KEGG   PATHWAY: pcad00630
Entry
pcad00630                   Pathway                                
Name
Glyoxylate and dicarboxylate metabolism - Physeter macrocephalus (sperm whale)
Class
Metabolism; Carbohydrate metabolism
Pathway map
pcad00630  Glyoxylate and dicarboxylate metabolism
pcad00630

Module
pcad_M00621  Glycine cleavage system [PATH:pcad00630]
pcad_M00741  Propanoyl-CoA metabolism, propanoyl-CoA => succinyl-CoA [PATH:pcad00630]
Other DBs
GO: 0046487 0043648
Organism
Physeter macrocephalus (sperm whale) [GN:pcad]
Gene
102974196  [KO:K00049] [EC:1.1.1.79 1.1.1.81]
102974755  AGXT2; alanine--glyoxylate aminotransferase 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
102974990  ACSS2; acetyl-coenzyme A synthetase, cytoplasmic isoform X1 [KO:K01895] [EC:6.2.1.1]
102975610  SHMT2; serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
102975788  SHMT1; serine hydroxymethyltransferase, cytosolic isoform X2 [KO:K00600] [EC:2.1.2.1]
102976260  AFMID; kynurenine formamidase isoform X1 [KO:K01432] [EC:3.5.1.9]
102976741  ACO1; cytoplasmic aconitate hydratase [KO:K01681] [EC:4.2.1.3]
102977348  ACAT1; acetyl-CoA acetyltransferase, mitochondrial isoform X2 [KO:K00626] [EC:2.3.1.9]
102978051  MMUT; methylmalonyl-CoA mutase, mitochondrial [KO:K01847] [EC:5.4.99.2]
102978840  GLYCTK; glycerate kinase isoform X1 [KO:K11529] [EC:2.7.1.165]
102979032  HOGA1; 4-hydroxy-2-oxoglutarate aldolase, mitochondrial isoform X9 [KO:K18123] [EC:4.1.3.16]
102979403  AGXT; alanine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
102980142  [KO:K01895] [EC:6.2.1.1]
102980300  ACO2; aconitate hydratase, mitochondrial [KO:K01681] [EC:4.2.1.3]
102980545  ACAT2; acetyl-CoA acetyltransferase, cytosolic [KO:K00626] [EC:2.3.1.9]
102980839  CS; citrate synthase, mitochondrial [KO:K01647] [EC:2.3.3.1]
102981569  MCEE; methylmalonyl-CoA epimerase, mitochondrial isoform X2 [KO:K05606] [EC:5.1.99.1]
102982015  GCSH; glycine cleavage system H protein, mitochondrial [KO:K02437]
102982047  AMT; aminomethyltransferase, mitochondrial isoform X1 [KO:K00605] [EC:2.1.2.10]
102982726  PGP; glycerol-3-phosphate phosphatase [KO:K19269] [EC:3.1.3.18 3.1.3.48]
102983410  PCCA; propionyl-CoA carboxylase alpha chain, mitochondrial isoform X1 [KO:K01965] [EC:6.4.1.3]
102984437  PCCB; propionyl-CoA carboxylase beta chain, mitochondrial [KO:K01966] [EC:6.4.1.3 2.1.3.15]
102985021  MDH2; malate dehydrogenase, mitochondrial [KO:K00026] [EC:1.1.1.37]
102985917  CAT; catalase isoform X2 [KO:K03781] [EC:1.11.1.6]
102987468  HAO2; 2-Hydroxyacid oxidase 2 isoform X1 [KO:K11517] [EC:1.1.3.15]
102987631  [KO:K02437]
102987935  [KO:K00026] [EC:1.1.1.37]
102989047  GLUL; glutamine synthetase isoform X1 [KO:K01915] [EC:6.3.1.2]
102991152  HAO1; 2-Hydroxyacid oxidase 1 [KO:K11517] [EC:1.1.3.15]
102991479  [KO:K02437]
102992090  MDH1; malate dehydrogenase, cytoplasmic [KO:K00025] [EC:1.1.1.37]
102995086  GLDC; glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
102995210  HYI; putative hydroxypyruvate isomerase isoform X3 [KO:K01816] [EC:5.3.1.22]
102996392  DLD; dihydrolipoyl dehydrogenase, mitochondrial [KO:K00382] [EC:1.8.1.4]
112062286  [KO:K02437]
112062707  [KO:K02437]
112062708  [KO:K02437]
112062732  [KO:K02437]
112063108  [KO:K02437]
112065493  [KO:K00049] [EC:1.1.1.79 1.1.1.81]
112066001  [KO:K02437]
112066928  [KO:K02437]
112066947  [KO:K02437]
Compound
C00007  Oxygen
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00024  Acetyl-CoA
C00025  L-Glutamate
C00026  2-Oxoglutarate
C00027  Hydrogen peroxide
C00033  Acetate
C00036  Oxaloacetate
C00037  Glycine
C00042  Succinate
C00048  Glyoxylate
C00049  L-Aspartate
C00058  Formate
C00064  L-Glutamine
C00065  L-Serine
C00091  Succinyl-CoA
C00100  Propanoyl-CoA
