KEGG   PATHWAY: spen00053
Entry
spen00053                   Pathway                                
Name
Ascorbate and aldarate metabolism - Solanum pennellii
Class
Metabolism; Carbohydrate metabolism
Pathway map
spen00053  Ascorbate and aldarate metabolism
spen00053

Module
spen_M00114  Ascorbate biosynthesis, plants, fructose-6P => ascorbate [PATH:spen00053]
Other DBs
GO: 0019852 0019577 0019572
Organism
Solanum pennellii [GN:spen]
Gene
107022673  UDP-glucose 6-dehydrogenase 5-like [KO:K00012] [EC:1.1.1.22]
107009687  UDP-glucose 6-dehydrogenase 2 [KO:K00012] [EC:1.1.1.22]
107011368  UDP-glucose 6-dehydrogenase 3 [KO:K00012] [EC:1.1.1.22]
107014631  UDP-glucose 6-dehydrogenase 1-like [KO:K00012] [EC:1.1.1.22]
107018439  UDP-sugar pyrophosphorylase isoform X1 [KO:K12447] [EC:2.7.7.64]
107008640  glucuronokinase 1 [KO:K16190] [EC:2.7.1.43]
107031864  inositol oxygenase 1-like [KO:K00469] [EC:1.13.99.1]
107004244  inositol oxygenase 2-like [KO:K00469] [EC:1.13.99.1]
107004201  probable inositol oxygenase isoform X2 [KO:K00469] [EC:1.13.99.1]
107005771  inositol oxygenase 4 [KO:K00469] [EC:1.13.99.1]
107022581  inositol oxygenase 1-like [KO:K00469] [EC:1.13.99.1]
107005847  inositol oxygenase 5-like [KO:K00469] [EC:1.13.99.1]
107004247  probable inositol oxygenase [KO:K00469] [EC:1.13.99.1]
107029195  aldo-keto reductase family 4 member C10-like [KO:K00002] [EC:1.1.1.2]
107030686  aldose reductase [KO:K00002] [EC:1.1.1.2]
107027329  L-gulonolactone oxidase 3 [KO:K00103] [EC:1.1.3.8]
107029833  probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
107031214  GDP-mannose 3,5-epimerase 2 [KO:K10046] [EC:5.1.3.18 5.1.3.-]
107006921  GDP-mannose 3,5-epimerase 1 [KO:K10046] [EC:5.1.3.18 5.1.3.-]
107023056  GDP-L-galactose phosphorylase 2-like [KO:K14190] [EC:2.7.7.69]
107011245  GDP-L-galactose phosphorylase 2-like [KO:K14190] [EC:2.7.7.69]
107014064  LOW QUALITY PROTEIN: inositol monophosphatase 2-like [KO:K10047] [EC:3.1.3.25 3.1.3.93]
107016217  inositol monophosphatase 1 isoform X1 [KO:K10047] [EC:3.1.3.25 3.1.3.93]
107002996  inositol monophosphatase 3 [KO:K10047] [EC:3.1.3.25 3.1.3.93]
107004365  bifunctional phosphatase IMPL2, chloroplastic [KO:K18649] [EC:3.1.3.25 3.1.3.93 3.1.3.15]
107025374  bifunctional phosphatase IMPL2, chloroplastic-like [KO:K18649] [EC:3.1.3.25 3.1.3.93 3.1.3.15]
107006598  L-galactose dehydrogenase [KO:K17744] [EC:1.1.1.316]
107002402  L-galactono-1,4-lactone dehydrogenase, mitochondrial [KO:K00225] [EC:1.3.2.3]
107005177  UDP-glucuronate 4-epimerase 1-like [KO:K08679] [EC:5.1.3.6]
107018589  UDP-glucuronate 4-epimerase 3 [KO:K08679] [EC:5.1.3.6]
107019967  UDP-glucuronate 4-epimerase 6-like [KO:K08679] [EC:5.1.3.6]
107026026  UDP-glucuronate 4-epimerase 1 [KO:K08679] [EC:5.1.3.6]
107031906  UDP-glucuronate 4-epimerase 3-like [KO:K08679] [EC:5.1.3.6]
107012886  UDP-glucuronate 4-epimerase 2-like [KO:K08679] [EC:5.1.3.6]
107031284  UDP-glucuronate 4-epimerase 6 [KO:K08679] [EC:5.1.3.6]
107008171  UDP-glucuronate 4-epimerase 3 [KO:K08679] [EC:5.1.3.6]
107026957  UDP-glucuronate 4-epimerase 5 [KO:K08679] [EC:5.1.3.6]
