KEGG   PATHWAY: pcad04612
Entry
pcad04612                   Pathway                                
Name
Antigen processing and presentation - Physeter macrocephalus (sperm whale)
Class
Organismal Systems; Immune system
Pathway map
pcad04612  Antigen processing and presentation
pcad04612

Other DBs
GO: 0019885 0019886 0042591
Organism
Physeter macrocephalus (sperm whale) [GN:pcad]
Gene
102973375  [KO:K03283]
102973764  [KO:K06752]
102973944  [KO:K06752]
102974164  HSPA2; heat shock-related 70 kDa protein 2 [KO:K26598]
102974203  RFXAP; regulatory factor X-associated protein [KO:K08063]
102974358  [KO:K03283]
102974479  [KO:K06752]
102974923  [KO:K01365] [EC:3.4.22.15]
102976012  [KO:K06752]
102976287  [KO:K06752]
102976852  [KO:K08057]
102977193  CD8B; T-cell surface glycoprotein CD8 beta chain [KO:K06459]
102977953  CD8A; T-cell surface glycoprotein CD8 alpha chain isoform X2 [KO:K06458]
102978403  [KO:K04079]
102978546  [KO:K06752]
102979785  CTSS; cathepsin S isoform X1 [KO:K01368] [EC:3.4.22.27]
102979796  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
102980083  [KO:K04079]
102981551  IFNG; interferon gamma [KO:K04687]
102981790  RFXANK; DNA-binding protein RFXANK isoform X2 [KO:K08062]
102982689  HSPA8; LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein [KO:K03283]
102983069  TNF; tumor necrosis factor [KO:K03156]
102983768  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
102983803  [KO:K03283]
102983822  CTSB; cathepsin B isoform X1 [KO:K01363] [EC:3.4.22.1]
102984407  CANX; calnexin [KO:K08054]
102985047  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
102985058  TAPBP; tapasin [KO:K08058]
102985933  [KO:K06751]
102986227  [KO:K03283]
102987950  [KO:K06697]
102988543  [KO:K01365] [EC:3.4.22.15]
102988570  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
102988583  B2M; beta-2-microglobulin isoform X2 [KO:K08055]
102989030  [KO:K03283]
102989082  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
102989263  HSPA4; heat shock 70 kDa protein 4 [KO:K09489]
102989333  NFYB; nuclear transcription factor Y subunit beta isoform X1 [KO:K08065]
102989950  [KO:K08055]
102990464  RFX5; DNA-binding protein RFX5 [KO:K08061]
102990601  HSPA6; LOW QUALITY PROTEIN: heat shock 70 kDa protein 6 [KO:K03283]
102990676  PSME3; proteasome activator complex subunit 3 [KO:K06698]
102991609  IFI30; gamma-interferon-inducible lysosomal thiol reductase [KO:K08059]
102992696  NFYA; nuclear transcription factor Y subunit alpha isoform X1 [KO:K08064]
102992942  [KO:K06752]
102993456  CIITA; MHC class II transactivator isoform X1 [KO:K08060] [EC:2.7.11.1]
102993670  NFYC; nuclear transcription factor Y subunit gamma isoform X1 [KO:K08066]
102993785  PSME2; proteasome activator complex subunit 2 [KO:K06697]
102993966  CD74; HLA class II histocompatibility antigen gamma chain isoform X2 [KO:K06505]
102994322  [KO:K06752]
102994327  LGMN; legumain [KO:K01369] [EC:3.4.22.34]
102994605  [KO:K06752]
102994908  [KO:K03283]
102995173  TAP1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
102995190  [KO:K03283]
102995465  [KO:K03283]
102995730  TAP2; antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
102996148  CTSL; procathepsin L isoform X2 [KO:K01365] [EC:3.4.22.15]
102996245  [KO:K06751]
102996299  PSME1; proteasome activator complex subunit 1 [KO:K06696]
102996910  CALR; calreticulin [KO:K08057]
112064291  [KO:K06751]
112064292  [KO:K06751]
112064318  [KO:K06751]
112067373  [KO:K01365] [EC:3.4.22.15]
Reference
PMID:15771591
  Authors
Trombetta ES, Mellman I.
