KEGG   PATHWAY: tvc04310
Entry
tvc04310                    Pathway                                
Name
Wnt signaling pathway - Tachysurus vachellii
Description
Wnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, in many different species and organs. There are at least three different Wnt pathways: the canonical pathway, the planar cell polarity (PCP) pathway and the Wnt/Ca2+ pathway. In the canonical Wnt pathway, the major effect of Wnt ligand binding to its receptor is the stabilization of cytoplasmic beta-catenin through inhibition of the bea-catenin degradation complex. Beta-catenin is then free to enter the nucleus and activate Wnt-regulated genes through its interaction with TCF (T-cell factor) family transcription factors and concomitant recruitment of coactivators. Planar cell polarity (PCP) signaling leads to the activation of the small GTPases RHOA (RAS homologue gene-family member A) and RAC1, which activate the stress kinase JNK (Jun N-terminal kinase) and ROCK (RHO-associated coiled-coil-containing protein kinase 1) and leads to remodelling of the cytoskeleton and changes in cell adhesion and motility. WNT-Ca2+ signalling is mediated through G proteins and phospholipases and leads to transient increases in cytoplasmic free calcium that subsequently activate the kinase PKC (protein kinase C) and CAMKII (calcium calmodulin mediated kinase II) and the phosphatase calcineurin.
Class
Environmental Information Processing; Signal transduction
Pathway map
tvc04310  Wnt signaling pathway
tvc04310

Other DBs
GO: 0016055
Organism
Tachysurus vachellii [GN:tvc]
Gene
132854086  porcnl; porcupine O-acyltransferase like [KO:K00181] [EC:2.3.1.250]
132853639  porcn; protein-serine O-palmitoleoyltransferase porcupine [KO:K00181] [EC:2.3.1.250]
132862142  wnt1; protein Wnt-1 [KO:K03209]
132844550  wnt2ba; wingless-type MMTV integration site family, member 2Ba [KO:K00182]
132851647  wnt2; protein Wnt-2 [KO:K00182]
132853748  wnt2bb; wingless-type MMTV integration site family, member 2Bb [KO:K00182]
132849166  wnt3a; protein Wnt-3a [KO:K00312]
132858957  wnt3; proto-oncogene Wnt-3 [KO:K00312]
132838245  wnt4; protein Wnt-4a [KO:K00408]
132846311  wnt4b; wingless-type MMTV integration site family, member 4b [KO:K00408]
132858995  wnt5b; protein Wnt-5b [KO:K00444]
132853423  wnt5a; protein Wnt-5a [KO:K00444]
132844021  wnt6a; protein Wnt-6 [KO:K00445]
132850501  wnt6b; protein Wnt-6 [KO:K00445]
132838214  wnt7aa; wingless-type MMTV integration site family, member 7Aa [KO:K00572]
132862290  protein Wnt-7a isoform X1 [KO:K00572]
132857201  wnt7bb; protein Wnt-7b [KO:K00572]
132858663  wnt7ba; protein Wnt-7b [KO:K00572]
132855867  wnt8a; protein Wnt-8a ORF1 [KO:K00714]
132855959  protein Wnt-8a ORF2 [KO:K00714]
132847337  wnt8b; protein Wnt-8b [KO:K00714]
132849161  wnt9a; protein Wnt-9a [KO:K01064]
132861116  wnt9b; protein Wnt-9b [KO:K01064]
132850502  wnt10a; protein Wnt-10a [KO:K01357]
132862269  wnt10b; protein Wnt-10b [KO:K01357]
132863412  wnt11; protein Wnt-11 [KO:K01384]
132840957  wnt11f2; protein Wnt-11 [KO:K01384]
132859111  wnt16; protein Wnt-16 [KO:K01558]
132839086  dand5; DAN domain family member 5 [KO:K01645]
132855972  notum1b; inactive palmitoleoyl-protein carboxylesterase notum1b [KO:K19882] [EC:3.1.1.98]
132844051  notum2; carboxylesterase notum2 [KO:K19882] [EC:3.1.1.98]
132859057  wif1; wnt inhibitory factor 1 [KO:K01691]
132838555  sost; sclerostin [KO:K16834]
132860338  dkk1b; dickkopf-related protein 1b [KO:K02165]
132862514  dickkopf-related protein 2-like isoform X1 [KO:K02165]
132846679  dkk1a; dickkopf WNT signaling pathway inhibitor 1a [KO:K02165]
132846742  dkk2; dickkopf-related protein 2 [KO:K02165]
132853930  dickkopf-related protein 4-like [KO:K02165]
132860197  serpinf1; pigment epithelium-derived factor [KO:K19614]
132854880  sfrp1a; secreted frizzled-related protein 1a [KO:K02166]
132863630  sfrp1b; secreted frizzled-related protein 1b [KO:K02166]
132858383  sfrp2l; LOW QUALITY PROTEIN: secreted frizzled-related protein 2-like [KO:K02176]
132850423  frzb; secreted frizzled-related protein 3 [KO:K25481]
132847297  sfrp5; secreted frizzled-related protein 5 [KO:K02222]
132845714  rspo1; R-spondin-1 isoform X1 [KO:K19471]
