KEGG   PATHWAY: pcad00230
Entry
pcad00230                   Pathway                                
Name
Purine metabolism - Physeter macrocephalus (sperm whale)
Class
Metabolism; Nucleotide metabolism
Pathway map
pcad00230  Purine metabolism
pcad00230

Module
pcad_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:pcad00230]
pcad_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:pcad00230]
pcad_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:pcad00230]
pcad_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:pcad00230]
pcad_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:pcad00230]
pcad_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:pcad00230]
Other DBs
GO: 0006163 0042278
Organism
Physeter macrocephalus (sperm whale) [GN:pcad]
Gene
102973128  PRPS1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
102973146  GMPS; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
102973312  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 isoform X4 [KO:K00088] [EC:1.1.1.205]
102973347  AMPD2; AMP deaminase 2 isoform X4 [KO:K01490] [EC:3.5.4.6]
102973455  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
102973596  AK4; adenylate kinase 4, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
102974148  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
102974161  NME7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
102974384  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 isoform X1 [KO:K18424] [EC:3.6.1.29]
102974685  HDDC3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
102974886  PDE6A; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha [KO:K08718] [EC:3.1.4.35]
102975211  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
102975539  RRM2; ribonucleoside-diphosphate reductase subunit M2 isoform X2 [KO:K10808] [EC:1.17.4.1]
102975756  [KO:K00760] [EC:2.4.2.8]
102975950  AK7; adenylate kinase 7 isoform X1 [KO:K00939] [EC:2.7.4.3]
102975974  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X6 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
102976054  DCK; deoxycytidine kinase isoform X1 [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
102976143  AK5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
102976351  PGM2; phosphopentomutase isoform X2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
102976801  ENTPD2; LOW QUALITY PROTEIN: ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
102977178  HDDC2; 5'-deoxynucleotidase HDDC2 isoform X2 [KO:K07023] [EC:3.1.3.89]
102977471  NME1; nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
102977738  PDE6B; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K13756] [EC:3.1.4.35]
102978052  ADCY10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
102978644  GUCY2F; retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
102978761  GUCY2C; guanylyl cyclase C isoform X1 [KO:K12320] [EC:4.6.1.2]
102978885  [KO:K00940] [EC:2.7.4.6]
102978888  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
102979015  AK9; adenylate kinase 9 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
102979027  APRT; adenine phosphoribosyltransferase isoform X2 [KO:K00759] [EC:2.4.2.7]
102979298  [KO:K01519] [EC:3.6.1.66]
102979456  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
102979535  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type isoform X1 [KO:K01081] [EC:3.1.3.5]
102979545  ATIC; bifunctional purine biosynthesis protein ATIC [KO:K00602] [EC:2.1.2.3 3.5.4.10]
102979718  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
102979919  ADSS1; adenylosuccinate synthetase isozyme 1 isoform X1 [KO:K01939] [EC:6.3.4.4]
102980160  XDH; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
102980216  [KO:K22600] [EC:4.6.1.2]
102980772  ADSL; adenylosuccinate lyase isoform X3 [KO:K01756] [EC:4.3.2.2]
102981071  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
102981075  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X2 [KO:K12305] [EC:3.6.1.6]
102981161  GDA; guanine deaminase [KO:K01487] [EC:3.5.4.3]
102981199  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
102981246  DGUOK; deoxyguanosine kinase, mitochondrial isoform X2 [KO:K00904] [EC:2.7.1.113]
102981674  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
102981766  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
102981872  NT5E; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
102981879  LACC1; purine nucleoside phosphorylase LACC1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
102982019  [KO:K13755] [EC:3.1.4.17]
102982050  NPR1; atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
102982317  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
102982370  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
102982406  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
102982435  [KO:K01514] [EC:3.6.1.11]
102982915  NME3; nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
102982949  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 [KO:K01511] [EC:3.6.1.6]
102983042  [KO:K00365] [EC:1.7.3.3]
102983176  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
102983243  PNP; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
102983290  AMPD1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
102983319  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
102983368  NME6; nucleoside diphosphate kinase 6 isoform X1 [KO:K00940] [EC:2.7.4.6]
102983708  PRPS2; ribose-phosphate pyrophosphokinase 2 [KO:K00948] [EC:2.7.6.1]
102984013  PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X2 [KO:K18283] [EC:3.1.4.17]
102984028  AK3; GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
102984260  NUDT16; U8 snoRNA-decapping enzyme [KO:K16855] [EC:3.6.1.62 3.6.1.64]
