KEGG   PATHWAY: xma03320
Entry
xma03320                    Pathway                                
Name
PPAR signaling pathway - Xiphophorus maculatus (southern platyfish)
Description
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake.
Class
Organismal Systems; Endocrine system
Pathway map
xma03320  PPAR signaling pathway
xma03320

Organism
Xiphophorus maculatus (southern platyfish) [GN:xma]
Gene
102229773  cd36; platelet glycoprotein 4 [KO:K06259]
102231497  slc27a4; long-chain fatty acid transport protein 4 isoform X2 [KO:K08745] [EC:6.2.1.-]
102233139  slc27a1; long-chain fatty acid transport protein 1 [KO:K08745] [EC:6.2.1.-]
102232299  long-chain fatty acid transport protein 1-like isoform X1 [KO:K08745] [EC:6.2.1.-]
102228805  very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
102229067  very long-chain acyl-CoA synthetase [KO:K08746] [EC:6.2.1.- 6.2.1.3]
102224041  very long-chain acyl-CoA synthetase-like [KO:K08746] [EC:6.2.1.- 6.2.1.3]
102221783  fabp1; fatty acid-binding protein, liver [KO:K08750]
102229169  fabp2; fatty acid-binding protein, intestinal isoform X1 [KO:K08751]
102225496  fatty acid-binding protein, intestinal-like [KO:K08751]
102216737  fatty acid-binding protein, heart [KO:K08752]
102230447  fatty acid-binding protein, heart-like [KO:K08752]
102232459  fatty acid-binding protein, adipocyte-like isoform X1 [KO:K08753]
111612144  fatty acid-binding protein, adipocyte-like [KO:K08753]
102217901  gastrotropin [KO:K08755]
102231949  gastrotropin-like [KO:K08755]
102218712  fatty acid-binding protein, brain [KO:K08756]
111612273  fatty acid-binding protein, brain-like [KO:K08756]
102233829  fatty acid-binding protein, brain-like [KO:K08756]
102236028  peroxisome proliferator-activated receptor alpha-like [KO:K07294]
102229315  ppara; peroxisome proliferator-activated receptor alpha [KO:K07294]
102234004  rxra; retinoic acid receptor RXR-alpha isoform X4 [KO:K08524]
102218909  retinoic acid receptor RXR-beta-A-like isoform X1 [KO:K08524]
102217951  retinoic acid receptor RXR-beta-A isoform X2 [KO:K08525]
102222228  retinoic acid receptor RXR-gamma-B isoform X1 [KO:K08526]
102219133  ppard; peroxisome proliferator-activated receptor delta [KO:K04504]
102229218  pparg; peroxisome proliferator-activated receptor gamma isoform X2 [KO:K08530]
102231993  LOW QUALITY PROTEIN: hydroxymethylglutaryl-CoA synthase, cytoplasmic-like [KO:K01641] [EC:2.3.3.10]
102220007  apolipoprotein A-I [KO:K08757]
102230377  type-4 ice-structuring protein LS-12-like [KO:K08758]
102223091  phospholipid transfer protein-like [KO:K08761]
102234139  pltp; phospholipid transfer protein isoform X1 [KO:K08761]
102231048  NADP-dependent malic enzyme-like [KO:K00029] [EC:1.1.1.40]
102216866  me1; NADP-dependent malic enzyme [KO:K00029] [EC:1.1.1.40]
102222635  fatty acid desaturase 2-like [KO:K10226] [EC:1.14.19.3]
102222890  fatty acid desaturase 2-like [KO:K10226] [EC:1.14.19.3]
102223144  fatty acid desaturase 2-like [KO:K10226] [EC:1.14.19.3]
102220656  acyl-CoA desaturase-like [KO:K00507] [EC:1.14.19.1]
102235901  acyl-CoA desaturase-like isoform X1 [KO:K00507] [EC:1.14.19.1]
102216615  cholesterol 7-alpha-monooxygenase [KO:K00489] [EC:1.14.14.23]
102227191  7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase [KO:K07431] [EC:1.14.14.139]
102221658  nr1h3; oxysterols receptor LXR-alpha [KO:K08536]
102234938  sterol 26-hydroxylase, mitochondrial-like [KO:K00488] [EC:1.14.15.15]
102230910  cytochrome P450 27C1 isoform X1 [KO:K00488] [EC:1.14.15.15]
102234678  sterol 26-hydroxylase, mitochondrial-like [KO:K00488] [EC:1.14.15.15]