132845266  rspo2; R-spondin-2 [KO:K23097]
132845702  rspo3; R-spondin-3 [KO:K23098]
132838511  lgr4; leucine-rich repeat-containing G-protein coupled receptor 4 [KO:K04309]
132859330  leucine-rich repeat-containing G-protein coupled receptor 5-like [KO:K04308]
132862700  leucine-rich repeat-containing G-protein coupled receptor 6 [KO:K08399]
132840648  E3 ubiquitin-protein ligase RNF43 isoform X1 [KO:K15694] [EC:2.3.2.27]
132854570  znrf3; E3 ubiquitin-protein ligase znrf3 [KO:K16273] [EC:2.3.2.27]
132850290  fzd7a; frizzled-7a [KO:K02432]
132844945  fzd7b; frizzled-7b [KO:K02432]
132861548  fzd2; frizzled-2 [KO:K02235]
132843500  fzd3a; frizzled-3a isoform X1 [KO:K02329]
132852394  fzd3b; frizzled-3b isoform X1 [KO:K02329]
132857753  fzd4; frizzled-4 [KO:K02354]
132849925  fzd5; frizzled-5 [KO:K02375]
132845547  fzd8a; frizzled-8a [KO:K02375]
132840430  fzd6; frizzled-6 [KO:K02376]
132851403  fzd9b; frizzled-9b [KO:K02842]
132853933  fzd10; frizzled-10 [KO:K02842]
132841027  fzd9a; frizzled-9 isoform X1 [KO:K02842]
132855717  lrp5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
132859173  lrp6; low-density lipoprotein receptor-related protein 6 [KO:K03068]
132844397  bambib; BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) b [KO:K10162]
132864046  bambia; BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a [KO:K10162]
132845622  protein APCDD1-like [KO:K25812]
132845746  protein APCDD1-like isoform X1 [KO:K25812]
132839112  csnk1e; casein kinase I [KO:K08960] [EC:2.7.11.1]
132852629  ccdc88c; protein Daple isoform X1 [KO:K25811]
132848197  dvl3a; segment polarity protein dishevelled homolog DVL-3a [KO:K02353]
132848755  dvl2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
132861820  dvl1a; segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
132851000  segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
132845657  gbp; glycogen synthase kinase binding protein [KO:K03096]
132856430  csnk2a2b; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
132838186  csnk2a4; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
132856992  csnk2a2a; casein kinase 2, alpha prime polypeptide a [KO:K03097] [EC:2.7.11.1]
132845917  csnk2a1; casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
132864039  zgc:86598; STKc_CK2_alpha domain-containing protein [KO:K03097] [EC:2.7.11.1]
132842745  csnk2b; casein kinase II subunit beta [KO:K03115]
132838940  nkd1; protein naked cuticle homolog 1 isoform X1 [KO:K03213]
132840532  nkd2b; protein naked cuticle homolog 2-like [KO:K03213]
132847745  cxxc4; CXXC-type zinc finger protein 4 [KO:K03344]
132862152  CXXC-type zinc finger protein 4 [KO:K03344]
132844983  senp2; sentrin-specific protease 2 [KO:K03345] [EC:3.4.22.68]
132850410  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
132839315  gsk3bb; glycogen synthase kinase 3 beta, genome duplicate b isoform X1 [KO:K03083] [EC:2.7.11.26]
132860692  catenin beta-1-like [KO:K02105]
132845822  ctnnb1; catenin beta-1 isoform X1 [KO:K02105]
132837648  axin1; axin-1 isoform X1 [KO:K02157]
132839693  axin-1-like [KO:K02157]
132860944  axin2; axin-2 [KO:K04385]
132844846  axin-2-like [KO:K04385]
132851976  apc2; adenomatous polyposis coli protein 2 [KO:K02085]
132863415  apc; adenomatous polyposis coli protein isoform X1 [KO:K02085]
132856037  csnk1a1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
132860516  tcf7; transcription factor 7 isoform X1 [KO:K02620]
132853353  tcf7l1b; transcription factor 7-like 1-B [KO:K04490]
132837872  tcf7l2; transcription factor 7-like 2 isoform X1 [KO:K04491]
132847602  lef1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
132862751  lzts2b; leucine zipper putative tumor suppressor 2 homolog [KO:K26471]
132847214  lzts2a; leucine zipper putative tumor suppressor 2a isoform X1 [KO:K26471]
132862667  ctnnbip1; beta-catenin-interacting protein 1 [KO:K04493]
132859652  cby1; protein chibby homolog 1 [KO:K23402]
132848327  chd8; chromodomain-helicase-DNA-binding protein 8 isoform X1 [KO:K04494] [EC:5.6.2.-]
132840962  mcc; colorectal mutant cancer protein isoform X1 [KO:K26734]
132863773  ccar2; cell cycle and apoptosis regulator protein 2 isoform X1 [KO:K25816]
