KEGG   PATHWAY: svg04514
Entry
svg04514                    Pathway                                
Name
Cell adhesion molecules - Sturnus vulgaris (common starling)
Description
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
svg04514  Cell adhesion molecules
svg04514

Other DBs
GO: 0050839
Organism
Sturnus vulgaris (common starling) [GN:svg]
Gene
106860838  uncharacterized protein LOC106860838 isoform X1 [KO:K06492]
106857019  CD2; T-cell surface antigen CD2 [KO:K06449]
106857311  platelet receptor Gi24 [KO:K23268]
106861697  IGSF11; LOW QUALITY PROTEIN: immunoglobulin superfamily member 11 [KO:K06791]
106857016  CD80; T-lymphocyte activation antigen CD80 [KO:K05412]
106854007  programmed cell death 1 ligand 1-like isoform X1 [KO:K06745]
106855553  CD28; T-cell-specific surface glycoprotein CD28 [KO:K06470]
106857823  CD86; T-lymphocyte activation antigen CD86 [KO:K05413]
106855552  CTLA4; cytotoxic T-lymphocyte protein 4 [KO:K06538]
106853529  ICOSLG; ICOS ligand [KO:K06710]
106855551  inducible T-cell costimulator-like [KO:K06713]
106863901  class II histocompatibility antigen, B-L beta chain-like [KO:K06752]
106864545  LOW QUALITY PROTEIN: class II histocompatibility antigen, B-L beta chain-like [KO:K06752]
106857890  CD4; T-cell surface glycoprotein CD4 isoform X1 [KO:K06454]
106864610  LOW QUALITY PROTEIN: class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
106864696  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
106864697  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
106853168  CD8B; T-cell surface glycoprotein CD8 beta chain [KO:K06459]
106853735  PDCD1LG2; programmed cell death 1 ligand 2 isoform X1 [KO:K06708]
106861078  CD276; CD276 antigen isoform X1 [KO:K06746]
106860844  LOW QUALITY PROTEIN: V-set domain-containing T-cell activation inhibitor 1-like [KO:K06747]
106850412  PDCD1; programmed cell death protein 1 [KO:K06744]
106860881  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
106858386  CD40LG; CD40 ligand [KO:K03161]
106861370  ALCAM; CD166 antigen [KO:K06547]
106862600  ITGB2; integrin beta-2 [KO:K06464]
106858813  PTPRC; receptor-type tyrosine-protein phosphatase C [KO:K06478] [EC:3.1.3.48]
106861240  SIGLEC1; sialoadhesin [KO:K06548]
106856587  PVRL3; nectin-3 [KO:K06592]
106852803  CLDN12; claudin-12 [KO:K06087]
106862521  CLDN16; claudin-16 [KO:K06087]
106862527  CLDN1; claudin-1 [KO:K06087]
106858146  CLDN25; putative claudin-25 [KO:K06087]
106853779  CLDN2; claudin-2 [KO:K06087]
106859045  CLDN20; claudin-20 [KO:K06087]
106864847  CLDN5; claudin-5 [KO:K06087]
106859633  CLDN11; claudin-11 [KO:K06087]
106849593  claudin-19-like isoform X1 [KO:K06087]
106849718  CLDN18; claudin-18 isoform X1 [KO:K06087]
106860423  CLDN23; claudin-23 [KO:K06087]
106855644  claudin-22-like [KO:K06087]
106855732  CLDN14; claudin-14 [KO:K06087]
106856185  CLDN10; claudin-10 isoform X1 [KO:K06087]
106856250  claudin-4-like [KO:K06087]
106856251  claudin-4-like [KO:K06087]
106856278  claudin-3-like [KO:K06087]
106856368  claudin-16-like [KO:K06087]
106856379  CLDN19; claudin-19 [KO:K06087]
106856813  CLDN34; claudin-34 [KO:K06087]
106857034  OCLN; occludin [KO:K06088]
106863870  F11R; junctional adhesion molecule A [KO:K06089]
106859391  JAM2; junctional adhesion molecule B [KO:K06735]
106857484  JAM3; junctional adhesion molecule C [KO:K06785]
106860771  ESAM; endothelial cell-selective adhesion molecule [KO:K06787]
106860188  CDH5; cadherin-5 [KO:K06533]
106856962  PECAM1; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
106862844  XG; glycoprotein Xg [KO:K06520]
106856303  CD99L2; CD99 antigen-like protein 2 [KO:K06520]
106852322  SELPLG; P-selectin glycoprotein ligand 1 [KO:K06544]
