KEGG   PATHWAY: tvc00590
Entry
tvc00590                    Pathway                                
Name
Arachidonic acid metabolism - Tachysurus vachellii
Class
Metabolism; Lipid metabolism
Pathway map
tvc00590  Arachidonic acid metabolism
tvc00590

Other DBs
GO: 0019369
Organism
Tachysurus vachellii [GN:tvc]
Gene
132847722  pla2g12a; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
132855183  uncharacterized protein LOC132855183 [KO:K01047] [EC:3.1.1.4]
132837446  pla2g10; group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
132862888  pla2g3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
132863152  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
132858156  proca1; uncharacterized protein proca1 [KO:K01047] [EC:3.1.1.4]
132839705  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
132846984  pla2g12b; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
132853373  pla2g1b; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
132843521  pla2g4ab; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
132852018  cytosolic phospholipase A2 delta-like [KO:K16342] [EC:3.1.1.4]
132852019  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
132858325  pla2g4aa; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
132838682  pla2g6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
132842262  si:dkey-177p2.18; phospholipase B1, membrane-associated isoform X1 [KO:K14621] [EC:3.1.1.4 3.1.1.5]
132843263  phospholipase B1, membrane-associated-like [KO:K14621] [EC:3.1.1.4 3.1.1.5]
132852228  plb1; phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]
132852710  phospholipase B1, membrane-associated-like [KO:K14621] [EC:3.1.1.4 3.1.1.5]
132856181  phospholipase A and acyltransferase 3-like [KO:K16817] [EC:3.1.1.32 3.1.1.4]
132854613  ptgs1; prostaglandin G/H synthase 1 isoform X1 [KO:K00509] [EC:1.14.99.1]
132843522  ptgs2b; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
132858326  ptgs2a; prostaglandin G/H synthase 2a [KO:K11987] [EC:1.14.99.1]
132841140  ptges; prostaglandin E synthase [KO:K15729] [EC:5.3.99.3]
132853868  ptgesl; prostaglandin E synthase 2 [KO:K05309] [EC:5.3.99.3]
132862068  ptges3a; prostaglandin E synthase 3 isoform X1 [KO:K15730] [EC:5.3.99.3]
132860474  cbr1l; carbonyl reductase 1-like [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
132839121  cbr1; carbonyl reductase [NADPH] 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
132837929  prxl2b; prostamide/prostaglandin F synthase [KO:K15717] [EC:1.11.1.20]
132847687  hpgd; 15-hydroxyprostaglandin dehydrogenase [NAD(+)] [KO:K00069] [EC:1.1.1.141]
132859966  zgc:56585; 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform X1 [KO:K00069] [EC:1.1.1.141]
132851317  tbxas1; thromboxane-A synthase isoform X1 [KO:K01832] [EC:5.3.99.5]
132844499  prostacyclin synthase-like [KO:K01831] [EC:5.3.99.4]
132844567  ptgis; prostacyclin synthase [KO:K01831] [EC:5.3.99.4]
132847235  alox5a; polyunsaturated fatty acid 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
132859009  lta4h; leukotriene A-4 hydrolase isoform X1 [KO:K01254] [EC:3.3.2.6]
132848860  prostaglandin reductase-3-like [KO:K07119] [EC:1.3.1.48]
132852657  ptgr2; prostaglandin reductase 2 isoform X1 [KO:K13949] [EC:1.3.1.48]
132848870  prostaglandin reductase 1-like isoform X1 [KO:K13948] [EC:1.3.1.74 1.3.1.48]
132848873  prostaglandin reductase 1-like [KO:K13948] [EC:1.3.1.74 1.3.1.48]
132848885  ptgr1.1; prostaglandin reductase 1 isoform X1 [KO:K13948] [EC:1.3.1.74 1.3.1.48]
