KEGG   PATHWAY: tpal03013
Entry
tpal03013                   Pathway                                
Name
Nucleocytoplasmic transport - Thrips palmi (melon thrips)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
tpal03013  Nucleocytoplasmic transport
tpal03013

Other DBs
GO: 0050658
Organism
Thrips palmi (melon thrips) [GN:tpal]
Gene
117646699  aladin-like [KO:K14320]
117647988  nucleoporin NUP42-like [KO:K14321]
117644212  nucleoporin GLE1 [KO:K18723]
117649281  DEAD-box helicase Dbp80 [KO:K18655] [EC:5.6.2.7]
117654335  mRNA export factor-like [KO:K14298]
117654336  mRNA export factor-like [KO:K14298]
117646069  cell wall protein AWA1-like isoform X1 [KO:K14297]
117646124  nuclear pore complex protein Nup98-Nup96 [KO:K14297]
117649496  nuclear pore complex protein Nup214 [KO:K14317]
117643108  nuclear pore complex protein Nup88 [KO:K14318]
117643651  E3 SUMO-protein ligase RanBP2-like isoform X1 [KO:K12172] [EC:2.3.2.-]
117653877  ran GTPase-activating protein 1 [KO:K14319]
117651943  SUMO-conjugating enzyme UBC9-B [KO:K10577]
117653006  small ubiquitin-related modifier 2-A [KO:K12160]
117643690  small ubiquitin-related modifier-like isoform X1 [KO:K12160]
117645682  nuclear pore complex protein Nup160 homolog [KO:K14303]
117645660  nuclear pore complex protein Nup85 [KO:K14304]
117643509  protein SEC13 homolog [KO:K14004]
117652927  LOW QUALITY PROTEIN: nuclear pore complex protein Nup107 [KO:K14301]
117651247  nuclear pore complex protein Nup133 [KO:K14300]
117648292  nucleoporin SEH1 [KO:K14299]
117647611  nucleoporin Nup43 [KO:K14305]
117646398  nucleoporin Nup37 [KO:K14302]
117644130  protein ELYS [KO:K25129]
117648603  nuclear pore glycoprotein p62 [KO:K14306]
117646760  nuclear pore complex protein Nup58-like [KO:K14307]
117640783  nuclear pore complex protein Nup54 [KO:K14308]
117640210  nuclear pore complex protein Nup205 [KO:K14310]
117639008  nucleoporin NUP188 homolog [KO:K14311]
117641815  LOW QUALITY PROTEIN: nuclear pore complex protein Nup155 [KO:K14312]
117639519  nuclear pore complex protein Nup93-like isoform X1 [KO:K14309]
117644355  nucleoporin NUP35 [KO:K14313]
117648011  nucleoporin Ndc1 [KO:K14315]
117642731  nuclear pore membrane glycoprotein 210 [KO:K14314]
117651067  Krueppel homolog 2 [KO:K20724]
117650497  nucleoprotein TPR isoform X1 [KO:K09291]
117641588  LOW QUALITY PROTEIN: nuclear pore complex protein Nup50-like [KO:K14295]
117640071  nuclear pore complex protein Nup153-like [KO:K14296]
117647749  ubiquitin-like-specific protease 1A [KO:K03345] [EC:3.4.22.68]
117651357  importin subunit alpha-1 [KO:K15043]
117639245  importin subunit alpha-3 [KO:K23583]
117646718  importin subunit alpha-7 isoform X1 [KO:K15042]
117639592  importin subunit beta-1 isoform X1 [KO:K14293]
117647977  transportin-1 [KO:K18752]
117652128  transportin-3 [KO:K15436]
117653959  importin-4-like [KO:K20221]
117643243  importin-5 [KO:K20222]
117640254  importin-7 isoform X1 [KO:K20223]
117654191  importin-11 [KO:K25201]
117645290  importin-13 [KO:K25202]
117646749  snurportin-1 [KO:K13151]
117639032  exportin-1 [KO:K14290]
117650937  exportin-2 [KO:K18423]
117639332  exportin-T-like isoform X1 [KO:K14288]
117652309  LOW QUALITY PROTEIN: exportin-4-like [KO:K25203]
117648639  exportin-5 [KO:K14289]
117651737  exportin-6-A isoform X1 [KO:K25204]
117640968  exportin-7 isoform X1 [KO:K18460]
117645320  GTP-binding nuclear protein Ran [KO:K07936]
117641784  elongation factor 1-alpha 2-like [KO:K03231]
117641785  elongation factor 1-alpha 2 [KO:K03231]
117648453  phosphorylated adapter RNA export protein [KO:K14291]
117645554  nuclear cap-binding protein subunit 1 [KO:K12882]
117643280  nuclear cap-binding protein subunit 2 [KO:K12883]
117654347  60S ribosomal export protein NMD3 [KO:K07562]
117646824  RNA-binding protein 8A isoform X1 [KO:K12876]
117645364  protein mago nashi [KO:K12877]
117653918  protein CASC3-like [KO:K14323]
117651384  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
117647530  apoptotic chromatin condensation inducer in the nucleus-like [KO:K12875]
117652808  histone deacetylase complex subunit SAP18 [KO:K14324]
117650979  pinin [KO:K13114]
117645166  THO complex subunit 4 [KO:K12881]
117639086  regulator of nonsense transcripts 1 homolog isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
117651758  regulator of nonsense transcripts 2 isoform X1 [KO:K14327]
117652840  uncharacterized protein LOC117652840 isoform X1 [KO:K14328]
117641971  nuclear RNA export factor 1-like [KO:K14284]
117653323  NTF2-related export protein [KO:K14285]
117647509  ATP-dependent RNA helicase WM6 [KO:K12812] [EC:5.6.2.7]
117642204  serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
117646645  partner of Y14 and mago [KO:K14294]
117651078  THO complex subunit 1 isoform X1 [KO:K12878]
117646795  THO complex subunit 2 isoform X1 [KO:K12879]
117644430  THO complex subunit 5 homolog [KO:K13174]
117651700  THO complex subunit 6 [KO:K13175]
117652863  THO complex subunit 7 homolog [KO:K13176]
117641013  THO complex subunit 3 [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
tpal03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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