KEGG   PATHWAY: tvc04350
Entry
tvc04350                    Pathway                                
Name
TGF-beta signaling pathway - Tachysurus vachellii
Description
The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.
Class
Environmental Information Processing; Signal transduction
Pathway map
tvc04350  TGF-beta signaling pathway
tvc04350

Other DBs
GO: 0007179
Organism
Tachysurus vachellii [GN:tvc]
Gene
132837641  gdf6b; growth/differentiation factor 6-B [KO:K20012]
132837815  [KO:K04513]
132837902  id1; DNA-binding protein inhibitor ID-1 [KO:K04680]
132837975  bmp7a; bone morphogenetic protein 7a [KO:K16621]
132838005  emp3a; epithelial membrane protein 3 [KO:K26257]
132838046  skib; v-ski avian sarcoma viral oncogene homolog b [KO:K26503]
132838102  nbl1; neuroblastoma suppressor of tumorigenicity 1 [KO:K19558]
132838110  sp1; transcription factor Sp1 [KO:K04684]
132838113  fmoda; fibromodulin a [KO:K08121]
132838542  smad3a; mothers against decapentaplegic homolog 3a [KO:K23605]
132838577  sin3ab; paired amphipathic helix protein Sin3a isoform X1 [KO:K11644]
132838641  ep300a; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
132838804  smad6a; mothers against decapentaplegic homolog 6a [KO:K04677]
132838823  crebbpa; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
132839270  tfdp1b; transcription factor Dp-1b isoform X1 [KO:K04683]
132839984  tfr1b; transferrin receptor 1b isoform X1 [KO:K06503]
132840138  hamp; hepcidin-1 [KO:K23106]
132840151  skilb; SKI-like proto-oncogene b [KO:K18499]
132840432  bmp6; bone morphogenetic protein 6 isoform X1 [KO:K16620]
132840463  myca; transcriptional regulator Myc-A [KO:K04377]
132840558  cul1b; cullin-1b [KO:K03347]
132840750  ppp2r1ba; protein phosphatase 2, regulatory subunit A, beta a [KO:K03456]
132840833  ncor1; nuclear receptor corepressor 1 isoform X1 [KO:K04650]
132841658  [KO:K04688] [EC:2.7.11.1]
132842157  [KO:K04658]
132842187  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
132842383  lft1; lefty1 [KO:K04668]
132842528  ep300b; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
132842552  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
132842697  smad10a; mothers against decapentaplegic homolog 4 [KO:K04501]
132842781  hdac1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
132842934  tfa; transferrin-a [KO:K14736]
132843225  id2b; DNA-binding protein inhibitor ID-2b [KO:K17693]
132843239  grem1a; gremlin-1a [KO:K23318]
132843245  thbs1b; thrombospondin-1 [KO:K16857]
132843286  bmp2b; bone morphogenetic protein 2b [KO:K21283]
132843884  zfyve9a; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
132843992  gdf5; growth/differentiation factor 5 [KO:K04664]
132844397  bambib; BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) b [KO:K10162]
132844508  [KO:K19553]
132844528  acvr1bb; activin receptor type-1B [KO:K13567] [EC:2.7.11.30]
132844546  rhoca; ras homolog family member Ca [KO:K04513]
132844560  tfr1a; transferrin receptor 1a [KO:K06503]
132844565  [KO:K06503]
132844583  [KO:K22687]
132844682  cul1a; cullin-1a [KO:K03347]
132844710  rbl1; retinoblastoma-like protein 1 [KO:K04681]
132844840  [KO:K04678] [EC:2.3.2.26]
132844918  acvr2ab; activin receptor type-2A [KO:K04670] [EC:2.7.11.30]
132845009  bmpr2a; bone morphogenetic protein receptor type-2a isoform X1 [KO:K04671] [EC:2.7.11.30]
132845232  nog2; noggin-2 [KO:K04658]
132845253  acvr2ba; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
132845298  id4; DNA-binding protein inhibitor ID-4 [KO:K17695]
132845551  inhbaa; inhibin subunit beta Aa [KO:K04667]
132845580  tgfbr1b; TGF-beta receptor type-1b isoform X1 [KO:K04674] [EC:2.7.11.30]
132845689  gdf6a; growth/differentiation factor 6-A [KO:K20012]
132845693  tgfbr2b; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
132845709  tgfb2; transforming growth factor beta-2 proprotein [KO:K13376]
132845857  [KO:K13596] [EC:2.7.11.30]