107005484  UDP-glucuronate 4-epimerase 6-like [KO:K08679] [EC:5.1.3.6]
107005485  UDP-glucuronate 4-epimerase 6-like [KO:K08679] [EC:5.1.3.6]
107016409  D-galacturonate reductase-like [KO:K19642] [EC:1.1.1.365]
107028810  monodehydroascorbate reductase, chloroplastic/mitochondrial isoform X1 [KO:K08232] [EC:1.6.5.4]
107011268  monodehydroascorbate reductase 4, peroxisomal [KO:K08232] [EC:1.6.5.4]
107031233  monodehydroascorbate reductase [KO:K08232] [EC:1.6.5.4]
107029646  L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
107029648  L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
107023881  L-ascorbate peroxidase 1, cytosolic [KO:K00434] [EC:1.11.1.11]
107023536  L-ascorbate peroxidase 1, cytosolic-like [KO:K00434] [EC:1.11.1.11]
107023623  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial [KO:K00434] [EC:1.11.1.11]
107008867  L-ascorbate peroxidase 3-like [KO:K00434] [EC:1.11.1.11]
107029071  putative L-ascorbate peroxidase 6 isoform X2 [KO:K00434] [EC:1.11.1.11]
107005028  probable L-ascorbate peroxidase 6, chloroplastic/mitochondrial [KO:K00434] [EC:1.11.1.11]
107007774  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
107009391  L-ascorbate peroxidase 3 [KO:K00434] [EC:1.11.1.11]
107004866  glutathione S-transferase DHAR3, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
107020618  glutathione S-transferase DHAR2-like [KO:K21888] [EC:1.8.5.1 2.5.1.18]
107012865  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
107013548  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
107003297  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
107013895  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
107019029  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
107004828  L-ascorbate oxidase [KO:K00423] [EC:1.10.3.3]
107010225  L-ascorbate oxidase-like [KO:K00423] [EC:1.10.3.3]
107014538  aldehyde dehydrogenase family 2 member B7, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
107018675  aldehyde dehydrogenase family 2 member B7, mitochondrial [KO:K00128] [EC:1.2.1.3]
107011716  aldehyde dehydrogenase family 3 member F1 isoform X1 [KO:K00128] [EC:1.2.1.3]
107023702  aldehyde dehydrogenase family 3 member H1 [KO:K00128] [EC:1.2.1.3]
107008134  aldehyde dehydrogenase family 3 member F1-like [KO:K00128] [EC:1.2.1.3]
107011414  aldehyde dehydrogenase family 2 member B7, mitochondrial-like isoform X1 [KO:K00128] [EC:1.2.1.3]
107028772  aldehyde dehydrogenase family 2 member B7, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
107008790  glutaredoxin-C3-like [KO:K00128] [EC:1.2.1.3]
107014931  aldehyde dehydrogenase family 7 member B4 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
Compound
C00022  Pyruvate
C00026  2-Oxoglutarate
C00029  UDP-glucose
C00072  Ascorbate
C00096  GDP-mannose
C00137  myo-Inositol
C00167  UDP-glucuronate
C00191  D-Glucuronate
C00216  D-Arabinose
C00231  D-Xylulose 5-phosphate
C00259  L-Arabinose
C00333  D-Galacturonate
C00433  2,5-Dioxopentanoate
C00545  L-Arabinonate
C00558  D-Tagaturonate
C00617  UDP-D-galacturonate
