KEGG   PATHWAY: phas03015
Entry
phas03015                   Pathway                                
Name
mRNA surveillance pathway - Phyllostomus hastatus (greater spear-nosed bat)
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
Pathway map
phas03015  mRNA surveillance pathway
phas03015

Other DBs
GO: 0071028
Organism
Phyllostomus hastatus (greater spear-nosed bat) [GN:phas]
Gene
123804431  SMG5; protein SMG5 isoform X1 [KO:K11125]
123804528  RBM8A; RNA-binding protein 8A isoform X1 [KO:K12876]
123805024  NCBP2L; LOW QUALITY PROTEIN: nuclear cap-binding protein subunit 2-like [KO:K12883]
123805042  NXF3; LOW QUALITY PROTEIN: nuclear RNA export factor 3 [KO:K14284]
123805043  [KO:K14284]
123805092  CSTF2; cleavage stimulation factor subunit 2 isoform X1 [KO:K14407]
123805233  UPF3B; regulator of nonsense transcripts 3B isoform X1 [KO:K14328]
123805238  NXT2; NTF2-related export protein 2 isoform X1 [KO:K14285]
123805399  PCF11; pre-mRNA cleavage complex 2 protein Pcf11 isoform X1 [KO:K14400]
123805916  [KO:K18655] [EC:5.6.2.7]
123806015  [KO:K18655] [EC:5.6.2.7]
123806107  NUDT21; cleavage and polyadenylation specificity factor subunit 5 [KO:K14397]
123806328  GSPT1; eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform X1 [KO:K03267]
123806355  SMG1; serine/threonine-protein kinase SMG1 isoform X1 [KO:K08873] [EC:2.7.11.1]
123807085  ETF1; eukaryotic peptide chain release factor subunit 1 [KO:K03265]
123807189  RNPS1; RNA-binding protein with serine-rich domain 1 isoform X1 [KO:K14325]
123807483  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
123807496  UPF3A; regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
123808039  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
123808140  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
123808335  CPSF2; cleavage and polyadenylation specificity factor subunit 2 [KO:K14402]
123808782  PAPOLA; poly(A) polymerase alpha isoform X1 [KO:K14376] [EC:2.7.7.19]
123809453  PAPOLB; poly(A) polymerase beta [KO:K14376] [EC:2.7.7.19]
123809960  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
123810125  CSTF3; cleavage stimulation factor subunit 3 [KO:K14408]
123810374  WDR33; pre-mRNA 3' end processing protein WDR33 isoform X1 [KO:K15542]
123810399  DDX39B; spliceosome RNA helicase DDX39B [KO:K12812] [EC:5.6.2.7]
123811636  PAPOLG; poly(A) polymerase gamma isoform X1 [KO:K14376] [EC:2.7.7.19]
123812389  CPSF6; cleavage and polyadenylation specificity factor subunit 6 isoform X1 [KO:K14398]
123812564  PYM1; partner of Y14 and mago isoform X1 [KO:K14294]
123812713  MAGOHB; protein mago nashi homolog 2 isoform X1 [KO:K12877]
123813225  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
123813597  GSPT2; eukaryotic peptide chain release factor GTP-binding subunit ERF3B [KO:K03267]
123813623  PABPC4L; polyadenylate-binding protein 4-like [KO:K13126]
123813732  DAZAP1; DAZ-associated protein 1 isoform X1 [KO:K14411]
123813817  [KO:K13126]
123814419  WDR82; WD repeat-containing protein 82 [KO:K14962]
123814729  NXT1; NTF2-related export protein 1 [KO:K14285]
123815107  PABPC1L; polyadenylate-binding protein 1-like [KO:K13126]
123815173  [KO:K12877]
123815272  CSTF1; cleavage stimulation factor subunit 1 [KO:K14406]
123815281  [KO:K12877]
123815582  FIP1L1; pre-mRNA 3'-end-processing factor FIP1 isoform X1 [KO:K14405]
123815904  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
123816715  MSI2; RNA-binding protein Musashi homolog 2 isoform X1 [KO:K14411]
123816911  ALYREF; THO complex subunit 4 [KO:K12881]
123817018  SMG6; telomerase-binding protein EST1A isoform X1 [KO:K11124] [EC:3.1.-.-]
123817433  CASC3; protein CASC3 [KO:K14323]
123817607  EIF4A3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
123817708  CPSF4L; putative cleavage and polyadenylation specificity factor subunit 4-like protein [KO:K14404]
123818170  CPSF4; cleavage and polyadenylation specificity factor subunit 4 isoform X1 [KO:K14404]
