KEGG   PATHWAY: tod04612
Entry
tod04612                    Pathway                                
Name
Antigen processing and presentation - Talpa occidentalis (Iberian mole)
Class
Organismal Systems; Immune system
Pathway map
tod04612  Antigen processing and presentation
tod04612

Other DBs
GO: 0019885 0019886 0042591
Organism
Talpa occidentalis (Iberian mole) [GN:tod]
Gene
119248294  IFNG; interferon gamma [KO:K04687]
119253235  TNF; tumor necrosis factor isoform X1 [KO:K03156]
129144885  PSME1; proteasome activator complex subunit 1 [KO:K06696]
119238948  PSME2; proteasome activator complex subunit 2 [KO:K06697]
119230431  PSME3; proteasome activator complex subunit 3 isoform X1 [KO:K06698]
119241337  proteasome activator complex subunit 3-like [KO:K06698]
119252222  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
119252223  heat shock 70 kDa protein 1-like [KO:K03283]
119252224  HSPA1B; heat shock 70 kDa protein 1B [KO:K03283]
119240781  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
119239185  HSPA2; heat shock-related 70 kDa protein 2 [KO:K26598]
119243475  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
119252516  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
119239380  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
119239419  heat shock protein HSP 90-alpha [KO:K04079]
119233314  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
119258418  patr class I histocompatibility antigen, A-2 alpha chain-like isoform X2 [KO:K06751]
119258434  class I histocompatibility antigen, Gogo-OKO alpha chain-like isoform X2 [KO:K06751]
119258435  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
119242843  class I histocompatibility antigen, Gogo-OKO alpha chain-like isoform X2 [KO:K06751]
119242845  patr class I histocompatibility antigen, A-108 alpha chain-like [KO:K06751]
119243231  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119251067  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
119251071  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
119251072  class I histocompatibility antigen, Gogo-C*0203 alpha chain-like [KO:K06751]
119251075  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
119251077  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
119251117  patr class I histocompatibility antigen, B-2 alpha chain-like isoform X2 [KO:K06751]
119251138  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
119251165  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119251167  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119251183  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119251189  HLA class I histocompatibility antigen, A alpha chain-like [KO:K06751]
119251196  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
119251199  patr class I histocompatibility antigen, A-108 alpha chain-like isoform X1 [KO:K06751]
119251208  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
119251212  patr class I histocompatibility antigen, B-1 alpha chain-like [KO:K06751]
119251215  patr class I histocompatibility antigen, B-1 alpha chain-like isoform X1 [KO:K06751]
119251229  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
119251240  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119251268  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
119251270  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
119251277  patr class I histocompatibility antigen, A-108 alpha chain-like [KO:K06751]
119251278  patr class I histocompatibility antigen, A-108 alpha chain-like [KO:K06751]
119251289  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
119251297  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
119251301  patr class I histocompatibility antigen, A-108 alpha chain-like [KO:K06751]
119251308  class I histocompatibility antigen, Gogo-C*0203 alpha chain-like [KO:K06751]
119251309  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119251319  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
119251322  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119251332  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
119251343  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
119243833  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
119251946  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
119251966  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
119251970  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
119251974  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X1 [KO:K06751]
119251982  patr class I histocompatibility antigen, B-1 alpha chain-like [KO:K06751]
119251983  patr class I histocompatibility antigen, A-2 alpha chain-like isoform X1 [KO:K06751]
119251986  class I histocompatibility antigen, Gogo-C*0202 alpha chain-like isoform X1 [KO:K06751]
119251987  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
119251994  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
119251995  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
119251996  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
119251998  HLA class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
119252000  patr class I histocompatibility antigen, A-108 alpha chain-like isoform X4 [KO:K06751]
119252001  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
119252003  class I histocompatibility antigen, Gogo-OKO alpha chain-like isoform X2 [KO:K06751]
119252004  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