  Title
Cell biology of antigen processing in vitro and in vivo.
  Journal
Annu Rev Immunol 23:975-1028 (2005)
DOI:10.1146/annurev.immunol.22.012703.104538
Reference
PMID:15814328
  Authors
Inaba K, Inaba M.
  Title
Antigen recognition and presentation by dendritic cells.
  Journal
Int J Hematol 81:181-7 (2005)
DOI:10.1532/IJH97.04200
Reference
PMID:11905820
  Authors
Heath WR, Carbone FR.
  Title
Cross-presentation in viral immunity and self-tolerance.
  Journal
Nat Rev Immunol 1:126-34 (2001)
DOI:10.1038/35100512
Reference
PMID:15304636
  Authors
Abele R, Tampe R.
  Title
The ABCs of immunology: structure and function of TAP, the transporter associated with antigen processing.
  Journal
Physiology (Bethesda) 19:216-24 (2004)
DOI:10.1152/physiol.00002.2004
Reference
PMID:16200082
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
PMID:12776207
  Authors
Honey K, Rudensky AY.
  Title
Lysosomal cysteine proteases regulate antigen presentation.
  Journal
Nat Rev Immunol 3:472-82 (2003)
DOI:10.1038/nri1110
Reference
PMID:12974477
  Authors
Sercarz EE, Maverakis E.
  Title
Mhc-guided processing: binding of large antigen fragments.
  Journal
Nat Rev Immunol 3:621-9 (2003)
DOI:10.1038/nri1149
Reference
PMID:15224093
  Authors
Ackerman AL, Cresswell P.
  Title
Cellular mechanisms governing cross-presentation of exogenous antigens.
  Journal
Nat Immunol 5:678-84 (2004)
DOI:10.1038/ni1082
Reference
PMID:16181333
  Authors
Cresswell P, Ackerman AL, Giodini A, Peaper DR, Wearsch PA.
  Title
Mechanisms of MHC class I-restricted antigen processing and cross-presentation.
  Journal
Immunol Rev 207:145-57 (2005)
DOI:10.1111/j.0105-2896.2005.00316.x
Reference
PMID:15653312
  Authors
Zika E, Ting JP.
  Title
Epigenetic control of MHC-II: interplay between CIITA and histone-modifying enzymes.
  Journal
Curr Opin Immunol 17:58-64 (2005)
DOI:10.1016/j.coi.2004.11.008
Reference
PMID:11244040
  Authors
Reith W, Mach B.
  Title
The bare lymphocyte syndrome and the regulation of MHC expression.
  Journal
Annu Rev Immunol 19:331-73 (2001)
DOI:10.1146/annurev.immunol.19.1.331
Reference
PMID:15745856
  Authors
Lizee G, Basha G, Jefferies WA.
  Title
Tails of wonder: endocytic-sorting motifs key for exogenous antigen presentation.
  Journal
Trends Immunol 26:141-9 (2005)
DOI:10.1016/j.it.2005.01.005
Reference
PMID:15224094
  Authors
Watts C.
  Title
The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules.
  Journal
Nat Immunol 5:685-92 (2004)
DOI:10.1038/ni1088
Reference
PMID:15653315
  Authors
Kaufmann SH, Schaible UE.
  Title
Antigen presentation and recognition in bacterial infections.
  Journal
Curr Opin Immunol 17:79-87 (2005)
DOI:10.1016/j.coi.2004.12.004
Reference
PMID:20010787
  Authors
Groettrup M, Kirk CJ, Basler M
  Title
Proteasomes in immune cells: more than peptide producers?
  Journal
Nat Rev Immunol 10:73-8 (2010)
DOI:10.1038/nri2687
Related
pathway
pcad03050  Proteasome
pcad04650  Natural killer cell mediated cytotoxicity
pcad04660  T cell receptor signaling pathway
KO pathway
ko04612   

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