KEGG   PATHWAY: zab04150
Entry
zab04150                    Pathway                                
Name
mTOR signaling pathway - Zonotrichia albicollis (white-throated sparrow)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
zab04150  mTOR signaling pathway
zab04150

Organism
Zonotrichia albicollis (white-throated sparrow) [GN:zab]
Gene
102062190  SLC7A5; large neutral amino acids transporter small subunit 1 [KO:K13780]
102067917  SLC38A9; sodium-coupled neutral amino acid transporter 9 isoform X1 [KO:K14995]
102063891  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
106630574  V-type proton ATPase subunit B-like [KO:K02147]
102073501  V-type proton ATPase subunit B, brain isoform [KO:K02147]
102075354  ATP6V1C2; V-type proton ATPase subunit C 2 [KO:K02148]
102065926  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
102074137  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
102067946  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
102068807  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
102066398  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
102068492  ATP6V1H; V-type proton ATPase subunit H [KO:K02144]
102073710  ragulator complex protein LAMTOR1-like [KO:K20397]
102071589  LAMTOR1; ragulator complex protein LAMTOR1 [KO:K20397]
102061300  LAMTOR2; ragulator complex protein LAMTOR2 [KO:K20398]
102062471  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
102065858  LAMTOR5; ragulator complex protein LAMTOR5 [KO:K16344]
102070712  FLCN; folliculin [KO:K09594]
102061374  FNIP1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
102072942  FNIP2; folliculin-interacting protein 2 isoform X1 [KO:K20401]
102070034  ras-related GTP-binding protein A [KO:K16185]
102070214  ras-related GTP-binding protein A [KO:K16185]
102064025  RRAGC; ras-related GTP-binding protein C [KO:K16186]
102074914  SESN2; sestrin-2 isoform X1 [KO:K20394]
102065234  CASTOR2; cytosolic arginine sensor for mTORC1 subunit 2 isoform X3 [KO:K23081]
102072576  MIOS; GATOR complex protein MIOS [KO:K20407]
102068144  SEH1L; nucleoporin SEH1 isoform X1 [KO:K14299]
102063568  WDR24; GATOR complex protein WDR24 [KO:K20408]
102072197  WDR59; GATOR complex protein WDR59 isoform X1 [KO:K20409]
102062431  SEC13; protein SEC13 homolog [KO:K14004]
102061006  DEPDC5; GATOR complex protein DEPDC5 [KO:K20404]
102072002  NPRL2; GATOR complex protein NPRL2 [KO:K20405]
102062315  NPRL3; GATOR complex protein NPRL3 [KO:K20406]
102063901  SKP2; S-phase kinase-associated protein 2 [KO:K03875]
102061131  RNF152; E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
102068111  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
102062491  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
102072071  DEP domain-containing mTOR-interacting protein isoform X2 [KO:K20402]
102066054  DEPTOR; DEP domain-containing mTOR-interacting protein [KO:K20402]
102071502  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
102073031  TELO2; telomere length regulation protein TEL2 homolog isoform X1 [KO:K11137]
102068398  TTI1; TELO2-interacting protein 1 homolog [KO:K20403]
102064256  CLIP1; CAP-Gly domain-containing linker protein 1 [KO:K10421]
102068869  GRB10; growth factor receptor-bound protein 10 [KO:K20064]
102074648  LPIN2; phosphatidate phosphatase LPIN2 [KO:K15728] [EC:3.1.3.4]
102063601  phosphatidate phosphatase LPIN3 [KO:K15728] [EC:3.1.3.4]
102063551  LPIN1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
102073647  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
102073901  ULK2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
113460492  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
102071523  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
102072122  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
102068135  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
102063274  ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
102064437  RPS6KB1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
102075440  EIF4B; eukaryotic translation initiation factor 4B isoform X3 [KO:K03258]
102061107  RPS6; 40S ribosomal protein S6 [KO:K02991]
102074984  STRADA; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
102072705  STRADB; STE20-related kinase adapter protein beta isoform X1 [KO:K17532]
102072162  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
102064128  CAB39; calcium-binding protein 39 [KO:K08272]
102067121  CAB39L; calcium-binding protein 39-like [KO:K08272]
102067793  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
102063815  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
