KEGG   PATHWAY: ssen03440
Entry
ssen03440                   Pathway                                
Name
Homologous recombination - Solea senegalensis (Senegalese sole)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
ssen03440  Homologous recombination
ssen03440

Other DBs
GO: 0000724
Organism
Solea senegalensis (Senegalese sole) [GN:ssen]
Gene
122765986  ssbp1; single-stranded DNA-binding protein, mitochondrial [KO:K03111]
122779951  rad50; DNA repair protein RAD50 isoform X1 [KO:K10866] [EC:3.6.-.-]
122773214  mre11a; double-strand break repair protein MRE11 [KO:K10865]
122774845  nbn; nibrin [KO:K10867]
122773479  atm; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
122758997  breast cancer type 1 susceptibility protein-like [KO:K10605] [EC:2.3.2.27]
122763523  bard1; BRCA1-associated RING domain protein 1 [KO:K10683]
122779630  rbbp8; DNA endonuclease RBBP8 [KO:K20773] [EC:3.1.-.-]
122773951  brip1; Fanconi anemia group J protein isoform X1 [KO:K15362] [EC:5.6.2.3]
122778876  topbp1; DNA topoisomerase 2-binding protein 1 isoform X1 [KO:K10728]
122787043  abraxas1; BRCA1-A complex subunit Abraxas 1 [KO:K20774]
122780043  uimc1; uncharacterized protein uimc1 isoform X1 [KO:K20775]
122780358  babam1; BRISC and BRCA1-A complex member 1 [KO:K20776]
122783174  babam2; BRISC and BRCA1-A complex member 2 [KO:K12173]
122758124  brcc3; lys-63-specific deubiquitinase BRCC36 [KO:K11864] [EC:3.4.19.-]
122770474  palb2; partner and localizer of BRCA2 isoform X1 [KO:K10897]
122773327  brca2; breast cancer type 2 susceptibility protein isoform X1 [KO:K08775]
122760157  sem1; 26S proteasome complex subunit SEM1 [KO:K10881]
122775802  sycp3; synaptonemal complex protein 3 isoform X1 [KO:K19528]
122779791  replication protein A 70 kDa DNA-binding subunit-like isoform X1 [KO:K07466]
122774033  rpa1; replication protein A 70 kDa DNA-binding subunit [KO:K07466]
122774711  rpa2; replication protein A 32 kDa subunit isoform X1 [KO:K10739]
122786097  replication protein A 32 kDa subunit-like [KO:K10739]
122786495  rpa3; replication protein A 14 kDa subunit [KO:K10740]
122784153  rad51; DNA repair protein RAD51 homolog 1 [KO:K04482]
122776196  rad52; DNA repair protein RAD52 homolog [KO:K10873]
122777298  rad51c; DNA repair protein RAD51 homolog 3 [KO:K10870]
122779192  rad51d; DNA repair protein RAD51 homolog 4 [KO:K10871]
122759113  xrcc2; DNA repair protein XRCC2 isoform X1 [KO:K10879]
122783878  xrcc3; DNA repair protein XRCC3 isoform X1 [KO:K10880]
122780410  DNA repair and recombination protein RAD54-like [KO:K10875] [EC:5.6.2.-]
122781275  DNA repair and recombination protein RAD54-like [KO:K10875] [EC:5.6.2.-]
122775003  rad54b; DNA repair and recombination protein RAD54B [KO:K10877] [EC:5.6.2.-]
122785919  pold1; DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]
122769736  pold2; DNA polymerase delta subunit 2 [KO:K02328]
122768456  pold3; DNA polymerase delta subunit 3 isoform X1 [KO:K03504]
122770904  pold4; DNA polymerase delta subunit 4 [KO:K03505]
122775624  blm; Bloom syndrome protein homolog isoform X1 [KO:K10901] [EC:5.6.2.4]
122770105  top3b; DNA topoisomerase 3-beta-1 [KO:K03165] [EC:5.6.2.1]
122785538  top3a; DNA topoisomerase 3-alpha [KO:K03165] [EC:5.6.2.1]
122765913  mus81; crossover junction endonuclease MUS81 [KO:K08991] [EC:3.1.22.-]
122758863  eme1; crossover junction endonuclease EME1 isoform X1 [KO:K10882] [EC:3.1.22.-]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   
LinkDB

DBGET integrated database retrieval system