132845932  hjv; hemojuvelin [KO:K23100]
132845948  smad10b; mothers against decapentaplegic homolog 4 [KO:K04501]
132846276  nrros; transforming growth factor beta activator LRRC33 [KO:K26317]
132846284  tgif1; homeobox protein TGIF1 [KO:K19383]
132847019  bmp5; bone morphogenetic protein 5 isoform X1 [KO:K04663]
132847504  bmpr1aa; bone morphogenetic protein receptor, type IAa [KO:K04673] [EC:2.7.11.30]
132847643  smad1; mothers against decapentaplegic homolog 1 isoform X1 [KO:K04676]
132847742  cdkn2a/b; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
132847925  e2f5; transcription factor E2F5 [KO:K04682]
132848173  skila; ski-like protein isoform X1 [KO:K18499]
132848292  inhbab; inhibin subunit beta Ab [KO:K04667]
132848296  acvr1l; activin receptor type-1 isoform X1 [KO:K04675] [EC:2.7.11.30]
132848371  mycb; transcriptional regulator Myc-B [KO:K04377]
132848395  tmem53; transmembrane protein 53 [KO:K28359]
132849148  rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
132849264  tgfb1a; transforming growth factor, beta 1a [KO:K13375]
132849823  acvr2aa; activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
132850120  inhbb; inhibin beta B chain [KO:K22687]
132850132  tfdp1a; transcription factor Dp-1a [KO:K04683]
132850288  bmpr2b; bone morphogenetic protein receptor type-2 isoform X1 [KO:K04671] [EC:2.7.11.30]
132850330  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
132850383  [KO:K13568] [EC:2.7.11.30]
132850384  [KO:K04675] [EC:2.7.11.30]
132850956  amh; muellerian-inhibiting factor isoform X1 [KO:K04665]
132851229  smad3b; mothers against decapentaplegic homolog 3b [KO:K23605]
132851232  smad6b; mothers against decapentaplegic homolog 6b [KO:K04677]
132851380  si:dkey-5i3.5; transmembrane protein 53-A isoform X1 [KO:K28359]
132851433  adamtsl7; thrombospondin type-1 domain-containing protein 4 isoform X1 [KO:K23377]
132851542  fbn1; fibrillin-1 [KO:K06825]
132851562  zfyve9b; zinc finger FYVE domain-containing protein 9 [KO:K04679]
132851754  bmp16; bone morphogenetic protein 16 [KO:K21283]
132851967  ltbp1; latent-transforming growth factor beta-binding protein 1 isoform X1 [KO:K19559]
132852037  grem1b; gremlin-1 [KO:K23318]
132852113  grem2a; gremlin-2 [KO:K23318]
132852264  tgfb3; transforming growth factor beta-3 proprotein [KO:K13377]
132852340  bmp2a; bone morphogenetic protein 2 [KO:K21283]
132852387  bmp4; bone morphogenetic protein 4 [KO:K04662]
132852516  id3; DNA-binding protein inhibitor ID-3 [KO:K17694]
132852572  lft2; lefty2 [KO:K04668]
132852684  id2a; DNA-binding protein inhibitor ID-2a [KO:K17693]
132852724  gdf7; growth/differentiation factor 6-A [KO:K20013]
132852810  [KO:K16857]
132852911  rgmd; RGM domain family, member D [KO:K23096]
132853205  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
132853369  rhocb; rho-related GTP-binding protein RhoA-D [KO:K04513]
132853806  fmodb; fibromodulin [KO:K08121]
132854155  skia; v-ski avian sarcoma viral oncogene homolog a [KO:K26503]
132854163  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
132854299  spaw; southpaw [KO:K04666]
132854450  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
132854569  smad4b; mothers against decapentaplegic homolog 4 [KO:K04501]
132854875  fsta; follistatin-A [KO:K04661]
132854946  rgmb; RGM domain family member B [KO:K06847]
132855671  smad5; mothers against decapentaplegic homolog 5 [KO:K16790]
132855809  pitx2; pituitary homeobox 2 isoform X1 [KO:K04686]
132855840  tgfb5; transforming growth factor beta-2 proprotein [KO:K13376]
132856121  e2f4; transcription factor E2F4 [KO:K04682]
132856133  [KO:K22687]
132856659  sin3aa; SIN3 transcription regulator family member Aa [KO:K11644]
132856758  neo1a; neogenin 1a isoform X1 [KO:K06766]
132856815  ppp2caa; protein phosphatase 2 catalytic subunit alpha a [KO:K04382] [EC:3.1.3.16]
132856926  neo1b; neogenin isoform X1 [KO:K06766]
132856985  [KO:K04388] [EC:2.7.11.30]