119252005  patr class I histocompatibility antigen, A-108 alpha chain-like [KO:K06751]
119252018  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119252020  HLA class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
119252022  class I histocompatibility antigen, Gogo-OKO alpha chain-like isoform X2 [KO:K06751]
119252031  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119252033  class I histocompatibility antigen, Gogo-B*0201 alpha chain-like [KO:K06751]
119252034  class I histocompatibility antigen, Gogo-OKO alpha chain-like isoform X3 [KO:K06751]
119252037  class I histocompatibility antigen, Gogo-B*0201 alpha chain-like [KO:K06751]
119252039  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
119252040  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
119252045  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
119252048  patr class I histocompatibility antigen, A-108 alpha chain-like isoform X3 [KO:K06751]
119252056  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
119252057  class I histocompatibility antigen, Gogo-B*0201 alpha chain-like isoform X2 [KO:K06751]
119252059  patr class I histocompatibility antigen, A-2 alpha chain-like isoform X2 [KO:K06751]
119252060  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
119252067  patr class I histocompatibility antigen, A-2 alpha chain-like isoform X2 [KO:K06751]
119252069  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X2 [KO:K06751]
119252072  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119252075  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X1 [KO:K06751]
119252076  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
119252098  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
119252138  HLA class I histocompatibility antigen, B alpha chain-like [KO:K06751]
119252140  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
119252145  HLA class I histocompatibility antigen, B alpha chain-like isoform X2 [KO:K06751]
119252149  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119252151  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119252154  class I histocompatibility antigen, Gogo-C*0202 alpha chain-like [KO:K06751]
119252156  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
119252157  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
119252159  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like isoform X1 [KO:K06751]
119252162  patr class I histocompatibility antigen, B-2 alpha chain-like [KO:K06751]
119252164  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
119252165  HLA class I histocompatibility antigen, alpha chain G-like isoform X2 [KO:K06751]
119252167  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
119252170  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
119252172  class I histocompatibility antigen, Gogo-B*0201 alpha chain-like isoform X5 [KO:K06751]
119252178  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119252180  patr class I histocompatibility antigen, A-108 alpha chain-like [KO:K06751]
119252182  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119252186  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
119252187  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119252189  uncharacterized protein LOC119252189 isoform X3 [KO:K06751]
119252191  patr class I histocompatibility antigen, A-126 alpha chain-like isoform X1 [KO:K06751]
119236634  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
119252311  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
119253123  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
119253126  patr class I histocompatibility antigen, A-108 alpha chain-like isoform X1 [KO:K06751]
119253172  patr class I histocompatibility antigen, A-108 alpha chain-like [KO:K06751]
119253179  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
119253184  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
119253185  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
119253190  patr class I histocompatibility antigen, A-108 alpha chain-like [KO:K06751]
119253192  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119253199  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751]
119253215  patr class I histocompatibility antigen, A-108 alpha chain-like [KO:K06751]
119253216  patr class I histocompatibility antigen, A-108 alpha chain-like [KO:K06751]
119253231  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
119253263  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751]
119253903  class I histocompatibility antigen, Gogo-OKO alpha chain-like isoform X1 [KO:K06751]
119253926  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
119248584  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
119231963  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
119235108  CANX; calnexin isoform X1 [KO:K08054]
119238571  B2M; beta-2-microglobulin [KO:K08055]
119238557  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
119241009  CALR; calreticulin [KO:K08057]
119252341  TAPBP; tapasin isoform X1 [KO:K08058]
119252321  TAP1; antigen peptide transporter 1 isoform X2 [KO:K05653] [EC:7.4.2.14]
119251393  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
119251981  antigen peptide transporter 2-like [KO:K05654] [EC:7.4.2.14]
119252147  antigen peptide transporter 2-like [KO:K05654] [EC:7.4.2.14]
119259889  T-cell surface glycoprotein CD8 alpha chain-like [KO:K06458]
119259890  T-cell surface glycoprotein CD8 alpha chain-like isoform X2 [KO:K06458]
