KEGG   PATHWAY: spen00260
Entry
spen00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Solanum pennellii
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
spen00260  Glycine, serine and threonine metabolism
spen00260

Module
spen_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:spen00260]
spen_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:spen00260]
spen_M00555  Betaine biosynthesis, choline => betaine [PATH:spen00260]
spen_M00621  Glycine cleavage system [PATH:spen00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Solanum pennellii [GN:spen]
Gene
107003598  aspartokinase 2, chloroplastic-like isoform X1 [KO:K00928] [EC:2.7.2.4]
107023089  bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic-like [KO:K12524] [EC:2.7.2.4 1.1.1.3]
107004589  bifunctional aspartokinase/homoserine dehydrogenase, chloroplastic-like isoform X1 [KO:K12524] [EC:2.7.2.4 1.1.1.3]
107003617  uncharacterized protein LOC107003617 [KO:K00133] [EC:1.2.1.11]
107018408  homoserine kinase-like [KO:K00872] [EC:2.7.1.39]
107008113  homoserine kinase-like [KO:K00872] [EC:2.7.1.39]
107023188  threonine synthase, chloroplastic-like [KO:K01733] [EC:4.2.3.1]
107014407  threonine synthase, chloroplastic [KO:K01733] [EC:4.2.3.1]
107015676  probable low-specificity L-threonine aldolase 1 [KO:K01620] [EC:4.1.2.48]
107028019  serine hydroxymethyltransferase 3, chloroplastic-like [KO:K00600] [EC:2.1.2.1]
107020327  serine hydroxymethyltransferase 4 [KO:K00600] [EC:2.1.2.1]
107007366  serine hydroxymethyltransferase 3, chloroplastic-like [KO:K00600] [EC:2.1.2.1]
107010969  serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
107007701  serine hydroxymethyltransferase 4-like [KO:K00600] [EC:2.1.2.1]
107007833  serine hydroxymethyltransferase 7-like [KO:K00600] [EC:2.1.2.1]
107007093  serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
107004123  glycerate dehydrogenase [KO:K15893] [EC:1.1.1.29]
107027947  glyoxylate/hydroxypyruvate reductase HPR3-like [KO:K15919] [EC:1.1.1.79 1.1.1.81]
107009771  glyoxylate/hydroxypyruvate reductase HPR3-like [KO:K15919] [EC:1.1.1.79 1.1.1.81]
107018099  uncharacterized protein LOC107018099 [KO:K01834] [EC:5.4.2.11]
107016295  uncharacterized protein LOC107016295 isoform X3 [KO:K01834] [EC:5.4.2.11]
107008851  phosphoglycerate mutase-like protein 4 isoform X1 [KO:K15634] [EC:5.4.2.11]
107025856  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
107014459  D-glycerate 3-kinase, chloroplastic-like [KO:K15918] [EC:2.7.1.31]
107013660  D-glycerate 3-kinase, chloroplastic-like [KO:K15918] [EC:2.7.1.31]
107014730  D-3-phosphoglycerate dehydrogenase 3, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
107014487  D-3-phosphoglycerate dehydrogenase 3, chloroplastic-like [KO:K00058] [EC:1.1.1.95 1.1.1.399]
107032194  D-3-phosphoglycerate dehydrogenase 1, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
107011587  phosphoserine aminotransferase 2, chloroplastic-like [KO:K00831] [EC:2.6.1.52]
107023496  phosphoserine phosphatase, chloroplastic isoform X1 [KO:K01079] [EC:3.1.3.3]
107022669  uncharacterized protein LOC107022669 [KO:K00276] [EC:1.4.3.21]
107027112  uncharacterized protein LOC107027112 [KO:K00276] [EC:1.4.3.21]
107030611  primary amine oxidase 1-like [KO:K00276] [EC:1.4.3.21]
107020357  uncharacterized protein LOC107020357 [KO:K00276] [EC:1.4.3.21]
107012994  primary amine oxidase 1 [KO:K00276] [EC:1.4.3.21]