106852223  P-selectin-like [KO:K06496]
106855543  ITGA4; integrin alpha-4 [KO:K06483]
106855573  ITGB1; integrin beta-1 [KO:K05719]
106853670  ITGA9; integrin alpha-9 [KO:K06585]
106858415  VCAM1; vascular cell adhesion protein 1 [KO:K06527]
106857071  MADCAM1; mucosal addressin cell adhesion molecule 1 [KO:K06779]
106850973  CD34; hematopoietic progenitor cell antigen CD34 [KO:K06474]
106855827  GLG1; Golgi apparatus protein 1 [KO:K06816]
106852209  SELE; E-selectin [KO:K06494]
106863282  nectin-1-like [KO:K06081]
106851954  CDH2; cadherin-2 [KO:K06736]
106858126  NCAM1; neural cell adhesion molecule 1 [KO:K06491]
106857495  NCAM2; neural cell adhesion molecule 2 [KO:K06491]
106863827  L1CAM; neural cell adhesion molecule L1 [KO:K06550]
106858133  CADM1; cell adhesion molecule 1 [KO:K06781]
106862556  NEGR1; neuronal growth regulator 1 [KO:K06775]
106858587  NTNG1; netrin-G1 [KO:K07522]
106851562  LRRC4C; leucine-rich repeat-containing protein 4C [KO:K07523]
106851408  NTNG2; netrin-G2 [KO:K16359]
106861996  LRRC4; leucine-rich repeat-containing protein 4 [KO:K16351]
106850643  PTPRF; receptor-type tyrosine-protein phosphatase F isoform X1 [KO:K05695] [EC:3.1.3.48]
106864318  LRRC4B; leucine-rich repeat-containing protein 4B [KO:K16360]
106865081  SDC1; syndecan-1 [KO:K06257]
106855270  SDC2; syndecan-2 [KO:K16336]
106859982  SDC3; syndecan-3 [KO:K16337]
106857752  SDC4; syndecan-4 isoform X1 [KO:K16338]
106855922  ITGAV; integrin alpha-V [KO:K06487]
106864738  ITGB8; integrin beta-8 [KO:K06591]
106852788  ITGA8; integrin alpha-8 [KO:K06584]
106863843  neurexin-2-like [KO:K07377]
106849307  NRXN3; neurexin 3 isoform X1 [KO:K07377]
106857274  NRXN1; neurexin-1-beta [KO:K07377]
106858071  NLGN4X; neuroligin-4, X-linked isoform X1 [KO:K07378]
106853753  NLGN3; neuroligin-3 isoform X1 [KO:K07378]
106850299  NLGN1; neuroligin-1 isoform X1 [KO:K07378]
106859678  PTPRS; receptor-type tyrosine-protein phosphatase S [KO:K06778] [EC:3.1.3.48]
106850008  SLITRK1; SLIT and NTRK-like protein 1 [KO:K25832]
106862087  SLITRK2; SLIT and NTRK-like protein 2 [KO:K25833]
106862088  SLITRK4; SLIT and NTRK-like protein 4 [KO:K25835]
106855719  SLITRK5; SLIT and NTRK-like protein 5 [KO:K25836]
106855720  SLITRK6; SLIT and NTRK-like protein 6 [KO:K25837]
106852575  PTPRD; receptor-type tyrosine-protein phosphatase delta [KO:K06777] [EC:3.1.3.48]
106858076  SLITRK3; SLIT and NTRK-like protein 3 [KO:K25834]
106861092  CADM3; cell adhesion molecule 3 [KO:K06780]
106850094  NRCAM; neuronal cell adhesion molecule isoform X1 [KO:K06756]
106850093  CNTN1; contactin-1 [KO:K06759]
106850136  PTPRM; receptor-type tyrosine-protein phosphatase mu isoform X1 [KO:K05693] [EC:3.1.3.48]
106850946  CNTN2; contactin-2 [KO:K06760]
106850912  NFASC; neurofascin [KO:K06757]
106858622  CNTNAP1; contactin-associated protein 1 [KO:K07379]
106860686  CNTNAP2; contactin-associated protein-like 2 [KO:K07380]
106862338  MPZ; myelin protein P0 [KO:K06770]
106861285  CDH1; cadherin-1 [KO:K05689]
106859348  VCAN; versican core protein isoform X1 [KO:K06793]
106855475  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
106852109  B-cadherin-like [KO:K06796]
106851692  CDH4; cadherin-4 [KO:K06797]
106852027  CDH15; cadherin-15 [KO:K06809]
106861053  NEO1; neogenin [KO:K06766]
Reference
PMID:14690046
  Authors
Barclay AN.
  Title
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
  Journal
Semin Immunol 15:215-23 (2003)
DOI:10.1016/S1044-5323(03)00047-2
Reference
PMID:11910893
  Authors
Sharpe AH, Freeman GJ.
  Title
The B7-CD28 superfamily.
  Journal
Nat Rev Immunol 2:116-26 (2002)
DOI:10.1038/nri727
Reference
PMID:9597126
  Authors
Grewal IS, Flavell RA.
  Title
CD40 and CD154 in cell-mediated immunity.
