:K04374]
111671834  [KO:K04867]
111671870  [KO:K04856]
111671871  [KO:K07860]
111671879  angpt1; angiopoietin-1 isoform X1 [KO:K05465]
111671895  [KO:K04861]
111671911  [KO:K05460]
111671920  [KO:K04858]
111671959  [KO:K04389]
111671973  [KO:K04448]
111672005  rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
111672059  [KO:K18496]
111672131  [KO:K04526]
111672169  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
111672175  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
111672203  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
111672288  [KO:K05087] [EC:2.7.10.1]
111672426  map3k2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
111672585  vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
111672600  [KO:K16859]
111672807  [KO:K05866] [EC:3.1.3.48]
111673055  [KO:K04674] [EC:2.7.11.30]
111673084  [KO:K04402]
111673092  [KO:K05462]
111673106  [KO:K04445] [EC:2.7.11.1]
111673263  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111673299  [KO:K05466]
111673361  ptpn7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
111673426  [KO:K04359]
111673435  [KO:K17386]
111673746  grb2; growth factor receptor-bound protein 2 [KO:K04364]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
slal04070  Phosphatidylinositol signaling system
slal04110  Cell cycle
slal04115  p53 signaling pathway
slal04210  Apoptosis
slal04310  Wnt signaling pathway
KO pathway
ko04010   

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