123818226  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
123818336  SMG7; protein SMG7 isoform X1 [KO:K14409]
123818512  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
123819082  [KO:K12883]
123819123  [KO:K13126]
123819130  PABPC1L2B; LOW QUALITY PROTEIN: polyadenylate-binding protein 1-like 2 [KO:K13126]
123819527  PELO; protein pelota homolog [KO:K06965]
123820277  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
123820307  [KO:K12876]
123820519  ACIN1; apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
123820521  [KO:K14396]
123821109  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
123821387  HBS1L; HBS1-like protein isoform X1 [KO:K14416]
123821502  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
123822009  RNGTT; mRNA-capping enzyme isoform X1 [KO:K13917] [EC:2.7.7.50 3.6.1.74]
123822478  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
123822494  CPSF3; cleavage and polyadenylation specificity factor subunit 3 [KO:K14403] [EC:3.1.27.-]
123822712  SAP18; histone deacetylase complex subunit SAP18 [KO:K14324]
123822936  SYMPK; symplekin isoform X1 [KO:K06100]
123823520  GLE1; mRNA export factor GLE1 [KO:K18723]
123823614  MSI1; RNA-binding protein Musashi homolog 1 isoform X1 [KO:K14411]
123824185  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
123824331  PABPC5; polyadenylate-binding protein 5 [KO:K13126]
123825185  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
123825273  PNN; pinin [KO:K13114]
123825569  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
123826122  RNMT; mRNA cap guanine-N7 methyltransferase isoform X1 [KO:K00565] [EC:2.1.1.56]
123826856  NCBP2; nuclear cap-binding protein subunit 2 [KO:K12883]
123828222  UPF1; regulator of nonsense transcripts 1 isoform X1 [KO:K14326] [EC:5.6.2.5 5.6.2.3]
123828358  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
123828672  CSTF2T; cleavage stimulation factor subunit 2 tau variant [KO:K14407]
123828790  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
123829281  CPSF7; cleavage and polyadenylation specificity factor subunit 7 isoform X1 [KO:K14398]
123829482  NXF1; nuclear RNA export factor 1 [KO:K14284]
123829523  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
123829552  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
123829890  [KO:K13126]
123830018  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
123830444  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
123831025  MAGOH; protein mago nashi homolog [KO:K12877]
123831194  UPF2; regulator of nonsense transcripts 2 isoform X1 [KO:K14327]
123831447  CLP1; polyribonucleotide 5'-hydroxyl-kinase Clp1 [KO:K14399] [EC:2.7.1.78]
123831605  [KO:K23600]
123831627  SRRM1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
123831694  PABPC4; polyadenylate-binding protein 4 isoform X1 [KO:K13126]
123832003  SSU72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [KO:K15544] [EC:3.1.3.16]
123832074  [KO:K14324]
123832670  [KO:K15544] [EC:3.1.3.16]
123832806  [KO:K15544] [EC:3.1.3.16]
123832922  CPSF1; cleavage and polyadenylation specificity factor subunit 1 [KO:K14401]
123833059  PABPC1; polyadenylate-binding protein 1 [KO:K13126]
Reference
PMID:15040442
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
DOI:10.1038/nrm1310
Reference
PMID:16723977
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
DOI:10.1038/nrm1942
Reference
PMID:17183357
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
DOI:10.1038/nrm2080
Reference
PMID:18158581
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
DOI:10.1007/s00018-007-7474-3
Reference
PMID:16715045
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
DOI:10.1038/nsmb0406-299
Related
pathway
phas03013  Nucleocytoplasmic transport
phas03018  RNA degradation
phas03040  Spliceosome
KO pathway
ko03015   

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