  Journal
Annu Rev Immunol 16:111-35 (1998)
DOI:10.1146/annurev.immunol.16.1.111
Reference
PMID:16034094
  Authors
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
  Title
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
  Journal
J Immunol 175:1558-65 (2005)
DOI:10.4049/jimmunol.175.3.1558
Reference
PMID:12234363
  Authors
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
  Title
Cell adhesion and polarity during immune interactions.
  Journal
Immunol Rev 186:68-82 (2002)
DOI:10.1034/j.1600-065X.2002.18607.x
Reference
PMID:15071551
  Authors
Dejana E.
  Title
Endothelial cell-cell junctions: happy together.
  Journal
Nat Rev Mol Cell Biol 5:261-70 (2004)
DOI:10.1038/nrm1357
Reference
PMID:14519386
  Authors
Bazzoni G.
  Title
The JAM family of junctional adhesion molecules.
  Journal
Curr Opin Cell Biol 15:525-30 (2003)
DOI:10.1016/S0955-0674(03)00104-2
Reference
PMID:10798271
  Authors
Becker BF, Heindl B, Kupatt C, Zahler S.
  Title
Endothelial function and hemostasis.
  Journal
Z Kardiol 89:160-7 (2000)
DOI:10.1007/PL00007320
Reference
PMID:9150551
  Authors
Elangbam CS, Qualls CW Jr, Dahlgren RR.
  Title
Cell adhesion molecules--update.
  Journal
Vet Pathol 34:61-73 (1997)
DOI:10.1177/030098589703400113
Reference
PMID:12810109
  Authors
Muller WA.
  Title
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
  Journal
Trends Immunol 24:327-34 (2003)
DOI:10.1016/S1471-4906(03)00117-0
Reference
PMID:14519398
  Authors
Yamagata M, Sanes JR, Weiner JA.
  Title
Synaptic adhesion molecules.
  Journal
Curr Opin Cell Biol 15:621-32 (2003)
DOI:10.1016/S0955-0674(03)00107-8
Reference
PMID:15882774
  Authors
Ethell IM, Pasquale EB.
  Title
Molecular mechanisms of dendritic spine development and remodeling.
  Journal
Prog Neurobiol 75:161-205 (2005)
DOI:10.1016/j.pneurobio.2005.02.003
Reference
PMID:11050419
  Authors
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
  Title
Making memories stick: cell-adhesion molecules in synaptic plasticity.
  Journal
Trends Cell Biol 10:473-82 (2000)
DOI:10.1016/S0962-8924(00)01838-9
Reference
PMID:11860281
  Authors
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
  Title
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
  Journal
Mol Cell Neurosci 19:292-306 (2002)
DOI:10.1006/mcne.2001.1071
Reference
PMID:10964748
  Authors
Dunican DJ, Doherty P.
  Title
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
  Journal
Mol Cell Biol Res Commun 3:255-63 (2000)
DOI:10.1006/mcbr.2000.0225
Reference
PMID:12367625
  Authors
Girault JA, Peles E.
  Title
Development of nodes of Ranvier.
  Journal
Curr Opin Neurobiol 12:476-85 (2002)
DOI:10.1016/S0959-4388(02)00370-7
Reference
PMID:10664064
  Authors
Arroyo EJ, Scherer SS.
  Title
On the molecular architecture of myelinated fibers.
  Journal
Histochem Cell Biol 113:1-18 (2000)
DOI:10.1007/s004180050001
Reference
PMID:14556710
  Authors
Salzer JL.
  Title
Polarized domains of myelinated axons.
  Journal
Neuron 40:297-318 (2003)
DOI:10.1016/S0896-6273(03)00628-7
Reference
PMID:15561584
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Reference
PMID:15551862
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
PMID:15115723
  Authors
Siu MK, Cheng CY.
  Title
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
  Journal
Biol Reprod 71:375-91 (2004)
DOI:10.1095/biolreprod.104.028225
Reference
PMID:15056568
  Authors
Lee NP, Cheng CY.
  Title
Adaptors, junction dynamics, and spermatogenesis.
  Journal
Biol Reprod 71:392-404 (2004)
DOI:10.1095/biolreprod.104.027268
Reference
PMID:15728677
  Authors
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
  Title
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
  Journal
Development 132:1525-37 (2005)
DOI:10.1242/dev.01697
Reference
PMID:12500939
  Authors
Marthiens V, Gavard J, Lambert M, Mege RM.
  Title
Cadherin-based cell adhesion in neuromuscular development.
  Journal
Biol Cell 94:315-26 (2002)
DOI:10.1016/S0248-4900(02)00005-9
Reference
PMID:15923648
  Authors
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
  Title
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
  Journal
J Cell Sci 118:2355-62 (2005)
DOI:10.1242/jcs.02397
Related
pathway
svg04520  Adherens junction
svg04530  Tight junction
KO pathway
ko04514   
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