102069656  TSC1; hamartin isoform X1 [KO:K07206]
102062324  TSC2; tuberin isoform X1 [KO:K07207]
102074874  TBC1 domain family member 7 [KO:K20396]
102068369  RHEB; GTP-binding protein Rheb [KO:K07208]
102069614  WNT1; proto-oncogene Wnt-1 [KO:K03209]
102065801  WNT2B; protein Wnt-2b [KO:K00182]
102064975  protein Wnt-2 [KO:K00182]
102074256  proto-oncogene Wnt-3 [KO:K00312]
102074012  protein Wnt-3a [KO:K00312]
102065852  WNT4; protein Wnt-4 isoform X3 [KO:K00408]
102070934  WNT5B; protein Wnt-5b [KO:K00444]
102061441  WNT5A; protein Wnt-5a [KO:K00444]
102065522  WNT6; protein Wnt-6 isoform X1 [KO:K00445]
102074744  WNT7A; protein Wnt-7a [KO:K00572]
102060494  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
102063935  WNT8B; protein Wnt-8b [KO:K00714]
102067064  WNT8A; protein Wnt-8a [KO:K00714]
102074077  WNT9B; protein Wnt-9b [KO:K01064]
102074180  protein Wnt-9a [KO:K01064]
102065340  WNT10A; protein Wnt-10a [KO:K01357]
102067785  WNT11; protein Wnt-11 isoform X2 [KO:K01384]
102067264  protein Wnt-11b [KO:K01384]
102064289  WNT16; protein Wnt-16 [KO:K01558]
102070688  FZD1; frizzled-1 [KO:K02432]
102071639  FZD7; frizzled-7 [KO:K02432]
102073786  frizzled-2 [KO:K02235]
102065733  FZD3; frizzled-3 [KO:K02329]
102074824  FZD4; frizzled-4 [KO:K02354]
102067065  FZD5; frizzled-5 [KO:K02375]
102065738  FZD6; frizzled-6 isoform X1 [KO:K02376]
102065243  FZD9; frizzled-9 [KO:K02842]
102064645  FZD10; frizzled-10 [KO:K02842]
102071962  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
102061195  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
102066068  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X3 [KO:K02353]
102062558  DVL1; segment polarity protein dishevelled homolog DVL-1 [KO:K02353]
102066010  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
102065462  tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102073615  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102072773  INS; insulin [KO:K04526]
102063644  IGF1; insulin-like growth factor I [KO:K05459]
102069793  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
102066292  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102075088  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
102065734  son of sevenless homolog 2 [KO:K03099]
102064587  SOS1; son of sevenless homolog 1 [KO:K03099]
102070663  HRAS; GTPase HRas [KO:K02833]
102062345  KRAS; GTPase KRas [KO:K07827]
102063862  NRAS; GTPase NRas [KO:K07828]
102072406  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
102068297  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
102061434  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102064782  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102066965  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102071765  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X2 [KO:K04373] [EC:2.7.11.1]
102062175  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
102067821  RPS6KA1; ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
102070414  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
102067323  IRS1; insulin receptor substrate 1 [KO:K16172]
102072114  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
102070553  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102060529  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102064934  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102075147  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
102069576  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102064718  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
102075317  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
102070994  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102071413  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102074629  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
102074303  MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410]
102066491  RICTOR; rapamycin-insensitive companion of mTOR isoform X1 [KO:K08267]
102063611  PRR5; proline-rich protein 5 [KO:K20411]
102065740  PRR5L; proline-rich protein 5-like [KO:K20411]
102063234  RHOA; transforming protein RhoA [KO:K04513]
102068394  protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
102065127  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
102075037  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
zab00561  Glycerolipid metabolism
zab04010  MAPK signaling pathway
zab04140  Autophagy - animal
zab04810  Regulation of actin cytoskeleton
zab04910  Insulin signaling pathway
KO pathway
ko04150   
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