119259149  CD8B; T-cell surface glycoprotein CD8 beta chain [KO:K06459]
119258452  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
119250939  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
119237512  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
119246991  NKG2-C type II integral membrane protein-like [KO:K06541]
119246992  NKG2-C type II integral membrane protein-like [KO:K06541]
119246993  NKG2-C type II integral membrane protein-like [KO:K06541]
119246994  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
119246995  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
119246996  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
119246997  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
119246998  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
119246999  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
119247000  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
119247002  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
119247004  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
119247005  NKG2-C type II integral membrane protein-like [KO:K06541]
119247006  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
119247007  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
119240139  NKG2-F type II integral membrane protein-like [KO:K06541]
119247716  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
119247719  NKG2-A/NKG2-B type II integral membrane protein-like [KO:K06541]
119247720  NKG2-A/NKG2-B type II integral membrane protein-like isoform X1 [KO:K06541]
119248342  NKG2-A/NKG2-B type II integral membrane protein-like isoform X1 [KO:K06541]
119248345  NKG2-A/NKG2-B type II integral membrane protein-like isoform X1 [KO:K06541]
119237836  natural killer cells antigen CD94-like [KO:K06516]
119254057  natural killer cells antigen CD94-like [KO:K06516]
119247009  natural killer cells antigen CD94-like [KO:K06516]
119247011  natural killer cells antigen CD94-like [KO:K06516]
119247012  natural killer cells antigen CD94-like [KO:K06516]
119247013  natural killer cells antigen CD94-like [KO:K06516]
119247015  natural killer cells antigen CD94-like [KO:K06516]
119247016  natural killer cells antigen CD94-like [KO:K06516]
119247017  natural killer cells antigen CD94-like [KO:K06516]
119247020  natural killer cells antigen CD94-like [KO:K06516]
119247021  natural killer cells antigen CD94-like [KO:K06516]
119247023  natural killer cells antigen CD94-like [KO:K06516]
119248350  natural killer cells antigen CD94-like [KO:K06516]
119248351  natural killer cells antigen CD94-like [KO:K06516]
119240044  IFI30; gamma-interferon-inducible lysosomal thiol reductase [KO:K08059]
119239452  LGMN; legumain [KO:K01369] [EC:3.4.22.34]
119258045  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
119251395  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DP alpha 1 chain-like [KO:K06752]
119252077  boLa class II histocompatibility antigen, DQB*0101 beta chain-like [KO:K06752]
119252079  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DO beta chain-like [KO:K06752]
119252300  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
119252301  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
119252303  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
119252305  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DQ beta 2 chain-like [KO:K06752]
119252306  boLa class II histocompatibility antigen, DQB*0101 beta chain-like [KO:K06752]
119252307  HLA class II histocompatibility antigen, DQ alpha 2 chain-like [KO:K06752]
119252309  boLa class II histocompatibility antigen, DQB*0101 beta chain-like [KO:K06752]
119252310  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
119252317  SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752]
119252318  HLA class II histocompatibility antigen, DQ beta 1 chain-like isoform X1 [KO:K06752]
119252320  HLA class II histocompatibility antigen, DO beta chain [KO:K06752]
119252323  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
119252326  LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
119253063  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
119253072  LOW QUALITY PROTEIN: RLA class II histocompatibility antigen, DP alpha-1 chain-like [KO:K06752]
119253280  mamu class II histocompatibility antigen, DR alpha chain [KO:K06752]
119253282  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
119243266  CD74; HLA class II histocompatibility antigen gamma chain isoform X1 [KO:K06505]
119241446  HLA class II histocompatibility antigen gamma chain-like [KO:K06505]
119232076  CTSL; procathepsin L [KO:K01365] [EC:3.4.22.15]
119240824  LOW QUALITY PROTEIN: procathepsin L-like [KO:K01365] [EC:3.4.22.15]
119236327  CTSS; cathepsin S [KO:K01368] [EC:3.4.22.27]
119247775  CD4; T-cell surface glycoprotein CD4 isoform X3 [KO:K06454]
119241935  CIITA; MHC class II transactivator [KO:K08060] [EC:2.7.11.1]
119235396  RFX5; DNA-binding protein RFX5 [KO:K08061]
119241149  RFXANK; DNA-binding protein RFXANK [KO:K08062]
119258530  RFXAP; regulatory factor X-associated protein [KO:K08063]
119256146  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
119252434  NFYA; nuclear transcription factor Y subunit alpha isoform X1 [KO:K08064]
119247356  NFYB; nuclear transcription factor Y subunit beta [KO:K08065]
119236687  NFYC; nuclear transcription factor Y subunit gamma isoform X1 [KO:K08066]
Reference
  Authors
Trombetta ES, Mellman I.
