KEGG   PATHWAY: soy04141
Entry
soy04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Sitophilus oryzae (rice weevil)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
soy04141  Protein processing in endoplasmic reticulum
soy04141

Other DBs
GO: 0030433 0034976
Organism
Sitophilus oryzae (rice weevil) [GN:soy]
Gene
115886579  protein transport protein Sec61 subunit alpha [KO:K10956]
115881283  protein transport protein Sec61 subunit beta [KO:K09481]
115874263  translocation protein SEC62 [KO:K12275]
115877494  translocation protein SEC63 homolog [KO:K09540]
115884121  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 [KO:K12666]
115875439  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [KO:K12667]
115889372  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
115880216  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
115880314  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
115876373  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
115888153  tumor suppressor candidate 3 [KO:K19478]
115877549  oligosaccharyltransferase complex subunit ostc-B [KO:K26501]
115889614  mannosyl-oligosaccharide glucosidase [KO:K01228] [EC:3.2.1.106]
115888088  ribosome-binding protein 1 isoform X1 [KO:K14000]
115881288  nucleotide exchange factor SIL1-like [KO:K14001]
115891896  nucleotide exchange factor SIL1-like [KO:K14001]
115874742  hypoxia up-regulated protein 1 [KO:K09486]
115882663  endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
115880681  dnaJ homolog shv [KO:K09517]
115885460  dnaJ homolog subfamily C member 1 [KO:K09521]
115876484  dnaJ homolog subfamily C member 3 [KO:K09523]
115875562  dnaJ homolog subfamily C member 10-like isoform X1 [KO:K09530] [EC:1.8.4.-]
115886499  endoplasmin [KO:K09487]
115879909  neutral alpha-glucosidase AB [KO:K05546] [EC:3.2.1.207]
115881236  neutral alpha-glucosidase C-like [KO:K05546] [EC:3.2.1.207]
115891116  glucosidase 2 subunit beta [KO:K08288]
115888245  calnexin-like [KO:K08054]
115876636  protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
115886503  calreticulin [KO:K08057]
115886016  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA isoform X1 [KO:K01230] [EC:3.2.1.113]
115890163  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase [KO:K23741] [EC:3.2.1.209]
115884442  vesicular integral-membrane protein VIP36 [KO:K10082]
115879520  protein ERGIC-53 [KO:K10080]
115885593  prolactin regulatory element-binding protein isoform X1 [KO:K14003]
115884447  GTP-binding protein SAR1b isoform X1 [KO:K07953] [EC:3.6.5.-]
115884934  protein SEC13 homolog [KO:K14004]
115887961  protein transport protein Sec23A isoform X1 [KO:K14006]
115878385  protein transport protein Sec24A [KO:K14007]
115887838  protein transport protein Sec24C [KO:K14007]
115889519  UDP-glucose:glycoprotein glucosyltransferase isoform X1 [KO:K11718] [EC:2.4.1.-]
115891472  ER degradation-enhancing alpha-mannosidase-like protein 2 [KO:K10085]
115890123  LOW QUALITY PROTEIN: ER degradation-enhancing alpha-mannosidase-like protein 3 [KO:K10086]
115890086  protein disulfide-isomerase-like [KO:K09580] [EC:5.3.4.1]
115883552  protein disulfide-isomerase-like [KO:K09580] [EC:5.3.4.1]
115882349  protein disulfide-isomerase A6 homolog isoform X1 [KO:K09584] [EC:5.3.4.1]
115891131  thioredoxin domain-containing protein 5 homolog [KO:K13984] [EC:5.3.4.1]
115885736  ero1-like protein [KO:K10950] [EC:1.8.4.-]
115876970  endoplasmic reticulum lectin 1 [KO:K14008]
115882395  translocon-associated protein subunit alpha [KO:K13249]
115880441  translocon-associated protein subunit beta [KO:K13250]
115882522  translocon-associated protein subunit gamma [KO:K13251]
115876749  translocon-associated protein subunit delta [KO:K04571]
115875457  B-cell receptor-associated protein 31-like [KO:K14009]
115878978  translocating chain-associated membrane protein 1-like 1 [KO:K14010]
115884839  derlin-1 [KO:K11519]
115878826  derlin-2 [KO:K13989]
115879717  UBX domain-containing protein 1 [KO:K24348]
115889271  UBX domain-containing protein 4 isoform X1 [KO:K24348]
115888402  UBX domain-containing protein 6 [KO:K14011]
115874801  NSFL1 cofactor p47 isoform X1 [KO:K14012]
115880312  transitional endoplasmic reticulum ATPase TER94 [KO:K13525]
115875601  nuclear protein localization protein 4 homolog [KO:K14015]
115881597  ubiquitin recognition factor in ER-associated degradation protein 1 isoform X1 [KO:K14016]
115878848  heat shock protein 68-like [KO:K03283]