C00111  Glycerone phosphate
C00136  Butanoyl-CoA
C00149  (S)-Malate
C00158  Citrate
C00160  Glycolate
C00168  Hydroxypyruvate
C00197  3-Phospho-D-glycerate
C00209  Oxalate
C00258  D-Glycerate
C00266  Glycolaldehyde
C00311  Isocitrate
C00313  Oxalyl-CoA
C00332  Acetoacetyl-CoA
C00417  cis-Aconitate
C00552  meso-Tartaric acid
C00631  2-Phospho-D-glycerate
C00683  (S)-Methylmalonyl-CoA
C00798  Formyl-CoA
C00877  Crotonoyl-CoA
C00888  Pentanoyl-CoA
C00898  (R,R)-Tartaric acid
C00975  Dihydroxyfumarate
C00988  2-Phosphoglycolate
C01127  4-Hydroxy-2-oxoglutarate
C01146  2-Hydroxy-3-oxopropanoate
C01182  D-Ribulose 1,5-bisphosphate
C01213  (R)-Methylmalonyl-CoA
C01380  Ethylene glycol
C01732  Mesaconate
C01989  3-Ethylmalate
C01990  3-Oxalomalate
C02123  3-Propylmalate
C02405  Formyl phosphate
C03217  2-Hydroxy-3-oxoadipate
C03459  2-Hydroxy-3-oxosuccinate
C03548  trans-2,3-Epoxysuccinate
C03561  (R)-3-Hydroxybutanoyl-CoA
C03618  L-threo-3-Methylaspartate
C04348  L-Malyl-CoA
C05840  Iminoaspartate
C06027  L-erythro-3-Methylmalyl-CoA
C06028  2-Methylfumaryl-CoA
C06049  N-Formylderivatives
C18026  (2S)-Ethylmalonyl-CoA
C18324  (2S)-Methylsuccinyl-CoA
C19838  D-erythro-3-Hydroxyaspartate
C20238  (2R)-Ethylmalonyl-CoA
C22337  D-Ribulose 1-phosphate
Reference
PMID:10978349
  Authors
Njau RK, Herndon CA, Hawes JW.
  Title
Novel beta-hydroxyacid dehydrogenases in Escherichia coli and Haemophilus influenzae.
  Journal
J Biol Chem 275:38780-6 (2000)
DOI:10.1074/jbc.M007432200
Reference
PMID:18065535
  Authors
Zarzycki J, Schlichting A, Strychalsky N, Muller M, Alber BE, Fuchs G
  Title
Mesaconyl-coenzyme A hydratase, a new enzyme of two central carbon metabolic pathways in bacteria.
  Journal
J Bacteriol 190:1366-74 (2008)
DOI:10.1128/JB.01621-07
Reference
PMID:18819910
  Authors
Erb TJ, Retey J, Fuchs G, Alber BE
  Title
Ethylmalonyl-CoA mutase from Rhodobacter sphaeroides defines a new subclade of coenzyme B12-dependent acyl-CoA mutases.
  Journal
J Biol Chem 283:32283-93 (2008)
DOI:10.1074/jbc.M805527200
Reference
PMID:9596633
  Authors
Coschigano KT, Melo-Oliveira R, Lim J, Coruzzi GM
  Title
Arabidopsis gls mutants and distinct Fd-GOGAT genes. Implications for photorespiration and primary nitrogen assimilation.
  Journal
Plant Cell 10:741-52 (1998)
DOI:10.1105/tpc.10.5.741
Reference
PMID:16407450
  Authors
Masclaux-Daubresse C, Reisdorf-Cren M, Pageau K, Lelandais M, Grandjean O, Kronenberger J, Valadier MH, Feraud M, Jouglet T, Suzuki A
  Title
Glutamine synthetase-glutamate synthase pathway and glutamate dehydrogenase play distinct roles in the sink-source nitrogen cycle in tobacco.
  Journal
Plant Physiol 140:444-56 (2006)
DOI:10.1104/pp.105.071910
Reference
PMID:21252347
  Authors
Khomyakova M, Bukmez O, Thomas LK, Erb TJ, Berg IA
  Title
A methylaspartate cycle in haloarchaea.
  Journal
Science 331:334-7 (2011)
DOI:10.1126/science.1196544
Reference
PMID:11513957
  Authors
Serrano JA, Bonete MJ
  Title
Sequencing, phylogenetic and transcriptional analysis of the glyoxylate bypass operon (ace) in the halophilic archaeon Haloferax volcanii.
  Journal
Biochim Biophys Acta 1520:154-62 (2001)
DOI:10.1016/S0167-4781(01)00263-9
Related
pathway
pcad00010  Glycolysis / Gluconeogenesis
pcad00020  Citrate cycle (TCA cycle)
pcad00030  Pentose phosphate pathway
pcad00053  Ascorbate and aldarate metabolism
pcad00071  Fatty acid degradation
pcad00230  Purine metabolism
pcad00250  Alanine, aspartate and glutamate metabolism
pcad00260  Glycine, serine and threonine metabolism
pcad00270  Cysteine and methionine metabolism
pcad00620  Pyruvate metabolism
pcad00750  Vitamin B6 metabolism
pcad00910  Nitrogen metabolism
KO pathway
ko00630   

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