132847057  sirt1; NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
132848469  sox17; transcription factor SOX-17 [KO:K04495]
132855646  C-terminal-binding protein 1 isoform X1 [KO:K04496] [EC:1.1.1.428]
132855991  C-terminal-binding protein 1 isoform X1 [KO:K04496] [EC:1.1.1.428]
132861955  uncharacterized protein LOC132861955 isoform X1 [KO:K04496] [EC:1.1.1.428]
132852399  ctbp2a; C-terminal-binding protein 2a isoform X1 [KO:K04496] [EC:1.1.1.428]
132839030  tle3b; transducin-like enhancer protein 3-B isoform X1 [KO:K04497]
132853241  tle2b; transducin-like enhancer protein 4 [KO:K04497]
132853256  tle2a; transducin-like enhancer protein 2a isoform X1 [KO:K04497]
132848413  ctnnd2b; catenin delta-2b [KO:K23491]
132840574  ctnnd2a; catenin delta-2 isoform X1 [KO:K23491]
132842528  ep300b; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
132860854  crebbpb; CREB binding protein b isoform X1 [KO:K04498] [EC:2.3.1.48]
132838641  ep300a; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
132838823  crebbpa; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
132844454  ruvbl1; ruvB-like 1 [KO:K04499] [EC:5.6.2.4]
132854569  smad4b; mothers against decapentaplegic homolog 4 [KO:K04501]
132842697  smad10a; mothers against decapentaplegic homolog 4 [KO:K04501]
132863382  smad4a; mothers against decapentaplegic homolog 4a [KO:K04501]
132845948  smad10b; mothers against decapentaplegic homolog 4 [KO:K04501]
132851229  smad3b; mothers against decapentaplegic homolog 3b [KO:K23605]
132838542  smad3a; mothers against decapentaplegic homolog 3a [KO:K23605]
132854562  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
132861090  nlk1; nemo-like kinase, type 1 [KO:K04468] [EC:2.7.11.24]
132857770  nlk2; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
132848371  mycb; transcriptional regulator Myc-B [KO:K04377]
132840463  myca; transcriptional regulator Myc-A [KO:K04377]
132849017  transcription factor Jun-like [KO:K04448]
132843425  jun; transcription factor AP-1 [KO:K04448]
132841102  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
132855970  fosl1a; fos-related antigen 1a [KO:K04502]
132856637  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
132855556  ccnd2a; G1/S-specific cyclin-D2a [KO:K10151]
132859211  ccnd2b; G1/S-specific cyclin-D2b [KO:K10151]
132837892  ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
132837584  ccn4a; cellular communication network factor 4a isoform X1 [KO:K22471]
132845915  ccn4b; cellular communication network factor 4b isoform X1 [KO:K22471]
132853196  ppardb; peroxisome proliferator-activated receptor delta b [KO:K04504]
132852201  psen1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
132848952  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b [KO:K04345] [EC:2.7.11.11]
132837519  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
132839525  prkacab; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
132853762  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
132848547  cellular tumor antigen p53-like [KO:K04451]
132840785  tp53; cellular tumor antigen p53 isoform X1 [KO:K04451]
132851256  siah1; E3 ubiquitin-protein ligase Siah1 isoform X1 [KO:K04506] [EC:2.3.2.27]
132848336  cacybp; calcyclin-binding protein [KO:K04507]
132859931  skp1; S-phase kinase-associated protein 1 [KO:K03094]
132848270  tbl1xr1b; F-box-like/WD repeat-containing protein TBL1XR1b [KO:K04508]
132853612  tbl1xr1a; F-box-like/WD repeat-containing protein TBL1XR1a [KO:K04508]
132857215  fbxw11a; F-box and WD repeat domain-containing 11-A isoform X1 [KO:K03362]
132862912  fbxw11b; F-box and WD repeat domain-containing 11-B isoform X1 [KO:K03362]
132844682  cul1a; cullin-1a [KO:K03347]
132840558  cul1b; cullin-1b [KO:K03347]
132842552  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
132855685  gpc4; glypican-4 [KO:K08110]
132844308  ror1; inactive tyrosine-protein kinase transmembrane receptor ROR1 [KO:K05122] [EC:2.7.10.1]
132863290  ror2; tyrosine-protein kinase transmembrane receptor ROR2 isoform X1 [KO:K05123] [EC:2.7.10.1]
132844377  ryk; tyrosine-protein kinase RYK isoform X1 [KO:K05128] [EC:2.7.10.1]
132848978  vangl2; vang-like protein 2 isoform X1 [KO:K04510]