132857756  ppp2r1bb; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
132857979  [KO:K21283]
132858197  rps6kb1b; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
132858334  chrd; chordin [KO:K04657]
132858650  ndr2; nodal-related 2 [KO:K04666]
132858666  dcn; decorin [KO:K04660]
132858676  lemd3; inner nuclear membrane protein Man1 [KO:K19410]
132859071  ifng1; interferon gamma 1 isoform X1 [KO:K04687]
132859342  nog3; noggin-3 [KO:K04658]
132859754  smad7; mothers against decapentaplegic homolog 7 [KO:K19631]
132859931  skp1; S-phase kinase-associated protein 1 [KO:K03094]
132860172  ndr1; nodal-related 1 [KO:K04666]
132860460  tgfb1b; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
132860854  crebbpb; CREB binding protein b isoform X1 [KO:K04498] [EC:2.3.1.48]
132861356  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
132861737  smurf2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
132861900  tfr2; transferrin receptor protein 2 [KO:K23910]
132861962  acvr1ba; activin A receptor type 1Ba isoform X1 [KO:K13567] [EC:2.7.11.30]
132862012  rhoac; rho-related GTP-binding protein RhoA-C [KO:K04513]
132862013  [KO:K04680]
132862138  emp3b; epithelial membrane protein 3b [KO:K26257]
132862727  admp; anti-dorsalizing morphogenic protein [KO:K21283]
132862779  grem2b; gremlin-2b [KO:K23318]
132862968  zfyve16; zinc finger FYVE domain-containing protein 16 [KO:K04679]
132862990  smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
132863045  bmpr1bb; bone morphogenetic protein receptor, type IBb isoform X1 [KO:K13578] [EC:2.7.11.30]
132863095  smad9; mothers against decapentaplegic homolog 9 [KO:K16791]
132863110  lrrc32; transforming growth factor beta activator LRRC32 [KO:K26316]
132863148  fstb; follistatin b [KO:K04661]
132863256  bmpr1ab; bone morphogenetic protein receptor, type IAb [KO:K04673] [EC:2.7.11.30]
132863382  smad4a; mothers against decapentaplegic homolog 4a [KO:K04501]
132863759  ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
132863918  bmp8a; bone morphogenetic protein 8A [KO:K16622]
132863968  smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
132864046  bambia; BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a [KO:K10162]
Compound
C14819  Fe3+
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
  Journal
Cell 113:685-700 (2003)
DOI:10.1016/S0092-8674(03)00432-X
Reference
PMID:14534577
  Authors
Derynck R, Zhang YE.
  Title
Smad-dependent and Smad-independent pathways in TGF-beta family signalling.
  Journal
Nature 425:577-84 (2003)
DOI:10.1038/nature02006
Reference
PMID:11252892
  Authors
Massague J.
  Title
How cells read TGF-beta signals.
  Journal
Nat Rev Mol Cell Biol 1:169-78 (2000)
DOI:10.1038/35043051
Reference
PMID:14557817
  Authors
Siegel PM, Massague J.
  Title
Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer.
  Journal
Nat Rev Cancer 3:807-21 (2003)
DOI:10.1038/nrc1208
Reference
PMID:14769828
  Authors
Shimasaki S, Moore RK, Otsuka F, Erickson GF.
  Title
The bone morphogenetic protein system in mammalian reproduction.
  Journal
Endocr Rev 25:72-101 (2004)
DOI:10.1210/er.2003-0007
Reference
PMID:11252746
  Authors
De Robertis EM, Larrain J, Oelgeschlager M, Wessely O.
  Title
The establishment of Spemann's organizer and patterning of the vertebrate embryo.
  Journal
Nat Rev Genet 1:171-81 (2000)
DOI:10.1038/35042039
Reference
PMID:12163231
  Authors
Gumienny TL, Padgett RW.
  Title
The other side of TGF-beta superfamily signal regulation: thinking outside the cell.
  Journal
Trends Endocrinol Metab 13:295-9 (2002)
DOI:10.1016/S1043-2760(02)00615-X
Reference
PMID:11836504
  Authors
Hamada H, Meno C, Watanabe D, Saijoh Y.
  Title
Establishment of vertebrate left-right asymmetry.
  Journal
Nat Rev Genet 3:103-13 (2002)
DOI:10.1038/nrg732
Reference
PMID:12466190
  Authors
Chang H, Brown CW, Matzuk MM.
  Title
Genetic analysis of the mammalian transforming growth factor-beta superfamily.