C00618  3-Dehydro-L-gulonate
C00652  D-Arabinono-1,4-lactone
C00679  5-Dehydro-4-deoxy-D-glucarate
C00684  2-Dehydro-3-deoxy-L-arabinonate
C00800  L-Gulonate
C00818  D-Glucarate
C00878  D-Arabinonate
C00879  D-Galactarate
C01040  L-Gulono-1,4-lactone
C01041  Monodehydroascorbate
C01101  L-Ribulose 5-phosphate
C01114  L-Arabinono-1,4-lactone
C01115  L-Galactono-1,4-lactone
C01146  2-Hydroxy-3-oxopropanoate
C01620  Threonate
C01825  L-Galactose
C02280  GDP-L-galactose
C02670  D-Glucuronolactone
C03033  beta-D-Glucuronoside
C03064  3-Dehydro-L-threonate
C03289  L-xylo-Hexulonolactone
C03291  L-Xylulose 5-phosphate
C03826  2-Dehydro-3-deoxy-D-xylonate
C03921  2-Dehydro-3-deoxy-D-glucarate
C04037  1-Phospho-alpha-D-galacturonate
C04575  (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
C05385  D-Glucuronate 1-phosphate
C05411  L-Xylonate
C05412  L-Lyxonate
C05422  Dehydroascorbate
C06316  Dehydro-D-arabinono-1,4-lactone
C14899  3-Dehydro-L-gulonate 6-phosphate
C15923  L-Gulose
C15924  L-Gulose 1-phosphate
C15925  GDP-L-gulose
C15926  beta-L-Galactose 1-phosphate
C15930  L-Galactonate
C16186  L-Ascorbate 6-phosphate
C20889  D-Galactaro-1,5-lactone
C20896  D-Galactaro-1,4-lactone
C21955  L-Galactono-1,5-lactone
Reference
PMID:17222174
  Authors
Linster CL, Van Schaftingen E
  Title
Vitamin C. Biosynthesis, recycling and degradation in mammals.
  Journal
FEBS J 274:1-22 (2007)
DOI:10.1111/j.1742-4658.2006.05607.x
Reference
PMID:15564123
  Authors
Valpuesta V, Botella MA.
  Title
Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.
  Journal
Trends Plant Sci 9:573-7 (2004)
DOI:10.1016/j.tplants.2004.10.002
Reference
PMID:10517845
  Authors
Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.
  Title
Ascorbate biosynthesis in Arabidopsis cell suspension culture.
  Journal
Plant Physiol 121:535-43 (1999)
DOI:10.1104/pp.121.2.535
Reference
PMID:16595667
  Authors
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  Title
Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  Journal
J Biol Chem 281:15662-70 (2006)
DOI:10.1074/jbc.M601409200
Reference
PMID:17462988
  Authors
Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  Title
Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  Journal
J Biol Chem 282:18879-85 (2007)
DOI:10.1074/jbc.M702094200
Reference
PMID:14996803
  Authors
Campos E, Baldoma L, Aguilar J, Badia J.
  Title
Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.
  Journal
J Bacteriol 186:1720-8 (2004)
DOI:10.1128/JB.186.6.1720-1728.2004
Reference
PMID:12644495
  Authors
Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.
  Title
The ascorbate transporter of Escherichia coli.
  Journal
J Bacteriol 185:2243-50 (2003)
DOI:10.1128/JB.185.7.2243-2250.2003
Related
pathway
spen00020  Citrate cycle (TCA cycle)
spen00040  Pentose and glucuronate interconversions
spen00051  Fructose and mannose metabolism
spen00520  Amino sugar and nucleotide sugar metabolism
spen00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00053   
LinkDB

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