132850612  vangl1; vang-like protein 1 [KO:K04510]
132839323  vang-like protein 1 [KO:K04510]
132854134  prickle2a; prickle-like protein 2 [KO:K04511]
132837911  prickle2b; prickle-like protein 2b isoform X1 [KO:K04511]
132857113  prickle1a; prickle-like protein 1a [KO:K04511]
132853473  prickle3; prickle planar cell polarity protein 3-B isoform X1 [KO:K04511]
132840000  invs; inversin isoform X1 [KO:K19626]
132843305  daam1b; disheveled-associated activator of morphogenesis 1b isoform X1 [KO:K04512]
132852171  daam2; disheveled-associated activator of morphogenesis 2 isoform X1 [KO:K04512]
132852985  daam1a; disheveled-associated activator of morphogenesis 1 [KO:K04512]
132854163  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
132837815  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
132862012  rhoac; rho-related GTP-binding protein RhoA-C [KO:K04513]
132844546  rhoca; ras homolog family member Ca [KO:K04513]
132853205  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
132853369  rhocb; rho-related GTP-binding protein RhoA-D [KO:K04513]
132854388  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.1]
132846847  rock2a; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
132861415  rac1b; ras-related C3 botulinum toxin substrate 1b [KO:K04392]
132840369  rac1a; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
132861695  rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
132861572  rac3a; ras-related C3 botulinum toxin substrate 3a [KO:K07861]
132841492  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
132860001  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
132859543  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
132847307  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
132848715  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
132843282  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858] [EC:3.1.4.11]
132843283  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
132852067  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
132852337  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
132852545  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
132842039  camk2d2; calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
132848482  camk2d1; calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
132855394  camk2b1; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
132864275  camk2g1; calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1 isoform X5 [KO:K04515] [EC:2.7.11.17]
132863004  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
132859759  camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
132847498  camk2g2; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
132848538  protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
132854617  ppp3cca; protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X1 [KO:K04348] [EC:3.1.3.16]
132860314  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
132857438  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
132863758  ppp3ccb; protein phosphatase 3, catalytic subunit, gamma isozyme, b isoform X1 [KO:K04348] [EC:3.1.3.16]
132839253  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
132847007  ppp3r1a; calcineurin subunit B type 1 [KO:K06268]
132860690  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
132844847  prkcaa; protein kinase C, alpha, a isoform X1 [KO:K02677] [EC:2.7.11.13]
132861454  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
132839183  prkcba; protein kinase C, beta a isoform X1 [KO:K19662] [EC:2.7.11.13]
132845349  prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
132848409  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
132864289  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
132862258  nfatc2a; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
132844622  nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
132856699  nfatc3b; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
132838549  nfatc3a; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
132848147  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
Compound
C00076  Calcium cation
Reference
PMID:14635791
  Authors
Hatsell S, Rowlands T, Hiremath M, Cowin P.