  Journal
Endocr Rev 23:787-823 (2002)
DOI:10.1210/er.2002-0003
Reference
PMID:10021351
  Authors
Morita K, Chow KL, Ueno N.
  Title
Regulation of body length and male tail ray pattern formation of Caenorhabditis elegans by a member of TGF-beta family.
  Journal
Development 126:1337-47 (1999)
Reference
PMID:9847239
  Authors
Krishna S, Maduzia LL, Padgett RW.
  Title
Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.
  Journal
Development 126:251-60 (1999)
Reference
PMID:15063168
  Authors
Chen Y, Mironova E, Whitaker LL, Edwards L, Yost HJ, Ramsdell AF.
  Title
ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus.
  Journal
Dev Biol 268:280-94 (2004)
DOI:10.1016/j.ydbio.2003.12.035
Reference
PMID:10519551
  Authors
Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, Massague J, Niehrs C
  Title
Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.
  Journal
Nature 401:480-5 (1999)
DOI:10.1038/46794
Reference
PMID:19758997
  Authors
Yan X, Lin Z, Chen F, Zhao X, Chen H, Ning Y, Chen YG
  Title
Human BAMBI cooperates with Smad7 to inhibit transforming growth factor-beta signaling.
  Journal
J Biol Chem 284:30097-104 (2009)
DOI:10.1074/jbc.M109.049304
Reference
PMID:8093006
  Authors
Hildebrand A, Romaris M, Rasmussen LM, Heinegard D, Twardzik DR, Border WA, Ruoslahti E
  Title
Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta.
  Journal
Biochem J 302 ( Pt 2):527-34 (1994)
DOI:10.1042/bj3020527
Reference
PMID:10934147
  Authors
Soo C, Hu FY, Zhang X, Wang Y, Beanes SR, Lorenz HP, Hedrick MH, Mackool RJ, Plaas A, Kim SJ, Longaker MT, Freymiller E, Ting K
  Title
Differential expression of fibromodulin, a transforming growth factor-beta modulator, in fetal skin development and scarless repair.
  Journal
Am J Pathol 157:423-33 (2000)
DOI:10.1016/s0002-9440(10)64555-5
Reference
PMID:16642010
  Authors
Anderson GJ, Frazer DM
  Title
Iron metabolism meets signal transduction.
  Journal
Nat Genet 38:503-4 (2006)
DOI:10.1038/ng0506-503
Reference
PMID:26735394
  Authors
Canali S, Core AB, Zumbrennen-Bullough KB, Merkulova M, Wang CY, Schneyer AL, Pietrangelo A, Babitt JL
  Title
Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.
  Journal
Endocrinology 157:1146-62 (2016)
DOI:10.1210/en.2015-1747
Reference
PMID:26160612
  Authors
Ganz T, Nemeth E
  Title
Iron homeostasis in host defence and inflammation.
  Journal
Nat Rev Immunol 15:500-10 (2015)
DOI:10.1038/nri3863
Reference
PMID:15975920
  Authors
Babitt JL, Zhang Y, Samad TA, Xia Y, Tang J, Campagna JA, Schneyer AL, Woolf CJ, Lin HY
  Title
Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:29820-7 (2005)
DOI:10.1074/jbc.M503511200
Reference
PMID:15671031
  Authors
Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ
  Title
DRAGON, a bone morphogenetic protein co-receptor.
  Journal
J Biol Chem 280:14122-9 (2005)
DOI:10.1074/jbc.M410034200
Reference
PMID:33925597
  Authors
Vogt AS, Arsiwala T, Mohsen M, Vogel M, Manolova V, Bachmann MF
  Title
On Iron Metabolism and Its Regulation.
  Journal
Int J Mol Sci 22:ijms22094591 (2021)
DOI:10.3390/ijms22094591
Reference
PMID:20495575
  Authors
Ikushima H, Miyazono K
  Title
TGFbeta signalling: a complex web in cancer progression.
  Journal
Nat Rev Cancer 10:415-24 (2010)
DOI:10.1038/nrc2853
Reference
PMID:38267638
  Authors
Wu M, Wu S, Chen W, Li YP
  Title
The roles and regulatory mechanisms of TGF-beta and BMP signaling in bone and cartilage development, homeostasis and disease.
  Journal
Cell Res 34:101-123 (2024)
DOI:10.1038/s41422-023-00918-9
Related
pathway
tvc04010  MAPK signaling pathway
tvc04110  Cell cycle
tvc04120  Ubiquitin mediated proteolysis
tvc04210  Apoptosis
KO pathway
ko04350   

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