115889023  heat shock 70 kDa protein-like [KO:K03283]
115890005  heat shock cognate 71 kDa protein-like [KO:K03283]
115880627  heat shock protein 68-like [KO:K03283]
115880629  heat shock protein 68-like [KO:K03283]
115880725  heat shock 70 kDa protein-like [KO:K03283]
115891096  heat shock 70 kDa protein cognate 4 [KO:K03283]
115891184  heat shock 70 kDa protein cognate 4-like [KO:K03283]
115882076  heat shock 70 kDa protein cognate 2 [KO:K03283]
115882820  heat shock 70 kDa protein-like isoform X1 [KO:K03283]
115874365  heat shock protein 68-like [KO:K03283]
115878213  heat shock protein 68-like [KO:K03283]
115888062  heat shock protein 68-like [KO:K03283]
115888084  heat shock protein 68-like [KO:K03283]
115880806  dnaJ homolog subfamily A member 1 [KO:K09502]
115876249  dnaJ homolog subfamily A member 2-like [KO:K09503]
115882552  dnaJ protein homolog 1 [KO:K09507]
115891428  dnaJ homolog subfamily B member 12 [KO:K09518]
115875959  dnaJ homolog subfamily C member 5 homolog isoform X1 [KO:K09525]
115878742  heat shock protein 83 [KO:K04079]
115875897  heat shock 70 kDa protein 4 isoform X1 [KO:K09485]
115874057  BAG family molecular chaperone regulator 2 [KO:K09556]
115881681  hsp70-binding protein 1-like [KO:K09562]
115879819  protein lethal(2)essential for life isoform X1 [KO:K09542]
115882314  protein lethal(2)essential for life-like [KO:K09542]
115882469  protein lethal(2)essential for life-like [KO:K09542]
115882505  heat shock protein 27-like [KO:K09542]
115882527  protein lethal(2)essential for life-like [KO:K09542]
115882528  protein lethal(2)essential for life-like [KO:K09542]
115882529  protein lethal(2)essential for life-like [KO:K09542]
115880870  ubiquitin thioesterase OTU1 [KO:K13719] [EC:3.1.2.-]
115891868  LOW QUALITY PROTEIN: phospholipase A-2-activating protein-like [KO:K14018]
115874588  UV excision repair protein RAD23 homolog B [KO:K10839]
115882338  ubiquilin-4 [KO:K04523]
115890245  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase [KO:K01456] [EC:3.5.1.52]
115889731  ataxin-3-like [KO:K11863] [EC:3.4.22.-]
115884489  LOW QUALITY PROTEIN: ubiquitin conjugation factor E4 B-like [KO:K10597] [EC:2.3.2.27]
115875019  eukaryotic translation initiation factor 2-alpha kinase [KO:K08860] [EC:2.7.11.1]
115889356  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
115877808  activating transcription factor of chaperone isoform X1 [KO:K04374]
115874929  cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
115878082  wolframin isoform X1 [KO:K14020]
115889981  membrane-bound transcription factor site-1 protease isoform X1 [KO:K08653] [EC:3.4.21.112]
115883626  membrane-bound transcription factor site-2 protease [KO:K07765] [EC:3.4.24.85]
115886788  X-box-binding protein 1 [KO:K09027]
115881026  serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
115885179  mitogen-activated protein kinase kinase kinase 15 [KO:K04426] [EC:2.7.11.25]
115883425  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 7-like [KO:K04431] [EC:2.7.12.2]
115877401  dual specificity mitogen-activated protein kinase kinase 7-like [KO:K04431] [EC:2.7.12.2]
115881088  stress-activated protein kinase JNK isoform X1 [KO:K04440] [EC:2.7.11.24]
115879147  E3 ubiquitin-protein ligase MARCH6 [KO:K10661] [EC:2.3.2.27]
115879002  ubiquitin-conjugating enzyme E2 J1-like [KO:K10578] [EC:2.3.2.23]
115876471  ubiquitin-conjugating enzyme E2 J2-like [KO:K04554] [EC:2.3.2.23]
115885029  ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
115890198  ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
115877918  E3 ubiquitin-protein ligase synoviolin A isoform X1 [KO:K10601] [EC:2.3.2.27]
115877764  E3 ubiquitin-protein ligase RNF185-like [KO:K10666] [EC:2.3.2.27]
115882036  uncharacterized protein LOC115882036 [KO:K14025]
115880317  protein sel-1 homolog 1 [KO:K14026]
115874381  E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
115880045  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
115879800  E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
115874647  RING-box protein 1A [KO:K03868] [EC:2.3.2.32]
115874148  cullin-1-like [KO:K03347]
115882056  S-phase kinase-associated protein 1-like [KO:K03094]
115891049  LOW QUALITY PROTEIN: F-box only protein 44-like [KO:K10100]
115891561  F-box only protein 6-like [KO:K10100]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
soy00510  N-Glycan biosynthesis
soy03050  Proteasome
soy03060  Protein export
KO pathway
ko04141   
LinkDB

DBGET integrated database retrieval system