132855528  ltc4s; leukotriene C4 synthase [KO:K00807] [EC:4.4.1.20]
132862994  ggt1b; glutathione hydrolase 1 proenzyme [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
132862995  ggt5b; glutathione hydrolase 5 proenzyme [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
132853363  glutathione hydrolase 1 proenzyme-like isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
132853364  ggt5a; gamma-glutamyltransferase 5a [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
132853568  glutathione hydrolase 1 proenzyme-like isoform X1 [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
132853569  glutathione hydrolase 1 proenzyme-like [KO:K18592] [EC:2.3.2.2 3.4.19.13 3.4.19.14]
132845451  gpx4b; phospholipid hydroperoxide glutathione peroxidase [KO:K05361] [EC:1.11.1.12]
132852631  gpx4a; glutathione peroxidase 4a [KO:K05361] [EC:1.11.1.12]
132852639  phospholipid hydroperoxide glutathione peroxidase-like [KO:K05361] [EC:1.11.1.12]
132852660  phospholipid hydroperoxide glutathione peroxidase-like [KO:K05361] [EC:1.11.1.12]
132847605  cytochrome P450 2U1 [KO:K07422] [EC:1.14.14.80]
132848618  alox12; arachidonate 12-lipoxygenase, 12S-type [KO:K00458] [EC:1.13.11.31]
132852359  ephx2; bifunctional epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
Compound
C00157  Phosphatidylcholine
C00219  Arachidonate
C00427  Prostaglandin H2
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00696  Prostaglandin D2
C00909  Leukotriene A4
C01312  Prostaglandin I2
C02165  Leukotriene B4
C02166  Leukotriene C4
C02198  Thromboxane A2
C03577  20-Hydroxyleukotriene E4
C04577  15-OxoETE
C04671  (5Z)-11alpha-Hydroxy-9,15-dioxoprostanoate
C04707  (5Z,13E)-11alpha-Hydroxy-9,15-dioxoprost-5,13-dienoate
C04742  (15S)-15-Hydroxy-5,8,11-cis-13-trans-eicosatetraenoate
C04758  (5Z,13E)-9alpha-Hydroxy-11,15-dioxoprosta-5,13-dienoate
C04805  5(S)-HETE
C04822  8(R)-HPETE
C04835  (5Z,13E)-6,9alpha-Epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate
C04853  20-OH-Leukotriene B4
C05356  5(S)-HPETE
C05949  12-Keto-leukotriene B4
C05950  20-COOH-Leukotriene B4
C05951  Leukotriene D4
C05952  Leukotriene E4
C05953  Prostaglandin A2
C05954  Prostaglandin B2
C05955  Prostaglandin C2
C05956  Prostaglandin G2
C05957  Prostaglandin J2
C05958  Delta-12-Prostaglandin J2
C05959  11-epi-Prostaglandin F2alpha
C05960  15-Keto-prostaglandin F2alpha
C05961  6-Keto-prostaglandin F1alpha
C05962  6-Keto-prostaglandin E1
C05963  Thromboxane B2
C05964  11-Dehydro-thromboxane B2
C05965  12(S)-HPETE
C05966  15(S)-HPETE
C06314  Lipoxin A4
C06315  Lipoxin B4
C06462  Leukotriene F4
C13809  9,11,15-Trihydroxy-prosta-5,13-dien-1-oic acid
C14717  15-Deoxy-Delta12,14-PGJ2
C14732  5-OxoETE
C14748  20-HETE
C14749  19(S)-HETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
C14772  5,6-DHET
C14773  8,9-DHET
C14774  11,12-DHET
C14775  14,15-DHET
C14776  8(S)-HETE
C14777  12(S)-HETE
C14778  16(R)-HETE
C14779  9(S)-HETE
C14780  11(R)-HETE
C14781  15H-11,12-EETA
C14782  11,12,15-THETA
C14794  2,3-Dinor-8-iso prostaglandin F2alpha
C14795  2,3-Dinor-8-iso prostaglandin F1alpha
C14807  12-OxoETE
C14808  Hepoxilin A3
C14809  Trioxilin A3
C14810  Hepoxilin B3
C14811  Trioxilin B3
C14812  12(R)-HPETE
C14813  11H-14,15-EETA
C14814  11,14,15-THETA
C14815  5,6-Epoxytetraene
C14820  11(R)-HPETE
C14821  9(S)-HPETE
C14822  12(R)-HETE
C14823  8(S)-HPETE
C14824  8(R)-HETE
Reference
PMID:14636671
  Authors
Spector AA, Fang X, Snyder GD, Weintraub NL.