  Title
Cell biology of antigen processing in vitro and in vivo.
  Journal
Annu Rev Immunol 23:975-1028 (2005)
DOI:10.1146/annurev.immunol.22.012703.104538
Reference
  Authors
Inaba K, Inaba M.
  Title
Antigen recognition and presentation by dendritic cells.
  Journal
Int J Hematol 81:181-7 (2005)
DOI:10.1532/IJH97.04200
Reference
  Authors
Heath WR, Carbone FR.
  Title
Cross-presentation in viral immunity and self-tolerance.
  Journal
Nat Rev Immunol 1:126-34 (2001)
DOI:10.1038/35100512
Reference
  Authors
Abele R, Tampe R.
  Title
The ABCs of immunology: structure and function of TAP, the transporter associated with antigen processing.
  Journal
Physiology (Bethesda) 19:216-24 (2004)
DOI:10.1152/physiol.00002.2004
Reference
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
  Authors
Honey K, Rudensky AY.
  Title
Lysosomal cysteine proteases regulate antigen presentation.
  Journal
Nat Rev Immunol 3:472-82 (2003)
DOI:10.1038/nri1110
Reference
  Authors
Sercarz EE, Maverakis E.
  Title
Mhc-guided processing: binding of large antigen fragments.
  Journal
Nat Rev Immunol 3:621-9 (2003)
DOI:10.1038/nri1149
Reference
  Authors
Ackerman AL, Cresswell P.
  Title
Cellular mechanisms governing cross-presentation of exogenous antigens.
  Journal
Nat Immunol 5:678-84 (2004)
DOI:10.1038/ni1082
Reference
  Authors
Cresswell P, Ackerman AL, Giodini A, Peaper DR, Wearsch PA.
  Title
Mechanisms of MHC class I-restricted antigen processing and cross-presentation.
  Journal
Immunol Rev 207:145-57 (2005)
DOI:10.1111/j.0105-2896.2005.00316.x
Reference
  Authors
Zika E, Ting JP.
  Title
Epigenetic control of MHC-II: interplay between CIITA and histone-modifying enzymes.
  Journal
Curr Opin Immunol 17:58-64 (2005)
DOI:10.1016/j.coi.2004.11.008
Reference
  Authors
Reith W, Mach B.
  Title
The bare lymphocyte syndrome and the regulation of MHC expression.
  Journal
Annu Rev Immunol 19:331-73 (2001)
DOI:10.1146/annurev.immunol.19.1.331
Reference
  Authors
Lizee G, Basha G, Jefferies WA.
  Title
Tails of wonder: endocytic-sorting motifs key for exogenous antigen presentation.
  Journal
Trends Immunol 26:141-9 (2005)
DOI:10.1016/j.it.2005.01.005
Reference
  Authors
Watts C.
  Title
The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules.
  Journal
Nat Immunol 5:685-92 (2004)
DOI:10.1038/ni1088
Reference
  Authors
Kaufmann SH, Schaible UE.
  Title
Antigen presentation and recognition in bacterial infections.
  Journal
Curr Opin Immunol 17:79-87 (2005)
DOI:10.1016/j.coi.2004.12.004
Reference
  Authors
Groettrup M, Kirk CJ, Basler M
  Title
Proteasomes in immune cells: more than peptide producers?
  Journal
Nat Rev Immunol 10:73-8 (2010)
DOI:10.1038/nri2687
Related
pathway
tod03050  Proteasome
tod04650  Natural killer cell mediated cytotoxicity
tod04660  T cell receptor signaling pathway
KO pathway
ko04612   
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