107030474  LOW QUALITY PROTEIN: primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
107028398  primary amine oxidase-like [KO:K00276] [EC:1.4.3.21]
107027939  glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
107011011  aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
107020311  dihydrolipoyl dehydrogenase 1, mitochondrial [KO:K00382] [EC:1.8.1.4]
107007335  dihydrolipoyl dehydrogenase, mitochondrial-like [KO:K00382] [EC:1.8.1.4]
107002080  dihydrolipoyl dehydrogenase 2, chloroplastic-like [KO:K00382] [EC:1.8.1.4]
107020411  dihydrolipoyl dehydrogenase 1, chloroplastic-like isoform X1 [KO:K00382] [EC:1.8.1.4]
107009145  glycine cleavage system H protein 2, mitochondrial [KO:K02437]
107023420  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
107028767  glycine cleavage system H protein, mitochondrial-like [KO:K02437]
107017796  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
107032369  alanine--glyoxylate aminotransferase 2 homolog 2, mitochondrial-like [KO:K00827] [EC:2.6.1.44 2.6.1.40]
107020278  glutamate--glyoxylate aminotransferase 2 [KO:K14272] [EC:2.6.1.4 2.6.1.2 2.6.1.44]
107028658  glutamate--glyoxylate aminotransferase 2-like [KO:K14272] [EC:2.6.1.4 2.6.1.2 2.6.1.44]
107024144  choline monooxygenase, chloroplastic-like [KO:K00499] [EC:1.14.15.7]
107025561  choline monooxygenase, chloroplastic-like [KO:K00499] [EC:1.14.15.7]
107014316  betaine aldehyde dehydrogenase, chloroplastic [KO:K00130] [EC:1.2.1.8]
107021296  betaine aldehyde dehydrogenase, chloroplastic-like [KO:K00130] [EC:1.2.1.8]
107014931  aldehyde dehydrogenase family 7 member B4 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
107026843  probable sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
107029285  threonine dehydratase 2 biosynthetic, chloroplastic [KO:K01754] [EC:4.3.1.19]
107001633  threonine dehydratase 1 biosynthetic, chloroplastic-like [KO:K01754] [EC:4.3.1.19]
107002306  threonine dehydratase 1 biosynthetic, chloroplastic isoform X2 [KO:K01754] [EC:4.3.1.19]
107028643  serine racemase isoform X1 [KO:K12235] [EC:5.1.1.18]
107028645  serine racemase-like [KO:K12235] [EC:5.1.1.18]
107028646  serine racemase-like isoform X1 [KO:K12235] [EC:5.1.1.18]
107001745  tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
107002037  tryptophan synthase beta chain 1-like [KO:K01696] [EC:4.2.1.20]
107002507  tryptophan synthase beta chain 1 [KO:K01696] [EC:4.2.1.20]
107025901  tryptophan synthase beta chain 1-like [KO:K01696] [EC:4.2.1.20]
107007604  uncharacterized protein LOC107007604 [KO:K06001] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
spen00010  Glycolysis / Gluconeogenesis
spen00020  Citrate cycle (TCA cycle)
spen00230  Purine metabolism
spen00250  Alanine, aspartate and glutamate metabolism
spen00270  Cysteine and methionine metabolism
spen00290  Valine, leucine and isoleucine biosynthesis
spen00300  Lysine biosynthesis
spen00330  Arginine and proline metabolism
spen00460  Cyanoamino acid metabolism
spen00470  D-Amino acid metabolism
spen00564  Glycerophospholipid metabolism
spen00600  Sphingolipid metabolism
spen00620  Pyruvate metabolism
spen00630  Glyoxylate and dicarboxylate metabolism
spen00640  Propanoate metabolism
spen00860  Porphyrin metabolism
spen00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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