  Title
Beta-catenin and Tcfs in mammary development and cancer.
  Journal
J Mammary Gland Biol Neoplasia 8:145-58 (2003)
DOI:10.1023/A:1025944723047
Reference
PMID:14745971
  Authors
Yang Y.
  Title
Wnts and wing: Wnt signaling in vertebrate limb development and musculoskeletal morphogenesis.
  Journal
Birth Defects Res Part C Embryo Today 69:305-17 (2003)
DOI:10.1002/bdrc.10026
Reference
PMID:12446114
  Authors
Kalderon D.
  Title
Similarities between the Hedgehog and Wnt signaling pathways.
  Journal
Trends Cell Biol 12:523-31 (2002)
DOI:10.1016/S0962-8924(02)02388-7
Reference
PMID:14530294
  Authors
Nusse R.
  Title
Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface.
  Journal
Development 130:5297-305 (2003)
DOI:10.1242/dev.00821
Reference
PMID:15102436
  Authors
Jope RS, Johnson GV.
  Title
The glamour and gloom of glycogen synthase kinase-3.
  Journal
Trends Biochem Sci 29:95-102 (2004)
DOI:10.1016/j.tibs.2003.12.004
Reference
PMID:12967557
  Authors
Veeman MT, Axelrod JD, Moon RT.
  Title
A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling.
  Journal
Dev Cell 5:367-77 (2003)
DOI:10.1016/S1534-5807(03)00266-1
Reference
PMID:11433294
  Authors
Sun TQ, Lu B, Feng JJ, Reinhard C, Jan YN, Fantl WJ, Williams LT.
  Title
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.
  Journal
Nat Cell Biol 3:628-36 (2001)
DOI:10.1038/35083016
Reference
PMID:23256519
  Authors
Saito-Diaz K, Chen TW, Wang X, Thorne CA, Wallace HA, Page-McCaw A, Lee E
  Title
The way Wnt works: Components and mechanism.
  Journal
Growth Factors 31:1-31 (2013)
DOI:10.3109/08977194.2012.752737
Reference
PMID:19482104
  Authors
Carethers JM
  Title
Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis.
  Journal
Gastroenterology 137:33-6 (2009)
DOI:10.1053/j.gastro.2009.05.011
Reference
PMID:18838381
  Authors
Lin Z, Gao C, Ning Y, He X, Wu W, Chen YG
  Title
The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt/beta-catenin signaling.
  Journal
J Biol Chem 283:33053-8 (2008)
DOI:10.1074/jbc.M804039200
Reference
PMID:23151663
  Authors
Niehrs C
  Title
The complex world of WNT receptor signalling.
  Journal
Nat Rev Mol Cell Biol 13:767-79 (2012)
DOI:10.1038/nrm3470
Reference
PMID:28522145
  Authors
Abou Ziki MD, Mani A
  Title
Wnt signaling, a novel pathway regulating blood pressure? State of the art review.
  Journal
Atherosclerosis 262:171-178 (2017)
DOI:10.1016/j.atherosclerosis.2017.05.001
Reference
PMID:25808920
  Authors
He Y, Ki H, Kim H, Kim K
  Title
delta-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity.
  Journal
Cell Biol Int 39:954-61 (2015)
DOI:10.1002/cbin.10465
Reference
PMID:32888647
  Authors
Esaki N, Enomoto A, Takagishi M, Mizutani Y, Iida T, Ushida K, Shiraki Y, Mii S, Takahashi M
  Title
The Daple-CK1epsilon complex regulates Dvl2 phosphorylation and canonical Wnt signaling.
  Journal
Biochem Biophys Res Commun 532:406-413 (2020)
DOI:10.1016/j.bbrc.2020.08.066
Reference
PMID:28242765
  Authors
Yiew NKH, Chatterjee TK, Tang YL, Pellenberg R, Stansfield BK, Bagi Z, Fulton DJ, Stepp DW, Chen W, Patel V, Kamath VM, Litwin SE, Hui DY, Rudich SM, Kim HW, Weintraub NL
  Title
A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.
  Journal
J Biol Chem 292:6312-6324 (2017)
DOI:10.1074/jbc.M116.758078
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pathway
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tvc04110  Cell cycle
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tvc04510  Focal adhesion
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KO pathway
ko04310   
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