102225514  sterol 26-hydroxylase, mitochondrial-like isoform X1 [KO:K00488] [EC:1.14.15.15]
102231117  dbi; acyl-CoA-binding protein [KO:K08762]
102226696  acyl-CoA-binding protein [KO:K08762]
102224511  acbd7; acyl-CoA-binding domain-containing protein 7 [KO:K08762]
102225809  lipoprotein lipase-like [KO:K01059] [EC:3.1.1.34]
102226072  lipoprotein lipase-like [KO:K01059] [EC:3.1.1.34]
102235268  acsl5; long-chain-fatty-acid--CoA ligase 5 [KO:K01897] [EC:6.2.1.3]
102234334  long-chain-fatty-acid--CoA ligase 3-like [KO:K01897] [EC:6.2.1.3]
102218120  long-chain-fatty-acid--CoA ligase 1-like [KO:K01897] [EC:6.2.1.3]
102221393  acsl3; long-chain-fatty-acid--CoA ligase 3 [KO:K01897] [EC:6.2.1.3]
102220814  long-chain-fatty-acid--CoA ligase 1-like [KO:K01897] [EC:6.2.1.3]
102219420  long-chain-fatty-acid--CoA ligase 6-like [KO:K01897] [EC:6.2.1.3]
102237722  acsl4; long-chain-fatty-acid--CoA ligase 4 isoform X1 [KO:K01897] [EC:6.2.1.3]
102228381  acsl1; long-chain-fatty-acid--CoA ligase 1 isoform X1 [KO:K01897] [EC:6.2.1.3]
102219561  long-chain-fatty-acid--CoA ligase ACSBG2-like [KO:K15013] [EC:6.2.1.3]
102229939  acsbg2; long-chain-fatty-acid--CoA ligase ACSBG2 isoform X1 [KO:K15013] [EC:6.2.1.3]
102219640  ehhadh; peroxisomal bifunctional enzyme [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
102223074  acaa1; 3-ketoacyl-CoA thiolase, peroxisomal [KO:K07513] [EC:2.3.1.16]
102226285  non-specific lipid-transfer protein [KO:K08764] [EC:2.3.1.176]
102236229  acox1; peroxisomal acyl-coenzyme A oxidase 1 isoform X1 [KO:K00232] [EC:1.3.3.6]
102224659  acox3; peroxisomal acyl-coenzyme A oxidase 3 [KO:K00232] [EC:1.3.3.6]
102218697  carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
102225046  carnitine O-palmitoyltransferase 1, liver isoform-like [KO:K08765] [EC:2.3.1.21]
102219078  carnitine O-palmitoyltransferase 1, liver isoform-like isoform X1 [KO:K08765] [EC:2.3.1.21]
102228587  carnitine O-palmitoyltransferase 1, liver isoform-like isoform X1 [KO:K08765] [EC:2.3.1.21]
102234740  cpt2; carnitine O-palmitoyltransferase 2, mitochondrial [KO:K08766] [EC:2.3.1.21]
102229820  acadl; long-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1 [KO:K00255] [EC:1.3.8.8]
106700234  long-chain specific acyl-CoA dehydrogenase, mitochondrial-like [KO:K00255] [EC:1.3.8.8]
102232409  acadm; medium-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00249] [EC:1.3.8.7]
102225445  angiopoietin-related protein 4-like [KO:K08767]
102217459  angptl4; angiopoietin-related protein 4 [KO:K08767]
102224122  sorbs1; sorbin and SH3 domain-containing protein 1 isoform X1 [KO:K06086]
102218808  perilipin-2-like isoform X1 [KO:K17284]
102233329  uncharacterized protein LOC102233329 isoform X1 [KO:K17284]
102217919  plin2; perilipin-2 [KO:K17284]
102231522  integrin-linked protein kinase-like [KO:K06272] [EC:2.7.11.1]
102225759  ilk; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
102230385  pdpk1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
102218444  ubb; polyubiquitin-B isoform X1 [KO:K08770]
102229513  pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
102237618  pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
102232902  glycerol kinase isoform X1 [KO:K00864] [EC:2.7.1.30]
102225159  glycerol kinase-like isoform X1 [KO:K00864] [EC:2.7.1.30]
102218348  aquaporin-7-like isoform X1 [KO:K08771]
Compound
C02165  Leukotriene B4
C14762  13(S)-HODE
C14767  9(S)-HODE
C14776  8(S)-HETE
C15493  9-cis-Retinoic acid
Reference
PMID:15828220
  Authors
Takahashi N, Goto T, Kusudo T, Moriyama T, Kawada T.
