KEGG   PATHWAY: tcc00053
Entry
tcc00053                    Pathway                                
Name
Ascorbate and aldarate metabolism - Theobroma cacao (cacao)
Class
Metabolism; Carbohydrate metabolism
Pathway map
tcc00053  Ascorbate and aldarate metabolism
tcc00053

Module
tcc_M00114  Ascorbate biosynthesis, plants, fructose-6P => ascorbate [PATH:tcc00053]
Other DBs
GO: 0019852 0019577 0019572
Organism
Theobroma cacao (cacao) [GN:tcc]
Gene
18610282  UDP-glucose 6-dehydrogenase 1 [KO:K00012] [EC:1.1.1.22]
18604792  UDP-glucose 6-dehydrogenase 1 [KO:K00012] [EC:1.1.1.22]
18601622  UDP-glucose 6-dehydrogenase 2 [KO:K00012] [EC:1.1.1.22]
18592423  UDP-sugar pyrophosphorylase [KO:K12447] [EC:2.7.7.64]
18600854  glucuronokinase 1 [KO:K16190] [EC:2.7.1.43]
18610064  inositol oxygenase 1 [KO:K00469] [EC:1.13.99.1]
18606013  inositol oxygenase 4 [KO:K00469] [EC:1.13.99.1]
18588467  inositol oxygenase 2 [KO:K00469] [EC:1.13.99.1]
18596054  inositol oxygenase 1 [KO:K00469] [EC:1.13.99.1]
18597692  aldo-keto reductase family 4 member C9 [KO:K00002] [EC:1.1.1.2]
18597445  aldose reductase [KO:K00002] [EC:1.1.1.2]
18610063  aldo-keto reductase family 4 member C10 [KO:K00002] [EC:1.1.1.2]
108662286  aldo-keto reductase family 4 member C9-like [KO:K00002] [EC:1.1.1.2]
18597693  aldo-keto reductase family 4 member C9 [KO:K00002] [EC:1.1.1.2]
18597691  aldo-keto reductase family 4 member C9 [KO:K00002] [EC:1.1.1.2]
108662266  aldo-keto reductase family 4 member C8-like [KO:K00002] [EC:1.1.1.2]
18605342  aldo-keto reductase family 4 member C9 [KO:K00002] [EC:1.1.1.2]
18587950  L-gulonolactone oxidase 3 [KO:K00103] [EC:1.1.3.8]
18613903  probable L-gulonolactone oxidase 6 [KO:K00103] [EC:1.1.3.8]
18600196  GDP-mannose 3,5-epimerase 2 [KO:K10046] [EC:5.1.3.18 5.1.3.-]
18601891  GDP-L-galactose phosphorylase 1 [KO:K14190] [EC:2.7.7.69]
18593449  GDP-L-galactose phosphorylase 2 [KO:K14190] [EC:2.7.7.69]
18597288  inositol monophosphatase 3 [KO:K10047] [EC:3.1.3.25 3.1.3.93]
18607733  bifunctional phosphatase IMPL2, chloroplastic [KO:K18649] [EC:3.1.3.25 3.1.3.93 3.1.3.15]
18607308  L-galactose dehydrogenase [KO:K17744] [EC:1.1.1.316]
18598808  L-galactono-1,4-lactone dehydrogenase, mitochondrial [KO:K00225] [EC:1.3.2.3]
18589067  UDP-glucuronate 4-epimerase 1 [KO:K08679] [EC:5.1.3.6]
18614318  UDP-glucuronate 4-epimerase 3 [KO:K08679] [EC:5.1.3.6]
18606351  UDP-glucuronate 4-epimerase 5 [KO:K08679] [EC:5.1.3.6]
18602648  UDP-glucuronate 4-epimerase 6 [KO:K08679] [EC:5.1.3.6]
18609970  D-galacturonate reductase [KO:K19642] [EC:1.1.1.365]
18609969  D-galacturonate reductase [KO:K19642] [EC:1.1.1.365]
18609968  D-galacturonate reductase [KO:K19642] [EC:1.1.1.365]