  Title
Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function.
  Journal
Prog Lipid Res 43:55-90 (2004)
DOI:10.1016/S0163-7827(03)00049-3
Reference
PMID:15292194
  Authors
Harman CA, Rieke CJ, Garavito RM, Smith WL.
  Title
Crystal structure of arachidonic acid bound to a mutant of prostaglandin endoperoxide H synthase-1 that forms predominantly 11-hydroperoxyeicosatetraenoic acid.
  Journal
J Biol Chem 279:42929-35 (2004)
DOI:10.1074/jbc.M403013200
Reference
PMID:15205388
  Authors
Poloyac SM, Tortorici MA, Przychodzin DI, Reynolds RB, Xie W, Frye RF, Zemaitis MA.
  Title
The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney.
  Journal
Drug Metab Dispos 32:727-33 (2004)
DOI:10.1124/dmd.32.7.727
Reference
PMID:14660610
  Authors
Chuang SS, Helvig C, Taimi M, Ramshaw HA, Collop AH, Amad M, White JA, Petkovich M, Jones G, Korczak B.
  Title
CYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acids.
  Journal
J Biol Chem 279:6305-14 (2004)
DOI:10.1074/jbc.M311830200
Reference
PMID:14626496
  Authors
Sacerdoti D, Gatta A, McGiff JC.
  Title
Role of cytochrome P450-dependent arachidonic acid metabolites in liver physiology and pathophysiology.
  Journal
Prostaglandins Other Lipid Mediat 72:51-71 (2003)
DOI:10.1016/S1098-8823(03)00077-7
Reference
PMID:14622984
  Authors
Pfister SL, Spitzbarth N, Zeldin DC, Lafite P, Mansuy D, Campbell WB.
  Title
Rabbit aorta converts 15-HPETE to trihydroxyeicosatrienoic acids: potential role of cytochrome P450.
  Journal
Arch Biochem Biophys 420:142-52 (2003)
DOI:10.1016/j.abb.2003.09.026
Reference
PMID:11679404
  Authors
Fleming I.
  Title
Cytochrome p450 and vascular homeostasis.
  Journal
Circ Res 89:753-62 (2001)
DOI:10.1161/hh2101.099268
Reference
PMID:11328810
  Authors
Qu W, Bradbury JA, Tsao CC, Maronpot R, Harry GJ, Parker CE, Davis LS, Breyer MD, Waalkes MP, Falck JR, Chen J, Rosenberg RL, Zeldin DC.
  Title
Cytochrome P450 CYP2J9, a new mouse arachidonic acid omega-1 hydroxylase predominantly expressed in brain.
  Journal
J Biol Chem 276:25467-79 (2001)
DOI:10.1074/jbc.M100545200
Reference
PMID:10908295
  Authors
Tsao CC, Foley J, Coulter SJ, Maronpot R, Zeldin DC, Goldstein JA.
  Title
CYP2C40, a unique arachidonic acid 16-hydroxylase, is the major CYP2C in murine intestinal tract.
  Journal
Mol Pharmacol 58:279-87 (2000)
DOI:10.1124/mol.58.2.279
Reference
PMID:9812980
  Authors
Pfister SL, Spitzbarth N, Nithipatikom K, Edgemond WS, Falck JR, Campbell WB.
  Title
Identification of the 11,14,15- and 11,12, 15-trihydroxyeicosatrienoic acids as endothelium-derived relaxing factors of rabbit aorta.
  Journal
J Biol Chem 273:30879-87 (1998)
DOI:10.1074/jbc.273.47.30879
Related
pathway
tvc00591  Linoleic acid metabolism
KO pathway
ko00590   
LinkDB

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