102984421  ADSS2; adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
102984464  NTPCR; cancer-related nucleoside-triphosphatase isoform X2 [KO:K06928] [EC:3.6.1.15]
102984647  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
102984964  NME4; nucleoside diphosphate kinase, mitochondrial isoform X2 [KO:K00940] [EC:2.7.4.6]
102985075  ADCY7; adenylate cyclase type 7 isoform X4 [KO:K08047] [EC:4.6.1.1]
102985101  [KO:K00760] [EC:2.4.2.8]
102985678  ADA; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
102985761  PRPS1L1; LOW QUALITY PROTEIN: ribose-phosphate pyrophosphokinase 3 [KO:K00948] [EC:2.7.6.1]
102985820  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
102985912  AK6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
102986152  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
102986174  NUDT5; ADP-sugar pyrophosphatase isoform X3 [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
102986230  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform X1 [KO:K13296] [EC:3.1.4.17]
102986245  [KO:K13293] [EC:3.1.4.53]
102986284  [KO:K00948] [EC:2.7.6.1]
102986395  [KO:K01490] [EC:3.5.4.6]
102986526  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
102986887  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
102987472  [KO:K12322] [EC:4.6.1.2]
102987518  [KO:K00948] [EC:2.7.6.1]
102987998  ALLC; LOW QUALITY PROTEIN: probable inactive allantoicase [KO:K01477] [EC:3.5.3.4]
102988170  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
102988464  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
102988817  GUK1; guanylate kinase isoform X1 [KO:K00942] [EC:2.7.4.8]
102989136  ADCY3; adenylate cyclase type 3 isoform X3 [KO:K08043] [EC:4.6.1.1]
102989295  GMPR2; GMP reductase 2 isoform X7 [KO:K00364] [EC:1.7.1.7]
102989382  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
102989446  CANT1; soluble calcium-activated nucleotidase 1 isoform X2 [KO:K12304] [EC:3.6.1.6]
102989553  PDE10A; LOW QUALITY PROTEIN: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [KO:K18438] [EC:3.1.4.17 3.1.4.35]
102989661  PDE1A; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
102989992  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A [KO:K19021] [EC:3.1.4.17]
102990096  ADK; adenosine kinase isoform X2 [KO:K00856] [EC:2.7.1.20]
102990329  AK1; adenylate kinase isoenzyme 1 [KO:K00939] [EC:2.7.4.3]
102990360  NT5C2; cytosolic purine 5'-nucleotidase isoform X2 [KO:K01081] [EC:3.1.3.5]
102990405  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
102990588  ADA2; adenosine deaminase 2 [KO:K19572] [EC:3.5.4.4]
102990767  ENTPD5; nucleoside diphosphate phosphatase ENTPD5 isoform X1 [KO:K01511] [EC:3.6.1.6]
102990948  [KO:K00939] [EC:2.7.4.3]
102991189  GUCY2D; retinal guanylyl cyclase 1 [KO:K12321] [EC:4.6.1.2]
102991224  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
102991536  [KO:K00364] [EC:1.7.1.7]
102991571  PGM1; phosphoglucomutase-1 isoform X2 [KO:K01835] [EC:5.4.2.2]
102991665  NPR2; atrial natriuretic peptide receptor 2 isoform X2 [KO:K12324] [EC:4.6.1.2]
102991676  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
102991688  PDE1C; LOW QUALITY PROTEIN: dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
102991712  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
102991905  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
102992058  [KO:K00760] [EC:2.4.2.8]
102992148  [KO:K00088] [EC:1.1.1.205]
102992725  NT5C1B; LOW QUALITY PROTEIN: cytosolic 5'-nucleotidase 1B [KO:K01081] [EC:3.1.3.5]
102992792  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C [KO:K13293] [EC:3.1.4.53]
102993360  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
102994081  PPAT; amidophosphoribosyltransferase isoform X2 [KO:K00764] [EC:2.4.2.14]
102994352  GUCY1A1; guanylate cyclase soluble subunit alpha-1 isoform X2 [KO:K12318] [EC:4.6.1.2]
102994385  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X9 [KO:K13293] [EC:3.1.4.53]
102994548  PAICS; bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X2 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
102994635  GUCY1B1; guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
102994752  [KO:K07023] [EC:3.1.3.89]
102995162  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta isoform X5 [KO:K13758]
102995407  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
102995533  PFAS; phosphoribosylformylglycinamidine synthase isoform X1 [KO:K01952] [EC:6.3.5.3]
102995803  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
102995944  RRM1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
102995948  [KO:K11265] [EC:4.6.1.1]
102995999  FHIT; bis(5'-adenosyl)-triphosphatase isoform X1 [KO:K01522] [EC:3.6.1.29]
102996845  NUDT9; ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
102996960  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
112062191  [KO:K00760] [EC:2.4.2.8]
112062521  [KO:K01519] [EC:3.6.1.66]
112062704  [KO:K18437] [EC:3.1.4.53]
112064559  [KO:K00760] [EC:2.4.2.8]
112065402  URAD; LOW QUALITY PROTEIN: putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K13485] [EC:4.1.1.97]
112065994  [KO:K00760] [EC:2.4.2.8]
114484295  GMPR; LOW QUALITY PROTEIN: GMP reductase 1 [KO:K00364] [EC:1.7.1.7]
114487447  [KO:K00939] [EC:2.7.4.3]
114487448  [KO:K00939] [EC:2.7.4.3]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
pcad00030  Pentose phosphate pathway
pcad00220  Arginine biosynthesis
pcad00250  Alanine, aspartate and glutamate metabolism
pcad00260  Glycine, serine and threonine metabolism
pcad00340  Histidine metabolism
pcad00630  Glyoxylate and dicarboxylate metabolism
pcad00730  Thiamine metabolism
pcad00740  Riboflavin metabolism
pcad00790  Folate biosynthesis
KO pathway
ko00230   

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