18600776  monodehydroascorbate reductase 4, peroxisomal [KO:K08232] [EC:1.6.5.4]
18606587  monodehydroascorbate reductase 5, mitochondrial [KO:K08232] [EC:1.6.5.4]
18598191  monodehydroascorbate reductase [KO:K08232] [EC:1.6.5.4]
18593828  monodehydroascorbate reductase, seedling isozyme [KO:K08232] [EC:1.6.5.4]
18590832  APX; L-ascorbate peroxidase, cytosolic [KO:K00434] [EC:1.11.1.11]
18597892  L-ascorbate peroxidase 2, cytosolic [KO:K00434] [EC:1.11.1.11]
18610739  L-ascorbate peroxidase 3, peroxisomal [KO:K00434] [EC:1.11.1.11]
18607557  L-ascorbate peroxidase 3, peroxisomal [KO:K00434] [EC:1.11.1.11]
18587790  putative L-ascorbate peroxidase 6 [KO:K00434] [EC:1.11.1.11]
18592363  probable L-ascorbate peroxidase 6, chloroplastic [KO:K00434] [EC:1.11.1.11]
18586245  glutathione S-transferase DHAR2 [KO:K21888] [EC:1.8.5.1 2.5.1.18]
18601869  glutathione S-transferase DHAR3, chloroplastic [KO:K21888] [EC:1.8.5.1 2.5.1.18]
18590851  L-ascorbate oxidase [KO:K00423] [EC:1.10.3.3]
18589565  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
18589568  L-ascorbate oxidase homolog [KO:K00423] [EC:1.10.3.3]
18589829  aldehyde dehydrogenase family 3 member F1 [KO:K00128] [EC:1.2.1.3]
18609398  aldehyde dehydrogenase family 2 member B4, mitochondrial [KO:K00128] [EC:1.2.1.3]
18610826  aldehyde dehydrogenase family 3 member F1 [KO:K00128] [EC:1.2.1.3]
18611954  aldehyde dehydrogenase family 3 member H1 [KO:K00128] [EC:1.2.1.3]
18603880  aldehyde dehydrogenase family 2 member B4, mitochondrial [KO:K00128] [EC:1.2.1.3]
18600736  aldehyde dehydrogenase family 2 member B4, mitochondrial [KO:K00128] [EC:1.2.1.3]
18592364  aldehyde dehydrogenase family 3 member H1 [KO:K00128] [EC:1.2.1.3]
18596241  aldehyde dehydrogenase family 7 member B4 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
Compound
C00022  Pyruvate
C00026  2-Oxoglutarate
C00029  UDP-glucose
C00072  Ascorbate
C00096  GDP-mannose
C00137  myo-Inositol
C00167  UDP-glucuronate
C00191  D-Glucuronate
C00216  D-Arabinose
C00231  D-Xylulose 5-phosphate
C00259  L-Arabinose
C00333  D-Galacturonate
C00433  2,5-Dioxopentanoate
C00545  L-Arabinonate
C00558  D-Tagaturonate
C00617  UDP-D-galacturonate
C00618  3-Dehydro-L-gulonate
C00652  D-Arabinono-1,4-lactone
C00679  5-Dehydro-4-deoxy-D-glucarate
C00684  2-Dehydro-3-deoxy-L-arabinonate
C00800  L-Gulonate
C00818  D-Glucarate
C00878  D-Arabinonate
C00879  D-Galactarate
C01040  L-Gulono-1,4-lactone
C01041  Monodehydroascorbate
C01101  L-Ribulose 5-phosphate
C01114  L-Arabinono-1,4-lactone
C01115  L-Galactono-1,4-lactone
C01146  2-Hydroxy-3-oxopropanoate
C01620  Threonate
C01825  L-Galactose
C02280  GDP-L-galactose
C02670  D-Glucuronolactone
C03033  beta-D-Glucuronoside
C03064  3-Dehydro-L-threonate