  Title
[The structures and functions of peroxisome proliferator-activated receptors (PPARs)]
  Journal
Nippon Rinsho 63:557-64 (2005)
Reference
PMID:15828221
  Authors
Fujii H.
  Title
[PPARs-mediated intracellular signal transduction]
  Journal
Nippon Rinsho 63:565-71 (2005)
Reference
PMID:15828222
  Authors
Takada I, Kato S.
  Title
[PPARs target genes]
  Journal
Nippon Rinsho 63:573-7 (2005)
Reference
PMID:15828223
  Authors
Inoue H.
  Title
[Endogenous ligands for PPARs]
  Journal
Nippon Rinsho 63:578-83 (2005)
Reference
PMID:16476485
  Authors
Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W.
  Title
From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions.
  Journal
Prog Lipid Res 45:120-59 (2006)
DOI:10.1016/j.plipres.2005.12.002
Reference
PMID:16601267
  Authors
Desvergne B, Michalik L, Wahli W.
  Title
Transcriptional regulation of metabolism.
  Journal
Physiol Rev 86:465-514 (2006)
DOI:10.1152/physrev.00025.2005
Reference
PMID:14999402
  Authors
Mandard S, Muller M, Kersten S.
  Title
Peroxisome proliferator-activated receptor alpha target genes.
  Journal
Cell Mol Life Sci 61:393-416 (2004)
DOI:10.1007/s00018-003-3216-3
Reference
PMID:10529898
  Authors
Desvergne B, Wahli W.
  Title
Peroxisome proliferator-activated receptors: nuclear control of metabolism.
  Journal
Endocr Rev 20:649-88 (1999)
DOI:10.1210/edrv.20.5.0380
Reference
PMID:15673477
  Authors
Savage DB.
  Title
PPARgamma as a metabolic regulator: insights from genomics and pharmacology.
  Journal
Expert Rev Mol Med 2005:1-16 (2005)
DOI:10.1017/S1462399405008793
Reference
PMID:16511590
  Authors
Semple RK, Chatterjee VK, O'Rahilly S.
  Title
PPAR gamma and human metabolic disease.
  Journal
J Clin Invest 116:581-9 (2006)
DOI:10.1172/JCI28003
Reference
PMID:16360030
  Authors
Lehrke M, Lazar MA.
  Title
The many faces of PPARgamma.
  Journal
Cell 123:993-9 (2005)
DOI:10.1016/j.cell.2005.11.026
Reference
PMID:11921433
  Authors
Hauner H.
  Title
The mode of action of thiazolidinediones.
  Journal
Diabetes Metab Res Rev 18 Suppl 2:S10-5 (2002)
DOI:10.1002/dmrr.249
Related
pathway
xma00071  Fatty acid degradation
xma00120  Primary bile acid biosynthesis
xma00564  Glycerophospholipid metabolism
xma04920  Adipocytokine signaling pathway
KO pathway
ko03320   
LinkDB

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