C03289  L-xylo-Hexulonolactone
C03291  L-Xylulose 5-phosphate
C03826  2-Dehydro-3-deoxy-D-xylonate
C03921  2-Dehydro-3-deoxy-D-glucarate
C04037  1-Phospho-alpha-D-galacturonate
C04575  (4R,5S)-4,5,6-Trihydroxy-2,3-dioxohexanoate
C05385  D-Glucuronate 1-phosphate
C05411  L-Xylonate
C05412  L-Lyxonate
C05422  Dehydroascorbate
C06316  Dehydro-D-arabinono-1,4-lactone
C14899  3-Dehydro-L-gulonate 6-phosphate
C15923  L-Gulose
C15924  L-Gulose 1-phosphate
C15925  GDP-L-gulose
C15926  beta-L-Galactose 1-phosphate
C15930  L-Galactonate
C16186  L-Ascorbate 6-phosphate
C20889  D-Galactaro-1,5-lactone
C20896  D-Galactaro-1,4-lactone
C21955  L-Galactono-1,5-lactone
Reference
PMID:17222174
  Authors
Linster CL, Van Schaftingen E
  Title
Vitamin C. Biosynthesis, recycling and degradation in mammals.
  Journal
FEBS J 274:1-22 (2007)
DOI:10.1111/j.1742-4658.2006.05607.x
Reference
PMID:15564123
  Authors
Valpuesta V, Botella MA.
  Title
Biosynthesis of L-ascorbic acid in plants: new pathways for an old antioxidant.
  Journal
Trends Plant Sci 9:573-7 (2004)
DOI:10.1016/j.tplants.2004.10.002
Reference
PMID:10517845
  Authors
Davey MW, Gilot C, Persiau G, Ostergaard J, Han Y, Bauw GC, Van Montagu MC.
  Title
Ascorbate biosynthesis in Arabidopsis cell suspension culture.
  Journal
Plant Physiol 121:535-43 (1999)
DOI:10.1104/pp.121.2.535
Reference
PMID:16595667
  Authors
Conklin PL, Gatzek S, Wheeler GL, Dowdle J, Raymond MJ, Rolinski S, Isupov M, Littlechild JA, Smirnoff N.
  Title
Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme.
  Journal
J Biol Chem 281:15662-70 (2006)
DOI:10.1074/jbc.M601409200
Reference
PMID:17462988
  Authors
Linster CL, Gomez TA, Christensen KC, Adler LN, Young BD, Brenner C, Clarke SG.
  Title
Arabidopsis VTC2 Encodes a GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants.
  Journal
J Biol Chem 282:18879-85 (2007)
DOI:10.1074/jbc.M702094200
Reference
PMID:14996803
  Authors
Campos E, Baldoma L, Aguilar J, Badia J.
  Title
Regulation of expression of the divergent ulaG and ulaABCDEF operons involved in LaAscorbate dissimilation in Escherichia coli.
  Journal
J Bacteriol 186:1720-8 (2004)
DOI:10.1128/JB.186.6.1720-1728.2004
Reference
PMID:12644495
  Authors
Zhang Z, Aboulwafa M, Smith MH, Saier MH Jr.
  Title
The ascorbate transporter of Escherichia coli.
  Journal
J Bacteriol 185:2243-50 (2003)
DOI:10.1128/JB.185.7.2243-2250.2003
Related
pathway
tcc00020  Citrate cycle (TCA cycle)
tcc00040  Pentose and glucuronate interconversions
tcc00051  Fructose and mannose metabolism
tcc00520  Amino sugar and nucleotide sugar metabolism
tcc00630  Glyoxylate and dicarboxylate metabolism
KO pathway
ko00053   
LinkDB

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